{"id":231,"date":"2019-04-30T01:27:43","date_gmt":"2019-04-30T01:27:43","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/rosscaganlab\/?page_id=231"},"modified":"2019-04-30T02:18:08","modified_gmt":"2019-04-30T02:18:08","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/publications\/","title":{"rendered":"Publications and success stories"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.0.47&#8243;][et_pb_row custom_margin=&#8221;-40px||-60px|&#8221; _builder_version=&#8221;3.2.2&#8243; module_alignment=&#8221;center&#8221;][et_pb_column type=&#8221;1_4&#8243; _builder_version=&#8221;3.2.2&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_button button_text=&#8221;Colorectal Cancer&#8221; _builder_version=&#8221;3.0.47&#8243; custom_button=&#8221;on&#8221; button_text_size=&#8221;14px&#8221; button_text_color=&#8221;rgba(0,0,0,0.56)&#8221; button_bg_color=&#8221;#ffffff&#8221; 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button_one_border_width__hover_enabled=&#8221;off&#8221; button_two_border_width__hover_enabled=&#8221;off&#8221; button_border_color__hover_enabled=&#8221;off&#8221; button_one_border_color__hover_enabled=&#8221;off&#8221; button_two_border_color__hover_enabled=&#8221;off&#8221; button_border_radius__hover_enabled=&#8221;off&#8221; button_one_border_radius__hover_enabled=&#8221;off&#8221; button_two_border_radius__hover_enabled=&#8221;off&#8221; button_letter_spacing__hover_enabled=&#8221;off&#8221; button_one_letter_spacing__hover_enabled=&#8221;off&#8221; button_two_letter_spacing__hover_enabled=&#8221;off&#8221; button_bg_color__hover_enabled=&#8221;off&#8221; button_one_bg_color__hover_enabled=&#8221;off&#8221; button_two_bg_color__hover_enabled=&#8221;off&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row custom_margin=&#8221;-17px||-55px|&#8221; _builder_version=&#8221;3.2.2&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221;][et_pb_column type=&#8221;2_3&#8243; _builder_version=&#8221;3.2.2&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_text _builder_version=&#8221;3.2.2&#8243;]<\/p>\n<p><span style=\"color: #0c71c3;font-size: medium\"><strong>Publications and Success Stories<\/strong><\/span><\/p>\n<p class=\"p1\">Bangi E., Murgia C., Teague A., Sansom O., and Cagan R.<sup> <\/sup>(2016). Functional exploration of colorectal cancer genomes using <i>Drosophila<\/i>. Nature Communications, doi: 10.1038\/ncomms13615<i>. <\/i>PMC5141297<\/p>\n<ul>\n<li class=\"p1\">Novel fly colorectal cancer models were used to demonstrate that increasing genetic complexity can lead to drug resistance.<\/li>\n<\/ul>\n<p class=\"p1\"><span class=\"s3\">Kunal Kumar, Peter Man-Un Ung, Peng Wang, Hui Wang, Hailing Li, Mary K. Andrews, Andrew F. Stewart, Avner Schlessinger, Robert J. DeVita (2018). Novel Selective Thiadiazine DYRK1A Inhibitor Lead Scaffold with Human Pancreatic \u03b2-cell Proliferation Activity. Eur J Med Chem. 157: 1005\u20131016.<\/span><\/p>\n<ul>\n<li class=\"p1\">A computational screen of a virtual library led to identification of a novel DYK1A inhibitor, proposed to promote beta cell proliferation as a diabetes treatment.<span class=\"s3\"><\/span><\/li>\n<\/ul>\n<p class=\"p3\">Sonoshita, M., Scopton, A., Ung, P., Murray, M., Silber, L., Maldonado, A., Real, A., Schlessinger, A., Cagan, R., Dar, A. (2018). A Whole Animal Platform to Advance A Clinical Kinase Inhibitor\u00a0Into New Disease Space. Nature Chem Biol <span class=\"s1\">14(3):291-298<\/span>.\u00a0<\/p>\n<ul>\n<li class=\"p3\">Leveraging a platform that is a featured part of the Center, fly genetics and medicinal\/computational chemistry was used to develop sorafenib analogs.<\/li>\n<\/ul>\n<p class=\"p1\">Bangi E,\u00a0Ang C, Smibert P, Uzilov A,\u00a0Teague A,\u00a0Antipin Y,\u00a0Chen R, Hecht C, Gruszczynski N,\u00a0Yon W, Malyshev D,\u00a0Laspina D,\u00a0Selkridge I, Rainey H, Moe A,\u00a0Lau CY, Taik P,\u00a0Wilck E,\u00a0Bhardwaj A, Sung M, Kim S,\u00a0Yum K,\u00a0Sebra R, Donovan M,\u00a0Misiukiewicz K, Schadt E, Posner M,\u00a0and Cagan R. (2019). A Personalized Platform Identifies Trametinib Plus Zoledronate\u00a0For\u00a0A Patient With\u00a0KRAS-Mutant Metastatic Colorectal Cancer. Science Advances\u00a0<i>in press.<\/i><\/p>\n<ul>\n<li class=\"p1\">A fly-to-bedside study identifies a novel drug cocktail that led to partial response of a patient&#8217;s KRAS-mutant colorectal tumor.<\/li>\n<\/ul>\n<p class=\"p1\">Peter Ung, Masahiro Sonoshita, Alex P. Scopton, Arvin C. Dar, Ross L. Cagan, Avner Schlessinger (2019). Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network. PLOS Comp. <i>in press.<\/i><\/p>\n<ul>\n<li class=\"p1\">Pushing the Center&#8217;s platform, a virtual screen was used as the first step in a fly\/computational\/chemistry approach to develop a novel class of cancer hits.<\/li>\n<\/ul>\n<p class=\"p1\">\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.2.2&#8243; parallax=&#8221;off&#8221; parallax_method=&#8221;on&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/wp-content\/uploads\/sites\/265\/2019\/04\/Pubs-pic-2.jpg&#8221; _builder_version=&#8221;3.19.10&#8243;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.2.2&#8243;][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;3.2.2&#8243;][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Publications and Success Stories Bangi E., Murgia C., Teague A., Sansom O., and Cagan R. (2016). Functional exploration of colorectal cancer genomes using Drosophila. Nature Communications, doi: 10.1038\/ncomms13615. PMC5141297 Novel fly colorectal cancer models were used to demonstrate that increasing genetic complexity can lead to drug resistance. Kunal Kumar, Peter Man-Un Ung, Peng Wang, Hui [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-231","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/wp-json\/wp\/v2\/pages\/231","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/wp-json\/wp\/v2\/comments?post=231"}],"version-history":[{"count":4,"href":"https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/wp-json\/wp\/v2\/pages\/231\/revisions"}],"predecessor-version":[{"id":265,"href":"https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/wp-json\/wp\/v2\/pages\/231\/revisions\/265"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/rosscaganlab\/wp-json\/wp\/v2\/media?parent=231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}