{"id":25,"date":"2018-10-18T16:52:00","date_gmt":"2018-10-18T16:52:00","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/?page_id=25"},"modified":"2023-03-27T17:00:25","modified_gmt":"2023-03-27T17:00:25","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Selected publications<\/em><\/strong><\/p>\n

\u00a0<\/em><\/strong>2022<\/strong><\/p>\n

Benefits of dietary polyphenols in Alzheimer’s disease. <\/a>El Gaamouch F, Chen F, Ho L, Lin HY, Yuan C, Wong J, Wang J.FrontAging Neurosci<\/span>.\u00a02022;<\/span>14<\/span>:1019942<\/span>.\u00a0doi: 10.3389\/fnagi.2022.1019942.\u00a0<\/span>eCollection 2022.\u00a0<\/span>Review.\u00a0<\/span>PubMed PMID: 36583187<\/span>; PubMed Central PMCID: PMC9792677<\/span>.<\/p>\n

Peripheral and cognitive benefits of physical exercise in a mouse model of midlife metabolic syndrome. <\/a>El Gaamouch F, Lin HY, Wang Q, Zhao W, Pan J, Liu K, Wong J, Wu C, Yuan C, Cheng H, Qin W, Hao K, Zhang B, Wang J. <\/span>Sci Rep. 2022 Feb 28;12(1):3260. doi: 10.1038\/s41598-022-07252-x.<\/span>PMID:\u00a035228593<\/span><\/span><\/p>\n

\u00a0<\/em><\/strong>2021<\/strong><\/p>\n

Development of grape polyphenols as multi-targeting strategies for Alzheimer’s disease. <\/a><\/em><\/strong>El Gaamouch F, Liu K, Lin HY, Wu C, Wang J. <\/span>Neurochem Int. 2021 Jul;147:105046. doi: 10.1016\/j.neuint.2021.105046. Epub 2021 Apr 16.<\/span>PMID:\u00a033872681<\/span><\/span><\/p>\n

\u00a0<\/em><\/strong>2020<\/strong><\/p>\n

Sex-specific peripheral and central responses to stress-induced depression and treatment in a mouse model.\u00a0\u00a0<\/a>Deonaraine KK, Wang Q, Cheng H, Chan KL, Lin HY, Liu K, Parise LF, Cathomas F, Leclair KB, Flanigan ME, Li L, Aleyasin H, Guevara C, Hao K, Zhang B, Russo SJ, Wang J.\u00a0 J.\u00a0<\/span>Neurosci Res<\/span>.\u00a02020 Sep 11;<\/span>.\u00a0doi: 10.1002\/jnr.24724.\u00a0<\/span>[Epub ahead of print]\u00a0<\/span>PubMed PMID: 32918293<\/span>.<\/p>\n

Dietary phytochemicals modulate experience-dependent changes in Neurexin gene expression and alternative splicing in mice after chronic variable stress exposure.\u00a0<\/a>\u00a0Freire-Cobo C, Wang J. E<\/span>ur J Pharmacol<\/span>.\u00a02020 Sep 15;<\/span>883<\/span>:173362<\/span>.\u00a0doi: 10.1016\/j.ejphar.2020.173362.\u00a0<\/span>Epub 2020 Jul 11.\u00a0<\/span>PubMed PMID: 32663544<\/span>; PubMed Central PMCID: PMC7484199<\/span>.<\/p>\n

Characterization of 3(3,4-dihydroxy-phenyl) propionic acid as a novel microbiome-derived epigenetic modifier in attenuation of immune inflammatory response in human monocytes.\u00a0<\/a>Wang J, Blaze J, Haghighi F, Kim-Schulze S, Raval U, Trageser KJ, Pasinetti GM. M<\/span>ol Immunol<\/span>.\u00a02020 Sep;<\/span>125<\/span>:172-177<\/span>.\u00a0doi: 10.1016\/j.molimm.2020.07.003.\u00a0<\/span>Epub 2020 Jul 21.\u00a0<\/span>PubMed PMID: 32707536<\/span>; PubMed Central PMCID: PMC7423748<\/span><\/p>\n

SUMO E3 ligase PIAS1 is a potential biomarker indicating stress susceptibility.\u00a0<\/a>Lin HY, Liu YS, Huang CY, Cathomas F, Liu K, Wang J, Cheng HT, Lai SW, Liu YC, Chen CJ, Lin C, Lu DY. P<\/span>sychoneuroendocrinology<\/span>.\u00a02020 Jul 11;<\/span>120<\/span>:104800<\/span>.\u00a0doi: 10.1016\/j.psyneuen.2020.104800.\u00a0<\/span>[Epub ahead of print]\u00a0<\/span>PubMed PMID: 32688147<\/span>.<\/p>\n

Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress.\u00a0<\/a>\u00a0Wang J, Zhao D, Tiano S, Esteban-Fern\u00e1ndez A, Yuan B, Smith C, Brathwaite J, Jlayer Z, Wu Q, Simon JE, Trageser KJ, Pasinetti GM. T<\/span>ransl Psychiatry<\/span>.\u00a02020 Jun 9;<\/span>10<\/span>(1)<\/span>:183<\/span>.\u00a0doi: 10.1038\/s41398-020-0859-x.\u00a0<\/span>PubMed PMID: 32518327<\/span>; PubMed Central PMCID: PMC7283298<\/span>.<\/p>\n

Grape-derived polyphenols produce antidepressant effects via VGF- and BDNF-dependent mechanisms.\u00a0<\/a>\u00a0Jiang C, Sakakibara E, Lin WJ, Wang J, Pasinetti GM, Salton SR. A<\/span>nn N Y Acad Sci<\/span>.\u00a02019 Nov;<\/span>1455<\/span>(1)<\/span>:196-205<\/span>.\u00a0doi: 10.1111\/nyas.14098.\u00a0<\/span>Epub 2019 May 10.\u00a0<\/span>PubMed PMID: 31074515<\/span>; PubMed Central PMCID: PMC6834858<\/span>.<\/p>\n

2019<\/strong><\/p>\n

The gut microbiota composition affects dietary polyphenols-mediated cognitive resilience in mice by modulating the bioavailability of phenolic acids.\u00a0<\/a>\u00a0Frolinger T, Sims S, Smith C, Wang J, Cheng H, Faith J, Ho L, Hao K, Pasinetti GM. S<\/span>ci Rep<\/span>.\u00a02019 Mar 5;<\/span>9<\/span>(1)<\/span>:3546<\/span>.\u00a0doi: 10.1038\/s41598-019-39994-6.\u00a0<\/span>PubMed PMID: 30837576<\/span>; PubMed Central PMCID: PMC6401062<\/span>.<\/p>\n

2018<\/strong><\/p>\n

Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice.<\/a> Nature communications.<\/em> 2018; 9(1):477. PMID: 29396460<\/p>\n

Epigenetic modifications by polyphenolic compounds alter gene expression in the hippocampus.\u00a0<\/a>\u00a0Frolinger T, Herman F, Sharma A, Sims S, Wang J, Pasinetti GM. B<\/span>iol Open<\/span>.\u00a02018 Oct 4;<\/span>7<\/span>(10)<\/span>.\u00a0doi: 10.1242\/bio.035196.\u00a0<\/span>PubMed PMID: 29970476<\/span>; PubMed Central PMCID: PMC6215408<\/span>.<\/p>\n

An Extract of\u00a0Artemisia dracunculus<\/em>\u00a0L. Promotes Psychological Resilience in a Mouse Model of Depression.<\/a> Oxidative medicine and cellular longevity.<\/em> 2018; 2018:7418681. PMID: 29861834<\/p>\n

Polyphenolic Compounds Alter Stress-Induced Patterns of Global DNA Methylation in Brain and Blood.\u00a0<\/a>\u00a0Blaze J, Wang J, Ho L, Mendelev N, Haghighi F, Pasinetti GM. M<\/span>ol Nutr Food Res<\/span>.\u00a02018 Apr;<\/span>62<\/span>(8)<\/span>:e1700722<\/span>.\u00a0doi: 10.1002\/mnfr.201700722.\u00a0<\/span>Epub 2018 Mar 22.\u00a0<\/span>PubMed PMID: 29473292<\/span>; PubMed Central PMCID: PMC5953514<\/span>.<\/p>\n

A Comprehensive Database and Analysis Framework To Incorporate Multiscale Data Types and Enable Integrated Analysis of Bioactive Polyphenols.\u00a0<\/a>\u00a0Ho L, Cheng H, Wang J, Simon JE, Wu Q, Zhao D, Carry E, Ferruzzi MG, Faith J, Valcarcel B, Hao K, Pasinetti GM. M<\/span>ol Pharm<\/span>.\u00a02018 Mar 5;<\/span>15<\/span>(3)<\/span>:840-850<\/span>.\u00a0doi: 10.1021\/acs.molpharmaceut.7b00412.\u00a0<\/span>Epub 2018 Feb 5.\u00a0<\/span>PubMed PMID: 28665131<\/span>; PubMed Central PMCID: PMC6016761<\/span>.<\/p>\n

2016<\/strong><\/p>\n

Selective brain penetrable Nurr1 transactivator for treating Parkinson’s disease.<\/a> Oncotarget.<\/em> 2016; 7(7):7469-79. PMID: 26862735<\/p>\n

2015<\/strong><\/p>\n

Childhood and adolescent obesity and long-term cognitive consequences during aging.<\/a> The Journal of comparative neurology<\/em>. 2015; 523(10):1587. PMID: 25380530<\/p>\n

2014<\/strong><\/p>\n

Molecular topology as novel strategy for discovery of drugs with a\u03b2 lowering and anti-aggregation dual activities for Alzheimer’s disease.<\/a> PloS one<\/em>. 2014; 9(3):e92750. PMID: 24671215<\/p>\n

Targeting multiple pathogenic mechanisms with polyphenols for the treatment of Alzheimer’s disease-experimental approach and therapeutic implications.<\/a> Frontiers in aging neuroscience<\/em>. 2014; 6:42. PMID: 24672477<\/p>\n

Epigenetic mechanisms linking diabetes and synaptic impairments.<\/a> Diabetes. 2014; 63(2):645-54. PMID: 24154559<\/p>\n

Cocoa extracts reduce oligomerization of amyloid-\u03b2: implications for cognitive improvement in Alzheimer’s disease.<\/a> Journal of Alzheimer’s disease<\/em>. 2014; 41(2):643-50. PMID: 24957018<\/p>\n

2013<\/strong><\/p>\n

Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model.<\/a> Molecular nutrition & food research.<\/em> 2013; 57(12):2091-102.\u00a0PMID: 23963661<\/p>\n

Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer’s disease.<\/a> PloS one.<\/em> 2013; 8(6):e65232. PMID: 23762322<\/p>\n

Investigation of nebivolol as a novel therapeutic agent for the treatment of Alzheimer’s disease.<\/a> Journal of Alzheimer’s disease<\/em>. 2013; 33(4):1147-56. PMID: 23128558<\/p>\n

2012<\/strong><\/p>\n

Brain-targeted proanthocyanidin metabolites for Alzheimer’s disease treatment.<\/a> The Journal of neuroscience<\/em>. 2012; 32(15):5144-50. PMID: 22496560<\/p>\n

2011<\/strong><\/p>\n

Carvedilol as a potential novel agent for the treatment of Alzheimer’s disease.<\/a> Neurobiology of aging.<\/em> 2011; 32(12):2321.e1-12. PMID: 20579773<\/p>\n

Preclinical study of dimebon on \u03b2-amyloid-mediated neuropathology in Alzheimer’s disease.<\/a> Molecular neurodegeneration.<\/em> 2011; 6(1):7. PMID: 21247479<\/p>\n

Earlier<\/strong><\/p>\n

Potential application of grape derived polyphenols in Huntington\u2019s disease.<\/a> Translational neuroscience.<\/em> 2010; 1(2):95-100. PMID: 21331299<\/p>\n

Grape derived polyphenols attenuate tau neuropathology in a mouse model of Alzheimer’s disease.<\/a> Journal of Alzheimer’s disease.<\/em> 2010; 22(2):653-61. PMID: 20858961<\/p>\n

Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer’s disease.<\/a> The Journal of neuroscience<\/em>. 2008; 28(25):6388-92. PMID: 18562609<\/p>\n

Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease.<\/a> The Journal of clinical investigation.<\/em> 2007; 117(11):3393-402. PMID: 17965777<\/p>\n

Moderate consumption of Cabernet Sauvignon attenuates Abeta neuropathology in a mouse model of Alzheimer’s disease.<\/a> FASEB journal.<\/em> 2006; 20(13):2313-20. PMID: 17077308<\/p>\n

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer’s disease.<\/a> FASEB journal<\/em>. 2005; 19(6):659-61. PMID: 15650008<\/p>\n","protected":false},"excerpt":{"rendered":"

Selected publications \u00a02022 Benefits of dietary polyphenols in Alzheimer’s disease. El Gaamouch F, Chen F, Ho L, Lin HY, Yuan C, Wong J, Wang J.FrontAging Neurosci.\u00a02022;14:1019942.\u00a0doi: 10.3389\/fnagi.2022.1019942.\u00a0eCollection 2022.\u00a0Review.\u00a0PubMed PMID: 36583187; PubMed Central PMCID: PMC9792677. Peripheral and cognitive benefits of physical exercise in a mouse model of midlife metabolic syndrome. El Gaamouch F, Lin HY, Wang […]<\/p>\n","protected":false},"author":294,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"full-width.php","meta":{"footnotes":""},"class_list":["post-25","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/wp-json\/wp\/v2\/pages\/25","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/wp-json\/wp\/v2\/users\/294"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/wp-json\/wp\/v2\/comments?post=25"}],"version-history":[{"count":10,"href":"https:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/wp-json\/wp\/v2\/pages\/25\/revisions"}],"predecessor-version":[{"id":111,"href":"https:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/wp-json\/wp\/v2\/pages\/25\/revisions\/111"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/jun-wang-lab\/wp-json\/wp\/v2\/media?parent=25"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}