{"id":3794,"date":"2023-03-23T16:07:53","date_gmt":"2023-03-23T20:07:53","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=3794"},"modified":"2025-06-10T10:47:06","modified_gmt":"2025-06-10T14:47:06","slug":"option-two","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/saxenalab\/","title":{"rendered":"Home"},"content":{"rendered":"

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Established in 2015, VCTL is a highly specialized cGMP-compliant facility that serves an important role in supporting phase I and II clinical trials in cancer and other diseases.<\/p>\n

[\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Option2 Section16″ module_class=”Option2-Section16″ _builder_version=”4.9.0″ background_color=”#221F72″ background_enable_image=”off” width=”100%” custom_margin=”||||false|false” custom_padding=”0px|0px|0px|0px|false|false” mix_blend_mode=”multiply” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” locked=”off” collapsed=”off”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ background_color=”#221F72″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” width=”100%” module_alignment=”center” min_height=”100%” height=”100%” max_height=”100%” custom_margin=”0px|0px|0px|0px|false|false” custom_padding=”0px|0px|0px|0px|false|false”][et_pb_column type=”1_2″ admin_label=”Image Column” _builder_version=”4.9.0″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-content\/uploads\/sites\/504\/2024\/04\/IMG_7165-scaled.jpg” title_text=”IMG_7165″ show_bottom_space=”off” align=”center” force_fullwidth=”on” disabled_on=”off|off|off” module_class=”EtPbModule-Image_fullHeightImageColumn” _builder_version=”4.9.0″ min_height=”100%” height=”100%” max_height=”100%” custom_margin=”0px|0px|0px|0px|false|false” custom_padding=”0px|0px|0px|0px|false|false” animation_direction=”left” custom_css_main_element=”height: 100%;||\/*object-fit: cover;*\/” always_center_on_mobile=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ admin_label=”Content Column” _builder_version=”4.9.0″ background_position=”top_left” custom_padding=”80px||40px||false|false” custom_padding_tablet=”0px|0px|40px|40px|false|false” custom_padding_phone=”||40px||false|false” custom_padding_last_edited=”on|tablet” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_align=”left” header_text_color=”#FFFFFF” header_2_text_align=”left” header_2_text_color=”#FFFFFF” header_3_text_align=”left” header_3_text_color=”#FFFFFF” header_4_text_align=”left” header_4_text_color=”#FFFFFF” header_5_text_align=”left” header_5_text_color=”#FFFFFF” header_6_text_align=”left” header_6_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width_tablet=”900px” max_width_phone=”” max_width_last_edited=”on|desktop” custom_padding=”|40px|||false|false” animation_direction=”top”]<\/p>\n

VCTL Services<\/span><\/h2>\n

VCTL was designed with the aim of supporting phase I and II clinical trials in cancer and other diseases. With this goal in view, experts at the VCTL work collaboratively with investigators and sponsors to help them initiate and conduct early phase clinical studies. \u00a0These services include cGMP manufacturing (Viral and Non-Viral products), Analytical testing, Validation studies, Biobanking, Immune-analysis, etc.<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/services\/” button_text=”For More Info” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_color=”#d80b8c” button_bg_color=”#FFFFFF” button_border_radius=”0px” button_on_hover=”off” custom_padding=”15px|50px|15px||false|false” hover_transition_duration=”0ms”][\/et_pb_button][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” header_font=”||||” header_text_align=”left” header_text_color=”#FFFFFF” header_2_text_align=”left” header_2_text_color=”#FFFFFF” header_3_text_align=”left” header_3_text_color=”#FFFFFF” header_4_text_align=”left” header_4_text_color=”#FFFFFF” header_5_text_align=”left” header_5_text_color=”#FFFFFF” header_6_text_align=”left” header_6_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”|40px|||false|false” max_width_tablet=”900px” max_width_last_edited=”on|desktop”]<\/p>\n

Press Releases<\/h3>\n

“Mount Sinai Study Advances Understanding of Personalized Vaccines for Bladder Cancer”<\/p>\n

View Here – Experimental vaccine, teamed with immunotherapy, shows safety, feasibility, and strong immune responses<\/a><\/p>\n

“Personalized Cancer Vaccine Proves Promising in a Phase 1 Trial at Mount Sinai”<\/p>\n

View Here – A multi-peptide neoantigen cancer vaccine using relatively few antigens induced a strong immune response across multiple cancers<\/a><\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Title Over Text Next to Image – Section 5″ module_class=”section5_two_col_title_over_txt_next_to_img” _builder_version=”4.9.0″ _module_preset=”default” locked=”off” collapsed=”off”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” admin_label=”5 (Module)” _builder_version=”4.9.0″ background_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” module_alignment=”center” custom_padding=”6px||3px|||” global_module=”956″][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#00AEEF” header_font=”|700|||||||” header_text_color=”#00AEEF” header_font_size=”36px” module_alignment=”center” custom_margin=”||6px|||” custom_padding=”6.5%||6.5%||true|false”]<\/p>\n

\n

Facility Information<\/h1>\n<\/header>\n
\n

The VCTL occupies over 1,200 square feet of space on the 5th floor of the\u00a0<\/span>Leon and Norma Hess Center for Science and Medicine<\/a>. \u00a0It provides a dedicated, controlled space to manufacture human therapeutics for Phase I and II clinical studies in accordance with current Good Manufacturing Practice (cGMP) and compliant with FDA regulations\u00a0(CFR 21 Part 11, 210, and 211), that will ensure the safety, identity, purity and potency of the manufactured products.<\/p>\n<\/div>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/facility-information\/” button_text=”Find Out More” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” button_on_hover=”off” custom_padding=”15px|50px|15px||false|false” hover_transition_duration=”0ms”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-content\/uploads\/sites\/504\/2024\/05\/Picture1.png” title_text=”Picture1″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”49px|||||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Option2 Section17″ module_class=”Option2-Section17″ _builder_version=”4.9.0″ background_color=”#221F72″ use_background_color_gradient=”on” background_color_gradient_start=”#221f72″ background_color_gradient_end=”#d80b8c” background_enable_image=”off” width=”100%” module_alignment=”center” min_height=”975.4px” custom_margin=”||82px||false|false” custom_padding=”40px|0px|75px|0px|false|false” mix_blend_mode=”multiply” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” bottom_divider_arrangement=”above_content” custom_css_main_element=”padding-bottom: 40px !important;” locked=”off” collapsed=”off”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_size=”initial” background_position=”top_left” background_repeat=”repeat” module_alignment=”center” custom_margin=”0px|0px|0px|0px|false|false” custom_padding=”0px|0px|40px|0px|false|false”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ background_position=”top_left” custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-content\/uploads\/sites\/504\/2024\/04\/IMG_6895-scaled.jpg” title_text=”IMG_6895″ show_bottom_space=”off” align=”center” disabled_on=”off|off|off” admin_label=”Image” _builder_version=”4.9.0″ module_alignment=”center” animation_direction=”left” always_center_on_mobile=”off”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ background_position=”top_left”][et_pb_text admin_label=”Title Text” module_class=”Option2-Section17-TextModule_title Option2-Section17-TextModule_title_1110″ _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#000000″ text_line_height=”22px” header_font=”||||” header_text_color=”#000000″ header_4_text_color=”#000000″ header_5_text_color=”#000000″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”90%” custom_margin=”60px||-13px||false|false” animation_direction=”top”]<\/p>\n

Highlighted Publications<\/span><\/h1>\n

[\/et_pb_text][et_pb_divider _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”||11px|||”][\/et_pb_divider][et_pb_accordion _builder_version=”4.9.0″ _module_preset=”default”][et_pb_accordion_item title=”PGV001, a Multi-Peptide Personalized Neoantigen Vaccine Platform” open=”on” _builder_version=”4.9.0″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/40094414\/”]<\/p>\n

Saxena, M., Marron, T. U., Kodysh, J., Finnigan, J. P., Jr, Onkar, S., Kaminska, A., Tuballes, K., Guo, R., Sabado, R. L., Meseck, M., O’Donnell, T. J., Sebra, R. P., Parekh, S., Galsky, M. D., Blasquez, A., Gimenez, G., Bicak, M., Cimen Bozkus, C., Delbeau-Zagelbaum, D., Rodriguez, D., \u2026 Bhardwaj, N. (2025). PGV001, a Multi-Peptide Personalized Neoantigen Vaccine Platform: Phase I Study in Patients with Solid and Hematologic Malignancies in the Adjuvant Setting. Cancer discovery, 15(5), 930\u2013947.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Atezolizumab plus personalized neoantigen vaccination in urothelial cancer: a phase 1 trial” _builder_version=”4.9.0″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/40346292\/” open=”off”]<\/p>\n

Saxena, M., Anker, J. F., Kodysh, J., O’Donnell, T., Kaminska, A. M., Meseck, M., Hapanowicz, O., Niglio, S. A., Salazar, A. M., Shah, H. R., Kinoshita, Y., Brody, R., Rubinsteyn, A., Sebra, R. P., Bhardwaj, N., & Galsky, M. D. (2025). Atezolizumab plus personalized neoantigen vaccination in urothelial cancer: a phase 1 trial. Nature cancer, 10.1038\/s43018-025-00966-7.<\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Therapeutic cancer vaccines” _builder_version=”4.9.0″ _module_preset=”default” open=”off”]<\/p>\n

Saxena, M., van der Burg, S. H., Melief, C. J. M., & Bhardwaj, N. (2021).<\/em><\/p>\n

Therapeutic cancer vaccines.<\/strong>\u00a0Nature reviews. Cancer<\/em>,\u00a021<\/em>(6), 360\u2013378.<\/p>\n

View<\/a><\/strong><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”A T-cell-based immunogenicity protocol for evaluating human antigen-specific responses” _builder_version=”4.9.0″ _module_preset=”default” open=”off”]<\/p>\n

Cimen Bozkus, C., Blazquez, A. B., Enokida, T., & Bhardwaj, N. (2021).<\/em><\/p>\n

A T-cell-based immunogenicity protocol for evaluating human antigen-specific responses.\u00a0<\/strong>STAR protocols<\/em>,\u00a02<\/em>(3), 100758.<\/p>\n

View<\/strong><\/a><\/p>\n

[\/et_pb_accordion_item][et_pb_accordion_item title=”Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets” _builder_version=”4.9.0″ _module_preset=”default” open=”off”]<\/p>\n

Bhardwaj, N., Friedlander, P. A., Pavlick, A. C., Ernstoff, M. S., Gastman, B. R., Hanks, B. A., Curti, B. D., Albertini, M. R., Luke, J. J., Blazquez, A. B., Balan, S., Bedognetti, D., Beechem, J. M., Crocker, A. S., D’Amico, L., Danaher, P., Davis, T. A., Hawthorne, T., Hess, B. W., Keler, T., \u2026 Fling, S. P. (2020).<\/em><\/p>\n

Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets.<\/strong>\u00a0Nature cancer,\u00a01(12), 1204\u20131217.<\/em><\/p>\n

View<\/a><\/strong><\/p>\n

[\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Team Members – Section 21″ module_class=”section21_team_members” _builder_version=”4.9.0″ background_color=”#FFFFFF” background_enable_image=”off” min_height=”394.3px” custom_margin=”-3px||40px||false|false” custom_padding=”0px|0px|0px|0px|false|false” hover_transition_duration=”0ms” saved_tabs=”all” locked=”off” collapsed=”off”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”center” header_text_color=”#58595B” header_font_size=”32px” header_text_shadow_style=”preset2″]<\/p>\n

VCTL Leadership<\/h1>\n

[\/et_pb_text][et_pb_divider admin_label=”Divider” _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”||11px|||”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” column_padding_mobile=”on” custom_padding_last_edited=”on|phone” _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1280px” custom_margin=”4px|auto||auto||” custom_padding=”0px|0px|28px|0px|false|false” custom_padding_tablet=”0px||||false|false” custom_padding_phone=”0px||||false|false” hover_transition_duration=”0ms” use_custom_width=”on” custom_width_px=”1280px” collapsed=”off”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ background_color=”#ffffff” custom_padding=”|||” box_shadow_style=”preset1″ box_shadow_spread=”10px” box_shadow_color=”rgba(0,0,0,0.1)” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-content\/uploads\/sites\/504\/2024\/04\/Bardwaj-2.png” title_text=”Bardwaj (2)” show_bottom_space=”off” align=”center” src_last_edited=”off|desktop” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.9.0″ z_index=”0″ width=”80%” height=”200px” animation_direction=”top” hover_transition_duration=”0ms” locked=”off”][\/et_pb_image][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”23px” header_font=”||||||||” header_3_font=”||||||||” header_3_font_size=”24px” header_3_line_height=”1.7em” header_4_font=”|700||on|||||” header_4_text_color=”#bfbfbf” header_4_font_size=”13px” header_4_letter_spacing=”2px” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”center” module_alignment=”center” custom_margin=”12px|18px|12px|18px|false|false” custom_padding=”|||” hover_transition_duration=”0ms” locked=”off” inline_fonts=”Playfair Display”]<\/p>\n

Nina Bardwaj, MD PhD<\/strong>
Principal Investigator, Bardwaj Lab<\/p>\n

[\/et_pb_text][et_pb_toggle title=”Learn more…” open_toggle_background_color=”#FFFFFF” closed_toggle_background_color=”#FFFFFF” icon_color=”#00AEEF” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#EEEEEE” hover_transition_duration=”0ms” border_width_all=”0px”]<\/p>\n

Dr. Bhardwaj is an immunologist who has made seminal contributions to human dendritic cell biology, specifically with respect to their isolation, subset discovery, immunobiology, antigen presenting function, and use as vaccine adjuvants in humans. Dr. Nina Bhardwaj is\u00a0<\/span>the Director of Immunotherapy, Medical Director of the Vaccine\u00a0<\/span>and Cell Therapy Laboratory, and Co-Director of the Cancer\u00a0<\/span>immunology Program at the Tisch Cancer Institute. Additionally, <\/span>she is the Ward Coleman Chair in Cancer Research as well as a\u00a0<\/span>Professor of Medicine and Urology at the Icahn School of\u00a0<\/span>Medicine at Mount Sinai.<\/span><\/p>\n

[\/et_pb_toggle][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ background_color=”#ffffff” custom_padding=”|||” box_shadow_style=”preset1″ box_shadow_spread=”10px” box_shadow_color=”rgba(0,0,0,0.1)” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-content\/uploads\/sites\/504\/2024\/04\/Saxena.png” title_text=”Saxena” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.9.0″ height=”200px” animation_direction=”top” hover_transition_duration=”0ms”][\/et_pb_image][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”23px” header_font=”||||||||” header_3_font=”||||||||” header_3_font_size=”24px” header_3_line_height=”1.7em” header_4_font=”|700||on|||||” header_4_text_color=”#bfbfbf” header_4_font_size=”13px” header_4_letter_spacing=”2px” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”center” module_alignment=”center” custom_margin=”12px|18px|12px|18px|false|false” custom_padding=”|||” hover_transition_duration=”0ms” locked=”off” inline_fonts=”Playfair Display”]<\/p>\n

Mansi Saxena, PhD<\/strong>
Facility Director, Vaccine and Cell Therapy Laboratory<\/span><\/p>\n

mansi.saxena@mssm.edu<\/span><\/a><\/p>\n

[\/et_pb_text][et_pb_toggle title=”Learn more…” open_toggle_background_color=”#FFFFFF” closed_toggle_background_color=”#FFFFFF” icon_color=”#00AEEF” _builder_version=”4.9.0″ _module_preset=”default” hover_transition_duration=”0ms” border_width_all=”0px”]<\/p>\n

Dr. Mansi Saxena is an expert in cGMP production of cancer vaccines, cellular therapies, infectious disease vaccines; and has in depth knowledge of immune mechanisms regulating the tumor microenvironment. Dr. Saxena has been directly involved in development neoantigen peptide vaccine pipeline at Mount Sinai, PGV-001. Under this program, four clinical trials have been performed in various cancer setting, with more than 300 vaccines administered. In addition, Dr. Saxena directly oversaw the cGMP production of egg-based Newcastle Disease Virus based Covid-19 (NDV-HXP-S) vaccine Master Virus Seed that were used in several countries around the world. Notably, the live NDV-HXP-S vaccine manufactured at the VCTL was used in Phase-1 clinical trial at Mount Sinai, NY. Dr. Saxena also established the immune-monitoring program under the VCTL to investigate the immunogenicity of novel combinations of vaccines, immunotherapies and cell therapies in patients. Dr. Saxena has ably led the team since its inception in 2020 and currently the program serves as a single site for incisive cellular immune-monitoring services for several investigator initiated and externally sponsored trials at Mount Sinai. Dr. Saxena\u2019s key areas of focus include development of novel cell therapies, monoclonal antibodies, vaccines and combination of immunotherapies to treat cancer and other disease and translate the same from bench to bedside.<\/p>\n

[\/et_pb_toggle][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ background_color=”#ffffff” custom_padding=”|||” box_shadow_style=”preset1″ box_shadow_spread=”10px” box_shadow_color=”rgba(0,0,0,0.1)” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-content\/uploads\/sites\/504\/2024\/05\/Cimen-Bozkus.jpg” title_text=”Cimen Bozkus” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.9.0″ height=”200px” animation_direction=”top” hover_transition_duration=”0ms” locked=”off”][\/et_pb_image][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”23px” header_font=”||||||||” header_3_font=”||||||||” header_3_font_size=”24px” header_3_line_height=”1.7em” header_4_font=”|700||on|||||” header_4_text_color=”#bfbfbf” header_4_font_size=”13px” header_4_letter_spacing=”2px” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”center” module_alignment=”center” custom_margin=”12px|18px|12px|18px|false|false” custom_padding=”|||” hover_transition_duration=”0ms” locked=”off” inline_fonts=”Playfair Display”]<\/p>\n

Cansu Cimen Bozkus, PhD<\/strong>
Associate Director, Vaccine and Cell Therapy Laboratory<\/span>
cansu.cimenbozkus@mssm.edu<\/span><\/a><\/p>\n

[\/et_pb_text][et_pb_toggle title=”Learn more…” open_toggle_background_color=”#FFFFFF” icon_color=”#00AEEF” _builder_version=”4.9.0″ _module_preset=”default” hover_transition_duration=”0ms” border_width_all=”0px”][\/et_pb_toggle][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Option2 Section22″ module_class=”Option2-Section22″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”#221F72″ module_alignment=”center” custom_margin=”0px|0px|0px|0px|false|false” custom_padding=”0px|0px|0px|0px|false|false” hover_transition_duration=”0ms” locked=”off” collapsed=”off”][et_pb_row column_structure=”1_5,3_5,1_5″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_5″ _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” header_text_color=”#FFFFFF”]<\/p>\n

Cancer Immunotherapy: 2023 Research and a Look Ahead with Nina Bhardwaj, MD, PhD<\/span><\/h1>\n
In the following interview, Dr. Nina Bhardwaj offers insight into significant advancements in personalized immunotherapies, technological innovations, predictive biomarkers, and initiatives to improve health equity and accessibility to clinical trials.<\/span><\/div>\n
\u00a0<\/div>\n
The \u201cCancer Immunotherapy and You\u201d webinar series is produced by the Cancer Research Institute and is hosted by their sr. science writer, Arthur Brodsky, Ph.D.<\/div>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_5″ _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” width=”100%” max_width=”100%” module_alignment=”center” min_height=”56.25%” max_height=”1080px” custom_padding=”0px||0px||false|false”][et_pb_column type=”4_4″ admin_label=”Video Column” _builder_version=”4.9.0″ _module_preset=”default”][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=A-9X9FBVVn0″ module_class=”Option2-Section22-VideoModule Option2-Section22-VideoModule_max-height_1080″ _builder_version=”4.9.0″ _module_preset=”default” module_alignment=”center” max_height=”1080px” locked=”off”][\/et_pb_video][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Option2 – Simple Single Video Box – Option1-Section12″ module_class=”section-12-container” _builder_version=”4.9.0″ background_color=”#ededed” background_enable_image=”off” custom_margin=”||100px||false|false” custom_padding=”3%||||false|false” animation_direction=”bottom” hover_transition_duration=”0ms” custom_css_main_element=”padding-bottom: -5px !important;” box_shadow_style=”preset3″ box_shadow_vertical=”-200px” box_shadow_blur=”0px” box_shadow_color=”#FFFFFF” box_shadow_position=”inner” locked=”off” collapsed=”off”][et_pb_row _builder_version=”4.9.0″ min_height=”783.7px” custom_padding=”0px||0px|||”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#000000″ text_font_size=”18px” text_line_height=”23px” header_font=”|700|||||||” header_text_align=”center” header_text_color=”#000000″ header_font_size=”36px” header_line_height=”46px” header_2_font=”||||||||” text_orientation=”center” max_width=”700px” module_alignment=”center” custom_margin=”|||274px||”]<\/p>\n

Challenges and barriers to using cancer vaccines in the clinic<\/h1>\n

Mansi Saxena, PhD, Icahn School of Medicine at Mount Sinai, New York, NY, comments on remaining unanswered questions regarding the development of cancer vaccines. Manufacturing costs remain high due to their personalized nature, and using shared neoantigens may led to off the shelf products, reducing cost. More advanced algorithms will additionally validate potential neoantigens, but achieving durable responses will be difficult using vaccines alone. This interview took place at the American Association for Cancer Research (AACR) Annual Meeting 2023 in Orlando, FL.<\/p>\n

[\/et_pb_text][et_pb_video src=”https:\/\/www.youtube.com\/watch?v=9QcbSnnx2ds” image_src=”
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Contact Us<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” locked=”off” collapsed=”off”][et_pb_column type=”1_4″ _builder_version=”4.9.0″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px”]<\/p>\n

Related Resources<\/span><\/h3>\n
Cancer Immunology Program<\/span><\/a>
Clinical Trials<\/a><\/span>
Human Immune Monitoring Core<\/a><\/span>
Investigational Drug Service<\/a><\/span>
Office of Research Services<\/a><\/span>
Program for Protection of Human Subjects<\/a><\/span>
Tisch Cancer Institute<\/a><\/span><\/div>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off”]<\/p>\n

E-mail
<\/strong>vaccinecore@mssm.edu<\/a><\/p>\n

Phone
<\/strong>Tel: 212-824-8439<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off”]Lab Address<\/strong>
\n1470 Madison Avenue
\nHess Building 5-102
\nNew York, NY 10029<\/p>\n

 
\n[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default”]Mailing Address <\/strong><\/span><\/p>\n

Vaccine and Cell Therapy Laboratory<\/span>
\n Icahn School of Medicine<\/span>
\n at Mount Sinai<\/span>
\n 1470 Madison Avenue<\/span>
\n Hess Building 5-102<\/span>
\n New York, NY 10029<\/span>
\n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Established in 2015, VCTL is a highly specialized cGMP-compliant facility that serves an important role in supporting phase I and II clinical trials in cancer and other diseases.VCTL Services VCTL was designed with the aim of supporting phase I and II clinical trials in cancer and other diseases. With this goal in view, experts at […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3794","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-json\/wp\/v2\/pages\/3794","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-json\/wp\/v2\/comments?post=3794"}],"version-history":[{"count":61,"href":"https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-json\/wp\/v2\/pages\/3794\/revisions"}],"predecessor-version":[{"id":4853,"href":"https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-json\/wp\/v2\/pages\/3794\/revisions\/4853"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-json\/wp\/v2\/media?parent=3794"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}