{"id":245352,"date":"2026-04-09T20:22:42","date_gmt":"2026-04-09T20:22:42","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/karkilab\/?page_id=245352"},"modified":"2026-04-30T13:23:57","modified_gmt":"2026-04-30T17:23:57","slug":"news","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/karkilab\/news\/","title":{"rendered":"News"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.27.4&#8243; background_color=&#8221;#460072&#8243; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_fullwidth_menu menu_id=&#8221;7&#8243; submenu_direction=&#8221;downwards&#8221; fullwidth_menu=&#8221;off&#8221; active_link_color=&#8221;#FFFFFF&#8221; _builder_version=&#8221;4.27.4&#8243; menu_font=&#8221;Open Sans|600|||||||&#8221; menu_text_color=&#8221;#FFFFFF&#8221; menu_font_size=&#8221;16px&#8221; background_color=&#8221;#460072&#8243; text_orientation=&#8221;right&#8221; background_layout=&#8221;dark&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_fullwidth_menu][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/karkilab\/wp-content\/uploads\/sites\/315\/2026\/03\/AR-BG-3.png&#8221; parallax=&#8221;on&#8221; parallax_method=&#8221;off&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; width=&#8221;90%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; animation_style=&#8221;fade&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;1&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans|500|||||||&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; border_radii=&#8221;on|8px|8px|8px|8px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#8300E9&#8243; box_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div role=\"presentation\">\u00a0<\/div>\n<div role=\"presentation\">Sanutha Shetty, Amir Farmanbar, Pamela Toh, Ramazan Yildiz, YoungUK Jang, Samuel Duesman, Aidan Warnock, Diego Espinoza, Sarah A. Stanley, Prashant <span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span>, <b><i><span class=\"outlook-search-highlight\" data-markjs=\"true\">Abha<\/span> K. <span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span><\/i><\/b>. Disruption of Pre-B\u00f6tzinger Complex neuropeptidergic tonality controls fear and metabolic response. <b><i>Under revision<\/i><\/b><i>.<\/i>\u00a0<a class=\"ms-outlook-linkify\" href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.01.697304v1\">https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.01.697304v1<\/a><\/div>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans|500|||||||&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; border_radii=&#8221;on|8px|8px|8px|8px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#8300E9&#8243; box_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p>J. R. E. Carty, K. Devarakonda, R. M. O\u2019Connor, A. Krek, D. Espinoza, M. Jimenez-Gonzalez, A. Alvarsson, R. F. Hampton, R. Li, Y. Qiu, S. Petri, A. Shtekler, <b>A. <span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span><\/b>, Conner, M. Bayne, D. Garibay, J. Martin, V. Lehmann, L. Wang, K. Beaumont, I. Kurland, G. C. Yuan, P. J. Kenny &amp; S. A. Stanley. Amygdala\u2013liver signaling orchestrates glycaemic responses to stress. 2025. <b><i>Nature.<\/i><\/b><\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans|500|||||||&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; border_radii=&#8221;on|8px|8px|8px|8px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#8300E9&#8243; box_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><b><i><\/i><\/b>Shetty S, Duesman SJ, Patel S, Huyhn P, Shroff S, Das A, Chowhan D, Sebra R, Beaumont K, McAlpine CS, <span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span> P, <b><i><span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span> AK<\/i><\/b>. <i>Sexually dimorphic role of diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus<\/i>. <b><i>Biology of Sex Differences<\/i><\/b>. doi: 10.1101\/2023.11.17.567534. PubMed PMID: <b>39010139<\/b>. *Corresponding author<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; use_custom_gutter=&#8221;on&#8221; gutter_width=&#8221;2&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; width=&#8221;90%&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; animation_style=&#8221;fade&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;4&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans|500|||||||&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; border_radii=&#8221;on|8px|8px|8px|8px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#8300E9&#8243; box_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div role=\"presentation\">Duesman SJ, Shetty S, Patel S, Ogale N, Mohamed F, Sparman N, <span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span> P, <b><i><span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span> AK<\/i><\/b>. Sexually dimorphic role of the locus coeruleus PAC1 receptors in regulating acute stress-associated energy metabolism. <b><i>Front Behav Neurosci<\/i><\/b>. 2022;16:995573. doi: 10.3389\/fnbeh.2022.995573. eCollection 2022. PubMed PMID: 36275856; PubMed Central PMCID: PMC9580361. *Corresponding author<\/div>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;5&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans|500|||||||&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; border_radii=&#8221;on|8px|8px|8px|8px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#8300E9&#8243; box_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div role=\"presentation\"><b><i><span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span> AK<\/i><\/b>, Octeau CJ, Gonzalez S, Pennington ZT, Mohamed F, Trott J, Chavez J, Ngyuen E, Keces N, Hong WZ, Neve RL, Waschek J, Khakh BS, Fanselow MS. A Basomedial Amygdala to Intercalated Cells Microcircuit Expressing PACAP and Its Receptor PAC1 Regulates Contextual Fear. <b><i>J Neurosci<\/i><\/b>. 2021 Apr 14;41(15):3446-3461. doi: 10.1523\/JNEUROSCI.2564-20.2021. Epub 2021 Feb 26. PubMed PMID: 33637560; PubMed Central PMCID: PMC8051692. *Corresponding author<\/div>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;6&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans|500|||||||&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; border_radii=&#8221;on|8px|8px|8px|8px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#8300E9&#8243; box_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<div role=\"presentation\">Nagai J, <b><i><span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span> AK<\/i><\/b>, Gangwani MR, Hachisuka A, Coppola G, Masmanidis SC, Fanselow MS, Khakh BS. Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue. <b><i>Cell.<\/i><\/b>\u00a02019 May 16;177(5):1280-1292.e20. doi: 10.1016\/j.cell.2019.03.019. Epub 2019 Apr 25. PubMed PMID: 31031006; PubMed Central PMCID: PMC6526045.<\/div>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(255,255,255,0)&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; animation_style=&#8221;fade&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_text admin_label=&#8221;7&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; text_font=&#8221;Open Sans|500|||||||&#8221; background_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;||||false|false&#8221; custom_padding=&#8221;2em|2em|2em|2em|false|false&#8221; border_radii=&#8221;on|8px|8px|8px|8px&#8221; border_width_all=&#8221;2px&#8221; border_color_all=&#8221;#8300E9&#8243; box_shadow_style=&#8221;preset3&#8243; global_colors_info=&#8221;{}&#8221;]<\/p>\n<p><b><i><span class=\"outlook-search-highlight\" data-markjs=\"true\">Rajbhandari<\/span> AK<\/i><\/b>, Gonzalez ST, Fanselow MS. Stress-Enhanced Fear Learning, a Robust Rodent Model of Post-Traumatic Stress Disorder. <b><i>J Vis Exp<\/i><\/b>. 2018 Oct 13;(140). doi: 10.3791\/58306. PubMed PMID: 30371665; PubMed Central PMCID: PMC6235522.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; _builder_version=&#8221;4.16&#8243; background_color=&#8221;#000000&#8243; border_width_all=&#8221;0.5px&#8221; border_color_bottom=&#8221;#00aeef&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.16&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text admin_label=&#8221;Abha Karki Rajbhandari&#8221; _builder_version=&#8221;4.16&#8243; background_layout=&#8221;dark&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3>Contact Us<\/h3>\n<p><strong>Abha Karki Rajbhandari<\/strong><br \/>Principal Investigator<br \/><a href=\"mailto:abha.rajbhandari@mssm.edu\">abha.rajbhandari@mssm.edu<\/a><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.16&#8243; custom_padding=&#8221;|||&#8221; global_colors_info=&#8221;{}&#8221; custom_padding__hover=&#8221;|||&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0 Sanutha Shetty, Amir Farmanbar, Pamela Toh, Ramazan Yildiz, YoungUK Jang, Samuel Duesman, Aidan Warnock, Diego Espinoza, Sarah A. Stanley, Prashant Rajbhandari, Abha K. Rajbhandari. Disruption of Pre-B\u00f6tzinger Complex neuropeptidergic tonality controls fear and metabolic response. Under revision.\u00a0https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.01.697304v1J. R. E. Carty, K. Devarakonda, R. M. O\u2019Connor, A. Krek, D. Espinoza, M. Jimenez-Gonzalez, A. Alvarsson, R. [&hellip;]<\/p>\n","protected":false},"author":274,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-template-blank.php","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-245352","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/karkilab\/wp-json\/wp\/v2\/pages\/245352","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/karkilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/karkilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/karkilab\/wp-json\/wp\/v2\/users\/274"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/karkilab\/wp-json\/wp\/v2\/comments?post=245352"}],"version-history":[{"count":8,"href":"https:\/\/labs.icahn.mssm.edu\/karkilab\/wp-json\/wp\/v2\/pages\/245352\/revisions"}],"predecessor-version":[{"id":245432,"href":"https:\/\/labs.icahn.mssm.edu\/karkilab\/wp-json\/wp\/v2\/pages\/245352\/revisions\/245432"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/karkilab\/wp-json\/wp\/v2\/media?parent=245352"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}