{"id":81,"date":"2022-01-25T19:11:21","date_gmt":"2022-01-25T19:11:21","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/?page_id=81"},"modified":"2026-02-11T17:51:02","modified_gmt":"2026-02-11T17:51:02","slug":"kumar-lab","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/","title":{"rendered":"Kumar Lab"},"content":{"rendered":"

[et_pb_section bb_built=”1″ fullwidth=”on” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#000000″ next_background_color=”#ffffff” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_fullwidth_menu fullwidth_menu=”on” logo=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/MS_Icahn_K_Hrztl-1.png” logo_max_width=”90%” logo_max_height=”150px” _builder_version=”4.9.0″ _module_preset=”default” menu_font=”Open Sans|700|||||||” menu_text_color=”#FFFFFF” menu_font_size=”16px” menu_line_height=”1.2em” background_color=”#000000″ text_orientation=”right” background_layout=”dark” module_alignment=”center” custom_margin=”-2.5em||||false|false” custom_margin_tablet=”||||false|false” custom_margin_phone=”-2em||||false|false” custom_margin_last_edited=”on|tablet” custom_padding=”|4em|||false|false” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%” \/][\/et_pb_section][et_pb_section bb_built=”1″ fullwidth=”on” _builder_version=”4.9.0″ _module_preset=”default” prev_background_color=”#000000″ next_background_color=”#000000″ background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_fullwidth_slider use_bg_overlay=”on” bg_overlay_color=”rgba(0,0,0,0.3)” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/Picture-3.jpg” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%” button_bg_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_slide heading=”Kumar Lab” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/sinai.jpg” background_enable_image=”on” parallax=”on” sticky_transition=”on”][\/et_pb_slide][et_pb_slide heading=”Kumar Lab” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/Picture-4.jpg” background_enable_image=”on” sticky_transition=”on”][\/et_pb_slide][et_pb_slide heading=”Understanding Intracellular Stress Response in the Ocular and Neurological Diseases” _builder_version=”4.9.0″ _module_preset=”default” sticky_transition=”on”][\/et_pb_slide][\/et_pb_fullwidth_slider][et_pb_fullwidth_slider use_bg_overlay=”on” bg_overlay_color=”rgba(0,0,0,0.3)” disabled_on=”on|on|on” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/Picture-3.jpg” disabled=”on” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%” button_bg_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_slide heading=”Kumar Lab” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/sinai.jpg” background_enable_image=”on” parallax=”on” sticky_transition=”on”][\/et_pb_slide][et_pb_slide heading=”Kumar Lab” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/Picture-4.jpg” background_enable_image=”on” sticky_transition=”on”][\/et_pb_slide][et_pb_slide heading=”Understanding Intracellular Stress Response in the Ocular and Neurological Diseases” _builder_version=”4.9.0″ _module_preset=”default” sticky_transition=”on”][\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Research Section” module_id=”research” module_class=”research-section” _builder_version=”4.9.0″ _module_preset=”default” prev_background_color=”#000000″ next_background_color=”#000000″ background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”6em||6em||true|false” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_text admin_label=”Research text” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”20px” text_line_height=”1.8em” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”]<\/p>\n

We are an interdisciplinary group in Ophthalmology and Pharmacological Sciences at Icahn School of Medicine at Mount Sinai, New York. Our mission is to understand the contribution of the intracellular stress response, specifically Endoplasmic reticulum (ER) and mitochondrial stress and their crosstalk dysregulated in many neurological and ocular diseases. Our research model is corneal endothelium cells that undergo various intracellular stress, ultimately leading to apoptosis in Fuchs Endothelium Corneal Dystrophy (FECD). We use cutting-edge cellular and molecular biological techniques, genetics and pharmacological tools, single-cell genomics, RNA seq, large datasets, etc.<\/p>\n

[\/et_pb_text][et_pb_button admin_label=”PubMed” button_url=”https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/varun.kumar.1\/bibliography\/public\/” url_new_window=”on” button_text=”PubMed” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_size=”16px” button_bg_color=”#00aeef” button_border_width=”1px” button_border_color=”#00aeef” button_border_radius=”4px” button_font=”Open Sans|700|||||||” 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Funding<\/strong>:<\/h4>\n

National Institute of Health \/ National Eye Institute
\"\"<\/p>\n

New York Eye and Ear Foundation <\/p>\n

Sarah K. de Coizart Perpetual Charitable Trust <\/p>\n

 <\/h4>\n

Awards<\/strong>:<\/h4>\n

American Heart Association Postdoctoral Fellowship (2018-2020)<\/strong><\/p>\n

K99\/ R00 (NIH\/NEI) Pathway to Independence Award (2020-2025)<\/strong><\/p>\n

ARVO Travel Grant (2020)<\/strong><\/p>\n

Santel, Inc.\/ ARVO Travel Award (2021)<\/strong><\/p>\n

New York Eye and Ear Foundation Award (2022-2023)<\/strong><\/p>\n

Sarah K. de Coizart Perpetual Charitable Trust Award(2023-2025)<\/strong><\/p>\n

Meyer Family Foundation for Glaucoma Research (2025-2027)<\/strong><\/p>\n

Cornea Research Foundation of America (2026-2027)<\/strong><\/p>\n

New York Eye and Ear Foundation Award (2026-2027)<\/strong><\/p>\n

Sarah K. de Coizart Perpetual Charitable Trust Award(2026-2028)<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ admin_label=”Team Section” module_id=”research” module_class=”research-section” _builder_version=”4.9.0″ _module_preset=”default” prev_background_color=”#000000″ next_background_color=”#85d6fc” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”5em||||false|false” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_text admin_label=”Team” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#FFFFFF” text_font_size=”18px” header_4_font=”Open Sans||||||||” header_4_text_color=”#00aeef” header_4_font_size=”28px” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”]<\/p>\n

Team<\/strong><\/h4>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ use_custom_gutter=”on” gutter_width=”2″ _builder_version=”4.9.0″ _module_preset=”default” width=”100%” custom_margin=”||||false|false” custom_padding=”0em||6em||false|false” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_image admin_label=”Kumar Image” src=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/04\/Varun_Kumar-22a.jpg” title_text=”Varun Kumar ” url=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/Varun-Kumar-Mount-Sinai-CV.pdf” url_new_window=”on” _builder_version=”4.9.0″ _module_preset=”default” width=”80%” border_radii=”on|6px|6px|6px|6px” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%” \/][et_pb_text admin_label=”Kumar Profile” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”18px” text_line_height=”1.8em” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”]<\/p>\n

Principal Investigator\/ Assistant Professor<\/strong>
Varun Kumar, PhD
varun.kumar@mssm.edu<\/a><\/p>\n

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I am trained as a biomedical research scientist in the field of neuroscience and ophthalmology. My doctoral research involved the pathogenesis of ischemia-induced neurodegeneration with respect to mitochondria. My doctoral studies suggested that (1) Deletion of PKC epsilon reduces neurodegeneration after global cerebral ischemia. (2) This neurodegeneration is regulated by a transcription factor (ATF2, Activation Transcription Factor 2) (3) ATF2 translocate to mitochondria and its translocation is regulated via its phosphorylation by PKC epsilon. (4) Another PKC isozyme analogous to PKC epsilon is PKC delta, which contributes to ischemia induced neurodegeneration in our study. During my postdoctoral studies under Drs. Jeffrey L. Goldberg, Yaping Joyce Liao, Ula V Jurkunas and as Instructor, I investigated the role of endoplasmic reticulum, mitochondria and oxidative stress in diseases such as ischemic optic neuropathy, diabetes retinopathy and Fuchs endothelial corneal dystrophy (FECD). My postdoctoral studies suggested that (1) Retinal ganglion cells and oligodendrocytes are selectively vulnerable to ER stress in ischemic optic neuropathy. (2) Imbalance of oxidant-antioxidant system (Loss of NQO1) causes corneal endothelial cell loss in FECD. (3) There is a loss of mitochondrial quality control in FECD which is governed by mitophagy. We are currently investigating the interaction of one stress (ER stress) with another (oxidative or mitochondria stress), which will open new avenues for the drug discovery. At Mount Sinai, I will continue my research involving ER-mitochondrial crosstalk in FECD.<\/p>\n

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Medical Student<\/strong>
Anisha kashi
anisha.kasi@icahn.mssm.edu<\/a><\/p>\n

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Medical Student<\/strong>
Minwoo Kwon
minwoo.kwon@icahn.mssm.edu<\/a><\/p>\n

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Research Assistant (Volunteer)<\/strong>
Stefan Kim
yiwon.kim@mssm.edu<\/a><\/p>\n

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Research Assistant<\/strong>
Disha Jain
disha.jain2@mssm.edu<\/a><\/p>\n

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High School Student<\/strong>
Armaan DeWal
dewalarmaan@gmail.com<\/a><\/p>\n

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Undergraduate student (New York University, New York City)<\/strong>
Aidan Kumar
ak11782@nyu.edu<\/a><\/p>\n

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Undergraduate student (Cornell University, New York)<\/strong>
Arya Bairat
amb588@cornell.edu<\/a><\/p>\n

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Lab Updates<\/strong><\/h4>\n

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z_index_tablet=”0″ text_font=”Open Sans||||||||” text_font_size=”18px” background_pattern_color=”rgba(0,0,0,0.2)” background_mask_color=”#ffffff”]<\/p>\n

\nJanuary 2022<\/u><\/strong><\/p>\n

I started my career as an Assistant Professor (Ophthalmology and Pharmacological Sciences) at Icahn School of Medicine at Mount Sinai, New York.<\/p>\n

March 2022<\/u><\/strong><\/p>\n

We are opening doors for prospective undergraduate, graduate, and medical students, research assistants, PhD, and postdoctoral fellows to join our lab.<\/p>\n

April 2022<\/u><\/strong><\/p>\n

Medical Students Lukas Ritzer, William Steidl, and Michael Parise joined the lab to help in research activities.<\/p>\n

May 2022<\/u><\/strong><\/p>\n

Saba Qureshi joined as a postdoctoral fellow in the lab. Welcome Saba.<\/p>\n

June 2022<\/u><\/strong><\/p>\n

High School students Ananya Chaubal, Arham Akhyer, and Jannet Pawar joined the lab for the summer of 2022.<\/p>\n

June 2022<\/u><\/strong><\/p>\n

Stephanie Lee joined as a research assistant in the lab. Welcome Stephanie.<\/p>\n

September 2022<\/u><\/strong><\/p>\n

Michael Parise joined the residency program at Kettering Health, Ohio. Congratulations Michael.<\/p>\n

December 2022<\/u><\/strong><\/p>\n

We received a New York Eye and Ear Foundation Grant.<\/p>\n

April 2023<\/u><\/strong><\/p>\n

We received a Sarah K. de Coizart Perpetual Charitable Trust\/ Foundation grant.<\/p>\n

May 2023<\/u><\/strong><\/p>\n

We welcome high school students Ananya Chaubal, Arham Akhyer, and Jannet Pawar to rejoin the lab for summer 2023.<\/p>\n

June 2023<\/u><\/strong><\/p>\n

We welcome Hua Huang and Andrew Chen to join the lab as summer undergraduates.<\/p>\n

October 2023<\/u><\/strong><\/p>\n

Our paper has been accepted in IOVS. Congratulations to all the lab members. Special thanks to Saba, Stephanie, and William for all their efforts.<\/p>\n

May 2024<\/u><\/strong><\/p>\n

We welcome high school students Armaan Vaswani, Armaan Dewal, Ian Klimov, Tasmina Maysha to join the lab for summer 2024.<\/p>\n

September 2024<\/u><\/strong><\/p>\n

We welcome Aidan Kumar as a undergraduate volunteer, Stefan and Disha as a research assistant in September 2024.<\/p>\n

October 2024<\/u><\/strong><\/p>\n

We Varun kumar was selected as an NIH Early Career Reviewer program in October 2024.<\/p>\n

February 2025<\/u><\/strong><\/p>\n

We Varun kumar was awarded Mayer Family Foundation Grant for Glaucoma Research in February 2025.<\/p>\n

August 2025<\/u><\/strong><\/p>\n

We Varun kumar was selected among top 40 vision scientist in Emerging Vision Scientist Program in August 2025.<\/p>\n

September 2025<\/u><\/strong><\/p>\n

We Varun kumar was awarded the prestigious Cornea Research Foundation of America award in September 2025.<\/p>\n

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Lab Alumni<\/strong><\/h4>\n

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Name<\/u>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Year<\/u>\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Position<\/u><\/strong><\/p>\n

Michael Parise\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 2022-2023\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Resident Physician at Kettering, Ohio\u00a0<\/strong><\/p>\n

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Name<\/u>                                      Year<\/u>                                 Position<\/u><\/strong><\/p>\n

Ananya Chaubal                       2022-2023                        Bachelors of Science (Stony Brook University, New York) <\/strong><\/p>\n

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Name<\/u>                                      Year<\/u>                                 Position<\/u><\/strong><\/p>\n

Rayson Santiago                      2023-2024                        Masters of Science (Columbia University, New York) <\/strong><\/p>\n

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Name<\/u>                                      Year<\/u>                                 Position<\/u><\/strong><\/p>\n

Lukas Ritzer                       2022-2024                        Resident (Ophthalmology, Icahn school of medicine at Mount Sinia) <\/strong><\/p>\n

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Name<\/u>                                      Year<\/u>                                 Position<\/u><\/strong><\/p>\n

Stephanie Lee                       2022-2025                        MS (Biomedical Science, Georgetown University,USA) <\/strong><\/p>\n

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Name<\/u>                                      Year<\/u>                                 Position<\/u><\/strong><\/p>\n

Ian J Klimov                       2022-2024                        BS (Yale University,USA) <\/strong><\/p>\n

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Name<\/u>                                      Year<\/u>                                 Position<\/u><\/strong><\/p>\n

Armaan Vaswani                       2022-2024                        BS (Cornell Univerity, USA) <\/strong><\/p>\n

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Name<\/u>                                      Year<\/u>                                 Position<\/u><\/strong><\/p>\n

William Steidl                       2022-2025                        Resident (Neurology)  <\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section bb_built=”1″ specialty=”off” prev_background_color=”rgba(15,177,252,0.72)” _builder_version=”4.9.0″ box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” module_id=”lab” module_class=”lab-section” vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_row][et_pb_column type=”4_4″ custom_padding__hover=”|||” custom_padding=”|||” background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”][et_pb_text admin_label=”Lab fun” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#ffffff” text_font_size=”18px” header_4_font=”Open Sans||||||||” header_4_text_color=”#00aeef” header_4_font_size=”28px” text_text_shadow_horizontal_length=”text_text_shadow_style,%91object Object%93″ text_text_shadow_horizontal_length_tablet=”0px” 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header_6_text_shadow_vertical_length=”header_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_vertical_length_tablet=”0px” header_6_text_shadow_blur_strength=”header_6_text_shadow_style,%91object Object%93″ header_6_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px” vertical_offset_tablet=”0″ horizontal_offset_tablet=”0″ z_index_tablet=”0″ background_color_gradient_stops=”#2b87da 0%|#29c4a9 100%”]<\/p>\n

Lab Fun<\/strong><\/h4>\n

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2024<\/strong><\/h4>\n

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2023<\/strong><\/h4>\n

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2022<\/strong><\/h4>\n

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We are an interdisciplinary group in Ophthalmology and Pharmacological Sciences at Icahn School of Medicine at Mount Sinai, New York. Our mission is to understand the contribution of the intracellular stress response, specifically Endoplasmic reticulum (ER) and mitochondrial stress and their crosstalk dysregulated in many neurological and ocular diseases. Our research model is corneal endothelium […]<\/p>\n","protected":false},"author":274,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-template-blank.php","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-81","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-json\/wp\/v2\/pages\/81","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-json\/wp\/v2\/users\/274"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-json\/wp\/v2\/comments?post=81"}],"version-history":[{"count":148,"href":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-json\/wp\/v2\/pages\/81\/revisions"}],"predecessor-version":[{"id":529,"href":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-json\/wp\/v2\/pages\/81\/revisions\/529"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-json\/wp\/v2\/media?parent=81"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}