2022

Human distal airways contain a multipotent secretory cell that can regenerate alveoli.

Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Nature. 2022 Apr;604(7904):120-126. doi: 10.1038/s41586-022-04552-0. Epub 2022 Mar 30. PMID: 35355013; PMCID: PMC9297319.

Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5⁺ basal cell

Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. Nat Cell Biol. 2022 Jan;24(1):10-23. doi: 10.1038/s41556-021-00809-4. Epub 2021 Dec 30. PMID: 34969962; PMCID: PMC8761168.

2021

An inflammatory switch for stem cell plasticity

Kathiriya JJ, Peng T. Nat Cell Biol. 2021 Sep;23(9):928-929. doi: 10.1038/s41556-021-00752-4. PMID: 34475536; PMCID: PMC8440424.

2020

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future.

Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, Kotton DN, Rock JR, Snoeck HW, Vunjak-Novakovic G, Whitsett JA, Morrisey EE. Cell Stem Cell. 2020 Apr 2;26(4):482-502. doi: 10.1016/j.stem.2020.03.009. PMID: 32243808; PMCID: PMC7128675.

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

Strunz M, Simon LM, Ansari M, Kathiriya JJ, Angelidis I, Mayr CH, Tsidiridis G, Lange M, Mattner LF, Yee M, Ogar P, Sengupta A, Kukhtevich I, Schneider R, Zhao Z, Voss C, Stoeger T, Neumann JHL, Hilgendorff A, Behr J, O’Reilly M, Lehmann M, Burgstaller G, Königshoff M, Chapman HA, Theis FJ, Schiller HB. Nat Commun. 2020 Jul 16;11(1):3559. doi: 10.1038/s41467-020-17358-3. PMID: 32678092; PMCID: PMC7366678.

Gli1⁺ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung

Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T.  Nat Cell Biol. 2020 Nov;22(11):1295-1306. doi: 10.1038/s41556-020-00591-9. Epub 2020 Oct 12. PMID: 33046884; PMCID: PMC7642162.

Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration

Kathiriya JJ, Brumwell AN, Jackson JR, Tang X, Chapman HA.  Cell Stem Cell. 2020 Mar 5;26(3):346-358.e4. doi: 10.1016/j.stem.2019.12.014. Epub 2020 Jan 23. PMID: 31978363; PMCID: PMC7233183.

VEGF Drives the Car toward Better Gas Exchange

Kathiriya JJ, Chapman HA. Dev Cell. 2020 Mar 9;52(5):546-547. doi: 10.1016/j.devcel.2020.02.009. PMID: 32155436; PMCID: PMC7233181.

2018

PTEN Physically Interacts with and Regulates E2F1-mediated Transcription in Lung Cancer

Malaney P, Palumbo E, Semidey-Hurtado J, Hardee J, Stanford K, Kathiriya JJ, Patel D, Tian Z, Allen-Gipson D, Davé V.  Cell Cycle. 2018;17(8):947-962. doi: 10.1080/15384101.2017.1388970. Epub 2018 May 31. PMID: 29108454; PMCID: PMC6103743.

2017

Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis

Kathiriya JJ, Nakra N, Nixon J, Patel PS, Vaghasiya V, Alhassani A, Tian Z, Allen-Gipson D, Davé V. Cell Death Discov. 2017 Apr 10;3:17010. doi: 10.1038/cddiscovery.2017.10. PMID: 28417017; PMCID: PMC5385413.

Data on evolution of intrinsically disordered regions of the human kinome and contribution of FAK1 IDRs to cytoskeletal remodeling

Kathiriya JJ, Pathak RR, Bezginov A, Xue B, Uversky VN, Tillier ER, Davé V. Data Brief. 2016 Dec 8;10:315-324. doi: 10.1016/j.dib.2016.11.099. PMID: 28004021; PMCID: PMC5157709.

Structural pliability adjacent to the kinase domain highlights contribution of FAK1 IDRs to cytoskeletal remodeling

Kathiriya JJ, Pathak RR, Bezginov A, Xue B, Uversky VN, Tillier ERM, Davé V. Biochim Biophys Acta Proteins Proteom. 2017 Jan;1865(1):43-54. doi: 10.1016/j.bbapap.2016.10.002. Epub 2016 Oct 5. PMID: 27718363; PMCID: PMC5127739.

2014

Presence and utility of intrinsically disordered regions in kinases

Kathiriya JJ, Pathak RR, Clayman E, Xue B, Uversky VN, Davé V. Mol Biosyst. 2014 Nov;10(11):2876-88. doi: 10.1039/c4mb00224e. PMID: 25099472.

2012

BMP4 sufficiency to induce choroid plexus epithelial fate from embryonic stem cell-derived neuroepithelial progenitors

Kathiriya JJ, Pathak RR, Clayman E, Xue B, Uversky VN, Davé V. Mol Biosyst. 2014 Nov;10(11):2876-88. doi: 10.1039/c4mb00224e. PMID: 25099472.