{"id":12,"date":"2019-06-12T19:49:41","date_gmt":"2019-06-12T19:49:41","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/millarlab\/?page_id=12"},"modified":"2025-08-27T15:45:44","modified_gmt":"2025-08-27T15:45:44","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/millarlab\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”rgba(0,0,0,0.39)” background_image=”https:\/\/labs.icahn.mssm.edu\/millarlab\/wp-content\/uploads\/sites\/309\/2019\/11\/top-copy.jpg” custom_padding=”5em||5em|”][et_pb_row module_class=” et_pb_row_fullwidth” _builder_version=”3.25″ width=”89%” width_tablet=”80%” width_phone=”” width_last_edited=”on|desktop” max_width=”89%” max_width_tablet=”80%” max_width_phone=”” max_width_last_edited=”on|desktop” module_alignment=”center” make_fullwidth=”on”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ header_font=”Open Sans||||||||” text_orientation=”center”]<\/p>\n

Welcome to the Millar lab<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”|500|||||||”]<\/p>\n

Our research focuses on the roles of Wnt signaling and transcriptional and epigenetic regulatory mechanisms in development and regeneration of epithelial tissues and their appendages. Understanding these mechanisms is critical for developing new therapies to accelerate wound healing, treat hair loss diseases, and ameliorate smell and taste dysfunction.<\/p>\n

 <\/p>\n

In our published studies, we identified Wnt\/beta-catenin signaling as a key pathway required for initiating the formation of ectodermal appendages from multipotent cells in mammalian embryos, and in controlling development and patterning of haired versus hairy skin. By\u00a0analyzing genetic mouse models and tissues from human patients carrying mutations in the WNT10A gene, we showed that Wnt signaling plays a crucial role in regulating the functions of a wide variety of adult epithelial stem cells, as well as in controlling specialized differentiation programs in palmoplantar skin. We also identified critical functions for epigenetic regulators including micro-RNAs and chromatin modifiers in skin development and regeneration.<\/p>\n

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The Millar lab is part of the Black Family Institute; the Department of Cell, Regenerative and Developmental Biology; the Department of Oncological Sciences; and the Department of Dermatology. Dr. Millar is also a faculty member of the Development, Regeneration and Stem Cells (DRS) graduate program.<\/p>\n

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Links<\/strong><\/h3>\n

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Sarah Millar \u2013 Faculty Profile<\/strong><\/a><\/p>\n

Institute for Regenerative Medicine<\/a><\/strong><\/p>\n

Black Family Stem Cell Institute<\/a><\/strong><\/p>\n

Department of Cell, Developmental and Regenerative Biology<\/a><\/strong><\/p>\n

Skin Biology and Diseases Resource-based Center<\/a><\/strong><\/p>\n

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Department of Dermatology<\/a><\/strong><\/p>\n

Development, Regeneration and Stem Cells graduate program<\/a><\/strong><\/p>\n

Dr. Millar lecture SID 2017<\/a><\/strong><\/p>\n

Department of Oncological Sciences<\/a><\/strong><\/p>\n

Center for Epithelial Biology and Regeneration<\/a><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_divider divider_weight=”0.5″ _builder_version=”3.19.10″][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” _builder_version=”3.22″ custom_margin=”-5em||3em|”][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_text_color=”#0800f7″ text_font_size=”30px”]<\/p>\n

Current projects in the lab include:<\/strong><\/h3>\n

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1.\u00a0Determining the mechanisms that underlie the formation and maintenance of hairy versus hairless skin and regulate hair patterning<\/p>\n

2.\u00a0Delineating the functions of histone deacetylase chromatin modifiers in skin development, stem cells, and cancer<\/p>\n

3.\u00a0Identifying pioneer transcription factors that control development and stem cell activity in the skin<\/p>\n

4.Using novel genetic mouse models to uncover the cellular and molecular mechanisms involved in loss of taste and smell in COVID-19 disease<\/p>\n

 <\/p>\n

We are actively seeking graduate students and postdoctoral fellows to join our group!<\/p>\n

If you are interested in a rotation project or position in the Millar lab please contact Dr. Millar at sarah.millar@mssm.edu<\/a>.<\/strong><\/p>\n

[\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/millarlab\/wp-content\/uploads\/sites\/309\/2019\/09\/bottom.jpg” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″ border_radii=”on|3px|3px|3px|3px”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ background_color=”#000000″ border_width_bottom=”0.5px” border_color_bottom=”#d6d6d6″][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”3.25″][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”3.27.4″ background_layout=”dark”]<\/p>\n

Sarah E. Millar, Ph.D.<\/strong>
Director, Black Family Stem Cell Institute<\/strong>
Professor, Departments of Cell, Developmental and Regenerative Biology and Dermatology<\/strong>
Icahn School of Medicine at Mount Sinai
Icahn Building, Floor 13 Room 020C
1425 Madison Ave
New York, NY 10029
Tel: (212) 659-9412
Email: sarah.millar@mssm.edu<\/a><\/p>\n

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Nyomi Cepeda, Administrative <\/strong>Coordinator<\/b>
Black Family Stem Cell Institute
Icahn School of Medicine at Mount Sinai
Icahn Building, Floor 13 Room 79, Box 1496
1425 Madison Ave
New York, N.Y. 10029
Tel: 212-659-6897 (ext: 86897)
Cell: 646-581-8011
nyomi.cepeda2@mssm.edu<\/a><\/p>\n

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Kayrin Velez, Administrative Assistant<\/strong>
Black Family Stem Cell Institute
Icahn School of Medicine at Mount Sinai
Icahn Building, Floor 13 Room 70, Box 1496
1425 Madison Ave
New York, N.Y. 10029
Tel: 212-659-8131 (ext: 88131)
kayrin.velez@mssm.edu<\/a><\/p>\n

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\n[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” _builder_version=”3.22″ disabled=”on”][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/millarlab\/wp-content\/uploads\/sites\/309\/2019\/09\/top.jpg” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″][\/et_pb_image][et_pb_text _builder_version=”3.27.4″ text_text_color=”#0800f7″ text_font_size=”30px” text_line_height=”1em”]<\/p>\n

Welcome to the Millar lab!<\/strong><\/p>\n

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Our research focuses on cell-cell signaling and epigenetic mechanisms controlling development, stem cell function and regeneration of epithelial organs including the skin epidermis and ectodermal appendages such as hair follicles, mammary glands, taste papillae and teeth. We use genetic mouse models and\u00a0patient-derived and gene edited iPS cells to model human genetic skin disease and test novel therapeutic approaches. Current projects in the lab include testing new approaches to treat human ectodermal dysplasia; defining the mechanisms that control formation and maintenance of hairless versus hairy skin; and delineating the functions of histone deacetylases that modify chromatin developing, and regenerating skin and in skin cancer.<\/p>\n

[\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/millarlab\/wp-content\/uploads\/sites\/309\/2019\/09\/middle.jpg” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”3.23″][\/et_pb_image][et_pb_text _builder_version=”3.27.4″ text_font=”|500|||||||”]<\/p>\n

The Millar lab is part of the Black Family Institute; the Department of Cell, Regenerative and Developmental Biology; and the Department of Dermatology. Dr. Millar is also a faculty member of the Development, Regeneration and Stem Cells (DRS) graduate program.<\/p>\n

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Links<\/strong><\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”3.27.4″]<\/p>\n

Sarah Millar \u2013 Faculty Profile<\/a><\/p>\n

Black Family Stem Cell Institute<\/a><\/p>\n

Department of Cell, Developmental and Regenerative Biology<\/a><\/p>\n

Department of Dermatology<\/a><\/p>\n

Development, Regeneration and Stem Cells graduate program<\/a><\/p>\n

Dr. Millar lecture SID 2017<\/a><\/p>\n

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Rotation projects<\/strong><\/p>\n

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1. Investigate mechanisms that cause ectodermal dysplasia in patients with mutations in the WNT10A\u00a0<\/em>gene using patient-derived and gene-edited induced pluripotent stem cells (iPS) and test potential therapeutic strategies.<\/p>\n

2. Determine the mechanisms that underlie the formation and maintenance of hairy versus hairless skin and regulate hair patterning using genetic mouse models.<\/p>\n

3. Define the functions of histone deacetylase chromatin modifiers in skin development, stem cells and cancer.<\/p>\n

4. Identify pioneer transcription factors that control development and stem cell activity in skin and oral epithelia.<\/p>\n

 <\/p>\n

If you are interested in a rotation project or position in the Millar lab please contact Dr. Millar at sarah.millar@mssm.edu.<\/p>\n

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