[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1 ” module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-content\/uploads\/sites\/504\/2022\/07\/ai-002-1.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” saved_tabs=”all” locked=”off” collapsed=”off”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” border_color_all=”RGBA(0,0,0,0)”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text admin_label=”Text – Title” _builder_version=”4.9.0″ _module_preset=”b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa” header_font=”||||||||” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||10px||false|false” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop”]<\/p>\n
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[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” background_color=”#FFFFFF” custom_margin=”||||false|false” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/40346292\/” hover_enabled=”0″ border_width_all=”1px” module_alignment=”center” border_color_all=”#00AEEF” box_shadow_style=”preset3″ sticky_enabled=”0″]<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/40094414\/” border_width_all=”1px” background_color=”#FFFFFF” custom_margin=”||||false|false” module_alignment=”center” border_color_all=”#00AEEF” box_shadow_style=”preset3″]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default”]<\/p>\n
Saxena, M., Anker, J. F., Kodysh, J., O’Donnell, T., Kaminska, A. M., Meseck, M., Hapanowicz, O., Niglio, S. A., Salazar, A. M., Shah, H. R., Kinoshita, Y., Brody, R., Rubinsteyn, A., Sebra, R. P., Bhardwaj, N., & Galsky, M. D. (2025). Atezolizumab plus personalized neoantigen vaccination in urothelial cancer: a phase 1 trial.<\/a> Nature cancer<\/i>, 10.1038\/s43018-025-00966-7.<\/p>\n Saxena, M., Marron, T. U., Kodysh, J., Finnigan, J. P., Jr, Onkar, S., Kaminska, A., Tuballes, K., Guo, R., Sabado, R. L., Meseck, M., O’Donnell, T. J., Sebra, R. P., Parekh, S., Galsky, M. D., Blasquez, A., Gimenez, G., Bicak, M., Cimen Bozkus, C., Delbeau-Zagelbaum, D., Rodriguez, D., \u2026 Bhardwaj, N. (2025). PGV001, a Multi-Peptide Personalized Neoantigen Vaccine Platform: Phase I Study in Patients with Solid and Hematologic Malignancies in the Adjuvant Setting.<\/a> Cancer discovery<\/i>, 15<\/i>(5), 930\u2013947.<\/p>\n Patskovsky, Y., Natarajan, A., Patskovska, L., Nyovanie, S., Joshi, B., Morin, B., Brittsan, C., Huber, O., Gordon, S., Michelet, X., Schmitzberger, F., Stein, R. B., Findeis, M. A., Hurwitz, A., Van Dijk, M., Chantzoura, E., Yague, A. S., Pollack Smith, D., Buell, J. S., Underwood, D., \u2026 Krogsgaard, M. (2023). Molecular mechanism of phosphopeptide neoantigen immunogenicity. <\/a>Nature communications,\u00a014(1), 3763.<\/p>\n Gigoux, M., Holmstr\u00f6m, M. O., Zappasodi, R., Park, J. J., Pourpe, S., Bozkus, C. C., Mangarin, L. M. B., Redmond, D., Verma, S., Schad, S., George, M. M., Venkatesh, D., Ghosh, A., Hoyos, D., Molvi, Z., Kamaz, B., Marneth, A. E., Duke, W., Leventhal, M. J., Jan, M., \u2026 Merghoub, T. (2022).\u00a0Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.<\/a> Science translational medicine,\u00a014(649), eaba4380.<\/p>\n Salom\u00e9, B., Sfakianos, J. P., Ranti, D., Daza, J., Bieber, C., Charap, A., Hammer, C., Banchereau, R., Farkas, A. M., Ruan, D. F., Izadmehr, S., Geanon, D., Kelly, G., de Real, R. M., Lee, B., Beaumont, K. G., Shroff, S., Wang, Y. A., Wang, Y. C., Thin, T. H., \u2026 Horowitz, A. (2022). NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer.<\/a> Cancer cell,\u00a040(9), 1027\u20131043.e9.<\/p>\n Cimen Bozkus, C., Blazquez, A. B., Enokida, T., & Bhardwaj, N. (2021). A T-cell-based immunogenicity protocol for evaluating human antigen-specific responses.<\/a>\u00a0STAR protocols<\/em>,\u00a02<\/em>(3), 100758.<\/p>\n Hobbs, G., Cimen Bozkus, C., Moshier, E., Dougherty, M., Bar-Natan, M., Sandy, L., Johnson, K., Foster, J. E., Som, T., Macrae, M., Marble, H., Salama, M., El Jamal, S. M., Zubizarreta, N., Wadleigh, M., Stone, R., Bhardwaj, N., Iancu-Rubin, C., & Mascarenhas, J. (2021). PD-1 inhibition in advanced myeloproliferative neoplasms.<\/a>\u00a0Blood advances<\/em>,\u00a05<\/em>(23), 5086\u20135097.<\/p>\n Saxena, M., van der Burg, S. H., Melief, C. J. M., & Bhardwaj, N. (2021). Therapeutic cancer vaccines<\/a>.\u00a0Nature reviews. Cancer<\/em>,\u00a021<\/em>(6), 360\u2013378.<\/p>\n Bhardwaj, N., Friedlander, P. A., Pavlick, A. C., Ernstoff, M. S., Gastman, B. R., Hanks, B. A., Curti, B. D., Albertini, M. R., Luke, J. J., Blazquez, A. B., Balan, S., Bedognetti, D., Beechem, J. M., Crocker, A. S., D’Amico, L., Danaher, P., Davis, T. A., Hawthorne, T., Hess, B. W., Keler, T., \u2026 Fling, S. P. (2020). Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets<\/a>.\u00a0Nature cancer<\/em>,\u00a01<\/em>(12), 1204\u20131217.<\/p>\n Roudko, V., Bozkus, C. C., Orfanelli, T., McClain, C. B., Carr, C., O’Donnell, T., Chakraborty, L., Samstein, R., Huang, K. L., Blank, S. V., Greenbaum, B., & Bhardwaj, N. (2020). Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors.<\/a>\u00a0Cell<\/em>,\u00a0183<\/em>(6), 1634\u20131649.e17. https:\/\/doi.org\/10.1016\/j.cell.2020.11.004<\/p>\n Cimen Bozkus, C., Roudko, V., Finnigan, J. P., Mascarenhas, J., Hoffman, R., Iancu-Rubin, C., & Bhardwaj, N. (2019). Immune Checkpoint Blockade Enhances Shared Neoantigen-Induced T-cell Immunity Directed against Mutated Calreticulin in Myeloproliferative Neoplasms.<\/a>\u00a0Cancer discovery<\/em>,\u00a09<\/em>(9), 1192\u20131207.<\/p>\n Saxena, M., Sabado, R. L., La Mar, M., Mohri, H., Salazar, A. M., Dong, H., Correa Da Rosa, J., Markowitz, M., Bhardwaj, N., & Miller, E. (2019). Poly-ICLC, a TLR3 Agonist, Induces Transient Innate Immune Responses in Patients With Treated HIV-Infection: A Randomized Double-Blinded Placebo Controlled Trial.<\/a>\u00a0Frontiers in immunology<\/em>,\u00a010<\/em>, 725.<\/p>\n Saxena, M., Balan, S., Roudko, V., & Bhardwaj, N. (2018). Towards superior dendritic-cell vaccines for cancer therapy.<\/a>\u00a0Nature biomedical engineering<\/em>,\u00a02<\/em>(6), 341\u2013346.<\/p>\n Saxena, M., & Bhardwaj, N. (2018). Re-Emergence of Dendritic Cell Vaccines for Cancer Treatment.\u00a0<\/a>Trends in cancer<\/em>,\u00a04<\/em>(2), 119\u2013137.<\/p>\n Saxena, M., & Bhardwaj, N. (2017). Turbocharging vaccines: emerging adjuvants for dendritic cell based therapeutic cancer vaccines.<\/a>\u00a0Current opinion in immunology<\/em>,\u00a047<\/em>, 35\u201343.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Footer – Section 13″ module_class=”footer-section” _builder_version=”4.9.0″ background_color=”#c7eafb” background_image=”https:\/\/labs.icahn.mssm.edu\/saxenalab\/wp-content\/uploads\/sites\/504\/2022\/10\/Rectangle-3.png” max_width=”80%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|40px|0px||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” disabled=”on” global_module=”425″ saved_tabs=”all” locked=”off” collapsed=”on”][et_pb_row _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” 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