{"id":35,"date":"2022-10-14T15:28:30","date_gmt":"2022-10-14T15:28:30","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/?page_id=35"},"modified":"2023-01-10T21:31:48","modified_gmt":"2023-01-10T21:31:48","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_row _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; hover_enabled=&#8221;0&#8243; sticky_enabled=&#8221;0&#8243;]<\/p>\n<h1><strong>Publications<\/strong><\/h1>\n<p>1. Accili, D., Du, W., Kitamoto, T. Kuo, T., McKimpson W., Miyachi Y., Mukhanova M., Son J., Wang L. and Watanabe H. Reflections on the state of diabetes research and prospects for treatment. <span style=\"text-decoration: underline\"><em><a href=\"https:\/\/link.springer.com\/article\/10.1007\/s13340-022-00600-2\">Diabetol Int.<\/a><\/em><\/span> (2022). doi: 10.1007\/s13340-022-00600-2.<\/p>\n<p>2.\u00a0<span style=\"font-weight: 400\">Du W, Wang J, Kuo T, Wang L, McKimpson WM, Son J, Watanabe H, Lee Y, Ratner LE, McCune K, Chen Y, Grubbs BH, Thornton ME, Fan J, Sultana N, Diaz B, Lyshwarya Balasubramanian L, Gao N, Belvedere S, Accili D.\u00a0<\/span><span style=\"font-weight: 400\">Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals<\/span><span style=\"font-weight: 400\">, <\/span><a href=\"https:\/\/www.jci.org\/articles\/view\/162720\"><span style=\"font-weight: 400\">J Clin Invest\u00a0<\/span><\/a><span style=\"font-weight: 400\">\u00a02022. <\/span><span style=\"font-weight: 400\">PMID: 36282594 PMCID: PMC9754100 DOI: 10.1172\/JCI162720.<\/span><\/p>\n<p>3. Wang L*, Yu J, Zhou Q, Wang X, Mukhanova M, Du W, Sun L, Pajvani UB, Accili D. TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver. <span style=\"text-decoration: underline\"><em><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413121005416?via%3Dihub\">Cell Metab<\/a>.<\/em><\/span> 2022 Jan 4;34(1):158-170. (*Co-corresponding author). doi: 10.1016\/j.cmet.2021.11.013. PMCID: PMC8732315.<\/p>\n<p>4. Aaron N, Kraakman MJ, Zhou Q, Liu Q, Costa S, Yang J, Liu L, Yu L, Wang L, He Y, Fan L, Hirakawa H, Ding L, Lo J, Wang W, Zhao B, Guo E, Sun L, Rosen CJ, Qiang L. Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. <span style=\"text-decoration: underline\"><em><a href=\"https:\/\/elifesciences.org\/articles\/69209\">eLife.<\/a><\/em><\/span> 2021 Jun 22;10 :e69209. doi: 10.7554\/eLife.69209. PMCID: PMC8219379<\/p>\n<p>5. Wang L*, Liu Y, Stratigopoulos G, Panigrahi SK, Sui L, Zhang Y, LeDuc CA, Glover HJ, De Rosa MC, Burnett LC, Williams DJ, Shang L, Goland R, Tsang SH, Wardlaw SL, Egli D, Zheng D, Doege CA, Leibel RL. Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons.<em><span style=\"text-decoration: underline\"><a href=\"https:\/\/www.jci.org\/articles\/view\/146287\"> J Clin Invest.<\/a><\/span><\/em> 2021 Apr 15;131(8):e146287. (*Co-corresponding author, Cover story). DOI: 10.1172\/JCI146287. PMCID: PMC8262481<\/p>\n<p>6. Liu Q*, Yu J*, Wang L*, Tang Y, Zhou Q, Ji S, Wang Y, Santos L, Haeusler RA, Que J, Rajbhandari P, Lei X, Valenti L, Pajvani UB, Qin J, Qiang L. Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis.<em><span style=\"text-decoration: underline\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168827820301240?via%3Dihub\"> J Hepatol.<\/a><\/span><\/em> 2020 Mar:S0168-8278(20)30124-0. (*: co-first author). doi: 10.1016\/j.jhep.2020.02.025. PMID: 32135178.<\/p>\n<p>7. Wang L, Liu Q, Kitamoto T, Hou J, Qin J, Accili D. Identification of insulin-responsive transcription factors that regulate glucose production by hepatocytes. <em><span style=\"text-decoration: underline\"><a href=\"https:\/\/diabetesjournals.org\/diabetes\/article\/68\/6\/1156\/39716\/Identification-of-Insulin-Responsive-Transcription\">Diabetes.<\/a><\/span><\/em> 2019 Jun; 68(6): 1156-1167. doi: 10.2337\/db18-1236. PMCID: PMC6610019<\/p>\n<p>8. Wang L, De Solis AJ, Goffer Y, Kathryn E. Birkenbach KE, Engle SE, Tanis R , Levenson JM, Li X, Rausch R, Purohit M, Lee J, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Bru\u0308ning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G. Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. <a href=\"https:\/\/insight.jci.org\/articles\/view\/123337\"><em><span style=\"text-decoration: underline\">JCI Insight.\u00a0<\/span><\/em><\/a>2019 Feb; 4(3):e123337. doi: 10.1172\/jci.insight.123337. PMCID: PMC6413800.<\/p>\n<p>9. Wang L, Sui L, Panigrahi SK, Meece K, Doege CA, Wardlaw SL, Egli D, Leibel RL. PC1\/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons. <em><span style=\"text-decoration: underline\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2213671116303113?via%3Dihub\">Stem Cell Reports.<\/a><\/span><\/em> 2017 Feb; 14;8(2):264-277. doi: 10.1016\/j.stemcr.2016.12.021. PMCID: PMC5312251.<\/p>\n<p>10. Burnett LC, LeDuc CA, Sulsona CR, Paull D, Rausch R, Eddiry S, Carli JF, Morabito MV, Skowronski AA, Hubner G, Zimmer M, Wang L, Day R, Levy B, Fennoy I, Dubern B, Poitou C, Clement K, Butler MG, Rosenbaum M, Salles JP, Tauber M, Driscoll DJ, Egli D, Leibel RL. Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. <em><span style=\"text-decoration: underline\"><a href=\"https:\/\/www.jci.org\/articles\/view\/88648\">J Clin Invest.<\/a><\/span><\/em> 2017 Jan; 127(1):293-305. doi: 10.1172\/JCI88648. PMCID: PMC5199710.<\/p>\n<p>11. Wang L, Egli D, Leibel RL. Efficient generation of hypothalamic neurons from human pluripotent stem cells. <em><span style=\"text-decoration: underline\"><a href=\"https:\/\/currentprotocols.onlinelibrary.wiley.com\/doi\/10.1002\/cphg.3\">Curr Protoc Hum Genet<\/a><\/span><\/em>. 2016 Jul; 90:21.5.1-21.5.14. doi: 10.1002\/cphg.3. PMCID: PMC4963463.<\/p>\n<p>12. Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Martin Carli J, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. Differentiation of hypothalamic-like neurons from human pluripotent stem cells. <em><span style=\"text-decoration: underline\"><a href=\"https:\/\/www.jci.org\/articles\/view\/79220\">J Clin Invest.<\/a><\/span><\/em> 2015 Feb;125(2):796-808. doi: 10.1172\/JCI79220. PMCID: PMC431942.<\/p>\n<p>13. Stratigopoulos G, Martin Carli JF, O&#8217;Day DR, Wang L, Leduc CA, Lanzano P, Chung WK, Rosenbaum M, Egli D, Doherty DA, Leibel RL. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. <em><span style=\"text-decoration: underline\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1550413114001739?via%3Dihub\">Cell Metabolism<\/a><\/span><\/em>. 2014 May; 19(5):767-79. doi: 10.1016\/j.cmet.2014.04.009. PMCID: PMC4131684.<\/p>\n<p>14. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.<em><span style=\"text-decoration: underline\"><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/oby.20646\"> Obesity (Silver Spring)<\/a><\/span><\/em>. 2014 Feb; Suppl 1:S1-S17. doi: 10.1002\/oby.20646. PMCID: PMC4159941.<\/p>\n<p>15. Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, Rosenbaum M, Zhao Y, Gu W, Farmer SR, Accili D. Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of PPAR\u03b3.<em><span style=\"text-decoration: underline\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867412007829?via%3Dihub\"> Cell.<\/a><\/span><\/em> 2012 Aug;150(3):620-32. doi: 10.1016\/j.cell.2012.06.027. PMCID: PMC3413172.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Publications 1. Accili, D., Du, W., Kitamoto, T. Kuo, T., McKimpson W., Miyachi Y., Mukhanova M., Son J., Wang L. and Watanabe H. Reflections on the state of diabetes research and prospects for treatment. Diabetol Int. (2022). doi: 10.1007\/s13340-022-00600-2. 2.\u00a0Du W, Wang J, Kuo T, Wang L, McKimpson WM, Son J, Watanabe H, Lee Y, [&hellip;]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-35","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/wp-json\/wp\/v2\/pages\/35","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/wp-json\/wp\/v2\/comments?post=35"}],"version-history":[{"count":11,"href":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/wp-json\/wp\/v2\/pages\/35\/revisions"}],"predecessor-version":[{"id":156,"href":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/wp-json\/wp\/v2\/pages\/35\/revisions\/156"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/liheng-wang-lab\/wp-json\/wp\/v2\/media?parent=35"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}