{"id":1349,"date":"2022-10-13T17:37:32","date_gmt":"2022-10-13T21:37:32","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=1349"},"modified":"2024-03-06T15:38:23","modified_gmt":"2024-03-06T20:38:23","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/senlab\/","title":{"rendered":"Overview"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_image=”off” animation_style=”fade” animation_duration=”700ms” custom_padding=”||0px|||”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_gallery gallery_ids=”5276,5281,5286,5291″ fullwidth=”on” disabled_on=”on|off|off” module_class=”pa-multi-line-highlight” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” auto=”on”][\/et_pb_gallery][et_pb_slider arrows_custom_color=”#EEEEEE” dot_nav_custom_color=”#141414″ disabled_on=”off|on|on” _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”6px|1px||||”][et_pb_slide use_bg_overlay=”off” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#FFFFFF” background_enable_color=”on” background_enable_image=”off” background_size=”contain” custom_padding=”|||0px|false|false” sticky_transition=”on”]<\/p>\n

\"\"<\/p>\n

[\/et_pb_slide][et_pb_slide _builder_version=”4.9.0″ _module_preset=”default” background_color=”#FFFFFF” background_enable_color=”on” background_enable_image=”off” background_size=”contain” sticky_transition=”on”]<\/p>\n

\"\"<\/p>\n

[\/et_pb_slide][et_pb_slide _builder_version=”4.9.0″ _module_preset=”default” background_color=”#FFFFFF” background_enable_color=”on” background_enable_image=”off” background_size=”contain” sticky_transition=”on”]<\/p>\n

\"\"<\/p>\n

[\/et_pb_slide][et_pb_slide _builder_version=”4.9.0″ _module_preset=”default” background_color=”#FFFFFF” background_enable_color=”on” background_enable_image=”off” background_size=”contain” sticky_transition=”on”]<\/p>\n

\"\"<\/p>\n

[\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_image=”off” background_blend=”soft-light” custom_padding=”0px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”|auto|36px|auto||” custom_padding=”0px||7px|||”][et_pb_column type=”2_5″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/senlab2\/wp-content\/uploads\/sites\/513\/2024\/01\/Overview-Figure-new-1-scaled-1.jpeg” title_text=”Overview-Figure-new-1-scaled” _builder_version=”4.9.0″ _module_preset=”default” width=”105%”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”18px” header_font_size=”2px” background_color=”#FFFFFF”]<\/p>\n

The\u00a0Sen lab focuses on the development of new treatment paradigms for clinically relevant molecular subsets of lung cancer, the leading cause of cancer mortality. Situated in the Icahn School of Medicine at the Mount Sinai Medical Center, New York, the Sen-Lab is taking an inter-disciplinary approach to study basic mechanisms and biological principles of tumor pathogenesis with a focus on lung cancer. We aim to elucidate the fundamental principles of cancer initiation, progression, and therapeutic response and resistance and to translate the findings to improve outcomes of patients with lung cancer.<\/span><\/p>\n

The overall goal of this research program spanning basic mechanistic discoveries, application of high throughput technologies, validation in cancer relevant mouse models, and translation platform is to understand the fundamental principles driving tumor progression spanning both cancer cell intrinsic signaling and contributions from the tumor microenvironment to improve therapy and survival of patients with lung cancer.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px|||||”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#141414″ text_font_size=”18px” custom_margin=”78px|||||”]<\/p>\n

Major Subtypes of Lung Cancer<\/strong><\/span><\/p>\n

Lung cancer is the leading cause of cancer-related death worldwide accounting for an estimated 100, 000 deaths annually in the United States. There are two main types of lung cancer: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). A third less common type of lung cancer is called carcinoid.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”18px” background_color=”#FFFFFF”]<\/p>\n

1. Non-Small Cell Lung Cancer: <\/strong>NSCLC accounts for about 80% of lung cancer diagnosis, which are typically adenocarcinoma, squamous cell carcinoma, or large cell carcinoma.<\/p>\n