{"id":5,"date":"2015-03-10T19:46:40","date_gmt":"2015-03-10T19:46:40","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/reddylab\/?page_id=5"},"modified":"2015-03-10T19:46:40","modified_gmt":"2015-03-10T19:46:40","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/reddylab\/","title":{"rendered":"Home"},"content":{"rendered":"<h2 style=\"text-align: center\"><\/h2>\n<div id=\"attachment_63\" class=\"wp-caption aligncenter\" style=\"width: 413px\"><a href=\"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-content\/uploads\/sites\/101\/2015\/03\/Reddy_landing24.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-63\" src=\"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-content\/uploads\/sites\/101\/2015\/03\/Reddy_landing24.png\" alt=\"\" width=\"413\" height=\"361\" srcset=\"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-content\/uploads\/sites\/101\/2015\/03\/Reddy_landing24.png 413w, https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-content\/uploads\/sites\/101\/2015\/03\/Reddy_landing24-300x262.png 300w\" sizes=\"auto, (max-width: 413px) 100vw, 413px\" \/><\/a><p class=\"wp-caption-text\">Model of rigosertib binding to the Ras Binding Domain (RBD) of C-RAF (pink ribbon) relative to the position of RAS (green ribbon), which is shown for comparison.<\/p><\/div>\n<h2 style=\"text-align: center\"><span style=\"font-size: 1.5em;text-align: center\">Welcome<\/span><\/h2>\n<p style=\"text-align: justify\">Our laboratory is interested in the study of genes that govern cell homeostasis and how these controls are dysregulated during the neoplastic process.\u00a0 We use a combination of biochemical, molecular, synthetic chemical and structural biological approaches, and in close collaboration with the clinical community, develop and test small molecule anti-cancer compounds. Several of these agents are now in various phases of clinical trials.<\/p>\n<p style=\"text-align: justify\">We are also interested in studying the role of oncogenes in normal development and tumorigenesis using genetically engineered animal models. Our analysis of conditional and traditional knock-out mouse models of the <em>myb<\/em> gene family have allowed us to define their roles in hematopoietic stem and progenitor cell development and maintenance as well as their role in the development of the mammary gland.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Welcome Our laboratory is interested in the study of genes that govern cell homeostasis and how these controls are dysregulated during the neoplastic process.\u00a0 We use a combination of biochemical, molecular, synthetic chemical and structural biological approaches, and in close collaboration with the clinical community, develop and test small molecule anti-cancer compounds. Several of these [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":1,"href":"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":124,"href":"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-json\/wp\/v2\/pages\/5\/revisions\/124"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/reddylab\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}