{"id":136,"date":"2015-02-05T19:49:43","date_gmt":"2015-02-05T19:49:43","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/parsonslab\/?page_id=136"},"modified":"2026-02-24T17:30:20","modified_gmt":"2026-02-24T17:30:20","slug":"136-2","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/projects\/136-2\/","title":{"rendered":"Metabolism and PTEN"},"content":{"rendered":"<h2 style=\"text-align: center\"><\/h2>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-content\/uploads\/sites\/93\/2015\/02\/Deepti.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-326 aligncenter\" src=\"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-content\/uploads\/sites\/93\/2015\/02\/Deepti.png\" alt=\"\" width=\"502\" height=\"298\" srcset=\"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-content\/uploads\/sites\/93\/2015\/02\/Deepti.png 502w, https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-content\/uploads\/sites\/93\/2015\/02\/Deepti-300x178.png 300w\" sizes=\"auto, (max-width: 502px) 100vw, 502px\" \/><\/a><\/p>\n<p style=\"text-align: center\"><strong>Saal et al., Proc Natl Acad Sci USA. 2007 May 1;104(18):7564-9<\/strong><\/p>\n<h2 style=\"text-align: center\"><strong><span style=\"color: #ac3e4e\">PTEN and Cellular Metabolism<\/span><\/strong><\/h2>\n<p style=\"text-align: justify\">Investigating metabolism is integral to understanding cancer: increased tumor growth is dependent on a cell\u2019s ability to produce more amino acids, nucleotides, and other building blocks \u2013 all of which are created through metabolic processes.\u00a0 In fact, it has been shown that changes in metabolic pathways affect tumor growth and maintenance.\u00a0 Our lab is studying how loss of the tumor suppressor Pten affects <em>in vitro<\/em> growth and metabolism.\u00a0 We are using mass spectrometry to determine how <em>Pten<\/em><sup>-\/-<\/sup> cells might reroute or upregulate certain metabolic pathways, and are systematically depleting nutrients to identify metabolites necessary for Pten-dependent growth.\u00a0 We are also investigating how loss of Pten alters gene expression and affects chromatin modifications using RNA-seq and ChIP-seq techniques and integrating these findings with our metabolism studies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Saal et al., Proc Natl Acad Sci USA. 2007 May 1;104(18):7564-9 PTEN and Cellular Metabolism Investigating metabolism is integral to understanding cancer: increased tumor growth is dependent on a cell\u2019s ability to produce more amino acids, nucleotides, and other building blocks \u2013 all of which are created through metabolic processes.\u00a0 In fact, it has been [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":91,"menu_order":5,"comment_status":"open","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-136","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-json\/wp\/v2\/pages\/136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-json\/wp\/v2\/comments?post=136"}],"version-history":[{"count":3,"href":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-json\/wp\/v2\/pages\/136\/revisions"}],"predecessor-version":[{"id":543,"href":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-json\/wp\/v2\/pages\/136\/revisions\/543"}],"up":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-json\/wp\/v2\/pages\/91"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/parsonslab\/wp-json\/wp\/v2\/media?parent=136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}