{"id":48,"date":"2021-09-02T01:22:52","date_gmt":"2021-09-02T01:22:52","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/pawlicalab2\/?page_id=48"},"modified":"2026-07-20T15:54:19","modified_gmt":"2026-07-20T15:54:19","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/","title":{"rendered":"HOME"},"content":{"rendered":"<h1 style=\"text-align: center;color: #000000;font-size: 22px;line-height: 1.3;margin-top: 0;margin-bottom: 10px\"><strong>Tiny genomes. Big questions.<\/strong><\/h1>\n<p style=\"text-align: center;color: #000000;font-size: 14.5px;line-height: 1.5;margin-top: 0;margin-bottom: 12px\">\nViruses cannot afford to waste space, yet they preserve noncoding RNA elements in their compact genomes. We study why these elements matter and how viruses use RNA regulatory pathways to control gene expression, shape host cell identity, and promote infection and persistence.<br \/>\nWe are especially interested in how viral noncoding RNAs manipulate post-transcriptional gene regulation through microRNAs and RNA-binding proteins.\n<\/p>\n<p style=\"text-align: center;color: #000000;font-size: 14.5px;line-height: 1.5;margin-bottom: 20px\"><em>Our lab combines molecular virology, RNA biology, biochemistry, genomics, and bioinformatics.<\/em><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" width=\"1896\" height=\"1052\" class=\"aligncenter wp-image-768\" style=\"margin: 20px auto 100px auto;max-width: 700px;width: 75%;height: auto\" src=\"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-content\/uploads\/sites\/407\/2026\/07\/Screenshot-2026-07-08-at-4.29.04-PM.png\" alt=\"Research themes of the Pawlica Lab\" srcset=\"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-content\/uploads\/sites\/407\/2026\/07\/Screenshot-2026-07-08-at-4.29.04-PM.png 1896w, https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-content\/uploads\/sites\/407\/2026\/07\/Screenshot-2026-07-08-at-4.29.04-PM-1280x710.png 1280w, https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-content\/uploads\/sites\/407\/2026\/07\/Screenshot-2026-07-08-at-4.29.04-PM-980x544.png 980w, https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-content\/uploads\/sites\/407\/2026\/07\/Screenshot-2026-07-08-at-4.29.04-PM-480x266.png 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 1896px, 100vw\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tiny genomes. Big questions. Viruses cannot afford to waste space, yet they preserve noncoding RNA elements in their compact genomes. We study why these elements matter and how viruses use RNA regulatory pathways to control gene expression, shape host cell identity, and promote infection and persistence. We are especially interested in how viral noncoding RNAs [&hellip;]<\/p>\n","protected":false},"author":493,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"off","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-48","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-json\/wp\/v2\/pages\/48","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-json\/wp\/v2\/users\/493"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-json\/wp\/v2\/comments?post=48"}],"version-history":[{"count":128,"href":"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-json\/wp\/v2\/pages\/48\/revisions"}],"predecessor-version":[{"id":881,"href":"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-json\/wp\/v2\/pages\/48\/revisions\/881"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/pawlicalab\/wp-json\/wp\/v2\/media?parent=48"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}