Publication

• Zhang J, Bhatt A, Maksaev G, Luo YL, Yuan P. Lipid-mediated gating of a miniature mechanosensitive MscS channel from Trypanosoma cruzi. Nat Commun 2025 Aug 8;16(1):7339. doi: 10.1038/s41467-025-62757-z. PMID: 40781240; PMCID: PMC12334622.

 

• Rashan EH, Bartlett AK, Khana DB, Zhang J, Jain R, Wade G, Abriata LA, Smith AJ, Baker ZN, Cook T, Caldwell A, Chevalier AR, Forny P, Pfleger BF, Peraro MD, Yuan P, Amador-Noguez D, Simcox JA, Pagliarini DJ. ACAD10 and ACAD11 enable mammalian 4-hydroxy acid lipid catabolism. Nat Struct Mol Biol 2025 Jun 19. doi: 10.1038/s41594-025-01596-4. Epub ahead of print. PMID: 40537578.

 

• Zhang J, Yuan P, Nichols CG, Maksaev G. Molecular basis of TRPV3 channel blockade by intracellular polyamines. Commun Biol 2025 May 10;8(1):727. doi: 10.1038/s42003-025-08103-x. PMID: 40348873; PMCID: PMC12065880.

 

• He Z, Tu YC, Tsai CW, Mount J, Zhang J, Tsai MF, Yuan P. Structure and function of the human mitochondrial MRS2 channel. Nat Struct Mol Biol 2025 Mar;32(3):459-468. doi: 10.1038/s41594-024-01420-5. Epub 2024 Nov 28. PMID: 39609651; PMCID: PMC11922672.

 

• Bitter RM, Zimmerman MI, Summers BT, Pinkner JS, Dodson KW, Hultgren SJ, Yuan P. Structural basis for adhesin secretion by the outer-membrane usher in type 1 pili. Proc Natl Acad Sci USA 2024 Oct;121(40):e2410594121. doi: 10.1073/pnas.2410594121. Epub 2024 Sep 24. PMID: 39316053; PMCID: PMC11459180.

 

• Burtscher V, Mount J, Huang J, Cowgill J, Chang Y, Bickel K, Chen J, Yuan P, Chanda B. Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun 2024 Jun 18;15(1):5216. doi: 10.1038/s41467-024-49599-x. PMID: 38890331; PMCID: PMC11189445.

 

• Zhang J, Maksaev G, Yuan P. Open structure and gating of the Arabidopsis mechanosensitive ion channel MSL10. Nat Commun 2023 Oct 7;14(1):6284. doi: 10.1038/s41467-023-42117-5. PMID: 37805510; PMCID: PMC10560256.

 

• Lansky S, Betancourt JM, Zhang J, Jiang Y, Kim ED, Paknejad N, Nimigean CM, Yuan P, Scheuring S. A pentameric TRPV3 channel with a dilated pore. Nature 2023 Sep;621(7977):206-214. doi: 10.1038/s41586-023-06470-1. Epub 2023 Aug 30. PMID: 37648856; PMCID: PMC10584365.

 

• Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T. Ligand and G-protein selectivity in the κ-opioid receptor. Nature 2023 May;617(7960):417-425. doi: 10.1038/s41586-023-06030-7. Epub 2023 May 3. PMID: 37138078; PMCID: PMC10172140.

 

• He Z, Zhao Y, Rau MJ, Fitzpatrick JAJ, Sah R, Hu H, Yuan P. Structural and functional analysis of human pannexin 2 channel. Nat Commun 2023 Mar 27;14(1):1712. doi: 10.1038/s41467-023-37413-z. PMID: 36973289; PMCID: PMC10043284.

 

• Maksaev G, Yuan P, Nichols CG. Blockade of TRPV channels by intracellular spermine. J Gen Physiol 2023 May 1;155(5):e202213273. doi: 10.1085/jgp.202213273. Epub 2023 Mar 13. PMID: 36912700; PMCID: PMC10038874.

 

• Petroff JT 2nd, Dietzen NM, Santiago-McRae E, Deng B, Washington MS, Chen LJ, Trent Moreland K, Deng Z, Rau M, Fitzpatrick JAJ, Yuan P, Joseph TT, Hénin J, Brannigan G, Cheng WWL. Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid modulation. Nat Commun 2022 Nov 17;13(1):7017. doi: 10.1038/s41467-022-34813-5. PMID: 36385237; PMCID: PMC9668969.

 

• Mount J, Maksaev G, Summers BT, Fitzpatrick JAJ, Yuan P. Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel. Nat Commun 2022 Nov 12;13(1):6904. doi: 10.1038/s41467-022-34737-0. PMID: 36371466; PMCID: PMC9653487.

 

• Bitter RM, Oh S, Deng Z, Rahman S, Hite RK, Yuan P. Structure of the Wilson disease copper transporter ATP7B. Sci Adv 2022 Mar 4;8(9):eabl5508. doi: 10.1126/sciadv.abl5508. Epub 2022 Mar 4. PMID: 35245129; PMCID: PMC8896786.

 

• Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LT, Van Aelst L, Xi D, Yuan P, Brady DC, Chang CJ. Connecting copper and cancer: from transition metal signalling to metalloplasia. Nat Rev Cancer 2022 Feb;22(2):102-113. doi: 10.1038/s41568-021-00417-2. Epub 2021 Nov 11. PMID: 34764459; PMCID: PMC8810673.

 

• Deng Z, Zhao Y, Feng J, Zhang J, Zhao H, Rau MJ, Fitzpatrick JAJ, Hu H, Yuan P. Cryo-EM structure of a proton-activated chloride channel TMEM206. Sci Adv 2021 Feb 24;7(9):eabe5983. doi: 10.1126/sciadv.abe5983. PMID: 33627432; PMCID: PMC7904269.

 

• Deng Z, Maksaev G, Schlegel AM, Zhang J, Rau M, Fitzpatrick JAJ, Haswell ES, Yuan P. Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance. Nat Commun 2020 Jul 23;11(1):3690. doi: 10.1038/s41467-020-17538-1. PMID: 32704140; PMCID: PMC7378837.

 

• Deng Z, Maksaev G, Rau M, Xie Z, Hu H, Fitzpatrick JAJ, Yuan P. Gating of human TRPV3 in a lipid bilayer. Nat Struct Mol Biol 2020 Jul;27(7):635-644. doi: 10.1038/s41594-020-0428-2. Epub 2020 Jun 22. PMID: 32572252; PMCID: PMC7354234.

 

• Geng Y, Deng Z, Zhang G, Budelli G, Butler A, Yuan P, Cui J, Salkoff L, Magleby KL. Coupling of Ca²⁺ and voltage activation in BK channels through the αB helix/voltage sensor interface. Proc Natl Acad Sci USA 2020 Jun 23;117(25):14512-14521. doi: 10.1073/pnas.1908183117. Epub 2020 Jun 8. PMID: 32513714; PMCID: PMC7321994.

 

• Deng Z, He Z, Maksaev G, Bitter RM, Rau M, Fitzpatrick JAJ, Yuan P. Cryo-EM structures of the ATP release channel pannexin 1. Nat Struct Mol Biol 2020 Apr;27(4):373-381. doi: 10.1038/s41594-020-0401-0. Epub 2020 Mar 30. PMID: 32231289.

 

• Zangerl-Plessl EM, Lee SJ, Maksaev G, Bernsteiner H, Ren F, Yuan P, Stary-Weinzinger A, Nichols CG. Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels. J Gen Physiol 2020 Jan 6;152(1):e201912422. doi: 10.1085/jgp.201912422. PMID: 31744859; PMCID: PMC7034095.

 

• Yuan P. Structural biology of thermoTRPV channels. Cell Calcium 2019 Dec;84:102106. doi: 10.1016/j.ceca.2019.102106. Epub 2019 Nov 1. PMID: 31726322; PMCID: PMC6893863.

 

• Ren F, Logeman BL, Zhang X, Liu Y, Thiele DJ, Yuan P. X-ray structures of the high-affinity copper transporter Ctr1. Nat Commun 2019 Mar 27;10(1):1386. doi: 10.1038/s41467-019-09376-7. PMID: 30918258; PMCID: PMC6437178.

 

• Omattage NS, Deng Z, Pinkner JS, Dodson KW, Almqvist F, Yuan P, Hultgren SJ. Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli. Nat Microbiol 2018 Dec;3(12):1362-1368. doi: 10.1038/s41564-018-0255-y. Epub 2018 Oct 1. PMID: 30275511; PMCID: PMC6258349.

 

• Deng Z, Paknejad N, Maksaev G, Sala-Rabanal M, Nichols CG, Hite RK, Yuan P. Cryo-EM and X-ray structures of TRPV4 reveal insight into ion permeation and gating mechanisms. Nat Struct Mol Biol 2018 Mar;25(3):252-260. doi: 10.1038/s41594-018-0037-5. Epub 2018 Feb 26. PMID: 29483651; PMCID: PMC6252174.

 

• Geng Y, Ferreira JJ, Dzikunu V, Butler A, Lybaert P, Yuan P, Magleby KL, Salkoff L, Santi CM. A genetic variant of the sperm-specific SLO3 K⁺ channel has altered pH and Ca²⁺ sensitivities. J Biol Chem 2017 May 26;292(21):8978-8987. doi: 10.1074/jbc.M117.776013. Epub 2017 Apr 4. PMID: 28377504; PMCID: PMC5448129.

 

• Lee SJ, Ren F, Zangerl-Plessl EM, Heyman S, Stary-Weinzinger A, Yuan P, Nichols CG. Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids. J Gen Physiol. 2016 Sep;148(3):227-37. doi: 10.1085/jgp.201611616. Epub 2016 Aug 15. PMID: 27527100; PMCID: PMC5004336.

 

• Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R. Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel. Nature 2015 Nov 12;527(7577):198-203. doi: 10.1038/nature14958. Epub 2015 Oct 5. PMID: 26436452; PMCID: PMC4886347.

 

• Leonetti MD, Yuan P, Hsiung Y, Mackinnon R. Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel. Proc Natl Acad Sci USA 2012 Nov 20;109(47):19274-9. doi: 10.1073/pnas.1215078109. Epub 2012 Nov 5. PMID: 23129643; PMCID: PMC3511096.

 

• Yuan P, Leonetti MD, Hsiung Y, MacKinnon R. Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel. Nature 2011 Dec 4;481(7379):94-7. doi: 10.1038/nature10670. PMID: 22139424; PMCID: PMC3319005.

 

• Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science 2010 Jul 9;329(5988):182-6. doi: 10.1126/science.1190414. Epub 2010 May 27. PMID: 20508092; PMCID: PMC3022345.