{"id":17,"date":"2016-06-07T21:02:48","date_gmt":"2016-06-07T21:02:48","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/panlab\/?page_id=17"},"modified":"2016-06-07T21:25:12","modified_gmt":"2016-06-07T21:25:12","slug":"the-nedd8-activator","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/panlab\/the-nedd8-activator\/","title":{"rendered":""},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-18\" src=\"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-content\/uploads\/sites\/90\/2016\/06\/Nedd8.png\" alt=\"Nedd8\" width=\"770\" height=\"596\" srcset=\"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-content\/uploads\/sites\/90\/2016\/06\/Nedd8.png 770w, https:\/\/labs.icahn.mssm.edu\/panlab\/wp-content\/uploads\/sites\/90\/2016\/06\/Nedd8-300x232.png 300w\" sizes=\"auto, (max-width: 770px) 100vw, 770px\" \/><\/p>\n<p><strong>The mechanism of activation of the Cullin-RING E3 ubiquitin ligases by Nedd8<\/strong><\/p>\n<p style=\"text-align: justify\">Activation of the Cullin-RING E3 ubiquitin ligases (CRLs) requires Nedd8, an Ub-like protein, which acts to covalently modify CRL\u2019s cullin subunit. Aside from its fundamental importance to the control of protein stability, Nedd8 has emerged as an effective target in anti-cancer efforts. Our research interests are to understand the function of Nedd8 in enhancing CRL-mediated proteolytic activity in both conformation dependent and independent fashion.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The mechanism of activation of the Cullin-RING E3 ubiquitin ligases by Nedd8 Activation of the Cullin-RING E3 ubiquitin ligases (CRLs) requires Nedd8, an Ub-like protein, which acts to covalently modify CRL\u2019s cullin subunit. Aside from its fundamental importance to the control of protein stability, Nedd8 has emerged as an effective target in anti-cancer efforts. Our [&hellip;]<\/p>\n","protected":false},"author":146,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-json\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-json\/wp\/v2\/users\/146"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":2,"href":"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":54,"href":"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-json\/wp\/v2\/pages\/17\/revisions\/54"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/panlab\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}