Marshall Laboratory

Research

Our vision is to be a leading research and education lab, generating paradigm-changing knowledge with a focus on equity, pleasure and empowerment through multi-disciplinary clinical and translational research, education and innovation.

We engineer sexual function–sparing cancer care rooted in rigorous science, advanced technology, and patient partnership.

We aim to redesign cancer treatment so that preserving sexual pleasure, embodiment, and equitable care is as fundamental a goal as curing the cancer itself.

Our federally-funded Sexual Toxicity After Radiotherapy (STAR) program’s mission is to transform our understanding of the impacts of radiotherapy and endocrine transitions, especially menopause, on the bulboclitoris and other erectile, mucosal, and sensate tissues, and on developing concrete ways to prevent, measure, and repair this damage for women, LGBTQ+ people, and people living with HIV across the lifespan.

Learn more about the importance of clitoris science and our mission here.

Our science

We integrate:

Functional anatomy & NTCP modeling – defining the bulboclitoris and related structures as organs at risk, quantifying dose–response relationships, and building normal‑tissue complication probability (NTCP) models that can be used directly in treatment planning.

Multiscale biologic profiling – applying spatial transcriptomics, imaging biomarkers, microbiome analyses, and radiomics to understand how radiation and the menopausal transition jointly reshape neurovascular, erectile and vaginal tissues.

Interventions & devices – co‑developing estrogen‑eluting vaginal hydrogels, hydrogel spacers, and other biomaterials to prevent injury (e.g. stenosis/adhesions), preserve lubrication and elasticity, and restore sensation after pelvic radiotherapy.

LGBTQ+ and sexual minority survivorship – characterizing sexual function and pleasure in lesbian, gay, bisexual, transgender, and nonbinary cancer survivors (e.g., after prostate, colorectal, and pelvic treatments) and designing inclusive interventions and care pathways.

Transparency & equity – empirically studying how conflicts of interest, pricing, and communication practices shape trust, decision‑making, and access to high‑value, sexual‑health–preserving care.

Who we are

The program is led by Dr. Deborah Marshall, a board-certified Radiation Oncologist, Menopause Society Certified Practitioner, and NIH High‑Risk, High‑Reward Early Independence Awardee whose team has secured more than $2 million in research funding as Principal Investigator and authored over 70 peer‑reviewed papers in journals including JAMA, JAMA Oncology, CA: A Cancer Journal for Clinicians, and The Lancet Oncology. Our group bridges radiation oncology, population health science, women’s health, biomedical engineering, and ethics to train the next generation of scientists and clinicians in oncosexual health.

Deborah C Marshall, MD

she/her/hers

PI
Radiation Oncology
Population Health Science and Policy
Blavatnik Family Women’s Health Research Institute
deborah.marshall@mountsinai.org

CV
Our current research to develop novel approaches to improve sexual outcomes for female and sexual/gender minority cancer patients:

Vaginal hydrogels to prevent scarring

Non-opioid mucosal analgesics

Multi-scale informatics

Standardization of anatomic contours

Female and LGBTQ+ oncosexual health care

Advanced pelvic imaging

Erectile-tissue sparing radiotherapy techniques

Measuring and maintaining sensation of the bulboclitoris, nipple and prostate

Our research has five major goals:

#1 To transform the paradigm of oncosexual health in female and LGBTQ+ persons

#2 To redefine sexual organs at risk in genitopelvic and breast radiotherapy, including the bulboclitoris and neurovasculature, nipple‑areolar complex, and anal/prostate structures

#3 To decode mechanisms of radiation injury and resilience across menopause, sex, HIV status, and other dimensions of inequity using advanced imaging, spatial transcriptomics, and radiomics.

#4 To design and test new interventions—such as estrogen‑eluting vaginal hydrogels and other engineered solutions—to prevent and reverse radiation‑induced and menopause-related sexual toxicities.

#5 To advance LGBTQ+‑inclusive oncosexual health, generating data and tools that center pleasure, function, and autonomy for all survivors.

Publications

Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review

March 2022 in the journal CA: A Cancer Journal for Clinicians

Marshall DC, Tarras ES, Ali A, Bloom J, Torres MA, Kahn JM. Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review. CA Cancer J Clin. 2022 Mar 17. doi: 10.3322/caac.21726. Epub ahead of print. PMID: 35298025.

A first radiotherapy application of functional bulboclitoris anatomy, a novel female sexual organ-at-risk, and organ-sparing feasibility study

August 2021 in the journal British Journal of Radiology

Marshall DC, Ghiassi-Nejad Z, Powers A, Reidenberg JS, Argiriadi P, Ru M, et al. A first radiotherapy application of functional bulboclitoris anatomy, a novel female sexual organ-at-risk, and organ-sparing feasibility study. Br J Radiol 2021; 94: 20201139.

Team

Deborah Marshall, MD MAS
PI

Lauren Carney, PhD
Assistant Scientist

Julia Brody-Barre
Clinical Research Coordinator

Shaniel Bowen
Post Doctoral Fellow

Daniel Dickstein, MD
Resident Researcher

Margo Downes
Medical Student Researcher

Lucy Greenwald
Medical Student Researcher

Nicole Munoz
Researcher Trainee

Andre Williams, MS
Anatomist

Trisha Majumdar
Researcher Trainee

Jared Sealy
Programmer/Analyst – Web Systems

Melissa Castillo
Medical Student Researcher 

Siya Gupta
Researcher Trainee

Amarachi Okorom
Medical Student Researcher

Kevin Huy Tran
Researcher Trainee

Current Funding

We are also grateful for the support of our past funders

Join our team!

We are always seeking exceptional humans (students, trainees, fellows, scientists) to join our team.

Email the PI to get in touch.

Deborah C Marshall, MD

Lab:
Icahn School of Medicine at Mount Sinai
Icahn Building, L2-70G

Clinic:
New York Proton Center
225 E 126th Street
New York, NY 10035

Phone: 212-241-7500