{"id":1349,"date":"2022-10-13T17:37:32","date_gmt":"2022-10-13T21:37:32","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=1349"},"modified":"2026-03-09T17:28:56","modified_gmt":"2026-03-09T21:28:56","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/","title":{"rendered":"McAlpine lab"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1″ module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”#221F72″ background_enable_image=”off” parallax=”on” height=”540px” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” saved_tabs=”all” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_image=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab\/wp-content\/uploads\/sites\/617\/2025\/12\/TG11-Il1b_Scale_Overlay.tif” width=”81%” border_color_all=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text admin_label=”Text – Title” _builder_version=”4.27.4″ _module_preset=”b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa” header_font=”||||||||” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||10px||false|false” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

Welcome to the McAlpine lab!<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” disabled_on=”off|off|off” admin_label=”Header Title Description – Section – Header – Fullwidth Slider ” module_id=”header-title-description-slider-section1″ _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/07\/ai-002-1.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_fullwidth_slider arrows_custom_color=”#D80B8C” dot_nav_custom_color=”#D80B8C” _builder_version=”4.27.4″ _module_preset=”default” background_color=”#00AEEF” global_colors_info=”{}”][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|tablet” disabled_on=”on|on|on” admin_label=”Fullwidth Two Column Header and Image (no slider) – Section 1 (Desktop only)” module_class=”section1_header_no_slider” _builder_version=”4.16″ _module_preset=”default” background_color=”#00aeef” background_image=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/10\/Background-2.png” parallax=”on” custom_margin=”||30px||false|false” custom_padding=”||||false|false” custom_padding_tablet=”0px||0px||false|false” custom_padding_phone=”” bottom_divider_style=”slant” bottom_divider_color=”#FFFFFF” bottom_divider_arrangement=”above_content” custom_css_main_element=”padding: 0px !important;” disabled=”on” locked=”on” collapsed=”on” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ disabled_on=”off|off|off” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” module_alignment=”right” custom_padding=”||||false|false” border_color_all=”RGBA(0,0,0,0)” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|desktop” global_colors_info=”{}”][et_pb_text admin_label=”Title – Text” _builder_version=”4.16″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” header_text_align=”left” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||2%||false|false” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|phone” custom_css_main_element=”\/*margin-right: 8vw!important;*\/” global_colors_info=”{}”]<\/p>\n

Welcome to the Rendl Lab<\/h1>\n

[\/et_pb_text][et_pb_text admin_label=”Description – Text” _builder_version=”4.16″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” header_text_align=”left” custom_margin=”||||false|false” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” custom_css_main_element=”\/*margin-right: 9vw!important;*\/” global_colors_info=”{}”]Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.
\n[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg” align=”right” force_fullwidth=”on” _builder_version=”4.16″ _module_preset=”default” custom_margin=”80px|0px|0px|0px|false|false” custom_padding=”20px|0px|0px|0px|false|false” box_shadow_style=”preset1″ box_shadow_spread=”15px” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” disabled=”on” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Welcome to the Rendl Lab” admin_label=”Blurb – Left Side Content” _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” body_text_color=”#FFFFFF” custom_margin=”80px||||false|false” global_colors_info=”{}”]<\/p>\n

Welcome to the Rendl Lab<\/h1>\n

Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.
\n[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb image=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg” icon_alignment=”right” admin_label=”Blurb – Right-Side Image” _builder_version=”4.16″ _module_preset=”default” custom_margin=”80px|-40%|0px||false|false” custom_margin_tablet=”|0%|||false|false” custom_margin_phone=”|0%|||false|false” custom_margin_last_edited=”on|phone” global_colors_info=”{}”][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Header and Image (no slider) – Section 1 (Tablet and Mobile only)” module_class=”section1_header_no_slider_mobile” _builder_version=”4.16″ background_color=”#00AEEF” background_image=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/10\/Background-2.png” parallax=”on” width=”100%” custom_margin=”||30px||false|false” custom_padding=”80px|0px|63px|0px||” mix_blend_mode=”multiply” bottom_divider_color=”#FFFFFF” bottom_divider_height=”150px” bottom_divider_flip=”horizontal” disabled=”on” locked=”on” collapsed=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”|||” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_text_color=”#FFFFFF” header_line_height=”1.7em” global_colors_info=”{}”]<\/p>\n

Welcome to the Rendl Lab<\/strong><\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” global_colors_info=”{}”]Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.
\n[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg” title_text=”AdobeStock_436735485″ disabled_on=”off|off|off” _builder_version=”4.16″ animation_style=”slide” animation_direction=”left” animation_intensity_slide=”10%” box_shadow_style=”preset1″ box_shadow_blur=”30px” box_shadow_color=”#58595B” always_center_on_mobile=”off” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 6 (Collections)” module_class=”section6_two_col_img_txt_over_btn” _builder_version=”4.16″ custom_margin=”30px||100px||false|false” custom_margin_tablet=”100px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px|false|false” custom_css_main_element=”padding: 0px !important;” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.16″ module_alignment=”center” custom_margin=”|auto|0px|auto||” custom_padding=”0px||0px|||” box_shadow_style=”preset1″ box_shadow_color=”#58595B” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ use_background_color_gradient=”on” background_color_gradient_direction=”35deg” background_color_gradient_stops=”#ff6a88 0%|#ff99ac 100%” background_color_gradient_start=”#ff6a88″ background_color_gradient_end=”#ff99ac” background_image=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/08\/Rectangle-3-copy-5.jpg” custom_padding=”|5%||5%” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2025\/11\/Screenshot-2025-11-18-at-8.19.44-AM-1024×737.png” title_text=”Screenshot 2025-11-18 at 8.19.44\u202fAM” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.27.4″ background_enable_image=”off” background_size=”initial” custom_margin=”-20px||-20px|” custom_padding=”|||” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ background_image=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/08\/ai-008-bwSm-1.png” background_position=”center_right” custom_padding=”40px|40px|40px|40px|true|true” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#000000″ text_line_height=”22px” header_font=”||||” header_text_color=”#000000″ header_4_text_color=”#FFFFFF” header_5_text_color=”#FFFFFF” background_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” max_width=”700px” custom_padding=”2%||5%||false|false” animation_style=”slide” animation_direction=”top” animation_intensity_slide=”4%” global_colors_info=”{}”]<\/p>\n

The heart and brain are vital co-dependent organs and communication between them is essential to health. We study the immune and neural connectivity that links the heart and brain in cardiovascular and neurological pathologies. Using mouse models and human trials, we study how lifestyle factors, like sleep and exercise, modulate these interactions. The McAlpine lab is highly multidisciplinary and incorporates innovative tools and approaches at the interface of immunology, cardiology, and neuroscience to study the fundamental impact of neuro-immune interactions and brain-body communication in heart and brain diseases.<\/p>\n

We are an interdisciplinary research team located in the Cardiovascular Research Institute<\/a>\u00a0at the Icahn School of Medicine at Mount Sinai<\/a> in New York City.<\/p>\n

We are also active members of many other institutes and centers at ISMMS, including the Friedman Brain Institute<\/a>, the Lipschultz Immunology Institute<\/a>, the Loeb Center for Alzheimer\u2019s Disease<\/a>, and the Brain and Body Research Institute<\/a>.<\/p>\n

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\u201cEvery affection of the mind that is attendant with either pain or pleasure, hope or fear, is the cause of an agitation whose influence extends to the heart\u201d<\/em> \u2013 Dr. William Harvey<\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Footer Fullwidth – Section 13″ module_class=”footer-section” _builder_version=”4.27.4″ background_color=”#c7eafb” background_image=”https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/10\/Rectangle-3.png” max_width=”100%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” global_module=”3741″ saved_tabs=”all” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto||147px||” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_social_media_follow _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” text_orientation=”center” global_colors_info=”{}”][et_pb_social_media_follow_network social_network=”linkedin” url=”https:\/\/www.linkedin.com\/school\/icahnmountsinai\/%20″ use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]linkedin[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”facebook” url=”https:\/\/www.facebook.com\/IcahnMountSinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]facebook[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”twitter” url=”https:\/\/twitter.com\/icahnmountsinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”youtube” url=”https:\/\/www.youtube.com\/user\/MountSinaiSchool” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]youtube[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”instagram” url=”https:\/\/www.instagram.com\/icahnmountsinai\/” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” follow_button=”off” url_new_window=”on”]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”24px” global_colors_info=”{}”]<\/p>\n

Contact Us<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.27.4″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n

Lab Address <\/strong>
Hess Center for Science and Medicine
1470 Madison Ave., 7-202
New York, NY 10029<\/p>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n

E-mail
<\/strong>Cameron.mcalpine@mssm.edu<\/p>\n

Phone
<\/strong>Tel: 212-824-9034<\/p>\n

Twitter\/X
<\/strong>@cam_phd<\/p>\n

BlueSky
<\/strong>@mcalpinelab.bsky.social<\/p>\n

 <\/p>\n

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Welcome to the McAlpine lab!Welcome to the Rendl Lab Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization. Welcome to the Rendl Lab Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization. Welcome […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

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Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

[\/et_pb_slide][et_pb_slide heading=\"Three\" _builder_version=\"4.9.0\" _module_preset=\"default\" header_text_align=\"left\" body_text_align=\"left\" background_image=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/07\/ai-002-1.jpg\" background_enable_image=\"on\" text_orientation=\"left\" custom_padding=\"|||80px|false|false\" sticky_transition=\"on\"]<\/p>

Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

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Welcome to the Rendl Lab<\/h1>

[\/et_pb_text][et_pb_text admin_label=\"Description - Text\" _builder_version=\"4.9.0\" _module_preset=\"da86b6f0-f83c-4c7c-bdd8-3019777ddffe\" text_font=\"||||||||\" text_text_color=\"#FFFFFF\" text_font_size=\"20px\" text_line_height=\"32px\" header_text_align=\"left\" custom_margin=\"||||false|false\" text_font_size_tablet=\"15px\" text_font_size_phone=\"14px\" text_font_size_last_edited=\"on|desktop\" custom_css_main_element=\"\/*margin-right: 9vw!important;*\/\"]<\/p>

Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"3_5\" _builder_version=\"4.9.0\" _module_preset=\"default\" background_color=\"RGBA(0,0,0,0)\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg\" align=\"right\" force_fullwidth=\"on\" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_margin=\"80px|0px|0px|0px|false|false\" custom_padding=\"20px|0px|0px|0px|false|false\" box_shadow_style=\"preset1\" box_shadow_spread=\"15px\"][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\"1_2,1_2\" disabled_on=\"on|on|on\" _builder_version=\"4.9.0\" _module_preset=\"default\" disabled=\"on\" collapsed=\"on\"][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\"][et_pb_blurb title=\"Welcome to the Rendl Lab\" admin_label=\"Blurb - Left Side Content\" _builder_version=\"4.9.0\" _module_preset=\"default\" header_text_color=\"#FFFFFF\" body_text_color=\"#FFFFFF\" custom_margin=\"80px||||false|false\"]<\/p>

Welcome to the Rendl Lab<\/h1>

Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\"][et_pb_blurb image=\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg\" icon_alignment=\"right\" admin_label=\"Blurb - Right-Side Image\" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_margin=\"80px|-40%|0px||false|false\" custom_margin_tablet=\"|0%|||false|false\" custom_margin_phone=\"|0%|||false|false\" custom_margin_last_edited=\"on|phone\"][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|on\" admin_label=\"Header and Image (no slider) - Section 1 (Tablet and Mobile only)\" module_class=\"section1_header_no_slider_mobile\" _builder_version=\"4.9.0\" background_color=\"#00AEEF\" background_image=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/10\/Background-2.png\" parallax=\"on\" width=\"100%\" custom_margin=\"||30px||false|false\" custom_padding=\"80px|0px|63px|0px||\" mix_blend_mode=\"multiply\" bottom_divider_color=\"#FFFFFF\" bottom_divider_height=\"150px\" bottom_divider_flip=\"horizontal\" locked=\"on\" collapsed=\"on\" disabled=\"on\"][et_pb_row column_structure=\"1_2,1_2\" _builder_version=\"3.25\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_margin=\"|||\" custom_padding=\"|||\"][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.9.0\" _module_preset=\"default\" header_text_color=\"#FFFFFF\" header_line_height=\"1.7em\"]<\/p>

Welcome to the Rendl Lab<\/strong><\/h1>

[\/et_pb_text][et_pb_text _builder_version=\"4.9.0\" _module_preset=\"default\" text_text_color=\"#FFFFFF\"]<\/p>

Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg\" title_text=\"AdobeStock_436735485\" disabled_on=\"off|off|off\" _builder_version=\"4.9.0\" animation_style=\"slide\" animation_direction=\"left\" animation_intensity_slide=\"10%\" box_shadow_style=\"preset1\" box_shadow_blur=\"30px\" box_shadow_color=\"#58595B\" always_center_on_mobile=\"off\"][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" admin_label=\"Two Column Image and Text over Button - Section 6 (Collections)\" module_class=\"section6_two_col_img_txt_over_btn\" _builder_version=\"4.9.0\" custom_margin=\"30px||100px||false|false\" custom_margin_tablet=\"100px||||false|false\" custom_margin_phone=\"\" custom_margin_last_edited=\"on|desktop\" custom_padding=\"0px|0px|0px|0px|false|false\" custom_css_main_element=\"padding: 0px !important;\" locked=\"on\" collapsed=\"on\"][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" _builder_version=\"4.9.0\" module_alignment=\"center\" custom_margin=\"|auto|0px|auto||\" custom_padding=\"0px||0px|||\" box_shadow_style=\"preset1\" box_shadow_color=\"#58595B\" collapsed=\"off\"][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" use_background_color_gradient=\"on\" background_color_gradient_start=\"#ff6a88\" background_color_gradient_end=\"#ff99ac\" background_color_gradient_direction=\"35deg\" background_image=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/08\/Rectangle-3-copy-5.jpg\" custom_padding=\"|5%||5%\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/08\/AdobeStock_182052860.png\" title_text=\"AdobeStock_182052860\" align=\"center\" align_tablet=\"center\" align_phone=\"\" align_last_edited=\"on|desktop\" _builder_version=\"4.9.0\" background_enable_image=\"off\" background_size=\"initial\" custom_margin=\"-20px||-20px|\" custom_padding=\"|||\" animation_style=\"zoom\" animation_direction=\"left\" animation_intensity_zoom=\"10%\" animation_starting_opacity=\"100%\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" background_image=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/08\/ai-008-bwSm-1.png\" background_position=\"center_right\" custom_padding=\"40px|40px|40px|40px|true|true\" custom_padding__hover=\"|||\"][et_pb_text disabled_on=\"off|off|off\" _builder_version=\"4.9.0\" header_font=\"|700|||||||\" header_text_color=\"#141414\" header_font_size=\"36px\" header_3_font=\"|700|||||||\" header_3_text_color=\"#2b2b2b\" header_3_font_size=\"28px\" header_3_line_height=\"1.5em\" custom_margin=\"||10px|\" custom_padding=\"5%||||false|false\"]<\/p>

Birth of the Hair Follicle Niche<\/strong><\/h1>

[\/et_pb_text][et_pb_text _builder_version=\"4.9.0\" text_font=\"||||||||\" text_text_color=\"#000000\" text_line_height=\"22px\" header_font=\"||||\" header_text_color=\"#000000\" header_4_text_color=\"#FFFFFF\" header_5_text_color=\"#FFFFFF\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" max_width=\"700px\" custom_padding=\"2%||5%||false|false\" animation_style=\"slide\" animation_direction=\"top\" animation_intensity_slide=\"4%\"]<\/p>

A central question in stem cell research is how cells specialize during organ development to become adult tissue-regenerative stem cells and their instructive niche. During hair follicle development, epidermal progenitors in nascent hair placodes receive niche signals from specialized cell clusters located underneath that are called Dermal Condensates.<\/p>

[\/et_pb_text][et_pb_text disabled_on=\"on|on|on\" _builder_version=\"4.9.0\" text_font=\"||||||||\" text_text_color=\"#141414\" text_line_height=\"1.9em\" header_font=\"||||||||\" header_2_font=\"||||||||\" module_alignment=\"center\" custom_margin=\"||30px|\" disabled=\"on\"]<\/p>

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ornare suspendisse sed nisi lacus sed viverra tellus in.<\/p>

[\/et_pb_text][et_pb_button button_text=\"Lorem ipsum dolor sit amet\" disabled_on=\"on|on|on\" _builder_version=\"4.9.0\" custom_button=\"on\" button_text_size=\"16px\" button_text_color=\"#FFFFFF\" button_bg_color=\"#00AEEF\" button_border_width=\"0px\" button_border_radius=\"0px\" button_font=\"||||||||\" button_icon=\"%%20%%\" button_icon_color=\"#FFFFFF\" button_on_hover=\"off\" custom_margin=\"20px|||\" custom_padding=\"12px|28px|12px|28px\" box_shadow_style=\"preset1\" box_shadow_vertical=\"10px\" box_shadow_blur=\"30px\" box_shadow_color=\"#58595B\" button_letter_spacing_hover=\"2px\" disabled=\"on\" locked=\"off\" button_text_size__hover_enabled=\"off\" button_one_text_size__hover_enabled=\"off\" button_two_text_size__hover_enabled=\"off\" button_text_color__hover_enabled=\"off\" button_one_text_color__hover_enabled=\"off\" button_two_text_color__hover_enabled=\"off\" button_border_width__hover_enabled=\"off\" button_one_border_width__hover_enabled=\"off\" button_two_border_width__hover_enabled=\"off\" button_border_color__hover_enabled=\"off\" button_one_border_color__hover_enabled=\"off\" button_two_border_color__hover_enabled=\"off\" button_border_radius__hover_enabled=\"off\" button_one_border_radius__hover_enabled=\"off\" button_two_border_radius__hover_enabled=\"off\" button_letter_spacing__hover_enabled=\"on\" button_letter_spacing__hover=\"2px\" button_one_letter_spacing__hover_enabled=\"off\" button_two_letter_spacing__hover_enabled=\"off\" button_bg_color__hover_enabled=\"off\" button_one_bg_color__hover_enabled=\"off\" button_two_bg_color__hover_enabled=\"off\"][\/et_pb_button][et_pb_button button_url=\"https:\/\/labs.icahn.mssm.edu\/design\/option1-research\" button_text=\"Find Out More\" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_button=\"on\" button_text_color=\"#FFFFFF\" button_bg_color=\"#00AEEF\" button_border_radius=\"0px\" box_shadow_style=\"preset1\" locked=\"off\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" admin_label=\"Two Column Image and Text over Button - Section 4\" module_class=\"section4_two_col_img_txt_over_btn\" _builder_
version=\"4.9.0\" background_color=\"#00AEEF\" background_image=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/12\/Background-1ALT.png\" parallax=\"on\" width=\"100%\" custom_margin=\"30px||||false|false\" custom_padding=\"80px|0px|63px|0px||\" mix_blend_mode=\"multiply\" bottom_divider_style=\"ramp2\" bottom_divider_color=\"#FFFFFF\" bottom_divider_height=\"150px\" bottom_divider_flip=\"horizontal\" bottom_divider_arrangement=\"above_content\" locked=\"on\" collapsed=\"on\"][et_pb_row column_structure=\"1_2,1_2\" _builder_version=\"3.25\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_margin=\"|||\" custom_padding=\"|||\"][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/08\/Stalled-follicles_03MR-2560x1440-1.jpg\" title_text=\"AdobeStock_436735485\" disabled_on=\"off|off|off\" _builder_version=\"4.9.0\" animation_style=\"slide\" animation_direction=\"left\" animation_intensity_slide=\"10%\" box_shadow_style=\"preset1\" box_shadow_color=\"#58595B\" always_center_on_mobile=\"off\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"||||||||\" text_text_color=\"#FFFFFF\" text_line_height=\"22px\" header_font=\"||||\" header_text_color=\"#FFFFFF\" header_4_text_color=\"#FFFFFF\" header_5_text_color=\"#FFFFFF\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" max_width=\"700px\" animation_style=\"slide\" animation_direction=\"top\" animation_intensity_slide=\"4%\"]<\/p>

Formation and Function of Stem Cell Niches<\/strong><\/h4>

Stem cells and their immediate environment, also called stem cell niche, are critical for the growth and continuous renewal of our organs, and are also key for new growth and repair during regeneration. Unlocking the secrets of how specialized niche cells operate to activate stem cells and progenitors holds great promise for regenerative medicine.<\/p>

Our laboratory aims to answer these fundamental questions in stem cell biology by utilizing the hair follicle mini-organ as a powerful model system. Deciphering how niche cells govern stem cell and progenitor functions in the hair follicle will also provide a rational basis for developing hair regenerative therapies. Fundamental questions towards this goal are:<\/p>

  1. How do niche cells acquire the stem cell-inducing properties?<\/li>
  2. What are the niche signals that control tissue growth and regeneration?<\/li>
  3. How do niche cells control progenitor death and tissue reorganization?<\/li><\/ol>

    [\/et_pb_text][et_pb_button button_url=\"https:\/\/labs.icahn.mssm.edu\/design\/option1-research\" button_text=\"Find Out More \" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_button=\"on\" button_text_color=\"#d80b8c\" button_bg_color=\"#FFFFFF\" button_border_radius=\"0px\" box_shadow_style=\"preset1\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" fullwidth=\"on\" admin_label=\"Paralax Background fullwidth Image - Section 3\" module_class=\"section3_paralax_bg_fullwidth_img\" _builder_version=\"4.9.0\" _module_preset=\"default\" locked=\"on\" collapsed=\"on\"][et_pb_fullwidth_image title_text=\"3\" _builder_version=\"4.9.0\" _module_preset=\"default\" background_image=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/10\/3.png\" parallax=\"on\" parallax_method=\"off\" min_height=\"217.5px\" custom_margin=\"-2px|||||\" filter_opacity=\"20%\"][\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section fb_built=\"1\" admin_label=\"Two Column Title Over Text Next to Image - Section 5\" module_class=\"section5_two_col_title_over_txt_next_to_img\" _builder_version=\"4.9.0\" _module_preset=\"default\" locked=\"on\" collapsed=\"on\"][et_pb_row column_structure=\"1_2,1_2\" make_equal=\"on\" admin_label=\"5 (Module)\" _builder_version=\"4.9.0\" background_color=\"#FFFFFF\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" module_alignment=\"center\" custom_padding=\"6px||3px|||\" global_module=\"956\"][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\"][et_pb_text _builder_version=\"4.9.0\" _module_preset=\"default\" text_text_color=\"#00AEEF\" header_font=\"|700|||||||\" header_text_color=\"#00AEEF\" header_font_size=\"36px\" module_alignment=\"center\" custom_padding=\"10%||10%||true|false\"]<\/p>

    Growth Control and Regeneration<\/strong><\/h1>

    How is tissue growth, homeostasis and renewal by stem cells regulated throughout life? Understanding the core molecular controls is fundamental for realizing the therapeutic potential of the instructive niche (Rezza et al, Current Topics in Developmental Biology 2014). After initial morphogenesis of hair follicles, the Dermal Condensate gives rise to the adult follicle inductive niche, the Dermal Papilla. Dermal Papilla cells signal to progenitors in the follicle bulb to control continuous production and outgrowth of hair. They are also critical for activating stem cells to regenerate a new follicle during the hair growth cycle. Remarkably, isolated niche cells can induce new hair formation after cell transplantation into skin in mice, a yet unrealized goal in human.<\/p>

    [\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/07\/ai-008.png\" title_text=\"ai-008\" _builder_version=\"4.9.0\" _module_preset=\"default\" background_color=\"#FFFFFF\"][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"on|on|off\" admin_label=\"Two Column Image Next to Title Over Text Over Button - Section 4 (Desktop Only)\" module_class=\"section4_two_col_img_next_to_title_over_txt_over_btn_desktop\" _builder_version=\"4.9.0\" _module_preset=\"default\" background_color=\"#00AEEF\" use_background_color_gradient=\"on\" background_color_gradient_start=\"#00aeef\" background_color_gradient_end=\"#d80b8c\" background_color_gradient_direction=\"33deg\" background_image=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/10\/Background-2.png\" parallax=\"on\" module_alignment=\"center\" height=\"558px\" custom_margin=\"||200px||false|false\" locked=\"off\" collapsed=\"on\"][et_pb_row column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\"][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/08\/2021-Hero-Shot-2-smallest-scaled-3.png\" title_text=\"2021-Hero-Shot-2-smallest-scaled-3\" _builder_version=\"4.9.0\" _module_preset=\"default\" width=\"91%\" max_width=\"91%\" min_height=\"550px\" height=\"550px\" max_height=\"550px\" custom_padding=\"40px||||false|false\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\"][et_pb_text _builder_version=\"4.9.0\" _module_preset=\"default\" text_text_color=\"#FFFFFF\" header_text_align=\"center\" header_text_color=\"#FFFFFF\" text_orientation=\"center\" custom_padding=\"||||false|false\"]<\/p>

    Tissue Regression and Reorganization<\/strong><\/h1>

    How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>

    [\/et_pb_text][et_pb_button button_url=\"https:\/\/labs.icahn.mssm.edu\/design\/option1-research\" button_text=\"Find Out More\" _builder_version=\"4.9.0\" _module_preset=\"default\" custom_button=\"on\" button_text_color=\"#d80b8c\" button_bg_color=\"#FFFFFF\" button_border_radius=\"0px\" box_shadow_style=\"preset1\" locked=\"off\"][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" disabled_on=\"off|off|on\" admin_label=\"One Column Image Over Title Over Text Over Button - Section 4 (Mobile and Tablet Only)\" module_class=\"section4_one_col_img_over_title_over_txt_over_btn_mobile_tablet\" _builder_version=\"4.9.0\" background_color=\"#00AEEF\" use_background_color_gradient=\"on\" background_color_gradient_start=\"#00aeef\" background_color_gradient_end=\"#d80b8c\" background_color_gradient_direction=\"33deg\" background_image=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/10\/Background-1.png\" parallax=\"on\" width=\"100%\" custom_margin=\"||100px||false|false\" custom_padding=\"80px|0px|63px|0px||\" bottom_divider_color=\"#FFFFFF\" bottom_divider_height=\"150px\" bottom_divider_flip=\"horizontal\" bottom_divider_arrangement=\"above_content\" locked=\"off\" collapsed=\"on\"][et_pb_row column_structure=\"1_2,1_2\" _builder_version=\"3.25\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" custom_margin=\"|||\" custom_padding=\"|||\"][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_image src=\"https:\/\/labs.icahn.mssm.edu\/mcalpinelab2\/wp-content\/uploads\/sites\/617\/2022\/08\/2021-Hero-Shot-2-smallest-scaled-3.png\" title_text=\"2021-Hero-Shot-2-smallest-scaled-3\" disabled_on=\"off|off|off\" _builder_version=\"4.9.0\" animation_style=\"slide\" animation_direction=\"left\" animation_intensity_slide=\"10%\" box_shadow_style=\"preset1\" box_shadow_color=\"#58595B\" always_center_on_mobile=\"off\"][\/et_pb_image][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"3.25\" background_position=\"top_left\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"||||||||\" text_text_color=\"#FFFFFF\" text_line_height=\"22px\" header_font=\"||||\" header_text_color=\"#FFFFFF\" header_4_text_color=\"#FFFFFF\" header_5_text_color=\"#FFFFFF\" background_size=\"initial\" background_position=\"top_left\" background_repeat=\"repeat\" max_width=\"700px\" animation_style=\"slide\" animation_direction=\"top\" animation_intensity_slide=\"4%\"]<\/p>

    Tissue Regression and Reorganization<\/strong><\/h1>

    How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>

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