{"id":2,"date":"2015-09-15T14:46:16","date_gmt":"2015-09-15T14:46:16","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/neveslab\/?page_id=2"},"modified":"2016-06-01T16:46:14","modified_gmt":"2016-06-01T16:46:14","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/neveslab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p><a href=\"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/06\/Presentation3.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-93\" src=\"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/06\/Presentation3.jpg\" alt=\"Presentation3\" width=\"720\" height=\"540\" srcset=\"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/06\/Presentation3.jpg 720w, https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/06\/Presentation3-300x225.jpg 300w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/><\/a><\/p>\n<p>Neurons modulate the strength of their communication by changing the number of neurotransmitter receptors at their post-synaptic membrane. This process requires the active trafficking of receptors from intracellular vesicles to the plasma membrane and \u00a0for many neurotransmitter receptors, this trafficking is controlled by the activity of the cyclic nucleotide regulated kinases PKA and PKG.\u00a0 The modulation of synaptic strength is dysregulated in a number of psychiatric disorders, thus identifying targets that reverse these maladaptive changes could have therapeutic value.<\/p>\n<p>One possible set of targets is phosphodiesterases (PDEs), the sole enzymes that degrade cAMP and cGMP, and control PKA and PKG activation. The PDEs superfamily is composed of 11 gene families exhibiting a wide range of affinities and catalytic efficiencies for cAMP or cGMP.\u00a0 The PDE superfamily also displays significant cross-regulation, where the activity of one PDE can affect the activity of others due to regulation by cAMP or cGMP.<\/p>\n<p>Our lab uses a systems biology approach, where we develop dynamical computational models of signaling to understand the contribution of each PDE to the trafficking of neurotransmitter receptors.<\/p>\n<p>We also measure in neurons cyclic nucleotide signaling and receptor trafficking using imaging \u2013based approaches that provide fine temporal and spatial resolution data.<\/p>\n<div id=\"attachment_34\" class=\"wp-caption aligncenter\" style=\"width: 646px\"><a href=\"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/05\/SEP_GLUR_research-resize.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-34 size-large\" src=\"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/05\/SEP_GLUR_research-resize-1024x639.jpg\" alt=\"SEP_GLUR\" width=\"646\" height=\"403\" srcset=\"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/05\/SEP_GLUR_research-resize-1024x639.jpg 1024w, https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/05\/SEP_GLUR_research-resize-300x187.jpg 300w, https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/05\/SEP_GLUR_research-resize.jpg 1230w\" sizes=\"auto, (max-width: 646px) 100vw, 646px\" \/><\/a><p class=\"wp-caption-text\">SEP GluA1 Receptor Trafficking<\/p><\/div>\n<div id=\"attachment_102\" class=\"wp-caption aligncenter\" style=\"width: 720px\"><a href=\"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/06\/fret_slides1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-102 size-full\" src=\"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/06\/fret_slides1.jpg\" alt=\"fret_slides\" width=\"720\" height=\"540\" srcset=\"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/06\/fret_slides1.jpg 720w, https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-content\/uploads\/sites\/141\/2016\/06\/fret_slides1-300x225.jpg 300w\" sizes=\"auto, (max-width: 720px) 100vw, 720px\" \/><\/a><p class=\"wp-caption-text\">cAMP FRET Signaling<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Neurons modulate the strength of their communication by changing the number of neurotransmitter receptors at their post-synaptic membrane. This process requires the active trafficking of receptors from intracellular vesicles to the plasma membrane and \u00a0for many neurotransmitter receptors, this trafficking is controlled by the activity of the cyclic nucleotide regulated kinases PKA and PKG.\u00a0 The [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":22,"href":"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":106,"href":"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-json\/wp\/v2\/pages\/2\/revisions\/106"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/neveslab\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}