{"id":17,"date":"2016-08-12T14:53:06","date_gmt":"2016-08-12T14:53:06","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/kovaciclab\/?page_id=17"},"modified":"2026-08-13T18:39:25","modified_gmt":"2026-08-13T18:39:25","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/kovaciclab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

For a complete list of publications, please click here<\/a>.<\/p>\n

BELOW ARE SELECTED PUBLICATIONS FROM 2022 ONWARDS<\/strong><\/p>\n

2026<\/strong><\/p>\n

\n

Xu Y, Jarrah S, Zhang S, Khlgatian MK, Brojakowska A, Du Y, Eskandari A, D’Escamard V, Kovacic JC#<\/strong><\/span>, Goukassian DA. Space radiation impairs long-term endothelial integrity and may promote atherosclerosis in ApoE-deficient mice. Clin Transl Med. 2026 Aug; 16(8): e70774. #Co-senior authorship<\/strong><\/p>\n

Brojakowska A, Bisserier M, Eskandari A, Jagana V, Khlgatian MK, Arakelyan A, Fogarty J, Kovacic JC<\/strong><\/span>, Goukassian DA. Cardiovascular risks and hazards associated with deep space exploration. Commun Med (Lond). 2026 Jun 23;6(1):354.<\/p>\n

Hall IF, Aikawa E, Sluimer J, Baker AH, Kovacic JC<\/strong><\/span>. Endothelial to mesenchymal transition in cardiovascular diseases: molecular insights and clinical perspectives. Eur Heart J. 2026 Mar 9;47(10):1144-1158.<\/p>\n

Wolhuter K, Ma L, Bryce NS, Contreras O, Mellett N, Zhong L, Thekkedam C, Iismaa SE, Giles C, Harvey RP, Hennessy T, Fouracre C, Bradley D, Meikle PJ, Bj\u00f6rkegren JLM, Kovacic JC<\/strong><\/span>. Multi-omic analysis of human PHACTR1 signaling networks. Commun Biol. 2026 Jan 19;9(1):265.<\/p>\n

 <\/p>\n<\/div>\n

2025<\/strong><\/p>\n

\n

Hall IF, Aikawa E, Sluimer J, Baker AH, Kovacic JC<\/strong><\/span>. Endothelial to mesenchymal transition in cardiovascular diseases: molecular insights and clinical perspectives. Eur Heart J. 2025 Oct 23:ehaf670. doi: 10.1093\/eurheartj\/ehaf670. Epub ahead of print.<\/p>\n

Ma L, Tamis-Holland JE, Mocci G, Wolhuter K, Bryce NS, Sajja S, Amadori L, Pradhan P, Chong PS, Sukhavasi K, Cheng H, Li L, Pang S, Schadt EE, Schunkert H, von Scheidt M, Ruusalepp A, Moreno PR, Hao K, Giannarelli C, Miller CL, Kovacic JC#<\/strong><\/span>, Bj\u00f6rkegren JLM#. A macrophage gene-regulatory network linked to clinical severity of coronary artery disease : The STARNET and NGS-PREDICT primary blood macrophage studies. Basic Res Cardiol. 2025 Aug;120(4):799-814. #Co-senior authorship<\/strong><\/p>\n

Tweet MS, Kovacic JC<\/strong><\/span>. The Australian-New Zealand SCAD observational cohort study: major adverse cardiovascular events are associated with ticagrelor combined with aspirin, FMD, and history of stroke. Eur Heart J. 2025 Jun 2;46(21):2024-2026.<\/p>\n<\/div>\n

 <\/p>\n

2024<\/strong><\/p>\n

d’Escamard V, Kadian-Dodov D, Ma L, Lu S, King A, Xu Y, Peng S, V Gangula B, Zhou Y, Thomas A, Michelis KC, Bander E, Bouchareb R, Georges A, Nomura-Kitabayashi A, Wiener RJ, Costa KD, Chepurko E, Chepurko V, Fava M, Barwari T, Anyanwu A, Filsoufi F, Florman S, Bouatia-Naji N, Schmidt LE, Mayr M, Katz MG, Hao K, Weiser-Evans MCM, Bj\u00f6rkegren JLM, Olin JW, Kovacic JC<\/strong><\/span>. Integrative gene regulatory network analysis discloses key driver genes of fibromuscular dysplasia. Nat Cardiovasc Res. 2024 Sep;3(9):1098-1122.<\/p>\n

Xu Y, Korayem A, Cruz-Solbes AS, Chandel N, Sakata T, Mazurek R, Mavropoulos SA, Kariya T, Aikawa T, Yamada KP, D’Escamard V, V’Gangula B, Baker AH, Ma L, Bj\u00f6rkegren JLM, Fuster V, Boehm M, Fish KM, Tadros R, Ishikawa K, Kovacic JC<\/strong><\/span>. Inhibition of endothelial to mesenchymal transition in a large animal preclinical arterio-venous fistula model leads to improved remodeling and reduced stenosis. Cardiovasc Res. 2024 Jul 26:cvae157. doi: 10.1093\/cvr\/cvae157. Online ahead of print.<\/p>\n

Miller MR, Landrigan PJ, Arora M, Newby DE, M\u00fcnzel T, Kovacic JC<\/strong><\/span>. Environmentally Not So Friendly: Global Warming, Air Pollution, and Wildfires: JACC Focus Seminar, Part 1. J Am Coll Cardiol. 2024 Jun 11;83(23):2291-2307.<\/p>\n

Miller MR, Landrigan PJ, Arora M, Newby DE, M\u00fcnzel T, Kovacic JC<\/strong><\/span>. Water, Soil, Noise, and Light Pollution: JACC Focus Seminar, Part 2. J Am Coll Cardiol. 2024 Jun 11;83(23):2308-2323.<\/p>\n

Hall IF, Kishta F, Xu Y, Baker AH, Kovacic JC<\/strong><\/span>. Endothelial to mesenchymal transition: at the axis of cardiovascular health and disease. Cardiovasc Res. 2024 Mar 14;120(3): 223-236.<\/p>\n

 <\/p>\n

2023<\/strong><\/p>\n

Xu Y and Kovacic JC<\/strong><\/span>. Endothelial to Mesenchymal Transition in Health and Disease. Annual Rev Physiol. 2023; 85: 245\u2013267<\/p>\n

Wolhuter K, Kong SMY, Stanley CP, Kovacic JC<\/strong><\/span>. The role of oxidants in PCI-induced endothelial dysfunction: can we harness redox signalling to improve clinical outcomes? Antioxidants and Redox Signaling. 2023, 38(13): 1022\u20131040.<\/p>\n

 <\/p>\n

2022<\/strong><\/p>\n

Iglesies-Grau J, Fernandez-Jimenez R, Diaz-Munoz R, Jaslow R, de Cos-Gandoy A, Santos-Beneit G, Hill CA, Turco A, Kadian-Dodov D, Kovacic JC<\/strong><\/span>, Fayad ZA, Fuster V. Subclinical Atherosclerosis in Young, Socioeconomically Vulnerable Hispanic and Non-Hispanic Black Adults. J Am Coll Cardiol. 2022; 80(3): 219-229.<\/p>\n

Figtree GA, Kovacic JC<\/strong><\/span>, McGuire HM. Human susceptibility to coronary artery disease: lessons from chimpanzee resilience. Nat Rev Cardiol. 2022; 19(8): 497-498.<\/p>\n

Ma L, Bryce NS, Turner AW, Di Narzo AF, Rahman K, Xu Y, Ermel R, Sukhavasi K, d’Escamard V, Chandel N, V’Gangula B, Wolhuter K, Kadian-Dodov D, Franzen O, Ruusalepp A, Hao K, Miller CL, Bj\u00f6rkegren JLM, Kovacic JC<\/strong><\/span>. The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1. PLoS Genet. 2022 Jun 17;18(6):e1010261. doi: 10.1371\/journal.pgen.1010261. Online ahead of print.<\/p>\n

Hao K, Ermel R, Sukhavasi K, Cheng H, Ma L, Li L, Amadori L, Koplev S, Franz\u00e9n O, d’Escamard V, Chandel N, Wolhuter K, Bryce NS, Venkata VRM, Miller CL, Ruusalepp A, Schunkert H, Bj\u00f6rkegren JLM, Kovacic JC<\/strong><\/span>. Integrative Prioritization of Causal Genes for Coronary Artery Disease. Circ Genom Precis Med. 2022 Feb;15(1):e003365.<\/p>\n

Tucker WJ, Fegers-Wustrow I, Halle M, Haykowsky MJ, Chung EH, Kovacic JC<\/strong><\/span>. Exercise for Primary and Secondary Prevention of Cardiovascular Disease: JACC Focus Seminar 1\/4. J Am Coll Cardiol. 2022; 80(11): 1091-1106.<\/p>\n

La Gerche A, Howden EJ, Haykowsky MJ, Lewis GD, Levine BD, Kovacic JC<\/strong><\/span>. Heart Failure With Preserved Ejection Fraction as an Exercise Deficiency Syndrome: JACC Focus Seminar 2\/4. J Am Coll Cardiol. 2022; 80(12): 1177-1191.<\/p>\n

Semsarian C, Gray B, Haugaa KH, Lampert R, Sharma S, Kovacic JC<\/strong><\/span>. Athletic Activity for Patients With Hypertrophic Cardiomyopathy and Other Inherited Cardiovascular Diseases: JACC Focus Seminar 3\/4. J Am Coll Cardiol. 2022; 80(13): 1268-1283.<\/p>\n

La Gerche A, Wasfy MM, Brosnan MJ, Claessen G, Fatkin D, Heidbuchel H, Baggish AL, Kovacic JC<\/strong><\/span>. The Athlete’s Heart-Challenges and Controversies: JACC Focus Seminar 4\/4. J Am Coll Cardiol. 2022 Aug 30;S0735-1097(22)05664-9.<\/p>\n","protected":false},"excerpt":{"rendered":"

For a complete list of publications, please click here. BELOW ARE SELECTED PUBLICATIONS FROM 2022 ONWARDS 2026 Xu Y, Jarrah S, Zhang S, Khlgatian MK, Brojakowska A, Du Y, Eskandari A, D’Escamard V, Kovacic JC#, Goukassian DA. Space radiation impairs long-term endothelial integrity and may promote atherosclerosis in ApoE-deficient mice. Clin Transl Med. 2026 Aug; […]<\/p>\n","protected":false},"author":481,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-17","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/kovaciclab\/wp-json\/wp\/v2\/pages\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/kovaciclab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/kovaciclab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/kovaciclab\/wp-json\/wp\/v2\/users\/481"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/kovaciclab\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":36,"href":"https:\/\/labs.icahn.mssm.edu\/kovaciclab\/wp-json\/wp\/v2\/pages\/17\/revisions"}],"predecessor-version":[{"id":323,"href":"https:\/\/labs.icahn.mssm.edu\/kovaciclab\/wp-json\/wp\/v2\/pages\/17\/revisions\/323"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/kovaciclab\/wp-json\/wp\/v2\/media?parent=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}