Publications

1. Accili, D., Du, W., Kitamoto, T. Kuo, T., McKimpson W., Miyachi Y., Mukhanova M., Son J., Wang L. and Watanabe H. Reflections on the state of diabetes research and prospects for treatment. Diabetol Int. (2022). doi: 10.1007/s13340-022-00600-2.

2. Du W, Wang J, Kuo T, Wang L, McKimpson WM, Son J, Watanabe H, Lee Y, Ratner LE, McCune K, Chen Y, Grubbs BH, Thornton ME, Fan J, Sultana N, Diaz B, Lyshwarya Balasubramanian L, Gao N, Belvedere S, Accili D. Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals, J Clin Invest  2022. PMID: 36282594 PMCID: PMC9754100 DOI: 10.1172/JCI162720.

3. Wang L*, Yu J, Zhou Q, Wang X, Mukhanova M, Du W, Sun L, Pajvani UB, Accili D. TOX4, an insulin receptor-independent regulator of hepatic glucose production, is activated in diabetic liver. Cell Metab. 2022 Jan 4;34(1):158-170. (*Co-corresponding author). doi: 10.1016/j.cmet.2021.11.013. PMCID: PMC8732315.

4. Aaron N, Kraakman MJ, Zhou Q, Liu Q, Costa S, Yang J, Liu L, Yu L, Wang L, He Y, Fan L, Hirakawa H, Ding L, Lo J, Wang W, Zhao B, Guo E, Sun L, Rosen CJ, Qiang L. Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells. eLife. 2021 Jun 22;10 :e69209. doi: 10.7554/eLife.69209. PMCID: PMC8219379

5. Wang L*, Liu Y, Stratigopoulos G, Panigrahi SK, Sui L, Zhang Y, LeDuc CA, Glover HJ, De Rosa MC, Burnett LC, Williams DJ, Shang L, Goland R, Tsang SH, Wardlaw SL, Egli D, Zheng D, Doege CA, Leibel RL. Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons. J Clin Invest. 2021 Apr 15;131(8):e146287. (*Co-corresponding author, Cover story). DOI: 10.1172/JCI146287. PMCID: PMC8262481

6. Liu Q*, Yu J*, Wang L*, Tang Y, Zhou Q, Ji S, Wang Y, Santos L, Haeusler RA, Que J, Rajbhandari P, Lei X, Valenti L, Pajvani UB, Qin J, Qiang L. Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis. J Hepatol. 2020 Mar:S0168-8278(20)30124-0. (*: co-first author). doi: 10.1016/j.jhep.2020.02.025. PMID: 32135178.

7. Wang L, Liu Q, Kitamoto T, Hou J, Qin J, Accili D. Identification of insulin-responsive transcription factors that regulate glucose production by hepatocytes. Diabetes. 2019 Jun; 68(6): 1156-1167. doi: 10.2337/db18-1236. PMCID: PMC6610019

8. Wang L, De Solis AJ, Goffer Y, Kathryn E. Birkenbach KE, Engle SE, Tanis R , Levenson JM, Li X, Rausch R, Purohit M, Lee J, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G. Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development. JCI Insight. 2019 Feb; 4(3):e123337. doi: 10.1172/jci.insight.123337. PMCID: PMC6413800.

9. Wang L, Sui L, Panigrahi SK, Meece K, Doege CA, Wardlaw SL, Egli D, Leibel RL. PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons. Stem Cell Reports. 2017 Feb; 14;8(2):264-277. doi: 10.1016/j.stemcr.2016.12.021. PMCID: PMC5312251.

10. Burnett LC, LeDuc CA, Sulsona CR, Paull D, Rausch R, Eddiry S, Carli JF, Morabito MV, Skowronski AA, Hubner G, Zimmer M, Wang L, Day R, Levy B, Fennoy I, Dubern B, Poitou C, Clement K, Butler MG, Rosenbaum M, Salles JP, Tauber M, Driscoll DJ, Egli D, Leibel RL. Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. J Clin Invest. 2017 Jan; 127(1):293-305. doi: 10.1172/JCI88648. PMCID: PMC5199710.

11. Wang L, Egli D, Leibel RL. Efficient generation of hypothalamic neurons from human pluripotent stem cells. Curr Protoc Hum Genet. 2016 Jul; 90:21.5.1-21.5.14. doi: 10.1002/cphg.3. PMCID: PMC4963463.

12. Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Martin Carli J, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest. 2015 Feb;125(2):796-808. doi: 10.1172/JCI79220. PMCID: PMC431942.

13. Stratigopoulos G, Martin Carli JF, O’Day DR, Wang L, Leduc CA, Lanzano P, Chung WK, Rosenbaum M, Egli D, Doherty DA, Leibel RL. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metabolism. 2014 May; 19(5):767-79. doi: 10.1016/j.cmet.2014.04.009. PMCID: PMC4131684.

14. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; Suppl 1:S1-S17. doi: 10.1002/oby.20646. PMCID: PMC4159941.

15. Qiang L, Wang L, Kon N, Zhao W, Lee S, Zhang Y, Rosenbaum M, Zhao Y, Gu W, Farmer SR, Accili D. Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of PPARγ. Cell. 2012 Aug;150(3):620-32. doi: 10.1016/j.cell.2012.06.027. PMCID: PMC3413172.