![\"\"](\"https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/green-1.png\")
<\/p>\n[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#000000″ locked=”off”][et_pb_fullwidth_menu fullwidth_menu=”on” logo=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/MS_Icahn_K_Hrztl-1.png” logo_max_width=”90%” logo_max_height=”150px” _builder_version=”4.9.0″ _module_preset=”default” menu_font=”Open Sans|700|||||||” menu_text_color=”#FFFFFF” menu_font_size=”16px” menu_line_height=”1.2em” background_color=”#000000″ text_orientation=”right” background_layout=”dark” module_alignment=”center” custom_margin=”-2.5em||||false|false” custom_margin_tablet=”||||false|false” custom_margin_phone=”-2em||||false|false” custom_margin_last_edited=”on|tablet” custom_padding=”|4em|||false|false” locked=”off”][\/et_pb_fullwidth_menu][\/et_pb_section][et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.9.0″ _module_preset=”default”][et_pb_fullwidth_header title=”Research” background_overlay_color=”rgba(0,0,0,0.5)” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/Picture-2.jpg”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Research Section” _builder_version=”4.9.0″ _module_preset=”default”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text admin_label=”Research Text” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”18px” text_line_height=”1.8em” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n
Kumar\u2019s lab aims to understand the role of the intracellular stress response, specifically the Endoplasmic reticulum and mitochondrial stress, and investigate their crosstalk under normal and pathological conditions. We currently focus on corneal endothelial cells that undergo ER and mitochondrial stress contributing to apoptosis in Fuchs Endothelium Corneal Dystrophy (FECD).<\/p>\n
FECD is a genetically complex, heterogenous, age-related degenerative disease of the corneal endothelium cells (CEnCs), characterized by extracellular matrix (ECM) protein deposition or corneal guttae, causing light scatter and accounting for glare and visual complaints in patients. This disease affects approximately 4 % of the USA population over the age of 40, with a higher incidence in Females. Currently, the only treatment for FECD is corneal transplantation, which carries substantial economic, medical, and social burdens. Understanding the disease pathogenesis is essential for developing pharmacological interventions to halt the disease.<\/p>\n
In FECD, CEnCs exhibits stress-induced senescence, antioxidant-oxidant imbalance, oxidation of DNA bases, heightened reactive oxygen species (ROS) production, mitochondrial and sustained ER stress. ER and mitochondrial stress are the two major types of intracellular stress factors possibly contributing to endothelium cell degeneration and apoptosis in FECD.<\/p>\n
<\/p>\n
<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ admin_label=”Research Questions” _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0em||||false|false”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text admin_label=”A” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”18px” text_line_height=”1.8em” background_color=”#b6d7ea” custom_padding=”20px|20px|20px|20px|true|true” border_radii=”on|4px|4px|4px|4px” border_color_all=”#bde1f9″ box_shadow_style=”preset3″]<\/p>\n
How do ER and mitochondria undergo stress and communicate their stress response under pathological conditions?<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text admin_label=”B” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”18px” text_line_height=”1.8em” background_color=”#b6d7ea” custom_padding=”20px|20px|20px|20px|true|true” border_radii=”on|4px|4px|4px|4px” border_color_all=”#bde1f9″ box_shadow_style=”preset3″]<\/p>\n What are the roles of ER-mitochondrial interactions\/contact sites which get altered in many neurological or ocular diseases?<\/strong>[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text admin_label=”C” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”18px” text_line_height=”1.8em” background_color=”#b6d7ea” custom_padding=”20px|20px|20px|20px|true|true” border_radii=”on|4px|4px|4px|4px” border_color_all=”#bde1f9″ box_shadow_style=”preset3″]<\/p>\n How does the disruption of the ER-mitochondrial axis contribute to ER and mitochondrial stress under pathological conditions?<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”18px” text_line_height=”1.8em”]<\/p>\n Endoplasmic Reticulum and Mitochondrial Crosstalk in Ocular and Neurological Disease<\/strong><\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/kumarlab\/wp-content\/uploads\/sites\/421\/2022\/01\/Picture-5a.png” title_text=”Picture 5a” align=”center” _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”18px” text_line_height=”1.8em”]<\/p>\n A coherent understanding of ER-mitochondrial crosstalk will aid in the development of specific therapeutic strategies associated with protein misfolding\/ER stress, mitophagy, and mitochondrial stress.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer. Section” _builder_version=”4.9.0″ _module_preset=”default” background_color=”#000000″ locked=”off”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text admin_label=”Contact Us” _builder_version=”4.9.0″ _module_preset=”default” text_font=”Open Sans|700|||||||” text_text_color=”#FFFFFF” header_3_font=”Open Sans|600|||||||” header_3_text_color=”#00aeef” background_layout=”dark”]<\/p>\nB:<\/strong><\/h3>\n
C:<\/strong><\/h3>\n
Contact Us<\/h3>\n