Publications

Most recent:

  • Fiaschi-Taesch NM, Kleinberger JW, Salim F, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Scott DK, Stewart AF. A Human Pancreatic Beta Cell G1/S Molecule Cell Cycle Atlas. Diabetes 2013 Mar;.
  • Fiaschi-Taesch NM, Kleinberger JW, Salim F, Troxell R, Wills R, Tanwir M, Casinelli G, Cox AE, Takane KK, Srinivas H, Scott DK, Stewart AF. Cytoplasmic-Nuclear Trafficking of G1/S Cell Cycle Molecules and Adult Human Beta Cell Replication: A Revised Model of Human Beta Cell G1/S Control. Diabetes 2013 Mar;.
  • Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O’Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK. ChREBP mediates glucose-stimulated pancreatic β-cell proliferation. Diabetes 2012 Aug; 61(8).
  • Wang P, Fiaschi-Taesch NM, Vasavada RC, Scott DK, García-Ocaña A, Stewart AF. Diabetes mellitus-advances and challenges in human β-cell proliferation. Nature reviews. Endocrinology 2015 Feb;.
  • Wang P, Alvarez-Perez JC, Felsenfeld DP, Liu H, Sivendran S, Bender A, Kumar A, Sanchez R, Scott DK, Garcia-Ocaña A, Stewart AF. A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nature medicine 2015 Mar;.
  • Zhang P, Kumar A, Katz LS, Li L, Paulynice M, Herman MA, Scott DK. Induction of the ChREBPβ isoform is essential for glucose-stimulated beta cell proliferation. Diabetes 2015 Sep;.
  • Martins FO, Delgado TC, Viegas J, Gaspar J, Scott DK, O’Doherty RM, Macedo MP, Jones JG. Mechanisms by which the thiazolidinedione troglitazone protects against sucrose-induced hepatic fat accumulation and hyperinsulinemia. British journal of pharmacology 2015 Oct;.
  • Lakshmipathi J, Alvarez-Perez JC, Rosselot C, Casinelli GP, Stamateris RE, Rausell-Palamos F, O’Donnell CP, Vasavada RC, Scott DK, Alonso LC, Garcia-Ocaña A. PKC-ζ is essential for pancreatic beta cell replication during insulin resistance by regulating mTOR and cyclin-D2. Diabetes 2016 Feb;.
  • Edmunds LR, Otero PA, Sharma L, D’Souza S, Dolezal JM, David S, Lu J, Lamm L, Basantani M, Zhang P, Sipula IJ, Li L, Zeng X, Ding Y, Ding F, Beck ME, Vockley J, Monga SP, Kershaw EE, O’Doherty RM, Kratz LE, Yates NA, Goetzman EP, Scott DK, Duncan AW, Prochownik EV. Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes. Oncotarget 2016 May;.
  • Zhang P, Chu T, Dedousis N, Mantell BS, Sipula I, Li L, Bunce KD, Shaw PA, Katz LS, Zhu J, Argmann C, O’Doherty RM, Peters DG, Scott DK. DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet. Mol Metab. 2017 Apr;.
  • Shtraizent N, DeRossi C, Nayar S, Sachidanandam R, Katz LS, Prince A, Koh AP, Vincek A, Hadas Y, Hoshida Y, Scott DK, Eliyahu E, Freeze HH, Sadler KC, Chu J. MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect. Elife 2017 Jun;.
  • Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, Takane KK, Walker LA, Saul S, Chen R, Scott DK, Ferrer J, Antipin Y, Donovan M, Uzilov AV, Reva B, Schadt EE, Losic B, Argmann C, Stewart AF. Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas. Nat Commun. 2017 Oct;.
  • Katz LS, Xu S, Ge K, Scott DK, Gershengorn MC. T3 and Glucose Coordinately Stimulate ChREBP-Mediated Ucp1 Expression in Brown Adipocytes From Male Mice. Endocrinology. 2018 Jan;.
  • Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M. Replication confers β cell immaturity. Nat Communications 2018 Feb;.
  • Kumar A, Katz LS, Schulz AM, Kim M, Honig LB, Li L, Davenport B, Homann D, Garcia-Ocaña A, Herman MA, Haynes CM, Chipuk JE, Scott DK. Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. Diabetes 2018 Aug;.
  • Davenport, B., Eberlein, J.,  van der Heide, V., Jhun, K.,Nguyen, T., Victorino, F., Trotta, A., Chipuk, J., Yi, Z.,  Zhang, W., Clambey, E., Scott, D.K., Homann, D. 2019. Aging of antiviral CD8+ memory T cells fosters increased survival, metabolic adaptations and lymphoid tissue homing.  J Immunol 2019;.
  • Wang P, Karakose E, Liu H, Swartz E, Ackeifi C, Zlatanic V, Wilson J, González BJ, Bender A, Takane KK, Ye L, Harb G, Pagliuca F, Homann D, Egli D, Argmann C, Scott DK, Garcia-Ocaña A, Stewart AF. Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells. Cell Metab 2019 Mar;.
  • Rosselot C, Kumar A, Lakshmipathi J, Zhang P, Lu G, Katz LS, Prochownik EV, Stewart AF, Lambertini L, Scott DK, Garcia-Ocaña A. Myc Is Required for Adaptive β-Cell Replication in Young Mice but Is Not Sufficient in One-Year-Old Mice Fed With a High-Fat Diet. Diabetes 2019 Oct;.
  • Levasseur, E.M., Yamada, K., Piñeros Alvarez, A.R., Wu, W., Syed, F., Orr, K.S., Mastracci, T.L. Mosley, A.L., Liu, Y.,  Bernal-Mizrachi, E.,  Alonso, L., Scott, D.K., Garcia-Ocaña, A., Tersey, S.A., and Mirmira, R.G. 2019. Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis. Sci Signal 2019;.
  • Karakose, E.,  Wang, H.,  Inabnet, W., Thakker, R.V., Libutti, S.,  Fernandez-Ranvier, G.,  MD, Suh, H., Kinoshita, Y.,  Donovan, M., Wang, P.,  PhD, Uzilov, A.,  Argmann, C., Schadt, E.E.,  Stewart, A.F.,  Scott, D.K.,  and Lambertini, L. 2019. Aberrant Methylation of the 11p15 Imprinted Region Underlies Abnormal Chromatin Arrangement, Insulin Expression and Cell Proliferation in Human Insulinomas. (in revision, Nature Comm)
  • Ackeifi, C.,  Swartz, E.,  Kumar, K.,  Liu, H.,  Chalada, S.,  PhD, Karakose, E.,  Scott, D.K.,  Garcia-Ocaña, A.,  Sanchez, R., DeVita, R.J.,  Stewart, A.F.,  Wang, P. 2019. Pharmacologic and Genetic Approaches Define Human Pancreatic Beta Cell Mitogenic Targets of DYRK1A Inhibitors. JCI Insight. 2020;.
  • Ackeifi, C., Wang, P., Karakose, E., Manning Fox, J.E., González, B.J., Liu, H., Wilson, J., Swartz, E., Berrouet, C., Li, Y., Kumar, K., MacDonald, P.E., Sanchez, R., Thorens, B., DeVita, R., Homann, D., Egli, D., Scott, D.K., Garcia-Ocaña, A., Stewart, A.F. GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human cell regeneration. Sci. Trans. Med. 2020.
  • Maachi H, Fergusson G, Ethier M, Brill GN, Katz LS, Honig LB, Metukuri MR, Scott DK, Ghislain J, Poitout V. HB-EGF Signaling Is Required for Glucose-Induced Pancreatic β-Cell Proliferation in Rats. Diabetes. 2020 Mar;.