{"id":387,"date":"2018-07-23T13:57:49","date_gmt":"2018-07-23T13:57:49","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/liralab\/?page_id=387"},"modified":"2018-07-23T15:37:03","modified_gmt":"2018-07-23T15:37:03","slug":"inflammation-and-cancer","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/liralab\/inflammation-and-cancer\/","title":{"rendered":"Inflammation and Cancer"},"content":{"rendered":"<p><strong><a href=\"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-content\/uploads\/sites\/72\/2018\/07\/InflammationCancer.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-397 alignleft\" src=\"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-content\/uploads\/sites\/72\/2018\/07\/InflammationCancer.png\" alt=\"\" width=\"432\" height=\"768\" srcset=\"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-content\/uploads\/sites\/72\/2018\/07\/InflammationCancer.png 432w, https:\/\/labs.icahn.mssm.edu\/liralab\/wp-content\/uploads\/sites\/72\/2018\/07\/InflammationCancer-169x300.png 169w\" sizes=\"auto, (max-width: 432px) 100vw, 432px\" \/><\/a>Inflammation and cancer.<\/strong> Our lab has a longstanding interest in the connection between inflammation and cancer. We have contributed to the identification of two viral-induced chemokine receptor oncogenes, and have studied for many years the influence of the inflammation in tumor development. In recent years we have focused our research on the interplay between growth factors such as EGFR and immune molecules such as TLR4 and CX3CL1 in cancer. In a recent study we examined the mechanisms dictating the site-specific development of neoplasms in the intestine, using an animal model of serrated polyps developed in our lab. We showed that the geographic localization of the polyps was dependent on a host-specific, site-specific microbiota. We demonstrated that the presence of the microbiota within the tumors triggered a significant inflammatory response that included recruitment of neutrophils to the polyp. Blockade of neutrophil recruitment reduced the number and size of the polyps, suggesting an important role for inflammation in the process. These results strongly implicate the microbiota as a major factor contributing to development of this specific kind of neoplasms, in addition to the well-established somatic mutations in BRAF, and K-Ras.<\/p>\n<p><strong>a.<\/strong> Bongers G, Muniz LR, Pacer ME, Iuga AC, Thirunarayanan N, Slinger E, Smit MJ, Reddy EP, Mayer L, Furtado GC, Harpaz N, Lira SA. A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. Gastroenterology. 2012 Sep;143(3):730-40.<\/p>\n<p><strong>b.<\/strong> Tard\u00e1guila M, Mira E, Garc\u00eda-Cabezas MA, Feijoo AM, Quintela-Fandino M, Azcoitia I, Lira SA, Ma\u00f1es S. CX3CL1 promotes breast cancer via transactivation of the EGF pathway. Cancer Res. 2013 Jul 15;73(14):4461-73.<\/p>\n<p><strong>c<\/strong>. Santaolalla R, Sussman DA, Ruiz JR, Davies JM, Pastorini C, Espa\u00f1a CL, Sotolongo J, Burlingame O, Bejarano PA, Philip S, Ahmed MM, Ko J, Dirisina R, Barrett TA, Shang L, Lira SA, Fukata M, Abreu MT. TLR4 activates the \u03b2-catenin pathway to cause intestinal neoplasia. PLoS One. 2013;8(5):e63298.<\/p>\n<p><strong>d.<\/strong> Bongers G, Pacer ME, Geraldino TH, Chen L, He Z, Hashimoto D, Furtado GC, Ochando J, Kelley KA, Clemente JC, Merad M, van Bakel H, Lira SA. Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice. J Exp Med. 2014 Mar 10;211(3):457-72.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inflammation and cancer. Our lab has a longstanding interest in the connection between inflammation and cancer. We have contributed to the identification of two viral-induced chemokine receptor oncogenes, and have studied for many years the influence of the inflammation in tumor development. In recent years we have focused our research on the interplay between growth [&hellip;]<\/p>\n","protected":false},"author":48,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-387","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-json\/wp\/v2\/pages\/387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-json\/wp\/v2\/users\/48"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-json\/wp\/v2\/comments?post=387"}],"version-history":[{"count":6,"href":"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-json\/wp\/v2\/pages\/387\/revisions"}],"predecessor-version":[{"id":401,"href":"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-json\/wp\/v2\/pages\/387\/revisions\/401"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/liralab\/wp-json\/wp\/v2\/media?parent=387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}