[\/et_pb_text][et_pb_text admin_label=”Citation” _builder_version=”4.9.0″ text_line_height=”1.6em” module_alignment=”center” min_height=”95.4px” custom_margin=”-4px||-2px||false|false” custom_padding=”0px||10px||false|false” text_line_height_tablet=”” text_line_height_phone=”” text_line_height_last_edited=”on|desktop”]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ admin_label=”Martino NCB 2023″ _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1150px” module_alignment=”center” custom_margin=”-1px|124px|22px|126px||” custom_padding=”0px||0px|||” border_color_bottom=”#d6d6d6″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Abstract” _builder_version=”4.9.0″ text_line_height=”1.6em” module_alignment=”center” min_height=”421.5px” custom_margin=”-1px||-2px|1px|false|false” custom_padding=”0px||0px|0px|false|false” text_line_height_tablet=”” text_line_height_phone=”” text_line_height_last_edited=”on|desktop”]<\/p>\n Substantial follicle remodelling during the regression phase of the hair growth cycle is coordinated by the contraction of the dermal sheath smooth muscle, but how dermal-sheath-generated forces are regulated is unclear. Here, we identify spatiotemporally controlled endothelin signalling\u2014a potent vasoconstriction-regulating pathway\u2014as the key activating mechanism of dermal sheath contraction. Pharmacological blocking or genetic ablation of both endothelin receptors, ETA and ETB, impedes dermal sheath contraction and halts follicle regression. Epithelial progenitors at the club hair\u2013epithelial strand bottleneck produce the endothelin ligand ET-1, which is required for follicle regression. ET signalling in dermal sheath cells and downstream contraction is dynamically regulated by cytoplasmic Ca2+ levels through cell membrane and sarcoplasmic reticulum calcium channels. Together, these findings illuminate an epithelial\u2013mesenchymal interaction paradigm in which progenitors\u2014destined to undergo programmed cell death\u2014control the contraction of the surrounding sheath smooth muscle to orchestrate homeostatic tissue regression and reorganization for the next stem cell activation and regeneration cycle.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2023\/02\/2023_Martino_figure-1024×782.jpg” title_text=”spatiotemporal contraction regulation by endothelin signalling” url=”https:\/\/drive.google.com\/file\/d\/1Pq-WX3LCdJTK0_z6xx87j6lVLQ9BHmIx\/view” url_new_window=”on” admin_label=”Regression Cartoon” _builder_version=”4.9.0″ _module_preset=”default” width=”100%” custom_margin=”|13px||||” custom_padding=”5px|0px|||false|false”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Martino NCB 2023″ _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1150px” module_alignment=”center” custom_margin=”-1px|124px|35px|126px||” custom_padding=”0px||0px|||” border_width_bottom=”3px” border_color_bottom=”#d6d6d6″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Research Briefing & In The News” _builder_version=”4.9.0″ text_line_height=”1.6em” module_alignment=”center” custom_margin=”0px||-2px||false|false” custom_padding=”0px||0px||false|false” hover_enabled=”0″ text_line_height_tablet=”” text_line_height_phone=”” text_line_height_last_edited=”on|desktop” sticky_enabled=”0″]<\/p>\n Research Briefing<\/em><\/strong><\/p>\n Nature Cell Biology<\/em><\/a> 25, 220\u2013221 (2023) <\/span>pdf<\/a><\/p>\n In The News<\/strong><\/em><\/span><\/p>\n Improved understanding of pathways could lead to new hair loss therapies<\/a><\/span><\/p>\n Mount Sinai Researchers Identify Details of Muscle\u2019s Role in Regulating Hair Growth Cycle<\/a> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Martino DS Review 2021″ _builder_version=”4.9.0″ min_height=”631.4px” custom_padding=”||0px|||” collapsed=”on”][et_pb_row admin_label=”Martino DS Review 2021″ _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1150px” module_alignment=”center” custom_margin=”|124px|18px|126px||” custom_padding=”3px||0px|||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Citation” _builder_version=”4.9.0″ text_line_height=”1.6em” module_alignment=”center” min_height=”95.4px” custom_margin=”||-2px||false|false” custom_padding=”0px||10px||false|false” text_line_height_tablet=”” text_line_height_phone=”” text_line_height_last_edited=”on|desktop”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ admin_label=”Martino DS Review 2021″ _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1150px” module_alignment=”center” custom_margin=”-1px|124px|35px|126px||” custom_padding=”0px||28px|||” border_width_bottom=”3px” border_color_bottom=”#d6d6d6″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Abstract” _builder_version=”4.9.0″ text_line_height=”1.6em” module_alignment=”center” min_height=”421.5px” custom_margin=”-1px||0px|1px|false|false” custom_padding=”0px||0px|0px|false|false” text_line_height_tablet=”” text_line_height_phone=”” text_line_height_last_edited=”on|desktop”]<\/p>\n Hair follicles cyclically regenerate throughout adult mammalian life, owing to a resident population of epithelial hair follicle stem cells. Stem cell (SC) activity drives bouts of follicle growth, which are periodically interrupted by follicle regression and rest. These phases and the transitions between them are tightly spatiotemporally coordinated by signalling crosstalk between stem\/progenitor cells and the various cell types of the microenvironment, or niche. The dermal papilla (DP) is a cluster of specialized mesenchymal cells that have long been recognized for important niche roles in regulating hair follicle SC activation, as well as progenitor proliferation and differentiation during follicle growth. In addition to the DP, the mesenchyme of the murine pelage follicle is also comprised of a follicle-lining smooth muscle known as the dermal sheath (DS), which has been far less studied than the DP yet may be equally specialized and important for hair cycling. In this review, we define the murine pelage DS in comparison with human DS and discuss recent work that highlights the emergent importance of the DS in the hair follicle SC niche. Last, we examine potential therapeutic applications for the DS in hair regeneration and wound healing.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2023\/02\/2021_Martino_figure-1024×698.jpg” title_text=”2021_Martino_figure” url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2023\/02\/2021_Martino_Rendl_Exp-Dermatol_The-dermal-sheath.pdf” url_new_window=”on” admin_label=”DS Cartoon” _builder_version=”4.9.0″ _module_preset=”default” width=”100%” custom_margin=”|13px||||” custom_padding=”5px|0px|||false|false”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Heitman SCIENCE 2020″ _builder_version=”4.9.0″ min_height=”676.4px” collapsed=”off”][et_pb_row admin_label=”Heitman SCIENCE 2020″ _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1150px” module_alignment=”center” custom_margin=”|124px|18px|126px||” custom_padding=”35px||0px|||”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Citation” _builder_version=”4.9.0″ text_line_height=”1.6em” module_alignment=”center” min_height=”95.4px” custom_margin=”-4px||-2px||false|false” custom_padding=”0px||10px||false|false” text_line_height_tablet=”” text_line_height_phone=”” text_line_height_last_edited=”on|desktop”]<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ admin_label=”Heitman SCIENCE 2020″ _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1150px” module_alignment=”center” custom_margin=”-1px|124px|18px|126px||” custom_padding=”0px||0px|||” border_color_bottom=”#d6d6d6″][et_pb_column type=”3_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Abstract” _builder_version=”4.9.0″ text_line_height=”1.6em” module_alignment=”center” min_height=”321.5px” custom_margin=”-1px||-2px|1px|false|false” custom_padding=”0px||0px|0px|false|false” text_line_height_tablet=”” text_line_height_phone=”” text_line_height_last_edited=”on|desktop”]<\/p>\n Tissue homeostasis requires the balance of growth by cell production and regression through cell loss. In the hair cycle, during follicle regression, the niche traverses the skin through an unknown mechanism to reach the stem cell reservoir and trigger new growth. Here, we identify the dermal sheath that lines the follicle as the key driver of tissue regression and niche relocation through the smooth muscle contractile machinery that generates centripetal constriction force. We reveal that the calcium-calmodulin\u2013myosin light chain kinase pathway controls sheath contraction. When this pathway is blocked, sheath contraction is inhibited, impeding follicle regression and niche relocation. Thus, our study identifies the dermal sheath as smooth muscle that drives follicle regression for reuniting niche and stem cells in order to regenerate tissue structure during homeostasis.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2023\/02\/2020_Heitman_figure-1024×754.jpg” title_text=”2020_Heitman_figure” url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2020\/01\/2020_Heitman.pdf” url_new_window=”on” admin_label=”Regression Cartoon” _builder_version=”4.9.0″ _module_preset=”default” width=”100%” custom_margin=”|13px||||” custom_padding=”5px|0px|||false|false”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row admin_label=”Heitman SCIENCE 2020″ _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1150px” module_alignment=”center” custom_margin=”-1px|124px|35px|126px||” custom_padding=”0px||0px|||” border_width_bottom=”3px” border_color_bottom=”#d6d6d6″][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text admin_label=”Research Briefing & In The News” _builder_version=”4.9.0″ text_line_height=”1.6em” module_alignment=”center” custom_margin=”0px||-2px||false|false” custom_padding=”0px||0px||false|false” hover_enabled=”0″ text_line_height_tablet=”” text_line_height_phone=”” text_line_height_last_edited=”on|desktop” sticky_enabled=”0″]<\/p>\n In The News<\/strong><\/em><\/p>\n Hair growth finding could make baldness ‘optional’<\/a><\/span><\/p>\n Mount Sinai Researchers Discover That Muscle Surrounding Hair Follicles Is Essential to New Hair Growth<\/a> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”BUTTONS” _builder_version=”4.9.0″ min_height=”108.4px” custom_padding=”||2px|||”][et_pb_row column_structure=”1_3,1_3,1_3″ admin_label=”BUTTONS” _builder_version=”4.9.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”1000px” module_alignment=”center” min_height=”104.8px” custom_margin=”|124px|-3px|126px||” custom_padding=”45px||60px|||”][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/all-publications\/” button_text=”All Publications” button_alignment=”center” admin_label=”All Publications” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_size=”20px” button_border_width=”0px” button_border_radius=”34px” button_letter_spacing=”2px” box_shadow_style=”preset1″][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%28rendl+m%5BAuthor%5D%29+AND+%28%28sinai%5BAffiliation%5D%29+OR+%28rockefeller%5BAffiliation%5D%29+OR+%28vienna%5BAffiliation%5D%29%29&sort=date” url_new_window=”on” button_text=”PubMed” button_alignment=”center” admin_label=”PubMed” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_size=”20px” button_border_width=”0px” button_border_radius=”34px” button_letter_spacing=”2px” box_shadow_style=”preset1″][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_button button_url=”https:\/\/scholar.google.com\/citations?hl=en&user=SoCNNRwAAAAJ&view_op=list_works&sortby=pubdate” url_new_window=”on” button_text=”Google Scholar” button_alignment=”center” admin_label=”Google Scholar” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_size=”20px” button_border_width=”0px” button_border_radius=”34px” button_letter_spacing=”2px” box_shadow_style=”preset1″][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Selected Publications:Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regressionPieter Martino*, Raghava Sunkara*, Nicholas Heitman, Martina Rangl, Alexia Brown, Nivedita Saxena, Laura Grisanti, Donald Kohan, Masashi Yanagisawa, Michael RendlNature Cell Biology (2023)\u00a0 pdfSubstantial follicle remodelling during the regression phase of the hair growth cycle is coordinated by the contraction of the dermal sheath smooth […]<\/p>\n","protected":false},"author":320,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":" [et_pb_section fb_built=\"1\" fullwidth=\"on\" _builder_version=\"3.0.47\"][et_pb_fullwidth_header title=\"Publications\" _builder_version=\"3.19.10\" background_image=\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/03\/light-blue-background.jpg\"][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=\"1\" _builder_version=\"3.0.47\"][et_pb_row _builder_version=\"3.0.48\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\"][et_pb_column type=\"4_4\" _builder_version=\"3.0.47\" parallax=\"off\" parallax_method=\"on\"][et_pb_text _builder_version=\"3.19.10\"]<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> \u00a0<\/p> #denotes equal contribution [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-40","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-json\/wp\/v2\/pages\/40","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-json\/wp\/v2\/users\/320"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-json\/wp\/v2\/comments?post=40"}],"version-history":[{"count":131,"href":"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-json\/wp\/v2\/pages\/40\/revisions"}],"predecessor-version":[{"id":1069,"href":"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-json\/wp\/v2\/pages\/40\/revisions\/1069"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-json\/wp\/v2\/media?parent=40"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2023\/02\/2023_Martino_cover-232x300.jpg\")
<\/a>Progenitor-derived endothelin controls dermal sheath contraction for hair follicle regression
<\/strong><\/span>Pieter Martino*, Raghava Sunkara*, <\/span>Nicholas Heitman, Martina Rangl, Alexia Brown, Nivedita Saxena, Laura Grisanti, Donald Kohan, Masashi Yanagisawa, Michael Rendl<\/span>
Nature Cell Biology <\/span><\/em>(2023)<\/span>\u00a0 pdf<\/a><\/span><\/p>\n
<\/em><\/span><\/p>\n![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2023\/02\/2021_Martino_cover-232x300.jpg\")
<\/a>The dermal sheath: An emerging component of the hair follicle stem cell niche
<\/strong><\/span>Pieter Martino, <\/span>Nicholas Heitman, Michael Rendl<\/span>
Experimental Dermatology <\/span><\/em>(2021)<\/span>\u00a0 pdf<\/a><\/span><\/p>\n![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2023\/02\/2020_Heitman_cover-232x300.jpg\")
<\/a>Dermal sheath contraction powers stem cell niche relocation during hair cycle regression
<\/strong><\/span>Nicholas Heitman, Rachel Sennett, Ka-Wai Mok, Nivedita Saxena, Devika Srivastava, Pieter Martino, Laura Grisanti, Zichen Wang, Avi Ma\u2019ayan, Pantelis Rompolas, Michael Rendl<\/span>
Science <\/span><\/em>(2020)<\/span>\u00a0 pdf<\/a><\/span><\/p>\n
<\/em><\/span><\/p>\nReviews<\/h3>
![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/2018_Heitman.jpg\")
Heitman N#, Saxena N#, Rendl M.
Advancing insights into stem cell niche complexities with next-generation technologies.<\/strong>
Current Opinion in Cell Biology<\/em> 2018, 55:87-95. pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/2014-Rezza.jpg\")
Rezza A, Sennett R, Rendl M.
Adult Stem Cell Niches: Cellular and Molecular Components.<\/strong>
Current Topics in Developmental Biology\u00a0<\/em>2014, 107C:333-372. pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/2012-Sennett.jpg\")
Sennett R, Rendl M.
Mesenchymal-epithelial interactions during hair follicle morphogenesis and cycling.<\/strong>
Seminars in Cell Developmental Biology\u00a0<\/em>2012, 23:917-27.\u00a0pdf<\/a><\/p>\u00a0<\/h2>
Articles, Letters, Perspectives, Previews<\/h3>
![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/2018_Mok.jpg\")
Mok KW#<\/sup>, Saxena N#<\/sup>, Heitman N#<\/sup>, Grisanti L, Srivastava D, Muraro M, Jacob T, Sennett R, Su Y, Yang LM, Ma\u2019ayan A, Ornitz DM, Kasper M, Rendl M.
Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent.<\/strong>
Developmental Cell\u00a0<\/em>2019, 48:32-48.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/2018_Mok-Rendl.jpg\")
Mok KW#<\/sup>, Saxena N#<\/sup>, Rendl M.
More Than the Sum of Its Parts: Single-Cell Transcriptomics Reveals Epidermal Cell States.<\/strong>
Cell Reports<\/em>\u00a02018, 25:823-824.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/Rezza-et-al.-2016-Cell-Reports-Signaling-Networks.jpg\")
Rezza A, Wang Z, Sennett R, Qiao W, Wang D, Heitman N, Mok KW, Clavel C, Yi R, Zandstra P, Ma'ayan A, Rendl M.
Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles.<\/strong>
Cell Reports<\/em>\u00a02016, 14:3001-18.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/Sennett-et-al.-2015-Developmental-cell-An-Integrated-Transcriptome-Atlas.jpg\"){kind=spacer}
Sennett R, Wang Z, Rezza A, Grisanti L, Roitershtein N, Sicchio C, Mok KW, Heitman NJ, Clavel C, Ma'ayan A, Rendl M.
An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin.<\/strong>
Developmental Cell\u00a0<\/em>2015, Epub.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/Sennett-Rendl-2015-Science.jpg\")
Sennett R, Rendl M.
Developmental biology. A scar is born: origins of fibrotic skin tissue.<\/strong>
Science\u00a0<\/em>2015, 348:284-5.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/Rezza-et-al-2015.jpg\")
Rezza A, Sennett R, Tanguy M, Clavel C, Rendl M.
PDGF signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation.<\/strong>
Experimental Dermatology\u00a0<\/em>2015, 24:468-70.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/Sennett-et-al.-2014-Experimental-dermatology-Cxcr4.jpg\")
Sennett R, Rezza A, Dauber KL, Clavel C, Rendl M.
Cxcr4 is transiently expressed in both epithelial and mesenchymal compartments of nascent hair follicles but is not required for follicle formation.<\/strong>
Experimental Dermatology\u00a0<\/em>2014, 23:748-50.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/2013-Tsai.jpg\")
Tsai SY#<\/sup>, Sennett R#<\/sup>, Rezza A, Clavel C, Grisanti L, Zemla R, Najam S, Rendl M.
Wnt\/\u03b2-catenin signaling in dermal condensates is required for hair follicle formation.<\/strong>
Developmental Biology\u00a0<\/em>2014, 385:179-88.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/2013-Grisanti.jpg\")
Grisanti L, Rezza A, Clavel C, Sennett R, Rendl M.
Enpp2\/Autotaxin in Dermal Papilla Precursors is Dispensable for Hair Follicle Morphogenesis.<\/strong>
Journal of Investigative Dermatology\u00a0<\/em>2013, 133:2332-9.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/2012-Clavel.jpg\")
Clavel C, Grisanti L, Zemla R, Rezza A, Barros R, Sennett R, Mazloom AR, Chung CY, Cai X, Cai CL, Pevny L, Nicolis S, Ma\u2019ayan A, Rendl M.
Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors.<\/strong>
Developmental Cell\u00a0<\/em>2012, 23:981-994. pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/2012-Grisanti.jpg\")
Grisanti L, Clavel C, Cai-X, Rezza A, Tsai ST, Sennett R, Mumau M, Cai CL*, Rendl M*.
Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation.<\/strong>
Journal of Investigative Dermatology\u00a0<\/em>2012, Sep 20, Epub.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/201106-SC.jpg\")
Tsai SY, Bouwman BAM, Ang YS, Kim S, Lee DF, Lemischka-IR, Rendl M.
Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.<\/strong>
Stem Cells\u00a0<\/em>2011, 29:964-71.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/201002-SC.jpg\")
Tsai SY, Clavel C, Kim S, Ang YS, Grisanti L, Lee DF, Kelley K, Rendl M.
Oct4 and Klf4 reprogram dermal papilla cells into induced pluripotent stem cells.<\/strong>
Stem Cells<\/em>\u00a02010, 28:221-8. pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/200802-GD.jpg\")
Rendl M, Polak L, Fuchs E.
BMP signaling in dermal papilla cells is required for their hair follicle inductive properties.
<\/strong>Genes and Development<\/em>\u00a02008, 22:543-57.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/200511-PLoS.jpg\")
Rendl M, Lewis L, Fuchs E.
Molecular dissection of mesenchymal\u2013epithelial interactions in the hair follicle.<\/strong>\u00a0
<\/strong>PLoS Biology<\/em>\u00a02005, 3(11): e331.\u00a0pdf<\/a><\/p>\u00a0<\/h2>
Other selected publications (from a total of 38)<\/h3>
![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/Siegle-et-al.-2014-Nature-Communications.jpg\")
Siegle JM, Basin A, Sastre-Perona A, Yonekubo Y, Brown J, Sennett R, Rendl M, Tsirigos A, Carucci JA, Schober M.
SOX2 is a cancer-specific regulator of tumour initiating potential in cutaneous squamous cell carcinoma.<\/strong>
Nature Communications\u00a0<\/em>2014, 5:4511.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/201104-CELL.jpg\")
Ang YS, Tsai SY, Lee DF, Monk J, Su J, Ratnakumar K, Ding J, Ge Y, Darr H3, Chang B, Wang J, Rendl M, Bernstein E, Schaniel C, Lemischka IR.
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional networke.<\/strong>
Cell\u00a0<\/em>2011, 145:183-97.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/201104-JCS.jpg\")
Driskell R, Clavel C, Rendl M*, Watt FM*.
Dermal Papilla Cells at a glance.<\/strong>
Journal of Cell Science\u00a0<\/em>2011, 124:1179-82. pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/200908-NG.jpg\")
Nguyen H, Merrill BJ, Polak L, Nikolova M, Rendl M, Shaver TM, Pasolli HA, Fuchs E.
Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.<\/strong>
Nature Genetics\u00a0<\/em>2009, 41:1068-75.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/200902-CSC.jpg\")
Greco V, Chen T, Rendl M, Schober M, Pasolli HA, Stokes N, Dela Cruz-Racelis J, Fuchs E.
A two-step mechanism for stem cell activation during hair regeneration.<\/strong>
Cell Stem Cell<\/em>\u00a02009, 4:155-69.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/200610-CELL.jpg\")
Nguyen H, Rendl M, Fuchs E.
Tcf3 governs stem cell features and represses cell fate determination in skin.
<\/strong>Cell<\/em>\u00a02006, 127:171-83.\u00a0pdf<\/a><\/p>![\"\"](\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2019\/04\/200402-SCI.jpg\")
Tumbar T, Guasch G, Greco V, Blanpain C, Lowry WE, Rendl M, Fuchs E.
Defining the epithelial stem cell niche in skin.<\/strong>
Science<\/em>\u00a02004, 303:359-63.\u00a0pdf<\/a><\/p>
* denotes co-corresponding author<\/p>