{"id":1492,"date":"2022-11-18T07:09:04","date_gmt":"2022-11-18T12:09:04","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=1492"},"modified":"2025-11-19T14:20:12","modified_gmt":"2025-11-19T19:20:12","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1″ module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#221F72″ background_enable_image=”off” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” saved_tabs=”all” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” border_color_all=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text admin_label=”Text – Title” _builder_version=”4.27.4″ _module_preset=”b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa” header_font=”||||||||” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||10px||false|false” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

Research<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ background_image=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/12\/9-alt-1024×569.png” parallax=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb content_max_width=”1100px” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

All organs and tissues are interconnected through networks of leukocytes, blood vessels, and nerves.<\/h3>\n

We study brain-body axes in chronic cardiovascular and neurological diseases. Using murine models and human trials we focus on how lifestyle factors, like sleep and exercise, influence these brain-body circuits.<\/h3>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2025\/11\/IMG_3207-1.png” title_text=”IMG_3207″ _builder_version=”4.27.4″ _module_preset=”default” animation_style=”zoom” animation_intensity_zoom=”30%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2025\/11\/Screenshot-2025-11-18-at-12.55.52-PM-1024×269.png” title_text=”Screenshot 2025-11-18 at 12.55.52\u202fPM” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#00AEEF” animation_style=”zoom” animation_intensity_zoom=”10%” box_shadow_style=”preset1″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb _builder_version=”4.27.4″ _module_preset=”default” background_color=”#FFFFFF” box_shadow_style=”preset3″ global_colors_info=”{}”]<\/p>\n

Sleep and the brain-heart axis<\/strong><\/h2>\n

We study the fundamental mechanisms of neuronal-, vascular-, and immune-mediated brain-heart bidirectional communication with an emphasis on how lifestyle factors such as sleep, stress, and exercise modulate these interactions. By studying sleep and exercise \u2013 evolutionarily conserved regulators of cardiovascular and immune health \u2013 we learn from nature to identify new, potent, and unanticipated personalized therapeutic opportunities. We study the neural output and the cardio- and immunoceptive mechanisms associating sleep, behavior, and inflammation in atherosclerosis and myocardial infarction.<\/p>\n

 <\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb content_max_width=”1100px” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Relevant publications:\u00a0<\/p>\n

Myocardial infarction augments sleep to limit cardiac inflammation and damage.<\/a> Huynh P., Hoffmann J., Gerhardt T., Kiss M., Zuraikat F., Cohen O., Wolfram C., Yates A., Leunig A., Heiser M., Gaebel L., GianeselliM., Goswami S., Khamhoung A., Downey J., Yoon S., Chen Z., Roudko V., Dawson T., Ferreira da Silva J., Ameral N., Morgenroth-Rebin J., D\u2019Souza D., Koekkoek L., Jacob W., Munitz J., Lee D., Fullard J., van Leent M., Roussos P., Kim-Schulze S., Shah N., Kleinstiver B., Swirski F., Leistner D., St-Onge M-P., McAlpine C. <\/b>Nature.<\/em> 2024. (8037):168-177<\/p>\n

Sleep exerts lasting effects on hematopoietic stem cell function and diversity<\/a>.\u00a0McAlpine C,<\/strong> Kiss M, Zuraikat F, Cheek D, Schiroli G, Amatullah H, Huynh P, Bhatti M, Wong LP, Yates A, Poller W, Mindur J, Chan C, Janssen H, Downey J, Singh S, Sadreyev R, Nahrendorf M, Jeffrey K, Scadden D, Naxerova K, St-Onge MP, Swirski FK.\u00a0Journal of Experimental Medicine<\/em>, 2022, 219(11)1-16<\/p>\n

Sleep modulates haematopoiesis and protects against atherosclerosis.<\/a> McAlpine CS<\/strong>, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK.\u00a0<\/span>Nature.<\/em> 2019 Feb;566(7744):383-387. doi: 10.1038\/s41586-019-0948-2. Epub 2019 Feb 13.\u00a0<\/span>PMID: 30760925<\/span><\/span><\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2025\/11\/Screenshot-2025-11-18-at-12.18.36-PM-1024×445.png” title_text=”Screenshot 2025-11-18 at 12.18.36\u202fPM” _builder_version=”4.27.4″ _module_preset=”default” animation_style=”zoom” animation_intensity_zoom=”10%” box_shadow_style=”preset2″ global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb _builder_version=”4.27.4″ _module_preset=”default” background_color=”#FFFFFF” box_shadow_style=”preset3″ global_colors_info=”{}”]<\/p>\n

Neuro-immune interactions mediate communication between the brain and periphery in chronic disease<\/strong><\/h2>\n

The immune system plays an important role in the pathophysiology of neurodegenerative diseases including Alzheimer\u2019s disease (AD) and multiple sclerosis (MS). However how the brain communicates to peripheral immune organs is poorly understood. We pursue research exploring medullary organ innervation and how neuro-immune circuits program peripheral and central inflammation in neurodegenerative and chronic inflammatory disorders. As rapid responders and communicators, the nervous and immune systems are ideally positioned to transmit critical and meaningful information between the brain and periphery. We focus on hematopoietic growth factors and neuropeptides and how they control brain and peripheral organ health.<\/p>\n

\n
\u00a0<\/div>\n<\/div>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb content_max_width=”1100px” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n

Relevant publications:\u00a0<\/p>\n

Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis<\/a>. Yates AG, Khamhoung A, Gaebel L, Jacob W, Radford-Smith DE, Kiss MG, Huynh P, Gerhardt T, Heiser M, Cohen O, Swirski FK, Anthony DC, Sumowski J, Katz Sand I, McAlpine C<\/strong>.\u00a0<\/b>Nature Communications<\/em>. 16(1):3683<\/p>\n

Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.<\/a>\u00a0Kiss M., Mindur J., Yates A., Lee D., Fullar J., Anzai A., Poller W., Christie K., Iwamoto Y., Roudko V., Downey J., Chan C., Huynh P., Janssen H., Ntranos A., Hoffmann J., Jacob W., Goswami S., Singh S., Leppert D., Kuhle J., Kim-Schulze S., Nahrendorf M., Kleinstiver B., Probert F., Roussos P., Swirski F., McAlpine C. <\/strong>Immunity<\/em>, 2023. (56)1-13.<\/p>\n

Astrocytic interleukin-3 programs microglia and limits Alzheimer\u2019s disease.<\/a>McAlpine CS<\/strong>, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK.\u00a0<\/span>Nature<\/em>. 2021 Jul;595(7869):701-706. doi: 10.1038\/s41586-021-03734-6. Epub 2021 Jul 14.<\/span>PMID: 34262178<\/span><\/span><\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Footer Fullwidth – Section 13″ module_class=”footer-section” _builder_version=”4.27.4″ background_color=”#c7eafb” background_image=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/10\/Rectangle-3.png” max_width=”100%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” saved_tabs=”all” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto||147px||” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_social_media_follow _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” text_orientation=”center” global_colors_info=”{}”][et_pb_social_media_follow_network social_network=”linkedin” url=”https:\/\/www.linkedin.com\/school\/icahnmountsinai\/%20″ use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]linkedin[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”facebook” url=”https:\/\/www.facebook.com\/IcahnMountSinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]facebook[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”twitter” url=”https:\/\/twitter.com\/icahnmountsinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”youtube” url=”https:\/\/www.youtube.com\/user\/MountSinaiSchool” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]youtube[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”instagram” url=”https:\/\/www.instagram.com\/icahnmountsinai\/” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”24px” global_colors_info=”{}”]<\/p>\n

Contact Us<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n

Lab Address <\/strong>
Hess Center for Science and Medicine
1470 Madison Ave., 7-202
New York, NY 10029<\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n

E-mail
<\/strong>Cameron.mcalpine@mssm.edu<\/p>\n

Phone
<\/strong>Tel: 212-824-9034<\/p>\n

Twitter\/X
<\/strong>@cam_phd<\/p>\n

BlueSky
<\/strong>@mcalpinelab.bsky.social<\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

ResearchAll organs and tissues are interconnected through networks of leukocytes, blood vessels, and nerves. We study brain-body axes in chronic cardiovascular and neurological diseases. Using murine models and human trials we focus on how lifestyle factors, like sleep and exercise, influence these brain-body circuits.Sleep and the brain-heart axis We study the fundamental mechanisms of neuronal-, […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

We take a multidisciplinary approach to investigate the immune system in sleep, cardiovascular disease, and neurodegenerative diseases.<\/p>

Project 1. Investigating sleep and the brain-heart axis<\/strong><\/h2>

The brain and heart are vital co-dependent organs and hubs of the nervous and circulatory systems respectively. Communication between these organs is critical to health and occurs through neuronal innervation and vascular supply of immune cells and molecules. The heart-brain axis is calibrated by many factors and one of the most important is sleep. Humans should spend a third of their lives asleep, yet we are becoming increasingly sleep-insufficient. Sleep is essential for proper brain and heart function. We study bidirectional integrations between sleep and the heart-brain axis.<\/p>

Myocardial infarction augments sleep to limit cardiac inflammation and damage.<\/a> Huynh P., Hoffmann J., Gerhardt T., Kiss M., Zuraikat F., Cohen O., Wolfram C., Yates A., Leunig A., Heiser M., Gaebel L., GianeselliM., Goswami S., Khamhoung A., Downey J., Yoon S., Chen Z., Roudko V., Dawson T., Ferreira da Silva J., Ameral N., Morgenroth-Rebin J., D\u2019Souza D., Koekkoek L., Jacob W., Munitz J., Lee D., Fullard J., van Leent M., Roussos P., Kim-Schulze S., Shah N., Kleinstiver B., Swirski F., Leistner D., St-Onge M-P., McAlpine C.\u00a0<\/b>Nature.<\/em> 2024, 635(8037):168-177<\/p>

Increased stem cell proliferation in atherosclerosis accelerates clonal hematopoiesis. <\/a>Heyde A*, Rohde D*, McAlpine CS*<\/strong>, Zhang S, Hoyer FF, Gerold JM, Cheek D, Iwamoto Y, Schloss MJ, Vandoorne K, Iborra-Egea O, Mu\u00f1oz-Guijosa C, Bayes-Genis A, Reiter JG, Craig M, Swirski FK, Nahrendorf M, Nowak MA, Naxerova K.<\/span>Cell.<\/em> 2021 Mar 4;184(5):1348-1361.e22.\u00a0<\/span><\/p>

Sleep modulates haematopoiesis and protects against atherosclerosis.<\/a> McAlpine CS<\/strong>, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK.\u00a0<\/span>Nature.<\/em> 2019 Feb;566(7744):383-387. doi: 10.1038\/s41586-019-0948-2. Epub 2019 Feb 13.\u00a0<\/span><\/p>

Sleep exerts lasting effects on hematopoietic stem cell function and diversity<\/a>.\u00a0McAlpine C,<\/strong> Kiss M, Zuraikat F, Cheek D, Schiroli G, Amatullah H, Huynh P, Bhatti M, Wong LP, Yates A, Poller W, Mindur J, Chan C, Janssen H, Downey J, Singh S, Sadreyev R, Nahrendorf M, Jeffrey K, Scadden D, Naxerova K, St-Onge MP\u2020<\/sup><\/strong>, Swirski FK\u00a0Journal of Experimental Medicine<\/em>, 2022, 219(11)1-16<\/p>

Project 2. How do immune cells and their products coordinate communication between the CNS and periphery in neurodegenerative disorders?\u00a0<\/strong><\/h2>

The immune system plays an important role in the pathophysiology of neurodegenerative diseases including Alzheimer\u2019s disease (AD) and multiple sclerosis (MS). We pursue research exploring glial cell communication and the role of growth factors in mediating the biology of astrocytes, microglia, and the peripheral immune system in neurodegeneration. Interleukin-3 is a multifunctional cytokine and growth implicated in many inflammatory and autoimmune diseases. We have shown, in humans and mice, that astrocyte-sourced interleukin-3 (IL-3) programs IL-3RA-expressing microglia and other myeloid cells to generate immune recruitment and chemotactic programming. In the context of Alzheimer\u2019s disease (AD) this is beneficent as IL-3 endows with an acute immune response program, enhanced motility, and the capacity to cluster and clear aggregates of A\u03b2 and tau, ameliorating AD (McAlpine et al. Nature 2021). In multiple sclerosis (MS) IL-3 stimulation of myeloid chemoattraction is detrimental and perpetuates neuroinflammation and the recruitment of immune cells to the CNS to worsen MS and it\u2019s preclinical model EAE (Kiss et al. Immunity 2023). These data highlight the importance of balancing and fine-tuning inflammation in neurodegenerative diseases and position IL-3 as a critical player in neuroinflammatory balance that could be targeted to equilibrate immune responses in the brain.<\/p>

Myelopoiesis is temporally dynamic and is regulated by lifestyle to modify multiple sclerosis<\/a>. Yates AG, Khamhoung A, Gaebel L, Jacob W, Radford-Smith DE, Kiss MG, Huynh P, Gerhardt T, Heiser M, Cohen O, Swirski FK, Anthony DC, Sumowski J, Katz Sand I, McAlpine C<\/strong>.\u00a0<\/b>Nature Communications<\/em>. 16(1):3683<\/p>

Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.<\/a>\u00a0Kiss M., Mindur J., Yates A., Lee D., Fullar J., Anzai A., Poller W., Christie K., Iwamoto Y., Roudko V., Downey J., Chan C., Huynh P., Janssen H., Ntranos A., Hoffmann J., Jacob W., Goswami S., Singh S., Leppert D., Kuhle J., Kim-Schulze S., Nahrendorf M., Kleinstiver B., Probert F., Roussos P., Swirski F., McAlpine C. <\/strong>Immunity<\/em>, 2023. (56)1-13.<\/div>
\u00a0<\/div><\/div>
Astrocytic interleukin-3 programs microglia and limits Alzheimer\u2019s disease.<\/a>McAlpine CS<\/strong>, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK.\u00a0<\/span>Nature<\/em>. 2021 Jul;595(7869):701-706.\u00a0<\/span><\/div><\/div>","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-1492","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/wp-json\/wp\/v2\/pages\/1492","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/wp-json\/wp\/v2\/comments?post=1492"}],"version-history":[{"count":42,"href":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/wp-json\/wp\/v2\/pages\/1492\/revisions"}],"predecessor-version":[{"id":4891,"href":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/wp-json\/wp\/v2\/pages\/1492\/revisions\/4891"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/wp-json\/wp\/v2\/media?parent=1492"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}