{"id":10,"date":"2019-11-06T15:28:40","date_gmt":"2019-11-06T15:28:40","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/sialab\/?page_id=10"},"modified":"2021-07-19T13:43:56","modified_gmt":"2021-07-19T13:43:56","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/sialab\/publications\/","title":{"rendered":"Recent Publications"},"content":{"rendered":"

2021<\/strong><\/p>\n

von Felden J, Craig AJ, Garcia-Lezana T, Labgaa I, Haber PK, D’Avola D, Asgharpour A, Dieterich D, Bonaccorso A, Torres-Martin M, Sia D, Sung MW, Tabrizian P, Schwartz M, Llovet JM, Villanueva A. Mutations in circulating tumor DNA predict primary resistance to systemic therapies in advanced hepatocellular carcinoma. Oncogene.\u00a02021 Jan;40(1):140-151.\u00a0doi: 10.1038\/s41388-020-01519-1.\u00a0Epub 2020 Oct 23.\u00a0PubMed PMID: 33097857.<\/p>\n

Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, Decker A, Worley J, Caviglia JM, Yu L, Yin D, Saito Y, Savage T, Wells RG, Mack M, Zender L, Arpaia N, Remotti HE, Rabadan R, Sims P, Leblond AL, Weber A, Riener MO, Stockwell BR, Gaublomme J, Llovet JM, Kalluri R, Michalopoulos GK, Seki E, Sia D, Chen X, Califano A, Schwabe RF. Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations. Cancer Cell. 2021 Jun 14;39(6):866-882.e11. doi: 10.1016\/j.ccell.2021.03.012. Epub 2021 Apr 29. PubMed PMID: 33930309; NIHMSID:NIHMS1695680.<\/p>\n

Moeini A, Haber PK, Sia D. Cell of origin in biliary tract cancers and clinical implications. JHep Reports. 2021; 3(2). doi: https:\/\/doi.org\/10.1016\/j.jhepr.2021.100226<\/a>.<\/p>\n

Pinyol R, Torrecilla S, Wang H, Montironi C, Piqu\u00e9-Gili M, Torres-Martin M, Wei-Qiang L, Willoughby CE, Ramadori P, Andreu-Oller C, Taik P, Lee YA, Moeini A, Peix J, Faure-Dupuy S, Riedl T, Schuehle S, Oliveira CP, Alves VA, Boffetta P, Lachenmayer A, Roessler S, Minguez B, Schirmacher P, Dufour JF, Thung SN, Reeves HL, Carrilho FJ, Chang C, Uzilov AV, Heikenwalder M, Sanyal A, Friedman SL, Sia D, Llovet JM. Molecular characterization of hepatocellular carcinoma in patients with non-alcoholic steatohepatitis. J Hepatol.\u00a02021 May 13;.\u00a0doi: 10.1016\/j.jhep.2021.04.049.\u00a0[Epub ahead of print]\u00a0PubMed PMID: 33992698.<\/p>\n

2020<\/strong><\/p>\n

Montal R, Sia D, Montironi C, Leow QL, Esteban-Fabr\u00f3 R, Pinyol R, Torres-Martin M, Bassaganyas L, Moeini A, Peix J, Cabellos L, Maeda M, Villacorta C, Tabrizian P, Rodriguez L, Castellano G, Sempoux C, Minguez B, Pawlik T, Labgaa I, Roberts L, Sole M, Fiel MI, Thung S, Roayaie S, Villanueva A, Schwartz M, Llovet JM. Molecular Classification and Therapeutic Targets in Extrahepatic Cholangiocarcinoma. J of Hepatology<\/em>. 2020 Aug;73(2):315-327. PMID: 32173382.<\/p>\n

Carrillo-Reixach J, Torrens L, Simon-Coma M, Royo L, Domingo-S\u00e0bat M, Abril-Fornaguera J, Akers N, Sala M, Ragull S, Arnal M, Villalmanzo N, Cairo S, Villanueva A, Kappler R, Garrido M, Guerra L, S\u00e1bado C, Guill\u00e9n G, Mallo M, Pi\u00f1eyro D, V\u00e1zquez-Vitali M, Kuchuk O, Mateos ME, Ram\u00edrez G, Santamar\u00eda ML, Mozo Y, Soriano A, Grotzer M, Branchereau S, de Andoin NG, L\u00f3pez-Ibor B, L\u00f3pez-Almaraz R, Salinas JA, Torres B, Hern\u00e1ndez F, Uriz JJ, Fabre M, Blanco J, Paris C, Baj\u010diov\u00e1 V, Laureys G, Masnou H, Clos A, Belendez C, Guettier C, Sumoy L, Planas R, Jord\u00e0 M, Nonell L, Czauderna P, Morland B, Sia D, Losic B, Buendia MA, Sarrias MR, Llovet JM, Armengol C.\u00a0Epigenetic footprint enables molecular risk stratification of hepatoblastoma with clinical implications. J Hepatol.<\/em> 2020 Aug;73(2):328-341. PMID: 32240714.<\/p>\n

Losic B, Craig AJ, \u2026.Sia D, Schadt EE, Sebra R, Schwartz M, Llovet JM, Thung S, Stolovitzky G, Villanueva A. Intratumoral heterogeneity and clonal evolution in liver cancer. Nat Commun. 2020 Jan 15;11(1):291. doi: 10.1038\/s41467-019-14050-z. PubMed PMID: 31941899; PubMed Central PMCID: PMC6962317.<\/p>\n

von Felden J, \u2026Sia D, Sung MW, Tabrizian P, Schwartz M, Llovet JM, Villanueva A. Mutations in circulating tumor DNA predict primary resistance to systemic therapies in advanced hepatocellular carcinoma. Oncogene<\/em>. 2021 Jan;40(1):140-151. doi: 10.1038\/s41388-020-01519-1. PMID: 33097857.<\/p>\n

Bassaganyas L, .. Sia D, Llovet JM. Copy-Number Alteration Burden Differentially Impacts Immune Profiles and Molecular Features of Hepatocellular Carcinoma. Clin Cancer Res. 2020 Dec 1;26(23):6350-6361. doi: 10.1158\/1078-0432.CCR-20-1497. PMID: 32873569<\/p>\n

2019<\/strong>
\nMoeini A, Torrecilla S, Tovar V, Montironi C, Andreu-Oller C, Peix J, Higuera M, Pfister D, Ramadori P, Pinyol R, Sol\u00e9 M, Heikenw\u00e4lder M, Friedman SL, Sia D*, Llovet JM*. An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents. Gastroenterology<\/b> 2019 Nov;157(5):1383-1397.e11. doi: 10.1053\/j.gastro.2019.07.028. * co-corresponding authors<\/p>\n

Ruiz de Galarreta M, Bresnahan E, Molina-S\u00e1nchez P, Lindblad KE, Maier B, Sia D, Puigvehi M, Miguela V, Casanova-Acebes M, Dhainaut M, Villacorta-Martin C, Singhi AD, Moghe A, von Felden J, Tal Grinspan L, Wang S, Kamphorst AO, Monga SP, Brown BD, Villanueva A, Llovet JM, Merad M, Lujambio A. \u03b2-Catenin Activation Promotes Immune Escape and Resistance to Anti-PD-1 Therapy in Hepatocellular Carcinoma. Cancer Discov<\/b> 2019 Aug;9(8):1124-1141. doi: 10.1158\/2159-8290.CD-19-0074.\u00a0<\/span><\/p>\n

Montal R, Andreu-Oller C, Bassaganyas L, Esteban-Fabr\u00f3 R, Moran S, Montironi C, Moeini A, Pinyol R, Peix J, Cabellos L, Villanueva A, Sia D, Mazzaferro V, Esteller M, Llovet JM. Molecular portrait of high alpha-fetoprotein in hepatocellular carcinoma: implications for biomarker-driven clinical trials. Br J Cancer<\/b> 2019 Aug;121(4):340-343. doi: 10.1038\/s41416-019-0513-7.\u00a0<\/span><\/p>\n

Pinyol R, Montal R, Bassaganyas L, Sia D, Takayama T, Chau GY, Mazzaferro V, Roayaie S, Lee HC, Kokudo N, Zhang Z, Torrecilla S, Moeini A, Rodriguez-Carunchio L, Gane E, Verslype C, Croitoru AE, Cillo U, de la Mata M, Lupo L, Strasser S, Park JW, Camps J, Sol\u00e9 M, Thung SN, Villanueva A, Pena C, Meinhardt G, Bruix J, Llovet JM. Molecular predictors of prevention of recurrence in HCC with sorafenib as adjuvant treatment and prognostic factors in the phase 3 STORM trial. Gut<\/b> 2019 Jun;68(6):1065-1075. doi: 10.1136\/gutjnl-2018-316408.\u00a0<\/span><\/p>\n

Pinyol R, Sia D, Llovet JM. Immune Exclusion-Wnt\/CTNNB1 Class Predicts Resistance to Immunotherapies in HCC. Clin Cancer Res<\/b> 2019 Apr 1;25(7):2021-2023. doi: 10.1158\/1078-0432.CCR-18-3778.
\n<\/span><\/p>\n

2018<\/strong>
\nLlovet JM, Montal R, Sia D, Finn RS. Molecular therapies and precision medicine for hepatocellular carcinoma. Nat Rev Clin Oncol<\/b> 2018 Oct;15(10):599-616. doi: 10.1038\/s41571-018-0073-4.<\/p>\n

Labgaa I, Villacorta-Martin C, D’Avola D, Craig AJ, von Felden J, Martins-Filho SN, Sia D, Stueck A, Ward SC, Fiel MI, Mahajan M, Tabrizian P, Thung SN, Ang C, Friedman SL, Llovet JM, Schwartz M, Villanueva A. A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma. Oncogene<\/b> 2018 Jul;37(27):3740-3752. doi: 10.1038\/s41388-018-0206-3.\u00a0<\/span><\/p>\n

2017<\/strong>
\n<\/b>Torrecilla S*, Sia D*, Harrington AN*, Zhang Z, Cabellos L, Cornella H, Moeini A, Camprecios G, Leow WQ, Fiel MI, Hao K, Bassaganyas L, Mahajan M, Thung SN, Villanueva A, Florman S, Schwartz ME, Llovet JM. Trunk mutational events present minimal intra- and inter-tumoral heterogeneity in hepatocellular carcinoma. J Hepatol<\/b> 2017 Dec;67(6):1222-1231. doi: 10.1016\/j.jhep.2017.08.013.\u00a0<\/span><\/p>\n

Sia D, Llovet JM. Liver cancer: Translating ‘-omics’ results into precision medicine for hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol<\/b> 2017 Oct;14(10):571-572. doi: 10.1038\/nrgastro.2017.103.\u00a0<\/span><\/p>\n

Sia D, Jiao Y, Martinez-Quetglas I, Kuchuk O, Villacorta-Martin C, Castro de Moura M, Putra J, Camprecios G, Bassaganyas L, Akers N, Losic B, Waxman S, Thung SN, Mazzaferro V, Esteller M, Friedman SL, Schwartz M, Villanueva A, Llovet JM. Identification of an Immune-specific Class of Hepatocellular Carcinoma, Based on Molecular Features. Gastroenterology<\/b> 2017 Sep;153(3):812-826. doi: 10.1053\/j.gastro.2017.06.007.\u00a0<\/span><\/p>\n

Bollard J, Miguela V, Ruiz de Galarreta M, Venkatesh A, Bian CB, Roberto MP, Tovar V, Sia D, Molina-S\u00e1nchez P, Nguyen CB, Nakagawa S, Llovet JM, Hoshida Y, Lujambio A. Palbociclib (PD-0332991), a selective CDK4\/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma. Gut<\/b> 2017 Jul;66(7):1286-1296. doi: 10.1136\/gutjnl-2016-312268.\u00a0<\/span><\/p>\n

Moeini A, Sia D, Zhang Z, Camprecios G, Stueck A, Dong H, Montal R, Torrens L, Martinez-Quetglas I, Fiel MI, Hao K, Villanueva A, Thung SN, Schwartz ME, Llovet JM. Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity. J Hepatol<\/b> 2017 May;66(5):952-961. doi: 10.1016\/j.jhep.2017.01.010.\u00a0<\/span><\/p>\n

Tovar V, Cornella H, Moeini A, Vidal S, Hoshida Y, Sia D, Peix J, Cabellos L, Alsinet C, Torrecilla S, Martinez-Quetglas I, Lozano JJ, Desbois-Mouthon C, Sol\u00e9 M, Domingo-Domenech J, Villanueva A, Llovet JM. Tumour initiating cells and IGF\/FGF signalling contribute to sorafenib resistance in hepatocellular carcinoma. Gut<\/b> 2017 Mar;66(3):530-540. doi: 10.1136\/gutjnl-2015-309501.\u00a0<\/span><\/p>\n

Sia D, Villanueva A, Friedman SL, Llovet JM. Liver Cancer Cell of Origin, Molecular Class, and Effects on Patient Prognosis. Gastroenterology<\/b> 2017 Mar;152(4):745-761. doi: 10.1053\/j.gastro.2016.11.048.\u00a0<\/span><\/p>\n

Labgaa I, Torrecilla S, Martinez-Quetglas I, Sia D. Genetics of hepatocellular carcinoma: risk stratification, clinical outcome and implications for therapy. Digestive Disease Interventions. 2017; 01(02):055-065. doi: 10.1055\/s-0037-1603577.<\/p>\n

2016<\/strong>
\n<\/b>Abou-Alfa GK, Andersen JB, Chapman W, Choti M, Forbes SJ, Gores GJ, Hong TS, Harding JJ, Vander Heiden MG, Javle M, Kelley RK, Kwong LN, Lowery M, Merrell A, Miyabe K, Rhim A, Saha S, Sia D, Tanasanvimon S, Venook A, Valle JW, Walesky C, Whetstine J, Willenbring H, Zhu AX, Mayer D, Stanger BZ. Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference. J Gastrointest Oncol<\/b> 2016 Dec;7(6):819-827. doi: 10.21037\/jgo.2016.11.11.\u00a0<\/span><\/p>\n

Moran S, Mart\u00ednez-Card\u00fas A, Sayols S, Musul\u00e9n E, Bala\u00f1\u00e1 C, Estival-Gonzalez A, Moutinho C, Heyn H, Diaz-Lagares A, de Moura MC, Stella GM, Comoglio PM, Ruiz-Mir\u00f3 M, Matias-Guiu X, Pazo-Cid R, Ant\u00f3n A, Lopez-Lopez R, Soler G, Longo F, Guerra I, Fernandez S, Assenov Y, Plass C, Morales R, Carles J, Bowtell D, Mileshkin L, Sia D, Tothill R, Tabernero J, Llovet JM, Esteller M. Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis. Lancet Oncol<\/b> 2016 Oct;17(10):1386-1395. doi: 10.1016\/S1470-2045(16)30297-2.<\/p>\n

Moeini A, Sia D, Bardeesy N, Mazzaferro V, Llovet JM. Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma. Clin Cancer Res<\/b> 2016 Jan 15;22(2):291-300. doi: 10.1158\/1078-0432.CCR-14-3296.\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

2021 von Felden J, Craig AJ, Garcia-Lezana T, Labgaa I, Haber PK, D’Avola D, Asgharpour A, Dieterich D, Bonaccorso A, Torres-Martin M, Sia D, Sung MW, Tabrizian P, Schwartz M, Llovet JM, Villanueva A. Mutations in circulating tumor DNA predict primary resistance to systemic therapies in advanced hepatocellular carcinoma. Oncogene.\u00a02021 Jan;40(1):140-151.\u00a0doi: 10.1038\/s41388-020-01519-1.\u00a0Epub 2020 Oct 23.\u00a0PubMed […]<\/p>\n","protected":false},"author":380,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/sialab\/wp-json\/wp\/v2\/pages\/10","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/sialab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/sialab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/sialab\/wp-json\/wp\/v2\/users\/380"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/sialab\/wp-json\/wp\/v2\/comments?post=10"}],"version-history":[{"count":7,"href":"https:\/\/labs.icahn.mssm.edu\/sialab\/wp-json\/wp\/v2\/pages\/10\/revisions"}],"predecessor-version":[{"id":87,"href":"https:\/\/labs.icahn.mssm.edu\/sialab\/wp-json\/wp\/v2\/pages\/10\/revisions\/87"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/sialab\/wp-json\/wp\/v2\/media?parent=10"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}