{"id":172,"date":"2022-03-28T22:23:28","date_gmt":"2022-03-28T22:23:28","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/?page_id=172"},"modified":"2022-03-28T22:35:23","modified_gmt":"2022-03-28T22:35:23","slug":"poulikakos-lab","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/","title":{"rendered":"Poulikakos Lab"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-108 size-full\" src=\"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2014\/11\/PP.png\" alt=\"\" width=\"720\" height=\"540\" srcset=\"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2014\/11\/PP.png 720w, https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2014\/11\/PP-300x225.png 300w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/><\/p>\n<p style=\"text-align: justify\">Our laboratory investigates growth factor signaling regulation in normal and tumor cells. We exploit the selectivity of small molecule inhibitors, along with genetic (shRNA, CRISPR), biochemical and proteasome-directed degradation (PROTACs) approaches to interrogate the complexity of signaling networks that promote transformation, tumor maintenance and drug resistance. Our goal is to gain a deeper understanding of oncogenic signaling and use this knowledge to develop mechanism-based therapeutic pharmacologic strategies in cancer.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-170 alignleft\" src=\"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2022\/03\/Cell-Cover_Page_2-562x1024.jpg\" alt=\"\" width=\"250\" height=\"456\" srcset=\"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2022\/03\/Cell-Cover_Page_2-562x1024.jpg 562w, https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2022\/03\/Cell-Cover_Page_2-165x300.jpg 165w, https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2022\/03\/Cell-Cover_Page_2.jpg 604w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-169 alignright\" src=\"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2022\/03\/Cell-Cover_Page_1.jpg\" alt=\"\" width=\"250\" height=\"460\" srcset=\"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2022\/03\/Cell-Cover_Page_1.jpg 604w, https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2022\/03\/Cell-Cover_Page_1-163x300.jpg 163w, https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-content\/uploads\/sites\/98\/2022\/03\/Cell-Cover_Page_1-556x1024.jpg 556w\" sizes=\"auto, (max-width: 250px) 100vw, 250px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our laboratory investigates growth factor signaling regulation in normal and tumor cells. We exploit the selectivity of small molecule inhibitors, along with genetic (shRNA, CRISPR), biochemical and proteasome-directed degradation (PROTACs) approaches to interrogate the complexity of signaling networks that promote transformation, tumor maintenance and drug resistance. Our goal is to gain a deeper understanding of [&hellip;]<\/p>\n","protected":false},"author":158,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-172","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-json\/wp\/v2\/pages\/172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-json\/wp\/v2\/users\/158"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-json\/wp\/v2\/comments?post=172"}],"version-history":[{"count":9,"href":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-json\/wp\/v2\/pages\/172\/revisions"}],"predecessor-version":[{"id":186,"href":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-json\/wp\/v2\/pages\/172\/revisions\/186"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/poulikakoslab\/wp-json\/wp\/v2\/media?parent=172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}