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Papers Published Through Minerva Supercomputing

 

2023

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Acknowledgement Statements for Publications Utilizing Supercomputing Resources

 


2023

 

  1. M. S. Breen et al., Large 22q13.3 deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome. Human Genetics and Genomics Advances 4, 100145 (2023).
  2. M. S. Breilyn, E. E. Kenny, N. S. Abul-Husn, Diverse and unselected adults with clinically relevant ACADS variants lack evidence of metabolic disease. Mol Genet Metab 138, 106971 (2023).
  3. M. Déjosez et al., Bat pluripotent stem cells reveal unusual entanglement between host and viruses. Cell 186, 957-974.e928 (2023).
  4. S. Dyzenhaus et al., MRSA lineage USA300 isolated from bloodstream infections exhibit altered virulence regulation. Cell Host Microbe 31, 228-242.e228 (2023).
  5. C. Ethan et al., Relationship of hepatitis C risk to hepatitis C test acceptance among adult patients participating in an ED hepatitis C screening programme. Emergency Medicine Journal 10.1136/emermed-2022-212726, emermed-2022-212726 (2023).
  6. D. Greene et al., Genetic association analysis of 77,539 genomes reveals rare disease etiologies. Nature Medicine 29, 679-688 (2023).
  7. K. Hou et al., Causal effects on complex traits are similar for common variants across segments of different continental ancestries within admixed individuals. Nature Genetics 10.1038/s41588-023-01338-6 (2023).
  8. Y. Kong, E. A. Mead, G. Fang, Navigating the pitfalls of mapping DNA and RNA modifications. Nature Reviews Genetics 10.1038/s41576-022-00559-5 (2023).
  9. K. R. Kulkarni et al., An Interpretable and Predictive Connectivity-Based Neural Signature for Chronic Cannabis Use. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 8, 320-330 (2023).
  10. S. Lehrer, P. H. Rheinstein, Shingles vaccination reduces the risk of Parkinson’s disease. Chronic Dis Transl Med 9, 54-57 (2023).
  11. S. Lehrer, P. H. Rheinstein, Androgen Deprivation Therapy Unrelated to Alzheimer’s Disease in the UK Biobank Cohort. Anticancer Res 43, 437-440 (2023).
  12. J. E. Linder et al., Returning integrated genomic risk and clinical recommendations: The eMERGE study. Genet Med 25, 100006 (2023).
  13. G. Qin et al., Distinct niche structures and intrinsic programs of fallopian tube and ovarian surface epithelial cells. iScience 26, 105861 (2023).
  14. S. M. Rutledge et al., Association of HSD17B13 and PNPLA3 With Liver Enzymes and Fibrosis in Hispanic/Latino Individuals of Diverse Genetic Ancestries. Clin Gastroenterol Hepatol 10.1016/j.cgh.2022.12.025 (2023).
  15. M. Sebastin et al., The TeleKidSeq pilot study: incorporating telehealth into clinical care of children from diverse backgrounds undergoing whole genome sequencing. Pilot and Feasibility Studies 9, 47 (2023).
  16. X. Song et al., MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer. Nature Communications 14, 377 (2023).
  17. C. M. Storey et al., Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response. Mol Cancer Res 21, 307-315 (2023).
  18. R. C. Thompson et al., Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae. Nature Medicine 29, 236-246 (2023).
  19. M. Verbitsky et al., Genomic Disorders in CKD across the Lifespan. J Am Soc Nephrol 34, 607-618 (2023).
  20. R. Wang et al., Construction of a cross-species cell landscape at single-cell level. Nucleic Acids Res 51, 501-516 (2023).
  21. P. Xu et al., Multi-omic integration reveals cell-type-specific regulatory networks of insulin resistance in distinct ancestry populations. Cell Syst 14, 41-57.e48 (2023).

2022 

    1.  
    1. E. E. Abbott et al., Survival After Out-of-Hospital Cardiac Arrest: The Role of Racial Residential Segregation. Journal of Urban Health 99, 998-1011 (2022).
    2. D. Ahn et al., Gαs slow conformational transition upon GTP binding and a novel Gαs regulator. bioRxiv 10.1101/2022.10.10.511514, 2022.2010.2010.511514 (2022).
    3. C. J. Aranda et al., IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases. Allergy 10.1111/all.15601 (2022).
    4. T. Aydillo et al., Transcriptome signatures preceding the induction of anti-stalk antibodies elicited after universal influenza vaccination. npj Vaccines 7, 160 (2022).
    5. K. K. Badani et al., SARS-CoV-2 RNA Detected in Abdominal Insufflation Samples During Laparoscopic Surgery. European urology 81, 125-127 (2022).
    6. S. Badrinath et al., A vaccine targeting resistant tumours by dual T cell plus NK cell attack. Nature 10.1038/s41586-022-04772-4 (2022).
    7. A. M. Barrette et al., Anti-invasive efficacy and survival benefit of the YAP-TEAD inhibitor verteporfin in preclinical glioblastoma models. Neuro Oncol 24, 694-707 (2022).
    8. R. Birnbaum, B. Mahjani, R. J. F. Loos, A. J. Sharp, Clinical Characterization of Copy Number Variants Associated With Neurodevelopmental Disorders in a Large-scale Multiancestry Biobank. JAMA Psychiatry 79, 250-259 (2022).
    9. K. R. Bowles et al., Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD. Acta Neuropathologica 143, 225-243 (2022).
    10. G. Butler-Laporte et al., The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals. Clin Proteomics 19, 34 (2022).
    11. G. Carbonell et al., Quantitative chest computed tomography combined with plasma cytokines predict outcomes in COVID-19 patients. Heliyon 8, e10166 (2022).
    12. S. Carcamo et al., Altered BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma. Cell Reports 39 (2022).
    13. J. M. Carreño et al., Activity of convalescent and vaccine serum against SARS-CoV-2 Omicron. Nature 602, 682-688 (2022).
    14. S. T. Chen et al., Shift of lung macrophage composition is associated with COVID-19 disease severity and recovery. bioRxiv 10.1101/2022.01.11.475918, 2022.2001.2011.475918 (2022).
    15. T.-Y. Chen et al., Extracellular vesicles carry distinct proteo-transcriptomic signatures that are different from their cancer cell of origin. iScience 25, 104414 (2022).
    16. Cristiana Cruceanu, Ph.D. , et al., Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study. American Journal of Psychiatry 179, 375-387 (2022).
    17. W. H. Cuddleston et al., Spatiotemporal and genetic regulation of A-to-I editing throughout human brain development. Cell Rep 41, 111585 (2022).
    18. W. H. Cuddleston et al., Cellular and genetic drivers of RNA editing variation in the human brain. Nature Communications 13, 2997 (2022).
    19. O. Danziger, R. S. Patel, E. J. DeGrace, M. R. Rosen, B. R. Rosenberg, Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor. PLoS pathogens 18, e1010464-e1010464 (2022).
    20. R. De Gasperi et al., Numb is required for optimal contraction of skeletal muscle. Journal of Cachexia, Sarcopenia and Muscle n/a (2022).
    21. M. M. DeGrace et al., Defining the risk of SARS-CoV-2 variants on immune protection. Nature 605, 640-652 (2022).
    22. N. Del Rossi, J. G. Chen, G.-C. Yuan, R. Dries, Analyzing Spatial Transcriptomics Data Using Giotto. Current Protocols 2, e405 (2022).
    23. A. F. Di’Narzo et al., Integrative Analysis of the Inflammatory Bowel Disease Serum Metabolome Improves Our Understanding of Genetic Etiology and Points to Novel Putative Therapeutic Targets. Gastroenterology 162, 828-843.e811 (2022).
    24. D. Dima et al., Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping 43, 452-469 (2022).
    25. J. A. Duty et al., Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants. Med (N Y) 3, 705-721.e711 (2022).
    26. P. Encinas et al., Evolution of influenza A virus in intensive and free-range swine farms in Spain. Virus Evol 7, veab099 (2022).
    27. A. Escalera et al., Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission. Cell host & microbe 30, 373-387.e377 (2022).
    28. D. Esposito et al., ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation. Nature Communications 13, 703 (2022).
    29. M. E. Farkouh et al., Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week. Journal of the American College of Cardiology 79, 917-928 (2022).
    30. K. Farrell et al., Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta neuropathologica 143, 33-53 (2022).
    31. V. G. Fiore, X. Gu, Similar network compositions, but distinct neural dynamics underlying belief updating in environments with and without explicit outcomes. Neuroimage 247, 118821 (2022).
    32. I. S. Forrest et al., Population-Based Penetrance of Deleterious Clinical Variants. JAMA 327, 350-359 (2022).
    33. I. S. Forrest, G. N. Nadkarni, R. Do, Penetrance of Deleterious Clinical Variants—Reply. JAMA 327, 1927-1927 (2022).
    34. S. Frangou et al., Hippocampal volume reduction is associated with direct measure of insulin resistance in adults. Neuroscience Research 174, 19-24 (2022).
    35. S. Frangou et al., Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3–90 years. Human Brain Mapping 43, 431-451 (2022).
    36. X. Gao et al., Blocking PI3K p110β Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer. Molecular Cancer Research 20, 673-685 (2022).
    37. P. Garg et al., A phenome-wide association study identifies effects of copy-number variation of VNTRs and multicopy genes on multiple human traits. The American Journal of Human Genetics 109, 1065-1076 (2022).
    38. T. Ge et al., Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations. Genome medicine 14, 70 (2022).
    39. D. M. Gonzalez et al., Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure. Development 149 (2022).
    40. E. E. Gonzalez-Kozlova, Molecular Profiling of Liquid Biopsies for Precision Oncology. Adv Exp Med Biol 1361, 235-247 (2022).
    41. P. J. Halfmann et al., SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters. Nature 603, 687-692 (2022).
    42. S. C. Hanks et al., Extent to which array genotyping and imputation with large reference panels approximate deep whole-genome sequencing. American journal of human genetics 109, 1653-1666 (2022).
    43. K. Y. He et al., Rare coding variants in RCN3 are associated with blood pressure. BMC genomics 23, 148 (2022).
    44. M. M. Hernandez et al., RT-PCR/MALDI-TOF Diagnostic Target Performance Reflects Circulating SARS-CoV-2 Variant Diversity in New York City. J Mol Diagn 24, 738-749 (2022).
    45. M. M. Hernandez et al., Robust clinical detection of SARS-CoV-2 variants by RT-PCR/MALDI-TOF multitarget approach. Journal of Medical Virology 94, 1606-1616 (2022).
    46. M. M. Hernandez et al., A robust, highly multiplexed mass spectrometry assay to identify SARS-CoV-2 variants. medRxiv 10.1101/2022.05.28.22275691 (2022).
    47. H. M. Highland et al., Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits. American journal of human genetics 109, 669-679 (2022).
    48. G. Hindy et al., Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes. The American Journal of Human Genetics 109, 81-96 (2022).
    49. G. E. Hoffman et al., Sex Differences in the Human Brain Transcriptome of Cases With Schizophrenia. Biological psychiatry 91, 92-101 (2022).
    50. C. Hsuan, A. Zebrowski, M. P. Lin, D. G. Buckler, B. G. Carr, Emergency departments in the United States treating high proportions of patients with ambulatory care sensitive conditions: a retrospective cross-sectional analysis. BMC Health Services Research 22, 854 (2022).
    51. L. Huang et al., TOP-LD: A tool to explore linkage disequilibrium with TOPMed whole-genome sequence data. American journal of human genetics 109, 1175-1181 (2022).
    52. T. Jaquenoud, S. Keene, N. Shlayan, A. Federman, G. Pandey, An Effective Automated Algorithm to Isolate Patient Speech from Conversations with Clinicians. medRxiv 10.1101/2022.11.29.22282914, 2022.2011.2029.22282914 (2022).
    53. S. F. Kazim et al., Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures. Biological psychiatry 91, 346-358 (2022).
    54. T. Kehrer et al., Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis. bioRxiv 10.1101/2022.10.18.512708 (2022).
    55. T. N. Kelly et al., Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension. Hypertension 79, 1656-1667 (2022).
    56. A. Khan et al., Genome-wide polygenic score to predict chronic kidney disease across ancestries. Nature Medicine 28, 1412-1420 (2022).
    57. E. Kirkpatrick Roubidoux et al., Novel Epitopes of the Influenza Virus N1 Neuraminidase Targeted by Human Monoclonal Antibodies. Journal of virology 96, e0033222-e0033222 (2022).
    58. R. J. Klein et al., Prostate cancer polygenic risk score and prediction of lethal prostate cancer. NPJ Precis Oncol 6, 25-25 (2022).
    59. Y. Kong et al., Critical assessment of DNA adenine methylation in eukaryotes using quantitative deconvolution. Science 375, 515-522 (2022).
    60. N. Konstantinides et al., A complete temporal transcription factor series in the fly visual system. Nature 604, 316-322 (2022).
    61. K. R. Kulkarni et al., An interpretable and predictive connectivity-based neural signature for chronic cannabis use. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging https://doi.org/10.1016/j.bpsc.2022.04.009 (2022).
    62. S. Lehrer, P. H. Rheinstein, Druggable genetic targets in endometrial cancer✰,✰✰. Cancer Treatment and Research Communications 30, 100502 (2022).
    63. S. Lehrer, P. H. Rheinstein, Circulating Chlamydia Trachomatis Antigens in Subjects With Alzheimer’s Disease. In Vivo 36, 2650-2653 (2022).
    64. S. Lehrer, P. H. Rheinstein, Vaccination Reduces Risk of Alzheimer’s Disease, Parkinson’s Disease and Other Neurodegenerative Disorders. Discov Med 34, 97-101 (2022).
    65. S. Lehrer, P. H. Rheinstein, α-synuclein enfolds tyrosine hydroxylase and dopamine ß-hydroxylase, potentially reducing dopamine and norepinephrine synthesis. J Proteins Proteom 13, 109-115 (2022).
    66. S. Lehrer, P. H. Rheinstein, Breast cancer and body weight changes of young women in the UK Biobank cohort. Cancer 128, 3573 (2022).
    67. S. Lehrer, P. H. Rheinstein, Association of cannabis with chronic obstructive pulmonary disease and COVID-19 infection. Chronic Dis Transl Med 8, 238-241 (2022).
    68. S. Lehrer, P. H. Rheinstein, Genome-wide association study of dermatophytosis in the UK Biobank cohort. J Eur Acad Dermatol Venereol 36, 2482-2487 (2022).
    69. S. Lehrer, P. H. Rheinstein, EARS2 significantly coexpresses with PALB2 in breast and pancreatic cancer. Cancer Treat Res Commun 32, 100595 (2022).
    70. S. Lehrer, P. H. Rheinstein, Cannabis smoking and age-related macular degeneration in the UK Biobank cohort. J Fr Ophtalmol 45, 756-761 (2022).
    71. S. Lehrer, P. H. Rheinstein, The Association Between Selenium, Selenoprotein P (SEPP1), Fluid Intelligence, and Exercise in the UK Biobank Cohort. Cureus 14, e25353 (2022).
    72. S. Lehrer, P. H. Rheinstein, RE: Nitrogen-Based Bisphosphonate Use and Ovarian Cancer Risk in Women Aged 50 Years and Older. J Natl Cancer Inst 114, 1425-1426 (2022).
    73. S. Lehrer, P. H. Rheinstein, Neither tamoxifen nor aromatase inhibitors increase the risk of Parkinson disease in the UK Biobank cohort. Cancer 128, 2997-2998 (2022).
    74. S. Lehrer, P. H. Rheinstein, Cannabis, Intraocular Pressure, and the Growth Arrest-Specific 7 (GAS7) Gene: A Retrospective Analysis. Cureus 14, e23919 (2022).
    75. S. Lehrer, P. H. Rheinstein, Marijuana and Myocardial Infarction in the UK Biobank Cohort. Cureus 14, e22054 (2022).
    76. S. Lehrer, P. H. Rheinstein, Constipation and Cigarette Smoking Are Independent Influences for Parkinson’s Disease. Cureus 14, e21689 (2022).
    77. S. Lehrer, P. H. Rheinstein, Marijuana smoking and cataract. J Fr Ophtalmol 45, 267-271 (2022).
    78. S. Lehrer, P. H. Rheinstein, Cannabis smoking and glaucoma in the UK Biobank cohort. J Fr Ophtalmol 45, 423-429 (2022).
    79. S. Lehrer, P. H. Rheinstein, J. Schmeidler, A Component or Multiple Components of Bleeding Gums May Ameliorate Both Glaucoma and Alzheimer’s Disease. Cureus 14, e21004-e21004 (2022).
    80. S. Li et al., Inpatient Administration of Alpha-1-Adrenergic Receptor Blocking Agents Reduces Mortality in Male COVID-19 Patients. Front Med (Lausanne) 9, 849222-849222 (2022).
    81. Y.-C. Li, L. Wang, J. Law, T. M. Murali, G. Pandey, Integrating multimodal data through interpretable heterogeneous ensembles. bioRxiv 10.1101/2020.05.29.123497, 2020.2005.2029.123497 (2022).
    82. D. Liu et al., Rare schizophrenia risk variant burden is conserved in diverse human populations. medRxiv 10.1101/2022.01.03.22268662, 2022.2001.2003.22268662 (2022).
    83. R. A. Lizewski et al., SARS-CoV-2 Outbreak Dynamics in an Isolated US Military Recruit Training Center With Rigorous Prevention Measures. Epidemiology 33, 797-807 (2022).
    84. T. J. Loftus et al., Artificial intelligence-enabled decision support in nephrology. Nature Reviews Nephrology 10.1038/s41581-022-00562-3 (2022).
    85. R. W. Logan et al., Sex Differences in Molecular Rhythms in the Human Cortex. Biological psychiatry 91, 152-162 (2022).
    86. S. I. Machlovi et al., APOE4 confers transcriptomic and functional alterations to primary mouse microglia. Neurobiology of Disease 164, 105615 (2022).
    87. P. C. Mack et al., Longitudinal COVID-19-vaccination-induced antibody responses and Omicron neutralization in patients with lung cancer. Cancer Cell 10.1016/j.ccell.2022.04.012, S1535-6108(1522)00174-X (2022).
    88. H. E. Maier et al., Protection Associated with Previous SARS-CoV-2 Infection in Nicaragua. N Engl J Med 387, 568-570 (2022).
    89. G. A. Marx et al., Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment. Acta Neuropathologica Communications 10, 157 (2022).
    90. A. T. McKenzie et al., Interpretable deep learning of myelin histopathology in age-related cognitive impairment. bioRxiv 10.1101/2022.06.06.495016, 2022.2006.2006.495016 (2022).
    91. S. Menez et al., Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19. Am J Kidney Dis 79, 257-267.e251 (2022).
    92. G. Mestrallet, K. Sone, N. Bhardwaj, Strategies to overcome DC dysregulation in the tumor microenvironment. Front Immunol 13, 980709 (2022).
    93. K. Mukherjee, J. J. Bieker, EKLF/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release. Cell Rep 41, 111830 (2022).
    94. S. Mukherjee et al., Germline Pathogenic Variants Impact Clinicopathology of Advanced Lung Cancer. Cancer Epidemiology, Biomarkers & Prevention 10.1158/1055-9965.Epi-21-1287, OF1-OF10 (2022).
    95. N. Mullins et al., Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors. Biological psychiatry 91, 313-327 (2022).
    96. T. Nakao et al., Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Sci Adv 8, eabl6579 (2022).
    97. N. B. Olivero et al., Phylogenetic analysis and comparative genomics of SARS-CoV-2 from survivor and non-survivor COVID-19 patients in Cordoba, Argentina. BMC genomics 23, 510 (2022).
    98. S. N. Olsen et al., MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape. Molecular Cell 82, 1140-1155.e1111 (2022).
    99. A. Ozonoff et al., Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study. EBioMedicine 83, 104208 (2022).
    100. B. Pai et al., High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy. Acta Neuropathologica Communications 10, 149 (2022).
    101. A. L. Pan et al., Dual-Specificity Protein Phosphatase 4 (DUSP4) Overexpression Improves Learning Behavior Selectively in Female 5xFAD Mice, and Reduces β-Amyloid Load in Males and Females. Cells 11 (2022).
    102. R. Patel et al., Impact of body mass index on the efficacy of aromatase inhibitors in patients with metastatic breast cancer. Breast Cancer Research and Treatment 192, 313-319 (2022).
    103. G. A. Pathak et al., A first update on mapping the human genetic architecture of COVID-19. Nature 608, E1-E10 (2022).
    104. B. O. Petrazzini et al., Coronary Risk Estimation Based on Clinical Data in Electronic Health Records. Journal of the American College of Cardiology 79, 1155-1166 (2022).
    105. J. D. Ramírez et al., Hotspots for SARS-CoV-2 Omicron variant spread: Lessons from New York City. Journal of medical virology 94, 2911-2914 (2022).
    106. S. I. Ramos et al., An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics. Nature Communications 13, 7671 (2022).
    107. E. Reategui Schwarz et al., Everybody nose: molecular and clinical characteristics of nasal colonization during active methicillin-resistant Staphylococcus aureus bloodstream infection. BMC Infect Dis 22, 400-400 (2022).
    108. D. Reyes-Dumeyer et al., The National Institute on Aging Late-Onset Alzheimer’s Disease Family Based Study: A resource for genetic discovery. Alzheimer’s & Dementia n/a (2022).
    109. A. C. Ricardo et al., Hispanic ethnicity and mortality among critically ill patients with COVID-19. PloS one 17, e0268022-e0268022 (2022).
    110. F. Richter et al., Neonatal outcomes during the COVID-19 pandemic in New York City. Pediatric research 91, 477-479 (2022).
    111. L. Salas-Estrada, B. Fiorillo, M. Filizola, Metadynamics simulations leveraged by statistical analyses and artificial intelligence-based tools to inform the discovery of G protein-coupled receptor ligands. Front Endocrinol (Lausanne) 13, 1099715 (2022).
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    113. D. A. Schoenfeld et al., Loss of PBRM1 Alters Promoter Histone Modifications and Activates ALDH1A1 to Drive Renal Cell Carcinoma. Molecular Cancer Research 10.1158/1541-7786.Mcr-21-1039, OF1-OF15 (2022).
    114. C. Seah et al., Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression. Nature Neuroscience 25, 1434-1445 (2022).
    115. S. Sen et al., Structure-Based Discovery of a Novel Class of Small-Molecule Pure Antagonists of Integrin αVβ3. Journal of Chemical Information and Modeling 62, 5607-5621 (2022).
    116. S. C. Shah et al., Breastfeeding Is Associated with Lower Likelihood of Helicobacter Pylori Colonization in Babies, Based on a Prospective USA Maternal-Infant Cohort. Dig Dis Sci 67, 5149-5157 (2022).
    117. S. P. Smith et al., Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries. The American Journal of Human Genetics 109, 871-884 (2022).
    118. X. Song et al., MiXcan: a Framework for Cell-Type-Specific Transcriptome-Wide Association Studies with an Application to Breast Cancer. bioRxiv 10.1101/2022.03.15.484509, 2022.2003.2015.484509 (2022).
    119. X. Song et al., SNPs at SMG7 Associated with Time from Biochemical Recurrence to Prostate Cancer Death. Cancer Epidemiology, Biomarkers & Prevention 10.1158/1055-9965.EPI-22-0053, OF1-OF7 (2022).
    120. D. Stadlbauer et al., Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site. Nature Communications 13, 7864 (2022).
    121. S. A. Suckiel et al., Perspectives of diverse Spanish- and English-speaking patients on the clinical use of polygenic risk scores. Genetics in Medicine 24, 1217-1226 (2022).
    122. D. Sun et al., MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells. Sci Adv 8, eabo0876 (2022).
    123. Z. Sun et al., Blood Transcriptomes of SARS-CoV-2-Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity. J Am Soc Nephrol 33, 2108-2122 (2022).
    124. E. Takashita et al., Efficacy of Antibodies and Antiviral Drugs against Omicron BA.2.12.1, BA.4, and BA.5 Subvariants. N Engl J Med 387, 468-470 (2022).
    125. J. Tan et al., Murine Broadly Reactive Antineuraminidase Monoclonal Antibodies Protect Mice from Recent Influenza B Virus Isolates and Partially Inhibit Virus Transmission in the Guinea Pig Model. mSphere 7, e0092721 (2022).
    126. J. Tan et al., Human Anti-neuraminidase Antibodies Reduce Airborne Transmission of Clinical Influenza Virus Isolates in the Guinea Pig Model. Journal of Virology 96, e01421-01421 (2022).
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    129. D. M. Walker et al., Sex-Specific Transcriptional Changes in Response to Adolescent Social Stress in the Brain’s Reward Circuitry. Biological psychiatry 91, 118-128 (2022).
    130. C. Wang et al., Sex disparities in influenza: A multiscale network analysis. iScience 25, 104192 (2022).
    131. M. Wang et al., Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application. Molecular Neurodegeneration 17, 17 (2022).
    132. P. Wang et al., Disrupting the DREAM complex enables proliferation of adult human pancreatic β cells. The Journal of Clinical Investigation 132 (2022).
    133. T. Wang et al., The Human Pangenome Project: a global resource to map genomic diversity. Nature 604, 437-446 (2022).
    134. X. Wang et al., IL-17 Pathway Members as Potential Biomarkers of Effective Systemic Treatment and Cardiovascular Disease in Patients with Moderate-to-Severe Psoriasis. International journal of molecular sciences 23, 555 (2022).
    135. N. M. Wickramasinghe et al., PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes. Cell stem cell 29, 559-576.e557 (2022).
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2019

 

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2018


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2. Audrain M, Haure-Mirande J-V, Wang M, Kim SH, Fanutza T, Chakrabarty P, et al. Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Molecular Psychiatry. 2018. doi: 10.1038/s41380-018-0258-3.

3. Aushev VN, Lee E, Zhu J, Gopalakrishnan K, Li Q, Teitelbaum SL, et al. Novel Predictors of Breast Cancer Survival Derived from miRNA Activity Analysis. Clinical Cancer Research. 2018;24(3):581.

4. Ayata P, Badimon A, Strasburger HJ, Duff MK, Montgomery SE, Loh Y-HE, et al. Epigenetic regulation of brain region-specific microglia clearance activity. Nature Neuroscience. 2018;21(8):1049-60. doi: 10.1038/s41593-018-0192-3.

5. Barbosa M, Joshi RS, Garg P, Martin-Trujillo A, Patel N, Jadhav B, et al. Identification of rare <em>de novo</em> epigenetic variations in congenital disorders. bioRxiv. 2018.

6. Barbosa M, Joshi RS, Garg P, Martin-Trujillo A, Patel N, Jadhav B, et al. Identification of rare de novo epigenetic variations in congenital disorders. Nature communications. 2018;9(1):2064-. doi: 10.1038/s41467-018-04540-x. PubMed PMID: 29802345.

7. Bonnemaijer PWM, Iglesias AI, Nadkarni GN, Sanyiwa AJ, Hassan HG, Cook C, et al. Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations. Human Genetics. 2018;137(10):847-62. doi: 10.1007/s00439-018-1943-7.

8. Cates HM, Heller EA, Lardner CK, Purushothaman I, Peña CJ, Walker DM, et al. Transcription Factor E2F3a in Nucleus Accumbens Affects Cocaine Action via Transcription and Alternative Splicing. Biological Psychiatry. 2018;84(3):167-79. doi: https://doi.org/10.1016/j.biopsych.2017.11.027.

9. Cates HM, Li X, Purushothaman I, Kennedy PJ, Shen L, Shaham Y, et al. Genome-wide transcriptional profiling of central amygdala and orbitofrontal cortex during incubation of methamphetamine craving. Neuropsychopharmacology. 2018;43(12):2426-34. doi: 10.1038/s41386-018-0158-x.

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2013


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2. Marino KA, Filizola M. Investigating Small-Molecule Ligand Binding to G Protein-Coupled Receptors with Biased or Unbiased Molecular Dynamics Simulations. Methods in molecular biology (Clifton, NJ). 2018;1705:351-64. doi: 10.1007/978-1-4939-7465-8_17. PubMed PMID: PMC5745006.

3. Manasson J, Shen N, Garcia Ferrer Helga R, Ubeda C, Iraheta I, Heguy A, et al. Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis. Arthritis & Rheumatology. 2018;70(2):242-54. doi: 10.1002/art.40359.

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6. Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, et al. Trans-ethnic Evaluation Identifies Novel Low Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations. The Journal of Clinical Endocrinology & Metabolism. 2018:jc.2017-01802-jc.2017-. doi: 10.1210/jc.2017-01802.

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11. Barbosa M, Joshi RS, Garg P, Martin-Trujillo A, Patel N, Jadhav B, Watson CT, Gibson W, Chetnik K, Tessereau C, Mei H, De Rubeis S, Reichert J, Lopes F, Vissers LELM, Kleefstra T, Grice DE, Edelmann L, Soares G, Maciel P, Brunner HG, Buxbaum JD, Gelb BD, Sharp AJ. Identification of rare de novo epigenetic variations in congenital disorders. Nature Communications. 2018;9(1):2064. doi: 10.1038/s41467-018-04540-x. PubMed Central PMCID: PMC5970273; PMID: 29802345

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17. Wheeler E, Leong A, Liu C-T, Hivert M-F, Strawbridge RJ, Podmore C, et al. Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. PLoS Medicine. 2017;14(9):e1002383. doi: 10.1371/journal.pmed.1002383. PubMed PMID: PMC5595282.

18. Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension. 2017;70(3):e4.

19. Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, et al. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2017;9(2):600-14. doi: 10.1016/j.stemcr.2017.06.018. PubMed PMID: PMC5550034.

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22. Romero Navarro JA, Phillips-Mora W, Arciniegas-Leal A, Mata-Quirós A, Haiminen N, Mustiga G, et al. Application of Genome Wide Association and Genomic Prediction for Improvement of Cacao Productivity and Resistance to Black and Frosty Pod Diseases. Frontiers in Plant Science. 2017;8:1905. doi: 10.3389/fpls.2017.01905. PubMed PMID: PMC5694496.

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25. Rengasamy M, Zhang F, Vashisht A, Song W-M, Aguilo F, Sun Y, et al. The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer. Nucleic Acids Research. 2017;45(19):11106-20. doi: 10.1093/nar/gkx727. PubMed PMID: PMC5737218.

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27. Petralia F, Aushev VN, Gopalakrishnan K, Kappil M, W. Khin N, Chen J, et al. A new method to study the change of miRNA–mRNA interactions due to environmental exposures. Bioinformatics. 2017;33(14):i199-i207. doi: 10.1093/bioinformatics/btx256.

28. Peters LA, Perrigoue J, Mortha A, Iuga A, Song W-m, Neiman EM, et al. A functional genomics predictive network model identifies regulators of inflammatory bowel disease. Nature Genetics. 2017;49:1437. doi: 10.1038/ng.3947
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32. Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, et al. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nature Genetics. 2017;49:1385. doi: 10.1038/ng.3913
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37. Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, et al. Exome-wide association study of plasma lipids in >300,000 individuals. Nature Genetics. 2017;49:1758. doi: 10.1038/ng.3977
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39. Labonté B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, et al. Sex-specific transcriptional signatures in human depression. Nature Medicine. 2017;23:1102. doi: 10.1038/nm.4386
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40. Kapoor A, Martinez-Rosell G, Provasi D, de Fabritiis G, Filizola M. Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity. Scientific Reports. 2017;7(1):11255. doi: 10.1038/s41598-017-11483-8.

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43. Ito K, Park SH, Katsyv I, Zhang W, De Angelis C, Schiff R, et al. PTK6 regulates growth and survival of endocrine therapy-resistant ER+ breast cancer cells. npj Breast Cancer. 2017;3(1):45. doi: 10.1038/s41523-017-0047-1.

44. Hogstad B, Berres M-L, Chakraborty R, Tang J, Bigenwald C, Serasinghe M, et al. RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions. The Journal of Experimental Medicine. 2017.

45. Hellwege JN, Jeff JM, Wise LA, Gallagher CS, Wellons M, Hartmann KE, et al. A multi-stage genome-wide association study of uterine fibroids in African Americans. Human Genetics. 2017;136(10):1363-73. doi: 10.1007/s00439-017-1836-1. PubMed PMID: PMC5628188.

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48. Hamlin RE, Rahman A, Pak TR, Maringer K, Mena I, Bernal-Rubio D, et al. High-dimensional CyTOF analysis of dengue virus–infected human DCs reveals distinct viral signatures. JCI Insight. 2017;2(13):e92424. doi: 10.1172/jci.insight.92424. PubMed PMID: PMC5499363.

49. Graff M, Emery LS, Justice AE, Parra E, Below JE, Palmer ND, et al. Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos. Lipids in Health and Disease. 2017;16:200. doi: 10.1186/s12944-017-0591-6. PubMed PMID: PMC5639746.

50. Gong J, Nishimura KK, Fernandez-Rhodes L, Haessler J, Bien S, Graff M, et al. Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI. International Journal Of Obesity. 2017. doi: 10.1038/ijo.2017.304
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53. Dong L, Meng F, Wu L, Mitchell AV, Block CJ, Zhang B, et al. Cooperative oncogenic effect and cell signaling crosstalk of co-occurring HER2 and mutant PIK3CA in mammary epithelial cells. International Journal of Oncology. 2017;51(4):1320-30. doi: 10.3892/ijo.2017.4108. PubMed PMID: PMC5592866.

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      • 07/2016-07/2017: 85 in total

 

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Kozlenkov A, Jaffe AE, Timashpolsky A, Apontes P, Rudchenko S, Barbu M, Byne W, Hurd YL, Horvath S, Dracheva S. DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age. Genes (Basel). 2017 May 30;8(6). pii: E152. doi: 10.3390/genes8060152. PubMed PMID: 28556790.

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Integrative Network Analysis Identifies Novel Drivers of Pathogenesis and Progression in Newly Diagnosed Multiple Myeloma.” Lagana A, Perumal D, Melnekoff D, Readhead B, Kidd B, Leshchenko V, Kuo PY, Keats J, DeRome M, Yesil J, Auclair D, Lonial S, Chari A, Cho HJ, Barlogie B, Jagannath S, Dudley J, Parekh S.Leukemia, Leukemia. 2017 Jun 23. doi: 10.1038/leu.2017.197. PMID: 2864259

Hammerstad SS, Stefan M, Blackard J, Owen RP, Lee HJ, Concepcion E, Yi Z, Zhang W, Tomer Y. HEPATITIS C VIRUS E2 PROTEIN INDUCES UPREGULATION OF IL-8 PATHWAYS AND PRODUCTION OF HEAT SHOCK PROTEINS IN HUMAN THYROID CELLS. J Clin Endocrinol Metab. 2016 Nov 18:jc20163403. [Epub ahead of print] PubMed PMID: 27860532.

Di Cecilia S, Zhang F, Sancho-Medina A, Li S, Aguilo F, Sun Y, Rengasamy M, Zhang W, Del Vecchio L, Salvatore F, Walsh MJ. RBM-AS1 is critical for self-renewal of colon cancer stem-like cells. Cancer Res. 2016 Aug 12. pii: canres.1824.2015. [Epub ahead of print] PMID:27520449; PMCID:PMC5050123; DOI:10.1158/0008-5472.CAN-15-1824

Bardot E, Calderon D, Santoriello F, Han S, Cheung K, Jadhav B, Burtscher I, Artap S, Jain R, Epstein J, Lickert H, Gouon-Evans V, Sharp AJ, Dubois NC. Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential. Nat Commun. 2017 Feb 14;8:14428. PMID:28195173; PMCID:PMC5316866; DOI:10.1038/ncomms14428

Peter CJ, Fischer LK, Kundakovic M, Garg P, Jakovcevski M, Dincer A, Amaral AC, Ginns EI, Galdzicka M, Bryce CP, Ratner C, Waber DP, Mokler D, Medford G, Champagne FA, Rosene DL, McGaughy JA, Sharp AJ, Galler JR, Akbarian S. DNA Methylation Signatures of Early Childhood Malnutrition Associated With Impairments in Attention and Cognition. Biol Psychiatry. 2016 Nov 15;80(10):765-774.
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van Rooij FJ, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang LC, Schmidt H, Yang ML, Chen MH, Hayes J, Johnson AD, Yanek LR, Mueller C, Lange L, Floyd JS, Ghanbari M, Zonderman AB, Jukema JW, Hofman A, van Duijn CM, Desch KC, Saba Y, Ozel AB, Snively BM, Wu JY, Schmidt R, Fornage M, Klein RJ, Fox CS, Matsuda K, Kamatani N, Wild PS, Stott DJ, Ford I, Slagboom PE, Yang J, Chu AY, Lambert AJ, Uitterlinden AG, Franco OH, Hofer E, Ginsburg D, Hu B, Keating B, Schick UM, Brody JA, Li JZ, Chen Z, Zeller T, Guralnik JM, Chasman DI, Peters LL, Kubo M, Becker DM, Li J, Eiriksdottir G, Rotter JI, Levy D, Grossmann V, Patel KV, Chen CH; BioBank Japan Project, Ridker PM, Tang H, Launer LJ, Rice KM, Li-Gao R, Ferrucci L, Evans MK, Choudhuri A, Trompouki E, Abraham BJ, Yang S, Takahashi A, Kamatani Y, Kooperberg C, Harris TB, Jee SH, Coresh J, Tsai FJ, Longo DL, Chen YT, Felix JF, Yang Q, Psaty BM, Boerwinkle E, Becker LC, Mook-Kanamori DO, Wilson JG, Gudnason V, O’Donnell CJ, Dehghan A, Cupples LA, Nalls MA, Morris AP, Okada Y, Reiner AP, Zon LI, Ganesh SK. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017 Jan 5;100(1):51-63. doi: 10.1016/j.ajhg.2016.11.016. Epub 2016 Dec 22. PubMed PMID: 28017375; PubMed Central PMCID: PMC5223059.

Douvaras P, Sun B, Wang M, Kruglikov I, Lallos G, Zimmer M, Terrenoire C, Zhang B, Gandy S, Schadt E, Freytes DO, Noggle S, Fossati V. Directed Differentiation of Human Pluripotent Stem Cells to Microglia. Stem Cell Reports. 2017 May 18. pii: S2213-6711(17) 30177-7. doi: 10.1016/j.stemcr.2017.04.023. [Epub ahead of print] PMID: 28528700; PMCID:PMC5470097; DOI:10.1016/j.stemcr.2017.04.023

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Andrew T. McKenzie, Igor Katsyv, Won-Min Song, Minghui Wang, and Bin Zhang§. (2016) DGCA: A Comprehensive R Package for Differential Gene Correlation Analysis. BMC Systems Biology 10:106. PMID: 27846853; PMCID: PMC5111277; DOI:10.1186/s12918-016-0349-1

Hectors SJ, Wagner M, Bane O, Besa C, Lewis S, Remark R, Chen N, Fiel MI, Zhu H, Gnjatic S, Merad M, Hoshida Y, Taouli B. Quantification of hepatocellular carcinoma heterogeneity with multiparametric magnetic resonance imaging. Sci Rep. 2017 May 26;7(1):2452. doi: 10.1038/s41598-017-02706-z. PubMed PMID: 28550313; PubMed Central PMCID: PMC5446396.

Taouli B, Hoshida Y, Kakite S, Chen X, Tan PS, Sun X, Kihira S, Kojima K, Toffanin S, Fiel MI, Hirschfield H, Wagner M, Llovet JM. Imaging-based surrogate markers of transcriptome subclasses and signatures in hepatocellular carcinoma: preliminary results. Eur Radiol. 2017 Apr 24. doi: 10.1007/s00330-017-4844-6. [Epub ahead of print] PubMed PMID: 28439654.

Ono A, Goossens N, Finn RS, Schmidt WN, Thung SN, Im GY, Hoshida Y. Persisting risk of hepatocellular carcinoma after HCV cure monitored by a liver transcriptome signature. Hepatology. 2017 Apr 8. doi: 10.1002/hep.29203. [Epub ahead of print] PubMed PMID: 28390144.

Hicks DF, Goossens N, Blas-García A, Tsuchida T, Wooden B, Wallace MC, Nieto N, Lade A, Redhead B, Cederbaum AI, Dudley JT, Fuchs BC, Lee YA, Hoshida Y, Friedman SL. Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells. Sci Rep. 2017 Mar 3;7:42563. doi: 10.1038/srep42563. PubMed PMID: 28256512; PubMed Central PMCID: PMC5335661.

Van Renne N, Roca Suarez AA, Duong FH, Gondeau C, Calabrese D, Fontaine N, Ababsa A, Bandiera S, Croonenborghs T, Pochet N, De Blasi V, Pessaux P, Piardi T, Sommacale D, Ono A, Chayama K, Fujita M, Nakagawa H, Hoshida Y, Zeisel MB, Heim MH, Baumert TF, Lupberger J. miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis. Gut. 2017 Feb 3. pii: gutjnl-2016-312270. doi:10.1136/gutjnl-2016-312270. [Epub ahead of print] PubMed PMID: 28159835.

Kim RS, Hasegawa D, Goossens N, Tsuchida T, Athwal V, Sun X, Robinson CL, Bhattacharya D, Chou HI, Zhang DY, Fuchs BC, Lee Y, Hoshida Y, Friedman SL. The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy. Sci Rep. 2016 Dec 20;6:39342. doi:10.1038/srep39342. PubMed PMID: 27996033; PubMed Central PMCID: PMC5172197.

Bollard J, Miguela V, Ruiz de Galarreta M, Venkatesh A, Bian CB, Roberto MP, Tovar V, Sia D, Molina-Sánchez P, Nguyen CB, Nakagawa S, Llovet JM, Hoshida Y, Lujambio A. Palbociclib (PD-0332991), a selective CDK4/6 inhibitor, restricts tumour growth in preclinical models of hepatocellular carcinoma. Gut. 2017 Jul;66(7):1286-1296. doi: 10.1136/gutjnl-2016-312268. Epub 2016 Nov 14. PubMed PMID: 27849562.

Lu H, Rogowskyj J, Yu W, Venkatesh A, Khan N, Nakagawa S, Goossens N, Koh AP, Higashi T, Gunasekaran G, Schwarz ME, Hiotis SP, Xu X, Kinney W, Hoshida Y, Block T, Cuconati A, Du Y. Novel substituted aminothiazoles as potent and selective anti-hepatocellular carcinoma agents. Bioorg Med Chem Lett. 2016 Dec1;26(23):5819-5824. doi:10.1016/j.bmcl.2016.10.015. Epub 2016 Oct 10. PubMed PMID: 27793566.

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Asgharpour A, Cazanave SC, Pacana T, Seneshaw M, Vincent R, Banini BA, Kumar DP, Daita K, Min HK, Mirshahi F, Bedossa P, Sun X, Hoshida Y, Koduru SV, Contaifer D Jr, Warncke UO, Wijesinghe DS, Sanyal AJ. A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. J Hepatol. 2016 Sep;65(3):579-88. doi: 10.1016/j.jhep.2016.05.005. Epub 2016 May 31. PubMed PMID: 27261415; PubMed Central PMCID: PMC5012902.

Jiao J, Ooka K, Fey H, Fiel MI, Rahmman AH, Kojima K, Hoshida Y, Chen X, de Paula T, Vetter D, Sastre D, Lee KH, Lee YA, Bansal M, Friedman SL, Merad M, Aloman C. Interleukin-15 receptor α on hepatic stellate cells regulates hepatic fibrogenesis in mice. J Hepatol. 2016 Aug;65(2):344-53. doi: 10.1016/j.jhep.2016.04.020. Epub 2016 May 3. PubMed PMID: 27154062; PubMed Central PMCID: PMC5048472.

Zhang DY, Goossens N, Guo J, Tsai MC, Chou HI, Altunkaynak C, Sangiovanni A, Iavarone M, Colombo M, Kobayashi M, Kumada H, Villanueva A, Llovet JM, Hoshida Y, Friedman SL. A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection. Gut. 2016 Oct;65(10):1754-64. doi: 10.1136/gutjnl-2015-309655. Epub 2015 Jun 4. PubMed PMID: 26045137; PubMed Central PMCID: PMC4848165.

Kenny T, Schmidt H, Adelson K, Hoshida Y, Koh AP, Shah N, Mandeli JP, Ting J, Germain D. Patient-derived interstitial fluids and predisposition to aggressive sporadic breast cancer through collagen remodeling and inactivation of p53. Clin Cancer Res. 2017 Jun 19. pii: clincanres.0342.2017. doi: 10.1158/1078-0432.CCR-17-0342. [Epub ahead of print] PMID: 28630214

Goossens N, Singal AG, King LY, Andersson KL, Fuchs BC, Besa C, Taouli B, Chung RT, Hoshida Y. Cost-effectiveness of risk score-stratified hepatocellular carcinoma screening in patients with cirrhosis. Clin Transl Gastroenterol. 2017 PMID: 28640287; DOI: 10.1038/ctg.2017.26

Robert A Scott, Laura J Scott, Reedik Mägi, Letizia Marullo, Kyle J Gaulton, Marika Kaakinen, Natalia Pervjakova, Tune H Pers, Andrew D Johnson, John D Eicher, Anne U Jackson, Teresa Ferreira, Yeji Lee, Clement Ma, Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Lu Qi, Natalie R Van Zuydam, Anubha Mahajan, Han Chen, Peter Almgren, Ben F Voight, Harald Grallert, Martina Müller-Nurasyid, Janina S Ried, William N Rayner, Neil Robertson, Lennart C Karssen, Elisabeth M van Leeuwen, Sara M Willems, Christian Fuchsberger, Phoenix Kwan, Tanya M Teslovich, Pritam Chanda, Man Li, Yingchang Lu, Christian Dina, Dorothee Thuillier, Loic Yengo, Longda Jiang, Thomas Sparso, Hans A Kestler, Himanshu Chheda, Lewin Eisele, Stefan Gustafsson, Mattias Frånberg, Rona J Strawbridge, Rafn Benediktsson, Astradur B Hreidarsson, Augustine Kong, Gunnar Sigurðsson, Nicola D Kerrison, Jian’an Luan, Liming Liang, Thomas Meitinger, Michael Roden, Barbara Thorand, Tõnu Esko, Evelin Mihailov, Caroline Fox, Ching-Ti Liu, Denis Rybin, Bo Isomaa, Valeriya Lyssenko, Tiinamaija Tuomi, David J Couper, James S Pankow, Niels Grarup, Christian T Have, Marit E Jørgensen, Torben Jørgensen, Allan Linneberg, Marilyn C Cornelis, Rob M van Dam, David J Hunter, Peter Kraft, Qi Sun, Sarah Edkins, Katharine R Owen, John RB Perry, Andrew R Wood, Eleftheria Zeggini, Juan Tajes-Fernandes, Goncalo R Abecasis, Lori L Bonnycastle, Peter S Chines, Heather M Stringham, Heikki A Koistinen, Leena Kinnunen, Bengt Sennblad, Thomas W Mühleisen, Markus M Nöthen, Sonali Pechlivanis, Damiano Baldassarre, Karl Gertow, Steve E Humphries, Elena Tremoli, Norman Klopp, Julia Meyer, Gerald Steinbach, Roman Wennauer, Johan G Eriksson, Satu Mӓnnistö, Leena Peltonen, Emmi Tikkanen, Guillaume Charpentier, Elodie Eury, Stéphane Lobbens, Bruna Gigante, Karin Leander, Olga McLeod, Erwin P Bottinger, Omri Gottesman, Douglas Ruderfer, Matthias Blüher, Peter Kovacs, Anke Tonjes, Nisa M Maruthur, Chiara Scapoli, Raimund Erbel, Karl-Heinz Jöckel, Susanne Moebus, Ulf de Faire, Anders Hamsten, Michael Stumvoll, Panagiotis Deloukas, Peter J Donnelly, Timothy M Frayling, Andrew T Hattersley, Samuli Ripatti, Veikko Salomaa, Nancy L Pedersen, Bernhard O Boehm, Richard N Bergman, Francis S Collins, Karen L Mohlke, Jaakko Tuomilehto, Torben Hansen, Oluf Pedersen, Inês Barroso, Lars Lannfelt, Erik Ingelsson, Lars Lind, Cecilia M Lindgren, Stephane Cauchi, Philippe Froguel, Ruth JF Loos, Beverley Balkau, Heiner Boeing, Paul W Franks. An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes. 2017 May 31. pii: db161253. doi: 10.2337/db16-1253. PMID: 28566273

Mathias Gorski, Peter J Van Der Most, Alexander Teumer, Audrey Y Chu, Man Li, Vladan Mijatovic, Ilja M Nolte, Massimiliano Cocca, Daniel Taliun, Felicia Gomez, Yong Li, Bamidele Tayo, Adrienne Tin, Mary F Feitosa, Thor Aspelund, John Attia, Reiner Biffar, Murielle Bochud, Eric Boerwinkle, Ingrid Borecki, Erwin P Bottinger, Ming-Huei Chen, Vincent Chouraki, Marina Ciullo, Josef Coresh, Marilyn C Cornelis, Gary C Curhan, Adamo Pio d’Adamo, Abbas Dehghan, Laura Dengler, Jingzhong Ding, Gudny Eiriksdottir, Karlhans Endlich, Stefan Enroth, Tõnu Esko, Oscar H Franco, Paolo Gasparini, Christian Gieger, Giorgia Girotto, Omri Gottesman, Vilmundur Gudnason, Ulf Gyllensten, Stephen J Hancock, Tamara B Harris, Catherine Helmer, Simon Höllerer, Edith Hofer, Albert Hofman, Elizabeth G Holliday, Georg Homuth, Frank B Hu, Cornelia Huth, Nina Hutri-Kähönen, Shih-Jen Hwang, Medea Imboden, Åsa Johansson, Mika Kähönen, Wolfgang König, Holly Kramer, Bernhard K Krämer, Ashish Kumar, Zoltan Kutalik, Jean-Charles Lambert, Lenore J Launer, Terho Lehtimäki, Martin H De Borst, Gerjan Navis, Morris Swertz, Yongmei Liu, Kurt Lohman, Ruth JF Loos, Yingchang Lu, Leo-Pekka Lyytikäinen, Mark A McEvoy, Christa Meisinger, Thomas Meitinger, Andres Metspalu, Marie Metzger, Evelin Mihailov, Paul Mitchell, Matthias Nauck, Albertine J Oldehinkel, Matthias Olden, Brenda WJH Penninx, Giorgio Pistis, Peter P Pramstaller, Nicole Probst-Hensch, Olli T Raitakari, Rainer Rettig, Paul M Ridker, Fernando Rivadeneira, Antonietta Robino, Sylvia E Rosas, Douglas Ruderfer, Daniela Ruggiero, Yasaman Saba, Cinzia Sala, Helena Schmidt, Reinhold Schmidt, Rodney J Scott, Sanaz Sedaghat, Albert V Smith, Rossella Sorice, Benedicte Stengel, Sylvia Stracke, Konstantin Strauch, Daniela Toniolo, Andre G Uitterlinden, Sheila Ulivi, Jorma S Viikari, Uwe Völker, Peter Vollenweider, Henry Völzke, Dragana Vuckovic, Melanie Waldenberger, Jie Jin Wang, Qiong Yang, Daniel I Chasman, Gerard Tromp, Harold Snieder, Iris M Heid, Caroline S Fox, Anna Köttgen, Cristian Pattaro, Carsten A Böger, Christian Fuchsberger. Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 2017 May 26;7:46835. doi: 10.1038/srep46835. PMID: 28548086 PMCID: PMC5445557

Bo Yang, Wei Zhou, Jiao Jiao, Jonas B Nielsen, Michael R Mathis, Mahyar Heydarpour, Guillaume Lettre, Lasse Folkersen, Siddharth Prakash, Claudia Schurmann, Lars Fritsche, Gregory A Farnum, Maoxuan Lin, Mohammad Othman, Whitney Hornsby, Anisa Driscoll, Alexandra Levasseur, Marc Thomas, Linda Farhat, Marie-Pierre Dubé, Eric M Isselbacher, Anders Franco-Cereceda, Dong-Chuan Guo, Erwin P Bottinger, G Michael Deeb, Anna Booher, Sachin Kheterpal, Y Eugene Chen, Hyun Min Kang, Jacob Kitzman, Heather J Cordell, Bernard D Keavney, Judith A Goodship, Santhi K Ganesh, Gonçalo Abecasis, Kim A Eagle, Alan P Boyle, Ruth JF Loos, Per Eriksson, Jean-Claude Tardif, Chad M Brummett, Dianna M Milewicz, Simon C Body, Cristen J Willer. Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve. Nat Commun. 2017 May 25;8:15481. doi: 10.1038/ncomms15481. PMID:28541271

Nancy L Saccone, Leslie S Emery, Tamar Sofer, Stephanie M Gogarten, Diane M Becker, Erwin P Bottinger, Li-Shiun Chen, Robert C Culverhouse, Weimin Duan, Dana B Hancock, H Dean Hosgood, Eric O Johnson, Ruth JF Loos, Tin Louie, George Papanicolaou, Krista M Perreira, Erik J Rodriquez, Claudia Schurmann, Adrienne M Stilp, Adam A Szpiro, Gregory A Talavera, Kent D Taylor, James F Thrasher, Lisa R Yanek, Cathy C Laurie, Eliseo J Pérez-Stable, Laura J Bierut, Robert C Kaplan. Genome-wide association study of heavy smoking and daily/nondaily smoking in the Hispanic Community Health Study / Study of Latinos (HCHS/SOL). Nicotine Tob Res. 2017 May 17. doi: 10.1093/ntr/ntx107. [Epub ahead of print] PMID: 28520984

Jingjing Liang, Thu H Le, Digna R Velez Edwards, Bamidele O Tayo, Kyle J Gaulton, Jennifer A Smith, Yingchang Lu, Richard A Jensen, Guanjie Chen, Lisa R Yanek, Karen Schwander, Salman M Tajuddin, Tamar Sofer, Wonji Kim, James Kayima, Colin A McKenzie, Ervin Fox, Michael A Nalls, J Hunter Young, Yan V Sun, Jacqueline M Lane, Sylvia Cechova, Jie Zhou, Hua Tang, Myriam Fornage, Solomon K Musani, Heming Wang, Juyoung Lee, Adebowale Adeyemo, Albert W Dreisbach, Terrence Forrester, Pei-Lun Chu, Anne Cappola, Michele K Evans, Alanna C Morrison, Lisa W Martin, Kerri L Wiggins, Qin Hui, Wei Zhao, Rebecca D Jackson, Erin B Ware, Jessica D Faul, Alex P Reiner, Michael Bray, Joshua C Denny, Thomas H Mosley, Walter Palmas, Xiuqing Guo, George J Papanicolaou, Alan D Penman, Joseph F Polak, Kenneth Rice, Ken D Taylor, Eric Boerwinkle, Erwin P Bottinger, Kiang Liu, Neil Risch, Steven C Hunt, Charles Kooperberg, Alan B Zonderman, Cathy C Laurie, Diane M Becker, Jianwen Cai, Ruth JF Loos, Bruce M Psaty, David R Weir, Sharon LR Kardia, Donna K Arnett, Sungho Won, Todd L Edwards, Susan Redline, Richard S Cooper, DC Rao, Jerome I Rotter, Charles Rotimi, Daniel Levy, Aravinda Chakravarti, Xiaofeng Zhu, Nora Franceschini. Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations. PLoS Genet. 2017 May 12;13(5):e1006728. doi: 10.1371/journal.pgen.1006728. eCollection 2017 May. PMID: 28498854; PMCID: PMC5446189

Mathias Gorski, Peter J Van der Most, Alexander Teumer, Audrey Y Chu, Man Li, Vladan Mijatovic, Ilja M Nolte, Massimiliano Cocca, Daniel Taliun, Felicia Gomez, Yong Li, Bamidele Tayo, Adrienne Tin, Mary F Feitosa, Thor Aspelund, John Attia, Reiner Biffar, Murielle Bochud, Eric Boerwinkle, Ingrid Borecki, Erwin P Bottinger, Ming-Huei Chen, Vincent Chouraki, Marina Ciullo, Josef Coresh, Marilyn C Cornelis, Gary C Curhan, Adamo Pio d’Adamo, Abbas Dehghan, Laura Dengler, Jingzhong Ding, Gudny Eiriksdottir, Karlhans Endlich, Stefan Enroth, Tõnu Esko, Oscar H Franco, Paolo Gasparini, Christian Gieger, Giorgia Girotto, Omri Gottesman, Vilmundur Gudnason, Ulf Gyllensten, Stephen J Hancock, Tamara B Harris, Catherine Helmer, Simon Höllerer, Edith Hofer, Albert Hofman, Elizabeth G Holliday, Georg Homuth, Frank B Hu, Cornelia Huth, Nina Hutri-Kähönen, Shih-Jen Hwang, Medea Imboden, Åsa Johansson, Mika Kähönen, Wolfgang König, Holly Kramer, Bernhard K Krämer, Ashish Kumar, Zoltan Kutalik, Jean-Charles Lambert, Lenore J Launer, Terho Lehtimäki, Martin De Borst, Gerjan Navis, Morris Swertz, Yongmei Liu, Kurt Lohman, Ruth JF Loos, Yingchang Lu, Leo-Pekka Lyytikäinen, Mark A McEvoy, Christa Meisinger, Thomas Meitinger, Andres Metspalu, Marie Metzger, Evelin Mihailov, Paul Mitchell, Matthias Nauck, Albertine J Oldehinkel, Matthias Olden, Brenda WJH Penninx, Giorgio Pistis, Peter P Pramstaller, Nicole Probst-Hensch, Olli T Raitakari, Rainer Rettig, Paul M Ridker, Fernando Rivadeneira, Antonietta Robino, Sylvia E Rosas, Douglas Ruderfer, Daniela Ruggiero, Yasaman Saba, Cinzia Sala, Helena Schmidt, Reinhold Schmidt, Rodney J Scott, Sanaz Sedaghat, Albert V Smith, Rossella Sorice, Benedicte Stengel, Sylvia Stracke, Konstantin Strauch, Daniela Toniolo, Andre G Uitterlinden, Sheila Ulivi, Jorma S Viikari, Uwe Völker, Peter Vollenweider, Henry Völzke, Dragana Vuckovic, Melanie Waldenberger, Jie Jin Wang, Qiong Yang, Daniel I Chasman, Gerard Tromp, Harold Snieder, Iris M Heid, Caroline S Fox, Anna Köttgen, Cristian Pattaro, Carsten A Böger, Christian Fuchsberger. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 2017 Apr 28;7:45040. doi: 10.1038/srep45040.
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Anne E Justice, Thomas W Winkler, Mary F Feitosa, Misa Graff, Virginia A Fisher, Kristin Young, Llilda Barata, Xuan Deng, Jacek Czajkowski, David Hadley, Julius S Ngwa, Tarunveer S Ahluwalia, Audrey Y Chu, Nancy L Heard-Costa, Elise Lim, Jeremiah Perez, John D Eicher, Zoltán Kutalik, Luting Xue, Anubha Mahajan, Frida Renström, Joseph Wu, Qibin Qi, Shafqat Ahmad, Tamuno Alfred, Najaf Amin, Lawrence F Bielak, Amelie Bonnefond, Jennifer Bragg, Gemma Cadby, Martina Chittani, Scott Coggeshall, Tanguy Corre, Nese Direk, Joel Eriksson, Krista Fischer, Mathias Gorski, Marie Neergaard Harder, Momoko Horikoshi, Tao Huang, Jennifer E Huffman, Anne U Jackson, Johanne Marie Justesen, Stavroula Kanoni, Leena Kinnunen, Marcus E Kleber, Pirjo Komulainen, Meena Kumari, Unhee Lim, Jian’an Luan, Leo-Pekka Lyytikäinen, Massimo Mangino, Ani Manichaikul, Jonathan Marten, Rita PS Middelberg, Martina Müller-Nurasyid, Pau Navarro, Louis Pérusse, Natalia Pervjakova, Cinzia Sarti, Albert Vernon Smith, Jennifer A Smith, Alena Stančáková, Rona J Strawbridge, Heather M Stringham, Yun Ju Sung, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W van der Laan, Peter J van der Most, Jana V Van Vliet-Ostaptchouk, Sailaja L Vedantam, Niek Verweij, Jacqueline M Vink, Veronique Vitart, Ying Wu, Loic Yengo, Weihua Zhang, Jing Hua Zhao, Martina E Zimmermann, Niha Zubair, Gonçalo R Abecasis, Linda S Adair, Saima Afaq, Uzma Afzal, Stephan JL Bakker, Traci M Bartz, John Beilby, Richard N Bergman, Sven Bergmann, Reiner Biffar, John Blangero, Eric Boerwinkle, Lori L Bonnycastle, Erwin Bottinger, Daniele Braga, Brendan M Buckley, Steve Buyske, Harry Campbell, John C Chambers, Francis S Collins, Joanne E Curran, Gert J de Borst, Anton JM De Craen, Eco JC de Geus, George Dedoussis, Graciela E Delgado, Hester M den Ruijter, Gudny Eiriksdottir, Anna L Eriksson, Tõnu Esko, Jessica D Faul, Ian Ford, Terrence Forrester, Karl Gertow, Bruna Gigante, Nicola Glorioso, Jian Gong, Harald Grallert, Tanja B Grammer, Niels Grarup, Saskia Haitjema, Göran Hallmans, Anders Hamsten, Torben Hansen, Tamara B Harris, Catharina A Hartman, Maija Hassinen, Nicholas D Hastie, Andrew C Heath, Dena Hernandez, Lucia Hindorff, Lynne J Hocking, Mette Hollensted, Oddgeir L Holmen, Georg Homuth, Jouke Jan Hottenga, Jie Huang, Joseph Hung, Nina Hutri-Kähönen, Erik Ingelsson, Alan L James, John-Olov Jansson, Marjo-Riitta Jarvelin, Min A Jhun, Marit E Jørgensen, Markus Juonala, Mika Kähönen, Magnus Karlsson. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun. 2017 Apr 26;8:14977. doi: 10.1038/ncomms14977. PMID: 28443625 PMCID:PMC5414044

Maggie CY Ng, Mariaelisa Graff, Yingchang Lu, Anne E Justice, Poorva Mudgal, Ching-Ti Liu, Kristin Young, Lisa R Yanek, Mary F Feitosa, Mary K Wojczynski, Kristin Rand, Jennifer A Brody, Brian E Cade, Latchezar Dimitrov, Qing Duan, Xiuqing Guo, Leslie A Lange, Michael A Nalls, Hayrettin Okut, Salman M Tajuddin, Bamidele O Tayo, Sailaja Vedantam, Jonathan P Bradfield, Guanjie Chen, Wei-Min Chen, Alessandra Chesi, Marguerite R Irvin, Badri Padhukasahasram, Jennifer A Smith, Wei Zheng, Matthew A Allison, Christine B Ambrosone, Elisa V Bandera, Traci M Bartz, Sonja I Berndt, Leslie Bernstein, William J Blot, Erwin P Bottinger, John Carpten, Stephen J Chanock, Yii-Der Ida Chen, David V Conti, Richard S Cooper, Myriam Fornage, Barry I Freedman, Melissa Garcia, Phyllis J Goodman, Yu-Han H Hsu, Jennifer Hu, Chad D Huff, Sue A Ingles, Esther M John, Rick Kittles, Eric Klein, Jin Li, Barbara McKnight, Uma Nayak, Barbara Nemesure, Adesola Ogunniyi, Andrew Olshan, Michael F Press, Rebecca Rohde, Benjamin A Rybicki, Babatunde Salako, Maureen Sanderson, Yaming Shao, David S Siscovick, Janet L Stanford, Victoria L Stevens, Alex Stram, Sara S Strom, Dhananjay Vaidya, John S Witte, Jie Yao, Xiaofeng Zhu, Regina G Ziegler, Alan B Zonderman, Adebowale Adeyemo, Stefan Ambs, Mary Cushman, Jessica D Faul, Hakon Hakonarson, Albert M Levin, Katherine L Nathanson, Erin B Ware, David R Weir, Wei Zhao, Degui Zhi, Donna K Arnett, Struan FA Grant, Sharon LR Kardia, Olufunmilayo I Oloapde, DC Rao, Charles N Rotimi, Michele M Sale, L Keoki Williams, Babette S Zemel, Diane M Becker, Ingrid B Borecki, Michele K Evans, Tamara B Harris, Joel N Hirschhorn, Yun Li, Sanjay R Patel, Bruce M Psaty, Jerome I Rotter, James G Wilson, Donald W Bowden, L Adrienne Cupples, Christopher A Haiman, Ruth JF Loos, Kari E North. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLoS Genet. 2017 Apr 21;13(4):e1006719. doi: 10.1371/journal.pgen.1006719. eCollection 2017 Apr. PMID:28430825; PMCID:PMC5419579

Niha Zubair, Mariaelisa Graff, Jose Luis Ambite, William S Bush, Gleb Kichaev, Yingchang Lu, Ani Manichaikul, Wayne HH Sheu, Devin Absher, Themistocles L Assimes, Suzette J Bielinski, Erwin P Bottinger, Petra Buzkova, Lee-Ming Chuang, Ren-Hua Chung, Barbara Cochran, Logan Dumitrescu, Omri Gottesman, Jeffrey W Haessler, Christopher Haiman, Gerardo Heiss, Chao A Hsiung, Yi-Jen Hung, Chii-Min Hwu, Jyh-Ming J Juang, Loic Le Marchand, I-Te Lee, Wen-Jane Lee, Li-An Lin, Danyu Lin, Shih-Yi Lin, Rachel H Mackey, Lisa W Martin, Bogdan Pasaniuc, Ulrike Peters, Irene Predazzi, Thomas Quertermous, Alex P Reiner, Jennifer Robinson, Jerome I Rotter, Kelli K Ryckman, Pamela J Schreiner, Eli Stahl, Ran Tao, Michael Y Tsai, Lindsay L Waite, Tzung-Dau Wang, Steven Buyske, Yii-Der Ida Chen, Iona Cheng, Dana C Crawford, Ruth JF Loos, Stephen S Rich, Myriam Fornage, Kari E North, Charles Kooperberg, Cara L Carty. Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci. Hum Mol Genet. 2016 Dec 15;25(24):5500-5512. doi: 10.1093/hmg/ddw358. PMID: 28426890

Ingrid E Christophersen, Michiel Rienstra, Carolina Roselli, Xiaoyan Yin, Bastiaan Geelhoed, John Barnard, Honghuang Lin, Dan E Arking, Albert V Smith, Christine M Albert, Mark Chaffin, Nathan R Tucker, Molong Li, Derek Klarin, Nathan A Bihlmeyer, Siew-Kee Low, Peter E Weeke, Martina Müller-Nurasyid, J Gustav Smith, Jennifer A Brody, Maartje N Niemeijer, Marcus Dörr, Stella Trompet, Jennifer Huffman, Stefan Gustafsson, Claudia Schurmann, Marcus E Kleber, Leo-Pekka Lyytikäinen, Ilkka Seppälä, Rainer Malik, Andrea RVR Horimoto, Marco Perez, Juha Sinisalo, Stefanie Aeschbacher, Sébastien Thériault, Jie Yao, Farid Radmanesh, Stefan Weiss, Alexander Teumer, Seung Hoan Choi, Lu-Chen Weng, Sebastian Clauss, Rajat Deo, Daniel J Rader, Svati H Shah, Albert Sun, Jemma C Hopewell, Stephanie Debette, Ganesh Chauhan, Qiong Yang, Bradford B Worrall, Guillaume Paré, Yoichiro Kamatani, Yanick P Hagemeijer, Niek Verweij, Joylene E Siland, Michiaki Kubo, Jonathan D Smith, David R Van Wagoner, Joshua C Bis, Siegfried Perz, Bruce M Psaty, Paul M Ridker, Jared W Magnani, Tamara B Harris, Lenore J Launer, M Benjamin Shoemaker, Sandosh Padmanabhan, Jeffrey Haessler, Traci M Bartz, Melanie Waldenberger, Peter Lichtner, Marina Arendt, Jose E Krieger, Mika Kähönen, Lorenz Risch, Alfredo J Mansur, Annette Peters, Blair H Smith, Lars Lind, Stuart A Scott, Yingchang Lu, Erwin B Bottinger, Jussi Hernesniemi, Cecilia M Lindgren, Jorge A Wong, Jie Huang, Markku Eskola, Andrew P Morris, Ian Ford, Alex P Reiner, Graciela Delgado, Lin Y Chen, Yii-Der Ida Chen, Roopinder K Sandhu, Man Li, Eric Boerwinkle, Lewin Eisele, Lars Lannfelt, Natalia Rost, Christopher D Anderson, Kent D Taylor, Archie Campbell, Patrik K Magnusson, David Porteous, Lynne J Hocking, Efthymia Vlachopoulou, Nancy L Pedersen, Kjell Nikus, Marju Orho-Melander, Anders Hamsten, Jan Heeringa, Joshua C Denny, Jennifer Kriebel, Dawood Darbar, Christopher Newton-Cheh, Christian Shaffer, Peter W Macfarlane, Stefanie Heilmann-Heimbach, Peter Almgren, Paul L Huang, Nona Sotoodehnia, Elsayed Z Soliman, Andre G Uitterlinden, Albert Hofman, Oscar H Franco, Uwe Völker, Karl-Heinz Jöckel, Moritz F Sinner, Henry J Lin, Xiuqing Guo, Martin Dichgans, Erik Ingelsson, Charles Kooperberg, Olle Melander, Ruth JF Loos, Jari Laurikka, David Conen, Jonathan Rosand, Pim van der Harst, Marja-Liisa Lokki, Sekar Kathiresan, Alexandre Pereira, J Wouter Jukema, Caroline Hayward, Jerome I Rotter, Winfried März, Terho Lehtimäki, Bruno H Stricker, Mina K Chung. Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation. Nat Genet. 2017 Jun;49(6):946-952. doi: 10.1038/ng.3843. Epub 2017 Apr 17. PMID: 28416818

Fernández Rhodes L, Gong J, Haessler J, Franceschini, N, Graff M, Nishimura KK, Wang Y, Highland, HM, Yoneyama S, Bush WS, Goodloe R, Ritchie MD, Crawford D, Gross M, Fornage M, Buzkova P, Tao R, Isasi C, Avilés Santa L, Daviglus M, Mackey RH, Houston D, Gu CC, Ehret G, Nguyen KH, Lewis CE, Leppert M, Irvin MR, Lim U, Haiman CA, Le Marchand L, Schumacher F, Wilkens L, Lu Y, Bottinger EP, Loos RJL, Sheu WH, Guo X, Lee WJ, Hai Y, Hung YJ, Absher D, Wu IC, Taylor KD, Lee IT, Liu Y, Wang TD, Quertermous T, Juang, Rotter JI, Assimes T, Hsiung, CA, Chen YI, Prentice R, Kuller LH, Manson JE, Kooperberg C, Smokowski P, Robinson, WR, Gordon Larsen P, Li R, Hindorff L, Buyske S · Matise TC, Peters U, North KE.Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci. Hum Genet. 2017 Jun;136(6):771-800. doi: 10.1007/s00439-017-1787-6. Epub 2017 Apr 8. PMID: 28391526

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Chunyu Liu, Aldi T Kraja, Jennifer A Smith, Jennifer A Brody, Nora Franceschini, Joshua C Bis, Kenneth Rice, Alanna C Morrison, Yingchang Lu, Stefan Weiss, Xiuqing Guo, Walter Palmas, Lisa W Martin, Yii-Der Ida Chen, Praveen Surendran, Fotios Drenos, James P Cook, Paul L Auer, Audrey Y Chu, Ayush Giri, Wei Zhao, Johanna Jakobsdottir, Li-An Lin, Jeanette M Stafford, Najaf Amin, Hao Mei, Jie Yao, Arend Voorman, Martin G Larson, Megan L Grove, Albert V Smith, Shih-Jen Hwang, Han Chen, Tianxiao Huan, Gulum Kosova, Nathan O Stitziel, Sekar Kathiresan, Nilesh Samani, Heribert Schunkert, Panos Deloukas, Myocardial Infarction Genetics, CARDIoGRAM Exome Consortia, Man Li, Christian Fuchsberger, Cristian Pattaro, Mathias Gorski, Charles Kooperberg, George J Papanicolaou, Jacques E Rossouw, Jessica D Faul, Sharon LR Kardia, Claude Bouchard, Leslie J Raffel, André G Uitterlinden, Oscar H Franco, Ramachandran S Vasan, Christopher J O’Donnell, Kent D Taylor, Kiang Liu, Erwin P Bottinger, Omri Gottesman, E Warwick Daw, Franco Giulianini, Santhi Ganesh, Elias Salfati, Tamara B Harris, Lenore J Launer, Marcus Dörr, Stephan B Felix, Rainer Rettig, Henry Völzke, Eric Kim, Wen-Jane Lee, I-Te Lee, Wayne HH Sheu, Krystal S Tsosie, Digna R Velez Edwards, Yongmei Liu, Adolfo Correa, David R Weir, Uwe Völker, Paul M Ridker, Eric Boerwinkle, Vilmundur Gudnason, Alexander P Reiner, Cornelia M van Duijn, Ingrid B Borecki, Todd L Edwards, Aravinda Chakravarti, Jerome I Rotter, Bruce M Psaty, Ruth JF Loos, Myriam Fornage, Georg B Ehret, Christopher Newton-Cheh, Daniel Levy, Daniel I Chasman, CHD Exome+ Consortium, ExomeBP Consortium, GoT2DGenes Consortium, T2D-GENES Consortium, CKDGen Consortium. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016 Oct;48(10):1162-70. doi: 10.1038/ng.3660. Epub 2016 Sep 12. PMID: 27618448; PMCID: PMC5320952

Christian Fuchsberger, Jason Flannick, Tanya M Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John RB Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L Stitzel, Dorota Pasko, Stephen CJ Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie CY Ng, Nicholette D Palmer, Beverley Balkau, Alena Stančáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna MM Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent KL Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia HT Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Denis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Yvonne T van der Schouw, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor Jr, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen. The genetic architecture of type 2 diabetes. Nature. 2016 Aug 4;536(7614):41-7. Epub 2016 Jul 11.
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Salman M Tajuddin, Ursula M Schick, John D Eicher, Nathalie Chami, Ayush Giri, Jennifer A Brody, W David Hill, Tim Kacprowski, Jin Li, Leo-Pekka Lyytikäinen, Ani Manichaikul, Evelin Mihailov, Michelle L O’Donoghue, Nathan Pankratz, Raha Pazoki, Linda M Polfus, Albert Vernon Smith, Claudia Schurmann, Caterina Vacchi-Suzzi, Dawn M Waterworth, Evangelos Evangelou, Lisa R Yanek, Amber Burt, Ming-Huei Chen, Frank JA van Rooij, James S Floyd, Andreas Greinacher, Tamara B Harris, Heather M Highland, Leslie A Lange, Yongmei Liu, Reedik Mägi, Mike A Nalls, Rasika A Mathias, Deborah A Nickerson, Kjell Nikus, John M Starr, Jean-Claude Tardif, Ioanna Tzoulaki, Digna R Velez Edwards, Lars Wallentin, Traci M Bartz, Lewis C Becker, Joshua C Denny, Laura M Raffield, John D Rioux, Nele Friedrich, Myriam Fornage, He Gao, Joel N Hirschhorn, David CM Liewald, Stephen S Rich, Andre Uitterlinden, Lisa Bastarache, Diane M Becker, Eric Boerwinkle, Simon de Denus, Erwin P Bottinger, Caroline Hayward, Albert Hofman, Georg Homuth, Ethan Lange, Lenore J Launer, Terho Lehtimäki, Yingchang Lu, Andres Metspalu, Chris J O’Donnell, Rakale C Quarells, Melissa Richard, Eric S Torstenson, Kent D Taylor, Anne-Claire Vergnaud, Alan B Zonderman, David R Crosslin, Ian J Deary, Marcus Dörr, Paul Elliott, Michele K Evans, Vilmundur Gudnason, Mika Kähönen, Bruce M Psaty, Jerome I Rotter, Andrew J Slater, Abbas Dehghan, Harvey D White, Santhi K Ganesh, Ruth JF Loos, Tõnu Esko, Nauder Faraday, James G Wilson, Mary Cushman, Andrew D Johnson, Todd L Edwards, Neil A Zakai, Guillaume Lettre, Alex P Reiner, Paul L Auer. Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. Am J Hum Genet. 2016 Jul 7;99(1):22-39. doi: 10.1016/j.ajhg.2016.05.003. Epub 2016 Jun 23. PMID:27346689; PMCID:PMC5005433

John D Eicher, Nathalie Chami, Tim Kacprowski, Akihiro Nomura, Ming-Huei Chen, Lisa R Yanek, Salman M Tajuddin, Ursula M Schick, Andrew J Slater, Nathan Pankratz, Linda Polfus, Claudia Schurmann, Ayush Giri, Jennifer A Brody, Leslie A Lange, Ani Manichaikul, W David Hill, Raha Pazoki, Paul Elliot, Evangelos Evangelou, Ioanna Tzoulaki, He Gao, Anne-Claire Vergnaud, Rasika A Mathias, Diane M Becker, Lewis C Becker, Amber Burt, David R Crosslin, Leo-Pekka Lyytikäinen, Kjell Nikus, Jussi Hernesniemi, Mika Kähönen, Emma Raitoharju, Nina Mononen, Olli T Raitakari, Terho Lehtimäki, Mary Cushman, Neil A Zakai, Deborah A Nickerson, Laura M Raffield, Rakale Quarells, Cristen J Willer, Gina M Peloso, Goncalo R Abecasis, Dajiang J Liu, Panos Deloukas, Nilesh J Samani, Heribert Schunkert, Jeanette Erdmann, Myriam Fornage, Melissa Richard, Jean-Claude Tardif, John D Rioux, Marie-Pierre Dube, Simon de Denus, Yingchang Lu, Erwin P Bottinger, Ruth JF Loos, Albert Vernon Smith, Tamara B Harris, Lenore J Launer, Vilmundur Gudnason, Digna R Velez Edwards, Eric S Torstenson, Yongmei Liu, Russell P Tracy, Jerome I Rotter, Stephen S Rich, Heather M Highland, Eric Boerwinkle, Jin Li, Ethan Lange, James G Wilson, Evelin Mihailov, Reedik Mägi, Joel Hirschhorn, Andres Metspalu, Tõnu Esko, Caterina Vacchi-Suzzi, Mike A Nalls, Alan B Zonderman, Michele K Evans, Gunnar Engström, Marju Orho-Melander, Olle Melander, Michelle L O’Donoghue, Dawn M Waterworth, Lars Wallentin, Harvey D White, James S Floyd, Traci M Bartz, Kenneth M Rice, Bruce M Psaty, JM Starr, David CM Liewald, Caroline Hayward, Ian J Deary, Andreas Greinacher, Uwe Völker, Thomas Thiele, Henry Völzke, Frank JA van Rooij, André G Uitterlinden, Oscar H Franco, Abbas Dehghan, Todd L Edwards, Santhi K Ganesh, Sekar Kathiresan, Nauder Faraday, Paul L Auer, Alex P Reiner, Guillaume Lettre, Andrew D Johnson, Global Lipids Genetics Consortium, CARDIoGRAM Exome Consortium, Myocardial Infarction Genetics Consortium. Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. Am J Hum Genet. 2016 Jul 7;99(1):40-55. doi: 10.1016/j.ajhg.2016.05.005. Epub 2016 Jun 23. PMID: 27346686; PMCID: PMC5005441

Nathalie Chami, Ming-Huei Chen, Andrew J Slater, John D Eicher, Evangelos Evangelou, Salman M Tajuddin, Latisha Love-Gregory, Tim Kacprowski, Ursula M Schick, Akihiro Nomura, Ayush Giri, Samuel Lessard, Jennifer A Brody, Claudia Schurmann, Nathan Pankratz, Lisa R Yanek, Ani Manichaikul, Raha Pazoki, Evelin Mihailov, W David Hill, Laura M Raffield, Amber Burt, Traci M Bartz, Diane M Becker, Lewis C Becker, Eric Boerwinkle, Jette Bork-Jensen, Erwin P Bottinger, Michelle L O’Donoghue, David R Crosslin, Simon de Denus, Marie-Pierre Dubé, Paul Elliott, Gunnar Engström, Michele K Evans, James S Floyd, Myriam Fornage, He Gao, Andreas Greinacher, Vilmundur Gudnason, Torben Hansen, Tamara B Harris, Caroline Hayward, Jussi Hernesniemi, Heather M Highland, Joel N Hirschhorn, Albert Hofman, Marguerite R Irvin, Mika Kähönen, Ethan Lange, Lenore J Launer, Terho Lehtimäki, Jin Li, David CM Liewald, Allan Linneberg, Yongmei Liu, Yingchang Lu, Leo-Pekka Lyytikäinen, Reedik Mägi, Rasika A Mathias, Olle Melander, Andres Metspalu, Nina Mononen, Mike A Nalls, Deborah A Nickerson, Kjell Nikus, Chris J O’Donnell, Marju Orho-Melander, Oluf Pedersen, Astrid Petersmann, Linda Polfus, Bruce M Psaty, Olli T Raitakari, Emma Raitoharju, Melissa Richard, Kenneth M Rice, Fernando Rivadeneira, Jerome I Rotter, Frank Schmidt, Albert Vernon Smith, John M Starr, Kent D Taylor, Alexander Teumer, Betina H Thuesen, Eric S Torstenson, Russell P Tracy, Ioanna Tzoulaki, Neil A Zakai, Caterina Vacchi-Suzzi, Cornelia M van Duijn, Frank JA van Rooij, Mary Cushman, Ian J Deary, Digna R Velez Edwards, Anne-Claire Vergnaud, Lars Wallentin, Dawn M Waterworth, Harvey D White, James G Wilson, Alan B Zonderman, Sekar Kathiresan, Niels Grarup, Tõnu Esko, Ruth JF Loos, Leslie A Lange, Nauder Faraday, Nada A Abumrad, Todd L Edwards, Santhi K Ganesh, Paul L Auer, Andrew D Johnson, Alexander P Reiner, Guillaume Lettre. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J Hum Genet. 2016 Jul 7;99(1):8-21. doi: 10.1016/j.ajhg.2016.05.007. Epub 2016 Jun 23. PMID:27346685; PMCID:PMC5005438

Ching-Ti Liu, Sridharan Raghavan, Nisa Maruthur, Edmond Kato Kabagambe, Jaeyoung Hong, Maggie CY Ng, Marie-France Hivert, Yingchang Lu, Ping An, Amy R Bentley, Anne M Drolet, Kyle J Gaulton, Xiuqing Guo, Loren L Armstrong, Marguerite R Irvin, Man Li, Leonard Lipovich, Denis V Rybin, Kent D Taylor, Charles Agyemang, Nicholette D Palmer, Brian E Cade, Wei-Min Chen, Marco Dauriz, Joseph AC Delaney, Todd L Edwards, Daniel S Evans, Michele K Evans, Leslie A Lange, Aaron Leong, Jingmin Liu, Yongmei Liu, Uma Nayak, Sanjay R Patel, Bianca C Porneala, Laura J Rasmussen-Torvik, Marieke B Snijder, Sarah C Stallings, Toshiko Tanaka, Lisa R Yanek, Wei Zhao, Diane M Becker, Lawrence F Bielak, Mary L Biggs, Erwin P Bottinger, Donald W Bowden, Guanjie Chen, Adolfo Correa, David J Couper, Dana C Crawford, Mary Cushman, John D Eicher, Myriam Fornage, Nora Franceschini, Yi-Ping Fu, Mark O Goodarzi, Omri Gottesman, Kazuo Hara, Tamara B Harris, Richard A Jensen, Andrew D Johnson, Min A Jhun, Andrew J Karter, Margaux F Keller, Abel N Kho, Jorge R Kizer, Ronald M Krauss, Carl D Langefeld, Xiaohui Li, Jingling Liang, Simin Liu, William L Lowe, Thomas H Mosley, Kari E North, Jennifer A Pacheco, Patricia A Peyser, Alan L Patrick, Kenneth M Rice, Elizabeth Selvin, Mario Sims, Jennifer A Smith, Salman M Tajuddin, Dhananjay Vaidya, Mary P Wren, Jie Yao, Xiaofeng Zhu, Julie T Ziegler, Joseph M Zmuda, Alan B Zonderman, Aeilko H Zwinderman, Adebowale Adeyemo, Eric Boerwinkle, Luigi Ferrucci, M Geoffrey Hayes, Sharon LR Kardia, Iva Miljkovic, James S Pankow, Charles N Rotimi, Michele M Sale, Lynne E Wagenknecht, Donna K Arnett, Yii-Der Ida Chen, Michael A Nalls, Michael A Province, WH Linda Kao, David S Siscovick, Bruce M Psaty, James G Wilson, Ruth JF Loos, Josée Dupuis, Stephen S Rich, Jose C Florez, Jerome I Rotter, Andrew P Morris, James B Meigs, AAAG Consortium, CARe Consortium, COGENT-BP Consortium, eMERGE Consortium, MEDIA Consortium, MAGIC Consortium. Trans-ethnic Meta-analysis and Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am J Hum Genet. 2016 Jul 7;99(1):56-75. doi: 10.1016/j.ajhg.2016.05.006. Epub 2016 Jun 16. PMID:27321945; PMCID:PMC5005440

Yun Ju Sung, Thomas W Winkler, Alisa K Manning, Hugues Aschard, Vilmundur Gudnason, Tamara B Harris, Albert V Smith, Eric Boerwinkle, Michael R Brown, Alanna C Morrison, Myriam Fornage, Li‐An Lin, Melissa Richard, Traci M Bartz, Bruce M Psaty, Caroline Hayward, Ozren Polasek, Jonathan Marten, Igor Rudan, Mary F Feitosa, Aldi T Kraja, Michael A Province, Xuan Deng, Virginia A Fisher, Yanhua Zhou, Lawrence F Bielak, Jennifer Smith, Jennifer E Huffman, Sandosh Padmanabhan, Blair H Smith, Jingzhong Ding, Yongmei Liu, Kurt Lohman, Claude Bouchard, Tuomo Rankinen, Treva K Rice, Donna Arnett, Karen Schwander, Xiuqing Guo, Walter Palmas, Jerome I Rotter, Tamuno Alfred, Erwin P Bottinger, Ruth JF Loos, Najaf Amin, Oscar H Franco, Cornelia M Duijn, Dina Vojinovic, Daniel I Chasman, Paul M Ridker, Lynda M Rose, Sharon Kardia, Xiaofeng Zhu, Kenneth Rice, Ingrid B Borecki, Dabeeru C Rao, W James Gauderman, L Adrienne Cupples. An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group. Genet Epidemiol. 2016 Jul;40(5):404-15. doi: 10.1002/gepi.21978. Epub 2016 May 27. PMID:27230302; PMCID:PMC4911246

Lim E, Uddin M, De Rubeis S, Chan Y, Kamumbu A, Zhang X, D’Gama A, Kim S, Hill S, Goldberg A, Poultney C, Minshew N, Kushima I, Aleksic B, Ozaki N, Parellada M, Arando C, Penzo M, Carracedo A, Kolevzon A, Hultman C, Weiss L, Fromer M, Chiocchetti AG, Freitag C, Church G, Scherer S, Buxbaum JD, Walsh C. (In press) Rates, Distribution, and Implications of Post-zygotic Mutations in Autism Spectrum Disorder. Nature Neuroscience.

Pollak, J., Rai, K. G., Funk, C. C., Arora, S., Lee, E., Zhu, J., Price, N. D., Paddison, P. J., Ramirez, J. M., and Rostomily, R. C., ‘Ion Channel Expression Patterns in Glioblastoma Stem Cells with Functional and Therapeutic Implications for Malignancy’, PLoS One, 12 (2017), e0172884. PMID: 28264064; PMCID:PMC5338779; DOI:10.1371/journal.pone.0172884

Cohain, A., Divaraniya, A. A., Zhu, K., Scarpa, J. R., Kasarskis, A., Zhu, J., Chang, R., Dudley, J. T., and Schadt, E. E., ‘Exploring the Reproducibility of Probabilistic Causal Molecular Network Models’, Pac Symp Biocomput, 22 (2016), 120-31. PMID:27896968;PMCID:PMC5161348

Gong, Y., Wang, L., Chippada-Venkata, U., Dai, X., Oh, W. K., and Zhu, J.*, ‘Constructing Bayesian Networks by Integrating Gene Expression and Copy Number Data Identifies Nlgn4y as a Novel Regulator of Prostate Cancer Progression’, Oncotarget (2016). PMID: 27626693; PMCID:PMC5356583; DOI:10.18632/oncotarget.11925

Wang, L., Oh, W. K., and Zhu, J.*, ‘Disease-Specific Classification Using Deconvoluted Whole Blood Gene Expression’, Sci Rep, 6 (2016), 32976. PMID:27596246; PMCID:PMC5011717; DOI:10.1038/srep32976

Yang, J., Huang, T., Song, W. M., Petralia, F., Mobbs, C. V., Zhang, B., Zhao, Y., Schadt, E. E., Zhu, J., and Tu, Z., ‘Discover the Network Mechanisms Underlying the Connections between Aging and Age-Related Diseases’, Sci Rep, 6 (2016), 32566. PMID: 27582315; PMCID:PMC5007654; DOI:10.1038/srep32566

Epel, E. S., Puterman, E., Lin, J., Blackburn, E. H., Lum, P. Y., Beckmann, N. D., Zhu, J., Lee, E., Gilbert, A., Rissman, R. A., Tanzi, R. E., and Schadt, E. E., ‘Meditation and Vacation Effects Have an Impact on Disease-Associated Molecular Phenotypes’, Transl Psychiatry, 6 (2016), e880. PMID: 27576169; PMCID:PMC5022094; DOI:10.1038/tp.2016.164

Fromer, M., Roussos, P., Sieberts, S. K., Johnson, J. S., Kavanagh, D. H., Perumal, T. M., Ruderfer, D. M., Oh, E. C., Topol, A., Shah, H. R., Klei, L. L., Kramer, R., Pinto, D., Gumus, Z. H., Cicek, A. E., Dang, K. K., Browne, A., Lu, C., Xie, L., Readhead, B., Stahl, E. A., Xiao, J., Parvizi, M., Hamamsy, T., Fullard, J. F., Wang, Y. C., Mahajan, M. C., Derry, J. M., Dudley, J. T., Hemby, S. E., Logsdon, B. A., Talbot, K., Raj, T., Bennett, D. A., De Jager, P. L., Zhu, J., Zhang, B., Sullivan, P. F., Chess, A., Purcell, S. M., Shinobu, L. A., Mangravite, L. M., Toyoshiba, H., Gur, R. E., Hahn, C. G., Lewis, D. A., Haroutunian, V., Peters, M. A., Lipska, B. K., Buxbaum, J. D., Schadt, E. E., Hirai, K., Roeder, K., Brennand, K. J., Katsanis, N., Domenici, E., Devlin, B., and Sklar, P., ‘Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia’, Nat Neurosci (2016). PMID:27668389; PMCID:PMC5083142;DOI:10.1038/nn.4399

Katsyv, I., Wang, M., Song, W. M., Zhou, X., Zhao, Y., Park, S., Zhu, J., Zhang, B., and Irie, H. Y., ‘Eprs Is a Critical Regulator of Cell Proliferation and Estrogen Signaling in Er+ Breast Cancer’, Oncotarget (2016). PMID:27612429; PMCID:PMC5342500; DOI:10.18632/oncotarget.11870

Wang, Q., Lin, L., Yoo, S., Wang, W., Blank, S., Fiel, M. I., Kadri, H., Luan, W., Warren, L., Zhu, J., and Hiotis, S. P., ‘Impact of Non-Neoplastic Vs Intratumoural Hepatitis B Viral DNA and Replication on Hepatocellular Carcinoma Recurrence’, Br J Cancer, 115 (2016), 841-7. PMID:27537392; PMCID:PMC5046201 [Available on 2017-09-27] DOI:10.1038/bjc.2016.239

Collazo-Lorduy, A., Castillo-Martin, M., Wang, L., Patel, V., Iyer, G., Jordan, E., Al-Ahmadie, H., Leonard, I., Oh, W. K., Zhu, J., McBride, R. B., Cordon-Cardo, C., Solit, D. B., Sfakianos, J. P., and Galsky, M. D., ‘Urachal Carcinoma Shares Genomic Alterations with Colorectal Carcinoma and May Respond to Epidermal Growth Factor Inhibition’, Eur Urol (2016). Eur Urol. 2016 Nov;70(5):771-775. doi: 10.1016/j.eururo.2016.04.037. Epub 2016 May 10. PMID:27178450; PMCID:PMC5489411 [Available on 2017-11-01] DOI:10.1016/j.eururo.2016.04.037

Akerman I, Tu Z, Beucher A, Rolando DM, Sauty-Colace C, Benazra M, Nakic N, Yang J, Wang H, Pasquali L, Moran I, Garcia-Hurtado J, Castro N, Gonzalez-Franco R, Stewart AF, Bonner C, Piemonti L, Berney T, Groop L, Kerr-Conte J, Pattou F, Argmann C, Schadt E, Ravassard P, Ferrer J. Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks. Cell Metab. 2017 Feb 7;25(2):400-411. doi: 10.1016/j.cmet.2016.11.016. Epub 2016 Dec 29. PubMed PMID: 28041957; PubMed Central PMCID: PMC5300904.

Yang J, Huang T, Song WM, Petralia F, Mobbs CV, Zhang B, Zhao Y, Schadt EE, Zhu J, Tu Z. Discover the network mechanisms underlying the connections between aging and age-related diseases. Sci Rep. 2016 Sep 1;6:32566. doi: 10.1038/srep32566. PubMed PMID: 27582315; PubMed Central PMCID: PMC5007654.

Uzilov AV, Ding W, Fink MY, Antipin Y, Brohl AS, Davis C, Lau CY, Pandya C, Shah H, Kasai Y, Powell J, Micchelli M, Castellanos R, Zhang Z, Linderman M, Kinoshita Y, Zweig M, Raustad K, Cheung K, Castillo D, Wooten M, Bourzgui I, Newman LC, Deikus G, Mathew B, Zhu J, Glicksberg BS, Moe AS, Liao J, Edelmann L, Dudley JT, Maki RG, Kasarskis A, Holcombe RF, Mahajan M, Hao K, Reva B, Longtine J, Starcevic D, Sebra R, Donovan MJ, Li S, Schadt EE, Chen R. Development and clinical application of an integrative genomic approach to personalized cancer therapy. Genome Med. 2016 Jun 1;8(1):62. doi: 10.1186/ s13073-016-0313-0. PubMed PMID: 27245685; PubMed Central PMCID: PMC4888213.

 

      • 07/2015-07/2016: 7 in total

 

1. Valle-García D, Qadeer ZA, McHugh DS, Ghiraldini FG, Chowdhury AH, Hasson D, Dyer MA, Recillas-Targa F, Bernstein E. ATRX binds to atypical chromatin domains at the 3′ exons of zinc finger genes to preserve H3K9me3 enrichment. Epigenetics. (2016 Mar 30);11(6):398-414. http://www.ncbi.nlm.nih.gov/pubmed/27029610

2. Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JS, Martinez-Gil L, Fenouil R, Chen X, Edwards M, Metreveli G, Jordan S, Peralta Z, Munoz-Fontela C, Bouvier N, Merad M, Jin J, Weirauch M, Heinz S, Benner C, van Bakel H, Basler C, García-Sastre A, Bukreyev A, Marazzi I. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science. (2016 Apr 28); 352(6289).http://www.ncbi.nlm.nih.gov/pubmed/27127234

3. Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs DH, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LC, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity. (2016 Jan 19); 44(1):46-58. http://www.ncbi.nlm.nih.gov/pubmed/26789921

4. Pak TR, Altman DR, Attie O, Sebra R, Hamula CL, Lewis M, Deikus G, Newman LC, Fang G, Hand J, Patel G, Wallach F, Schadt EE, Huprikar S, van Bakel H, Kasarskis A, Bashir A.
Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia. Antimicrob Agents Chemother. (2015 Aug 31); 59(11):7117-20.http://www.ncbi.nlm.nih.gov/pubmed/26324280

5. Chung C-Y., Sun Z., Mullokandov G., Bosch-Gutierrez A., Qadeer Z.A., Cihan E., Rapp Z., Parsons R., Aguirre-Ghiso J.A., Farias E.F., Brown B.,Gaspar-Maia A., Bernstein E. Cbx8 acts non-canonically with Wdr5 to promote mammary tumorigenesis. Cell Reports(2016 Jun 22 ). http://www.ncbi.nlm.nih.gov/pubmed/27346354

6. Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, et al. Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci. Neuron. (2015 Sep 23);87(6):1215–33.http://www.ncbi.nlm.nih.gov/pubmed/26402605

7. Quilez J, Guilmatre A, Garg P, Highnam G, Mittelman D, Sharp AJ. Polymorphic tandem repeats within gene promoters act as modifiers of gene expression and DNA methylation in humans. Nucleic Acids. (2016 Apr 7); 44(8):3750-62.http://www.ncbi.nlm.nih.gov/pubmed/27060133

8. Watson CT, Roussos P, Garg P, Ho D, Azam N, Haroutunian V, Sharp AJ. Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease. Genome Med. (2016 Jan 19); 8(1):5.http://www.ncbi.nlm.nih.gov/pubmed/26803900

9. Gymrek M, Willems T, Guilmatre A, Zeng H, Markus B, Georgiev S, Daly MJ, Price AL, Pritchard J, Sharp AJ, Erlich Y. Abundant contribution of short tandem repeats to gene expression variation in humans. Nature Genet. (2015 Dec 7); 48(1):22-9.http://www.ncbi.nlm.nih.gov/pubmed/26642241

10. Li, C. W., Menconi, F., Osman, R., Mezei, M., Jacobson, E. M., Concepcion, E., David, C. S., Kastrinsky, D. B., Ohlmeyer, M., and Tomer, Y. Identifying a Small Molecule Blocking Antigen Presentation in Autoimmune Thyroiditis, J Biol Chem. (2015 Dec 24); 291(8): 4079-4090. http://www.ncbi.nlm.nih.gov/pubmed/26703475

11. Osman, R., Mezei, M., and Engel, S. The Role of Protein “Stability Patches” in Molecular Recognition: A Case Study of the Human Growth Hormone-Receptor Complex, J Comput Chem. (2015 Dec 21); 37(10): 913-919.http://www.ncbi.nlm.nih.gov/pubmed/26691434

12. Long, Q., Argmann, C., Houten, S. M., Huang, T., Peng, S., Zhao, Y., Tu, Z., and Zhu, J. *, ‘Inter-Tissue Coexpression Network Analysis Reveals Dpp4 as an Important Gene in Heart to Blood Communication’, Genome Med. (2016 Feb 9);8(1):15. http://www.ncbi.nlm.nih.gov/pubmed/26856537

13. Lee, E., Ito, K., Zhao, Y., Schadt, E. E., Irie, H. Y., and Zhu, J.*, Inferred miRNA activity identifies miRNA-mediated regulatory networks underlying multiple cancers, Bioinformatics (2015 Sep 10);32(1):96-105. http://www.ncbi.nlm.nih.gov/pubmed/26358730

14. Wang, L., Gong, Y., Chippada-Venkata, U., Heck, M. M., Retz, M., Nawroth, R., Galsky, M., Tsao, C. K., Schadt, E., de Bono, J., Olmos, D., Zhu, J.*, and Oh, W. K.*, A Robust Blood Gene Expression-Based Prognostic Model for Castration-Resistant Prostate Cancer, BMC Med. (2015 Aug 21);13:20.http://www.ncbi.nlm.nih.gov/pubmed/26297150

15. Kovatch, P., Costa, A., Giles, Z., Fluder, E., Cho, H., Mazurkova, S. (2015). Big Omics Data Experience. Supercomputing 2015. PMID: 30788464 PMCID: PMC6379072 DOI: 10.1145/2807591.2807595. http://dl.acm.org/citation.cfm?id=2807595