Donald Scott, PhD
Professor, Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease.
Dr. Scott’s group works on the nutritional regulation of cellular phenotype.  His lab works on molecular mechanisms that coordinate how nutrients, especially glucose, alter the regulation of genes to change the phenotype of cells.  His work focuses on two glucose-sensing transcription factors, ChREBP and c-Myc.  He found that ChREBP activity requires the presence of c-Myc and is currently working out the molecular mechanisms of this relationship.  In addition, his lab, in collaboration with colleagues from the Metabolism Institute (Drs. Garcia-Ocaña, Vasavada, and Stewart) found that ChREBP is required for glucose-stimulated beta cell proliferation.  This work is funded by the NIH, the American Diabetes Association, and the Juvenile Diabetes Research Foundation.