[\/et_pb_text][et_pb_slider use_bg_overlay=”off” use_text_overlay=”off” arrows_custom_color=”#000000″ dot_nav_custom_color=”#FFFFFF” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” custom_padding=”0px|0px|0px|0px||”][et_pb_slide _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” sticky_transition=”on”]<\/p>\n
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[\/et_pb_slide][et_pb_slide _builder_version=”4.9.0″ _module_preset=”default” sticky_transition=”on”][\/et_pb_slide][\/et_pb_slider][et_pb_text _builder_version=”4.9.0″ _module_preset=”default”]Pereira Lab has been performing several studies to understand the neurobiology of age-related cognitive decline and Alzheimer\u2019s disease using a translational approach. The lab\u2019s major focus is on furthering knowledge of the mechanisms of selective vulnerability of glutamatergic neural circuits to synaptic changes in aging and neuronal loss in Alzheimer\u2019s disease. Dr. Pereira and her lab members have been studying glutamatergic neuronal susceptibility with modern quantitative cell biology methods (at the synaptic and spine resolution with electron and confocal microscopy) in conjunction with molecular tools (next generation RNA sequencing, single cell sequencing, TRAP methodology) and functional assays in animal models and post-mortem Alzheimer\u2019s brains. The lab uses a diverse set of methodological approaches to relate anatomical and molecular findings to functional changes.<\/p>\n
Pereira Lab has also been investigating mechanisms by which chronic intermittent hypoxia, as it occurs in obstructive sleep apnea (OSA), can increase the risk and progression of Alzheimer\u2019s disease. The laboratory seeks to explore molecular mechanisms underlying these susceptibilities in order to pinpoint novel therapeutic targets. As a physician-scientist, Dr. Pereira has been translating basic science findings from the laboratory into clinical studies and a trial of potential novel treatments for patients with Alzheimer\u2019s disease.<\/p>\n
Read More<\/a>[\/et_pb_text][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_sidebar _builder_version=”4.9.0″ _module_preset=”default” header_text_color=”#000000″][\/et_pb_sidebar][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Welcome to the Pereira LabPereira Lab has been performing several studies to understand the neurobiology of age-related cognitive decline and Alzheimer\u2019s disease using a translational approach. The lab\u2019s major focus is on furthering knowledge of the mechanisms of selective vulnerability of glutamatergic neural circuits to synaptic changes in aging and neuronal loss in Alzheimer\u2019s disease. […]<\/p>\n","protected":false},"author":263,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":" [wds id=\"1\"] Pereira Lab has been performing several studies to understand the neurobiology of age-related cognitive decline and Alzheimer\u2019s disease using a translational approach. The lab\u2019s major focus is on furthering knowledge of the mechanisms of selective vulnerability of glutamatergic neural circuits to synaptic changes in aging and neuronal loss in Alzheimer\u2019s disease. Dr. Pereira and her lab members have been studying glutamatergic neuronal susceptibility with modern quantitative cell biology methods (at the synaptic and spine resolution with electron and confocal microscopy) in conjunction with molecular tools (next generation RNA sequencing, single cell sequencing, TRAP methodology) and functional assays in animal models and post-mortem Alzheimer\u2019s brains. The lab uses a diverse set of methodological approaches to relate anatomical and molecular findings to functional changes. Pereira Lab has also been investigating mechanisms by which chronic intermittent hypoxia, as it occurs in obstructive sleep apnea (OSA), can increase the risk and progression of Alzheimer\u2019s disease. The laboratory seeks to explore molecular mechanisms underlying these susceptibilities in order to pinpoint novel therapeutic targets. As a physician-scientist, Dr. Pereira has been translating basic science findings from the laboratory into clinical studies and a trial of potential novel treatments for patients with Alzheimer\u2019s disease. Read More<\/a><\/p>","_et_gb_content_width":"","footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/pereiralab\/wp-json\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/pereiralab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/pereiralab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/pereiralab\/wp-json\/wp\/v2\/users\/263"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/pereiralab\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":50,"href":"https:\/\/labs.icahn.mssm.edu\/pereiralab\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":873,"href":"https:\/\/labs.icahn.mssm.edu\/pereiralab\/wp-json\/wp\/v2\/pages\/17\/revisions\/873"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/pereiralab\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}