%PDF-1.7
%
375 0 obj
<>
endobj
364 0 obj
<>
endobj
374 0 obj
<>stream
Acrobat Distiller 8.1.0 (Windows)
Arbortext Advanced Print Publisher 9.1.440/W Unicode
2020-01-09T11:19-08:00
2020-01-02T21:07:18+08:00
2020-01-09T11:19-08:00
uuid:2555ed19-9b93-4588-a1d5-a268fc3481b8
uuid:aa113846-1dd1-11b2-0a00-d200b856e2ff
application/pdf
Science Journals — AAAS
endstream
endobj
353 0 obj
<>
endobj
2 0 obj
<>
endobj
6 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text]/XObject<>>>/Rotate 0/Thumb 351 0 R/Type/Page>>
endobj
1 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 3 0 R/Type/Page>>
endobj
7 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/Properties<>/Shading<>/XObject<>>>/Rotate 0/Thumb 66 0 R/Type/Page>>
endobj
8 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/Properties<>/Shading<>/XObject<>>>/Rotate 0/Thumb 101 0 R/Type/Page>>
endobj
9 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC/ImageI]/Properties<>/XObject<>>>/Rotate 0/Thumb 161 0 R/Type/Page>>
endobj
10 0 obj
<>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/Properties<>/XObject<>>>/Rotate 0/Thumb 326 0 R/Type/Page>>
endobj
418 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
443 0 obj
[448 0 R 449 0 R 450 0 R 451 0 R 452 0 R 453 0 R]
endobj
444 0 obj
<>stream
q
87.5 0 0 21.75 72 662.25 cm
/Im0 Do
Q
BT
/T1_0 1 Tf
10 0 0 10 72 622 Tm
(Dermal sheath contraction powers stem cell niche relocation during hair \
cycle regression)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 600.99997 Tm
(Wang, Avi Ma'ayan, Panteleimon Rompolas and Michael Rendl)Tj
0 1 TD
(Nicholas Heitman, Rachel Sennett, Ka-Wai Mok, Nivedita Saxena, Devika Sr\
ivastava, Pieter Martino, Laura Grisanti, Zichen)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 181.83997 554.99997 Tm
(originally published online December 19, 2019)Tj
-13.73 0 Td
(DOI: 10.1126/science.aax9131)Tj
5.50301 1 Td
( \(6474\), 161-166.)Tj
/T1_0 1 Tf
-1.668 0 Td
(367)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science\240)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 145.45605 458.99976 Tm
(, this issue p. 161)Tj
/T1_2 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_1 1 Tf
-3.125 1 Td
(niche relocation may be utilized in other stem cell niche systems.)Tj
0 1.00001 TD
(between the dermal papilla and hair follicle stem cells during hair foll\
icle regression. This biomechanical mechanism of)Tj
0 1 TD
(active smooth muscle that drives tissue remodeling through coordinated c\
ell contraction, enabling renewed contact )Tj
31.06694 1.00001 Td
( demonstrate that the follicle dermal sheath is an)Tj
/T1_2 1 Tf
-2.168 0 Td
(et al.)Tj
/T1_1 1 Tf
-28.89894 0 Td
(of the dermal papilla. Using mice as a model organism, Heitman )Tj
T*
(challenge for maintaining a functional proximity of stem cells to their \
niche, especially the specialized mesenchymal cells)Tj
T*
(regeneration after injury and during aging. Normal regression of hair fo\
llicles during the hair cycle poses a particular )Tj
3.125 1.00001 Td
(Regulation of adult stem cells by their microenvironment, or niche, is e\
ssential for tissue homeostasis and for)Tj
/T1_0 1 Tf
-3.125 1 Td
(Niche relocated by muscle contraction)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 393 Tm
(ARTICLE TOOLS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 391 Tm
(http://science.sciencemag.org/content/367/6474/161)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 350.99997 Tm
(MATERIALS)Tj
0 1.00001 TD
(SUPPLEMENTARY )Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 355 Tm
(http://science.sciencemag.org/content/suppl/2019/12/18/science.aax9131.D\
C1)Tj
ET
BT
0 g
/T1_0 1 Tf
6 0 0 6 79 315 Tm
(REFERENCES)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 304.99997 Tm
(http://science.sciencemag.org/content/367/6474/161#BIBL)Tj
0 g
0 1 TD
(This article cites 44 articles, 7 of which you can access for free)Tj
ET
BT
/T1_0 1 Tf
6 0 0 6 79 279 Tm
(PERMISSIONS)Tj
ET
BT
0 0 1 rg
/T1_1 1 Tf
8 0 0 8 187 277 Tm
(http://www.sciencemag.org/help/reprints-and-permissions)Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 193.38391 128 Tm
(Terms of Service)Tj
0 g
-15.17299 0 Td
(Use of this article is subject to the )Tj
ET
72 114 m
521 114 l
0 0 m
S
BT
ET
BT
/T1_1 1 Tf
8 0 0 8 357.45605 93.99997 Tm
( is a registered trademark of AAAS.)Tj
/T1_2 1 Tf
-3.55701 0 Td
(Science)Tj
/T1_1 1 Tf
-32.125 0 Td
(Science, 1200 New York Avenue NW, Washington, DC 20005. The title )Tj
3.83501 1 Td
(\(print ISSN 0036-8075; online ISSN 1095-9203\) is published by the Amer\
ican Association for the Advancement of)Tj
/T1_2 1 Tf
-3.83501 0 Td
(Science )Tj
ET
BT
/T1_1 1 Tf
8 0 0 8 72 71.99997 Tm
(Science. No claim to original U.S. Government Works)Tj
T*
(Copyright \251 2020 The Authors, some rights reserved; exclusive license\
e American Association for the Advancement of)Tj
ET
BT
/T1_1 1 Tf
0 -8 8 0 575 324.6521 Tm
(on January 9, 2020)Tj
-0.278 0 Td
( )Tj
0 0 1 rg
-13.50598 0 Td
(http://science.sciencemag.org/)Tj
0 g
-8.11398 0 Td
(Downloaded from )Tj
ET
endstream
endobj
447 0 obj
<>/Filter/FlateDecode/Height 87/Length 19684/Name/X/Subtype/Image/Type/XObject/Width 350>>stream
HyTS߽Ia
"6p\P縠x:Z.Suk:8ud,EԺУ:xtSVk9@na}/ Ҟ6Gy@{_rcL"bFSgjz"UH}>2Z
5f @a,uWP24
jѨ\i-~==Op(rw]EQڇMyƧH4E5(HQ_-*P1.#*kb"f_+XA¾ՆK$FxUFJeFq {vdcg8ZS#3_kX `9'p (3u_Od}uvn|TSI#
!y 3|].Fh{U_JA-M0bD22}[-(U~[yTk|H mL;ƶc 0X ?1Ar?oƀU]C:/^ّ,7(a"Gq?b#QUaS L6)$Hm[ANc tPĎvURl2!VV{^e(^I9Dã3l]]\3$!i;v{?.Ҕ}31,ER[^k4Nok#b7fIȐy`au^GUĉ
W&\y,$d<|rD;VӪn>Mј[Mi#DQ LY2Cme#BV~2`ls~s W&
=xAJE^dɡ>S=`_dgk+gqaنKgbK=E[> @AQbg(