{"id":133,"date":"2016-06-21T17:33:25","date_gmt":"2016-06-21T17:33:25","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/silvalab\/?page_id=133"},"modified":"2017-09-22T19:04:07","modified_gmt":"2017-09-22T19:04:07","slug":"about-us","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/silvalab\/","title":{"rendered":"Home"},"content":{"rendered":"<p><a href=\"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-content\/uploads\/sites\/184\/2016\/06\/Picture1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-12\" src=\"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-content\/uploads\/sites\/184\/2016\/06\/Picture1-300x291.jpg\" alt=\"Picture1\" width=\"300\" height=\"291\" srcset=\"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-content\/uploads\/sites\/184\/2016\/06\/Picture1-300x291.jpg 300w, https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-content\/uploads\/sites\/184\/2016\/06\/Picture1.jpg 484w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>An unprecedented amount of information has been gathered from the analysis of\u00a0cancer genomes. However, our ability to use this information to identify mechanisms that are critical for cancer cells&#8217; homeostasis and proliferation is still limited. Our lab has pioneered the integration of state-of-the-art genomics, functional studies, and systems biology methods to generate functional maps, allowing us to pinpoint key regulatory hubs that, when perturbed, compromise cancer cell viability. Thus, our research aims to use this data\u00a0to elucidate novel mechanisms crucial to cancer cells&#8217; survival\u00a0that represent potential\u00a0therapeutic opportunities.<\/p>\n<p>The overall interest of our group is to understand the <strong>molecular mechanisms that regulate mammary gland development and breast cancer tumor progression <\/strong>with the ultimate goal of rationally developing effective and safe patient-oriented therapies.<\/p>\n<p>The research projects in our laboratory are structured with\u00a0three main objectives in mind:<\/p>\n<ol>\n<li>Identification of cancer-relevant functions<\/li>\n<li>In-depth mechanistic characterization of these functions<\/li>\n<li>Translation of these findings to the clinic<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>An unprecedented amount of information has been gathered from the analysis of\u00a0cancer genomes. However, our ability to use this information to identify mechanisms that are critical for cancer cells&#8217; homeostasis and proliferation is still limited. Our lab has pioneered the integration of state-of-the-art genomics, functional studies, and systems biology methods to generate functional maps, allowing [&hellip;]<\/p>\n","protected":false},"author":169,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full-width.php","meta":{"footnotes":""},"class_list":["post-133","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-json\/wp\/v2\/pages\/133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-json\/wp\/v2\/users\/169"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-json\/wp\/v2\/comments?post=133"}],"version-history":[{"count":6,"href":"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-json\/wp\/v2\/pages\/133\/revisions"}],"predecessor-version":[{"id":158,"href":"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-json\/wp\/v2\/pages\/133\/revisions\/158"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/silvalab\/wp-json\/wp\/v2\/media?parent=133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}