
{"id":1349,"date":"2022-10-13T17:37:32","date_gmt":"2022-10-13T21:37:32","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=1349"},"modified":"2023-06-08T20:34:01","modified_gmt":"2023-06-09T00:34:01","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/","title":{"rendered":"Home"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Two Column Image and Text over Button &#8211; Section 4&#8243; module_class=&#8221;section4_two_col_img_txt_over_btn&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#58595B&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/papapetroulab2\/wp-content\/uploads\/sites\/491\/2022\/12\/Background-1ALT.png&#8221; parallax=&#8221;on&#8221; width=&#8221;100%&#8221; custom_margin=&#8221;30px||||false|false&#8221; custom_padding=&#8221;80px|0px|63px|0px||&#8221; mix_blend_mode=&#8221;multiply&#8221; bottom_divider_style=&#8221;ramp2&#8243; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_height=&#8221;150px&#8221; bottom_divider_flip=&#8221;horizontal&#8221; bottom_divider_arrangement=&#8221;above_content&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#58595B&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; background_position=&#8221;top_left&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_slider _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#58595B&#8221; width=&#8221;84.3%&#8221; custom_margin=&#8221;|121px||||&#8221; custom_padding=&#8221;2px|||||&#8221;][et_pb_slide _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; sticky_transition=&#8221;on&#8221;]<\/p>\n<p style=\"text-align: center\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/labs.icahn.mssm.edu\/papapetroulab2\/wp-content\/uploads\/sites\/491\/2023\/06\/New-Home-Figure.jpg\" width=\"478\" height=\"480\" alt=\"\" class=\"wp-image-4422 alignnone size-full\" srcset=\"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-content\/uploads\/sites\/491\/2023\/06\/New-Home-Figure.jpg 478w, https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-content\/uploads\/sites\/491\/2023\/06\/New-Home-Figure-300x300.jpg 300w, https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-content\/uploads\/sites\/491\/2023\/06\/New-Home-Figure-150x150.jpg 150w\" sizes=\"(max-width: 478px) 100vw, 478px\" \/><\/p>\n<p>[\/et_pb_slide][et_pb_slide _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; sticky_transition=&#8221;on&#8221;]<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/labs.icahn.mssm.edu\/papapetroulab2\/wp-content\/uploads\/sites\/491\/2023\/06\/New-Home-Figure-2.jpg\" width=\"1875\" height=\"1395\" alt=\"\" class=\"wp-image-4706 alignnone size-full\" srcset=\"https:\/\/labs.icahn.mssm.edu\/papapetroulab2\/wp-content\/uploads\/sites\/491\/2023\/06\/New-Home-Figure-2.jpg 1875w, https:\/\/labs.icahn.mssm.edu\/papapetroulab2\/wp-content\/uploads\/sites\/491\/2023\/06\/New-Home-Figure-2-1280x952.jpg 1280w, https:\/\/labs.icahn.mssm.edu\/papapetroulab2\/wp-content\/uploads\/sites\/491\/2023\/06\/New-Home-Figure-2-980x729.jpg 980w, https:\/\/labs.icahn.mssm.edu\/papapetroulab2\/wp-content\/uploads\/sites\/491\/2023\/06\/New-Home-Figure-2-480x357.jpg 480w\" sizes=\"(min-width: 0px) and (max-width: 480px) 480px, (min-width: 481px) and (max-width: 980px) 980px, (min-width: 981px) and (max-width: 1280px) 1280px, (min-width: 1281px) 1875px, 100vw\" \/><\/p>\n<p>[\/et_pb_slide][\/et_pb_slider][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; background_position=&#8221;top_left&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;22px&#8221; header_font=&#8221;||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_4_text_color=&#8221;#FFFFFF&#8221; header_5_text_color=&#8221;#FFFFFF&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; max_width=&#8221;889px&#8221; custom_margin=&#8221;|-57px||||&#8221; custom_padding=&#8221;|76px||0px||&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;top&#8221; animation_intensity_slide=&#8221;4%&#8221;]<\/p>\n<h2 style=\"text-align: center\"><span style=\"color: #ffffff\"><strong>Learning about\u00a0blood cancers from human induced\u00a0<\/strong><strong>pluripotent stem cells<\/strong><\/span><\/h2>\n<p><span style=\"color: #ffffff\"><strong><\/strong><\/span><\/p>\n<p style=\"text-align: left\"><span style=\"color: #ffffff\">We study malignant and pre-malignant disorders of hematopoiesis (myelodysplastic syndrome, MDS; myeloproliferative neoplasms, MPN; acute myeloid leukemia, AML; inherited bone marrow failure syndromes, IBMFS; and clonal hematopoiesis, CH) with human induced pluripotent stem cell (iPSC) models and primary patient cells.<\/span><\/p>\n<p style=\"text-align: left\"><span style=\"color: #ffffff\">We use somatic cell reprogramming and CRISPR-mediated genome editing technologies to develop genetically faithful human pluripotent stem cell models of blood diseases, with which we gain insights into disease mechanisms and discover new therapeutic targets.<\/span><\/p>\n<p style=\"text-align: left\"><span style=\"color: #ffffff\">We are an international team located in the<a href=\"http:\/\/icahn.mssm.edu\/about-us\/hess-center\" style=\"color: #ffffff\" target=\"_blank\" rel=\"noopener noreferrer\">\u00a0<span style=\"color: #00ccff\">Leon and Norma Hess Center for Science and Medicine<\/span><\/a>\u00a0at Icahn School of Medicine at Mount Sinai.<\/span><\/p>\n<p style=\"text-align: left\"><span style=\"color: #ffffff\">We are part of the <span style=\"color: #00ccff\"><a href=\"https:\/\/icahn.mssm.edu\/research\/cabct\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"color: #00ccff\">Center for Advancement of Blood Cancer Therapies<\/a><\/span> (CABCT) and work closely with the <span style=\"color: #00ccff\"><a href=\"https:\/\/icahn.mssm.edu\/research\/portal\/resources\/deans-cores\/stem-cell-engineering\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"color: #00ccff\">Stem Cell Engineering Core<\/a><\/span> (SCEC) and the <span style=\"color: #00ccff\"><a href=\"https:\/\/bings.mssm.edu\/\" target=\"_blank\" rel=\"noopener noreferrer\" style=\"color: #00ccff\">Bioinformatics for Next Generation Sequencing<\/a><\/span> (BiNGS) shared resource facility.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Footer Fullwidth &#8211; Section 13&#8243; module_class=&#8221;footer-section&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#FFFFFF&#8221; background_enable_image=&#8221;off&#8221; max_width=&#8221;100%&#8221; max_width_tablet=&#8221;&#8221; max_width_phone=&#8221;&#8221; max_width_last_edited=&#8221;on|phone&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;100px|||176px|false|false&#8221; custom_padding=&#8221;3px|0px|0px|0px|false|false&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;bottom&#8221; animation_intensity_slide=&#8221;14%&#8221; animation_starting_opacity=&#8221;100%&#8221; saved_tabs=&#8221;all&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221;][et_pb_row _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#FFFFFF&#8221; background_color_gradient_direction=&#8221;38deg&#8221; module_alignment=&#8221;center&#8221; min_height=&#8221;141.2px&#8221; custom_margin=&#8221;-26px|auto||147px||&#8221; custom_padding=&#8221;|||0px||&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_social_media_follow _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; text_orientation=&#8221;center&#8221;][et_pb_social_media_follow_network social_network=&#8221;twitter&#8221; url=&#8221;https:\/\/twitter.com\/PapapetrouMDPhD&#8221; icon_color=&#8221;#00AEEF&#8221; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221; follow_button=&#8221;off&#8221; url_new_window=&#8221;on&#8221;]twitter[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;24px&#8221;]<\/p>\n<p style=\"text-align: center\"><span style=\"color: #000000\"><strong>Contact Us<\/strong><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#FFFFFF&#8221; background_color_gradient_direction=&#8221;38deg&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|auto|-2px|auto||&#8221; custom_padding=&#8221;0px||8px|||&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.9.0&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;22px&#8221;]<\/p>\n<p><span style=\"color: #000000\"><b>Resources<\/b><\/span><\/p>\n<p><a href=\"https:\/\/icahn.mssm.edu\/about\/departments\/oncological-sciences\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #00aeef\">Department of Oncological Sciences<\/span><\/a><br \/> <a href=\"https:\/\/icahn.mssm.edu\/research\/black-family-stem-cell\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #00aeef\"> Black Family Stem Cell Institute<\/span><\/a><br \/> <a href=\"https:\/\/icahn.mssm.edu\/research\/tisch\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #00aeef\"> Tisch Cancer Institute<\/span><\/a><br \/> <a href=\"https:\/\/icahn.mssm.edu\/education\/graduate\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #00aeef\"> Graduate School of Biomedical Sciences<\/span><\/a><br \/> <a href=\"https:\/\/www.hematology.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #00aeef\"> American Society of Hematology<\/span><\/a><br \/> <a href=\"https:\/\/asgct.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #00aeef\"> American Society of Gene and Cell Therapy<\/span><\/a><br \/> <a href=\"https:\/\/www.isscr.org\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #00aeef\"> International Society for Stem Cell Research<\/span><\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;1.25em&#8221; header_font=&#8221;||||||||&#8221; header_4_font=&#8221;|700||on|||||&#8221; header_4_font_size=&#8221;16px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.5em&#8221; background_layout=&#8221;dark&#8221; locked=&#8221;off&#8221;]<\/p>\n<p><span style=\"color: #000000\"><strong>Papapetrou Lab<br \/> <\/strong>Department of Oncological Sciences<br \/> Icahn School of Medicine at Mount Sinai<br \/> One Gustave L. Levy Place<br \/> Box 1044A<br \/> New York, NY 10029<br \/> Phone: 212-824-9337<br \/> E-mail:<\/span><strong style=\"color: #000000\">\u00a0<\/strong><span style=\"color: #000000\"><span style=\"color: #00aeef\"><a href=\"mailto:eirini.papapetrou@mssm.edu\" style=\"color: #00aeef\">eirini.papapetrou@mssm.edu<\/a><\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;1.25em&#8221; header_font=&#8221;||||||||&#8221; header_4_font=&#8221;|700||on|||||&#8221; header_4_font_size=&#8221;16px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.5em&#8221; background_layout=&#8221;dark&#8221; locked=&#8221;off&#8221;]<\/p>\n<p><span style=\"color: #000000\"><strong>Courier<br \/> <\/strong><\/span><span style=\"color: #000000\">Hess Center for Science and Medicine<br \/> <\/span><span style=\"color: #000000\">1470 Madison Ave, 6th FL., Rm. 112<br \/> <\/span><span style=\"color: #000000\">New York, NY 10029<br \/> <\/span><span style=\"color: #000000\">Phone: \u00a0212-824-9337<br \/> <\/span>Lab: \u00a0S6-202<\/p>\n<p><span style=\"color: #000000\"><span style=\"font-size: 16px\"><strong>Support Staff<br \/> <\/strong><\/span>Genevieve Joseph<\/span><br \/> <span style=\"color: #000000\"> Administrative Assistant<\/span><br \/> <span style=\"color: #000000\"> Phone: \u00a0212-824-9367<\/span><br \/> <a href=\"mailto:genevieve.joseph@mssm.edu\"><span style=\"color: #00aeef\"> genevieve.joseph@mssm.edu<\/span><\/a><\/p>\n<p><span style=\"font-size: 16px\"><strong><\/strong><\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;0px|||||&#8221; global_module=&#8221;5072&#8243; saved_tabs=&#8221;all&#8221;][et_pb_column _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; type=&#8221;4_4&#8243;][et_pb_button button_text=&#8221;Support Our Lab&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; button_url=&#8221;https:\/\/giving.mountsinai.org\/site\/SPageServer\/;jsessionid=00000000.app20102b?NONCE_TOKEN=4ED6DBF3457A2186683BECC3DC528BA1&amp;pagename=investigators&#8221; url_new_window=&#8221;on&#8221; button_alignment=&#8221;center&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Learning about\u00a0blood cancers from human induced\u00a0pluripotent stem cells We study malignant and pre-malignant disorders of hematopoiesis (myelodysplastic syndrome, MDS; myeloproliferative neoplasms, MPN; acute myeloid leukemia, AML; inherited bone marrow failure syndromes, IBMFS; and clonal hematopoiesis, CH) with human induced pluripotent stem cell (iPSC) models and primary patient cells. We use somatic cell reprogramming and CRISPR-mediated [&hellip;]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-1349","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-json\/wp\/v2\/pages\/1349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-json\/wp\/v2\/comments?post=1349"}],"version-history":[{"count":61,"href":"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-json\/wp\/v2\/pages\/1349\/revisions"}],"predecessor-version":[{"id":5073,"href":"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-json\/wp\/v2\/pages\/1349\/revisions\/5073"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/papapetroulab\/wp-json\/wp\/v2\/media?parent=1349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}