{"id":1346,"date":"2018-01-20T01:48:23","date_gmt":"2018-01-20T01:48:23","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/peterlab\/?page_id=1346"},"modified":"2025-05-14T16:45:17","modified_gmt":"2025-05-14T16:45:17","slug":"ibd-parkinsons-disease","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/peterlab\/ibd-parkinsons-disease\/","title":{"rendered":"IBD – Parkinson’s Disease"},"content":{"rendered":"

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About the Study<\/span><\/strong><\/h2>\n

The genetics of IBD and Parkinson\u2019s is a collaborative research study led Drs. Inga Peter, Rachel Sanders-Pullman, and Susan Bressman.<\/p>\n

Inflammatory bowel disease (IBD) manifests itself as either Crohn\u2019s disease or ulcerative colitis. Approximately 1.4 million people in the US have been affected by IBD; the prevalence among Ashkenazi Jews is about two to four times higher than among non-Jewish whites.<\/p>\n

Parkinson\u2019s disease is a chronic, degenerative neurological disorder of the central nervous system. Mutations in the LRRK2 gene, the greatest genetic contributor to Parkinson\u2019s disease, were recently found in patients with IBD, placing individuals at greater risk of developing either (or both) diseases.<\/p>\n

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Aims<\/span><\/strong><\/h2>\n

We are studying genes, environmental factors, and bacteria in the gut that may increase the risk of getting Parkinson\u2019s Disease. The results from this study will contribute to our understanding of what causes this disease and help us develop new treatments.<\/p>\n

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News<\/span><\/strong><\/h2>\n

Our 2018 paper, Functional variants in the LRRK2 gene confer shared effects on risk for Crohn\u2019s disease and Parkinson\u2019s disease<\/strong> (see here<\/a>), gained media attention for providing new insight into the etiology of both IBD and Parkinson’s disease<\/p>\n