Advancing Women’s Health by Centering Female Sexual Pleasure as Biomedical Science

We develop the scientific foundations required to measure, protect, and restore female sexual pleasure, with a focus on bulboclitoral neurovascular biology, menopause-associated tissue remodeling, and radiation-related injury.  By treating sexual function as a biological outcome rather than an afterthought, our work addresses a long-standing gap in women’s health research and cancer survivorship care.

What has Been Missing From Women’s Health Research

For decades, women’s sexual health has been under-researched, with female sexual pleasure rarely treated as a measurable biological outcome.  Key genitopelvic organs, including the bulboclitoris, have been excluded from anatomical atlases, imaging protocols, and treatment planning frameworks.  Menopause has often been treated as a confounder rather than a core biological transition shaping tissue vulnerability.  These omissions have led to preventable injury and incomplete care. 

Our research contributes to the next era of women’s health by addressing these gaps with biological precision, rigorous measurement, and clinically actionable frameworks. 

We investigate how cancer therapies and endocrine transitions remodel female genital neurovascular tissue, leading to predictable and preventable losses in sexual function.  

Our Key Research Areas

1. Bulboclitoris and Female Erectile Tissue Biology
2. Menopause-Associated Neurovascular Remodeling
3. Radiation Injury and Oncosexual Survivorship

Support Bulboclitoris &
Oncosexual Health Research
Deborah C Marshall, MD

she/her/hers

PI, Assistant Professor
Radiation Oncology
Division Chief, Women’s Health
Population Health Science and Policy
Blavatnik Family Women’s Health Research Institute
Icahn School of Medicine at Mount Sinai

CV
Our current research to develop novel approaches to improve sexual outcomes for female and sexual/gender minority cancer patients:

Vaginal hydrogels to prevent scarring

Non-opioid mucosal analgesics

Multi-scale informatics

Standardization of anatomic contours

Female and LGBTQ+ oncosexual health care

Advanced pelvic imaging

Erectile-tissue sparing radiotherapy techniques

Measuring and maintaining sensation of the bulboclitoris, nipple and prostate

Our research has five major goals:

#1 To transform the paradigm of oncosexual health in female and LGBTQ+ persons

#2 To redefine sexual organs at risk in genitopelvic and breast radiotherapy, including the bulboclitoris and neurovasculature, nipple‑areolar complex, and anal/prostate structures

#3 To decode mechanisms of radiation injury and resilience across menopause, sex, HIV status, and other dimensions of inequity using advanced imaging, spatial transcriptomics, and radiomics.

#4 To design and test new interventions—such as estrogen‑eluting vaginal hydrogels and other engineered solutions—to prevent and reverse radiation‑induced and menopause-related sexual toxicities.

#5 To advance LGBTQ+‑inclusive oncosexual health, generating data and tools that center pleasure, function, and autonomy for all survivors.

Publications

Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review

March 2022 in the journal CA: A Cancer Journal for Clinicians

Marshall DC, Tarras ES, Ali A, Bloom J, Torres MA, Kahn JM. Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review. CA Cancer J Clin. 2022 Mar 17. doi: 10.3322/caac.21726. Epub ahead of print. PMID: 35298025.

A first radiotherapy application of functional bulboclitoris anatomy, a novel female sexual organ-at-risk, and organ-sparing feasibility study

August 2021 in the journal British Journal of Radiology

Marshall DC, Ghiassi-Nejad Z, Powers A, Reidenberg JS, Argiriadi P, Ru M, et al. A first radiotherapy application of functional bulboclitoris anatomy, a novel female sexual organ-at-risk, and organ-sparing feasibility study. Br J Radiol 2021; 94: 20201139.

Team

Deborah Marshall, MD MAS
PI

Lauren Carney, PhD
Assistant Scientist

Julia Brody-Barre
Clinical Research Coordinator

Shaniel Bowen
Post Doctoral Fellow

Daniel Dickstein, MD
Resident Researcher

Margo Downes
Medical Student Researcher

Lucy Greenwald
Medical Student Researcher

Nicole Munoz
Researcher Trainee

Andre Williams, MS
Anatomist

Trisha Majumdar
Researcher Trainee

Jared Sealy
Programmer/Analyst – Web Systems

Melissa Castillo
Medical Student Researcher 

Siya Gupta
Researcher Trainee

Amarachi Okorom
Medical Student Researcher

Kevin Huy Tran
Researcher Trainee

Current Funding

We are also grateful for the support of our past funders

Join our team!

We are always seeking exceptional humans (students, trainees, fellows, scientists) to join our team.

Email the PI to get in touch.

Deborah C Marshall, MD

Lab:
Icahn School of Medicine at Mount Sinai
Icahn Building, L2-70G

Clinic:
New York Proton Center
225 E 126th Street
New York, NY 10035

Phone: 212-241-7500