{"id":5,"date":"2022-06-28T18:16:22","date_gmt":"2022-06-28T18:16:22","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/?page_id=5"},"modified":"2025-12-17T13:55:02","modified_gmt":"2025-12-17T13:55:02","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/","title":{"rendered":"Home"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Header” _builder_version=”4.16″ use_background_color_gradient=”on” background_color_gradient_stops=”#000000 0%|rgba(0,0,0,0.6) 100%” background_color_gradient_start=”#000000″ background_color_gradient_end=”rgba(0,0,0,0.6)” background_image=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/neuron2-2.png” parallax=”on” parallax_method=”off” width=”100%” max_width=”100%” min_height=”1000px” height=”1200px” max_height=”3000px” custom_margin=”-210px||-5px||false|false” custom_padding=”0vw||250vw||false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ width=”100%” max_width=”1400px” min_height=”661.8px” custom_margin=”-12px|auto|214px|auto||” custom_padding=”220px||68px|||” use_custom_width=”on” custom_width_px=”700px” global_colors_info=”{}” max_width__hover_enabled=”on|desktop” max_width__hover=”1400px”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”||||||||” header_font=”Playfair Display|700|||||||” header_font_size=”48px” header_line_height=”1.5em” header_3_font=”Rubik|500||on|||||” header_3_text_color=”rgba(12,113,195,0.86)” header_3_font_size=”14px” header_3_letter_spacing=”2px” header_3_line_height=”2em” text_orientation=”center” background_layout=”dark” custom_margin=”||17px|||” custom_padding=”3px|||||” header_font_size_tablet=”38px” header_font_size_phone=”28px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Welcome to<\/h3>\n

DAI LAB<\/h1>\n

[\/et_pb_text][et_pb_divider color=”rgba(12,113,195,0.71)” divider_weight=”4px” _builder_version=”4.16″ max_width=”140px” module_alignment=”center” height=”4px” global_colors_info=”{}”][\/et_pb_divider][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Montserrat||||||||” text_font_size=”63px” text_letter_spacing=”-1px” text_line_height=”1.1em” width=”100%” max_width=”100%” module_alignment=”center” custom_margin=”2px|-24px||-20px|false|false” custom_padding=”54px|0px|58px|0px||” global_colors_info=”{}”]<\/p>\n

SYNAPTOPATHY OF NEUROPSYCHIATRIC DISORDERS<\/strong><\/span><\/p>\n

[\/et_pb_text][et_pb_button button_url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIifX0=@” button_text=”JOIN US” button_alignment=”center” _builder_version=”4.16″ _dynamic_attributes=”button_url” custom_button=”on” button_text_size=”15px” button_text_color=”#ffffff” button_bg_color=”rgba(12,113,195,0.47)” button_border_color=”RGBA(0,0,0,0)” button_border_radius=”41px” button_letter_spacing=”2px” button_font=”Rubik|700||on|||||” button_use_icon=”off” background_layout=”dark” custom_padding=”19px|32px|19px|32px|true|true” button_text_shadow_style=”preset3″ button_text_shadow_horizontal_length=”-0.02em” button_text_shadow_color=”#000000″ box_shadow_style=”preset3″ box_shadow_color=”rgba(239,59,36,0.24)” button_letter_spacing_hover=”2px” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”on” button_letter_spacing__hover=”2px” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_button][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(38,38,38,0.84)” width=”100%” max_width=”2560px” max_height=”100px” custom_padding=”1px||101px|||” global_colors_info=”{}” height__hover_enabled=”on|desktop”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Playfair Display||||||||” text_font_size=”19px” header_font=”Playfair Display||||||||” header_text_align=”center” header_font_size=”33px” custom_padding=”0px|||||” header_text_shadow_style=”preset3″ header_text_shadow_blur_strength=”1em” header_text_shadow_color=”#FFFFFF” global_colors_info=”{}”]<\/p>\n

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RESEARCH<\/h1>\n

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THE ULTIMATE AIM OF OUR “SYNTHERAPY” LAB IS TO FIND SYNAPTIC THERAPY TO TREAT GENETIC FACTOR OR STRESS FACTOR INDUCED NEUROPSYCHIATRIC DISORDERS.\u00a0<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” max_width=”1400px” custom_padding=”67px||124px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/lab-goals.png” title_text=”lab goals” align=”center” _builder_version=”4.16″ _module_preset=”default” width=”80%” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” background_color=”#000000″ width=”100%” max_width=”2560px” custom_padding=”1px||41px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_text_color=”rgba(255,255,255,0.69)” text_font_size=”16px” text_line_height=”1.2em” width=”80%” module_alignment=”center” custom_padding=”6px|||||” global_colors_info=”{}”]<\/p>\n

TO ACHIEVE THIS, we combine cutting-edge experimental techniques, including RNA sequencing, CRISPR\/CAS9, Immunostaining, Electrophysiology, and Behaviroal test, using mouse models and human stem cell models to provide key insights into the interdependence between synapse function and behavior, and generate a comprehensive molecular understanding of both, the adaptive nature of healthy brain function as well as pathological forms of genetic mutation-induced and stress-induced neuropsychiatric disorders.<\/p>\n

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PEOPLE<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/IMG_6705.jpg” title_text=”IMG_6705″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”|62px||||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_line_height=”0.2em” header_3_font=”Arial||||||||” header_3_font_size=”23px” header_3_letter_spacing=”-0.5px” global_colors_info=”{}”]<\/p>\n

Jinye Dai, PhD<\/span><\/h3>\n

Assistant Professor<\/span><\/p>\n

Department of Pharmacological Sciences<\/span><\/p>\n

Department of\u00a0Neuroscience<\/span><\/p>\n

Member of the Friedman Brain Institute<\/span><\/p>\n

jinye.dai@mssm.edu<\/em><\/span><\/p>\n

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Dr. Dai received her PhD degree from the Institute of Biophysics, the Chinese Academy of Sciences where she studied the fundamental mechanisms of synaptic transmission with Prof. Jianyuan Sun. Then, Dr. Dai completed her postdoctoral study at Stanford University School of Medicine with Prof. Thomas S\u00fcdhof. Dr. Dai\u2019s research interest is directed at better understanding of basic molecular mechanisms of brain synaptic function and neuropsychiatric disorders.\u00a0<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2023\/01\/EP.jpg” title_text=”EP” _builder_version=”4.16″ _module_preset=”default” custom_padding=”|62px||||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_line_height=”0.2em” header_3_font=”Arial||||||||” header_3_font_size=”23px” header_3_letter_spacing=”-0.5px” custom_padding=”2px|||||” global_colors_info=”{}”]<\/p>\n

Eric Purisic<\/span><\/h3>\n

Research Associate<\/span><\/p>\n

eric.purisic@mssm.edu<\/em><\/p>\n

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I received my BS in Integrative Neuroscience with a concentration on Cell and Molecular Neuroscience from Fordham University in 2022. While an undergraduate, I began working in Dr. Marija Kundakovic\u2019s lab where I studied the effects of early-life stress on the expression of a set of X-linked genes escaping X-inactivation. Due to this work, I have become very interested in the effects of stress on the brain on a cellular and molecular level, especially in specific brain regions involved in stress-related pathology. As a result of these interests, I joined the Dai Lab at the beginning of 2023 as a research associate. My long-term goal is to pursue a PhD in Neuroscience and advance our understanding of the cellular and molecular mechanisms of stress response and their role in the development of neuropsychiatric disorders. My interests outside of the lab include reading, playing video games, cooking, watching reality TV, and listening to 50,000 minutes of Spotify a year.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2023\/02\/Josh-2.jpg” title_text=”Josh” _builder_version=”4.16″ _module_preset=”default” custom_padding=”|62px||||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_line_height=”0.2em” header_3_font=”Arial||||||||” header_3_font_size=”23px” header_3_letter_spacing=”-0.5px” custom_padding=”2px|||||” global_colors_info=”{}”]<\/p>\n

Joshua Stamos<\/span><\/h3>\n

Postdoctoral Fellow<\/span><\/p>\n

joshua.stamos@mssm.edu<\/em><\/p>\n

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Dr. Stamos received his Ph.D. from Rutgers University where he worked with Dr. Mark West. There he\u00a0 studied the effects of binge eating behavior on cue procession in Nucleus Accumbens using single unit recordings. Following this he worked as a postdoc for the VA Hospital in New Jersey with Dr. Kevin Beck. Dr. Stamos\u2019 current research interests involve understanding neurobiological mechanisms for how stress-induced behavioral changes affect neural connection on the synaptic level.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2023\/11\/Tianhua.jpg” title_text=”Tianhua” _builder_version=”4.16″ _module_preset=”default” custom_padding=”|62px||||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_line_height=”0.2em” header_3_font=”Arial||||||||” header_3_font_size=”23px” header_3_letter_spacing=”-0.5px” custom_padding=”3px|||||” global_colors_info=”{}”]<\/p>\n

Tianhua Wang<\/span><\/h3>\n

Visiting Graduate Student<\/span><\/p>\n

tianhua.wang@mssm.edu<\/em><\/p>\n

 <\/p>\n

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I received my master’s degree from East China Normal University under\u00a0<\/span>the supervision of Dr. Huimin Wang and Dr. Chunxia Li. I am<\/span>\u00a0a PhD candidate at Philipps-University Marburg with Dr.\u00a0<\/span>Markus W\u00f6hr. I am currently visiting Dr. Jinye Dai lab within a collaboration. My research focuses on the social affective communication\u00a0<\/span>in rodents and its serotonin implicated molecular mechanism. My research\u00a0<\/span>interest is to understand the molecular mechanisms of social behavior\u00a0<\/span>and the related psychiatric disorders like autism spectrum disorder. I\u00a0<\/span>have a very smart and sweet cat – Her name is Lucky and she does bring\u00a0<\/span>me luck.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”0px|||||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2023\/11\/fiona.jpg” title_text=”fiona” _builder_version=”4.16″ _module_preset=”default” custom_padding=”|62px||||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_line_height=”0.2em” header_3_font=”Arial||||||||” header_3_font_size=”23px” header_3_letter_spacing=”-0.5px” custom_padding=”5px|||||” global_colors_info=”{}”]<\/p>\n

Fiona Yeung<\/span><\/h3>\n

High School Student<\/span><\/p>\n

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Fiona is a current senior at John F. Kennedy High School, Bellmore. Since the summer of 2023, she has worked under the mentorship of Dr. Jinye Dai and Dr. Joshua Stamos, where she has been able to explore various experimental techniques to investigate neurodevelopmental disorders from stress-induced changes in brain regions. Looking ahead, Fiona hopes to continue pursuing her passion for research during college and learn more about neurobiology and cellular and molecular biology. Fiona enjoys baking sweets, playing the violin, and tending to her aquariums in her free time.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/Picture19.png” title_text=”Picture19″ url=”@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9saW5rX3VybF9wYWdlIiwic2V0dGluZ3MiOnsicG9zdF9pZCI6IjIifX0=@” url_new_window=”on” _builder_version=”4.16″ _dynamic_attributes=”url” _module_preset=”default” custom_margin=”|62px||||” custom_padding=”|0px||||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Testimonial” _builder_version=”4.16″ min_height=”2752.4px” custom_margin=”-1px|||||” custom_padding=”0px|0px|40px|0px|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” width=”100%” max_width=”2560px” min_height=”100px” max_height=”100px” custom_padding=”1px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” header_font=”Playfair Display||||||||” header_font_size=”32px” background_color=”rgba(38,38,38,0.63)” min_height=”103px” custom_margin=”-2px||-82px|||” custom_padding=”27px|||||” text_text_shadow_style=”preset3″ text_text_shadow_blur_strength=”1em” text_text_shadow_color=”#FFFFFF” global_colors_info=”{}”]<\/p>\n

PUBLICATIONS<\/span><\/h1>\n

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paper highlights, see also google scholar<\/span><\/a> and pubmed<\/span><\/a><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” max_width=”2560px” min_height=”515.6px” custom_padding=”||50px|||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/elife.png” title_text=”elife” _builder_version=”4.16″ _module_preset=”default” custom_padding=”|126px||0px|false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_4_letter_spacing=”-1px” module_alignment=”left” min_height=”55.8px” custom_margin=”-7px||10px|-100px|false|false” custom_padding=”|0px|0px|100px||” global_colors_info=”{}”]<\/p>\n

Dai J<\/span>, Liakath-Ali K, Golf SR, S\u00fcdhof TC. Distinct Neurexin-Cerebellin Complexes Control AMPA-and NMDA-Receptor Responses in a Circuit-Dependent Manner. elife, 2022 LINK<\/span><\/em><\/span><\/a><\/span><\/h4>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_font_size=”13px” text_line_height=”1.1em” module_alignment=”left” min_height=”287.6px” custom_margin=”|||-100px|false|false” custom_padding=”0px|0px||100px||” global_colors_info=”{}”]<\/p>\n

At CA1\u2192subiculum synapses, alternatively spliced neurexin-1 (Nrxn1SS4+) and neurexin-3 (Nrxn3SS4+) enhance NMDA-receptors and suppress AMPA-receptors, respectively, without affecting synapse formation. Nrxn1SS4+\u00a0and Nrxn3SS4+\u00a0act by binding to secreted cerebellin-2 (Cbln2) that in turn activates postsynaptic GluD1 receptors. Whether neurexin-Cbln2-GluD1 signaling has additional functions besides regulating NMDA- and AMPA-receptors, and whether such signaling performs similar roles at other synapses, however, remains unknown. Here, we demonstrate using constitutive Cbln2 deletions in mice that at CA1\u2192subiculum synapses, Cbln2 performs no additional developmental roles besides regulating AMPA- and NMDA-receptors. Moreover, low-level expression of functionally redundant Cbln1 did not compensate for a possible synapse-formation function of Cbln2 at CA1\u2192subiculum synapses. In exploring the generality of these findings, we examined the prefrontal cortex where Cbln2 was recently implicated in spinogenesis, and the cerebellum where Cbln1 is known to regulate parallel-fiber synapses. In the prefrontal cortex, Nrxn1SS4+-Cbln2 signaling selectively controlled NMDA-receptors without affecting spine or synapse numbers, whereas Nrxn3SS4+-Cbln2 signaling had no apparent role. In the cerebellum, conversely, Nrxn3SS4+-Cbln1 signaling regulated AMPA-receptors, whereas now Nrxn1SS4+-Cbln1 signaling had no manifest effect. Thus, Nrxn1SS4+- and Nrxn3SS4+-Cbln1\/2 signaling complexes differentially control NMDA- and AMPA-receptors in different synapses in diverse neural circuits without regulating synapse or spine formation.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” max_width=”1400px” custom_padding=”55px||50px|||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/cbln2-erica-paper-1.jpg” title_text=”cbln2 erica paper” _builder_version=”4.16″ _module_preset=”default” custom_padding=”|130px|||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_4_letter_spacing=”-1px” min_height=”62.8px” custom_margin=”-7px||10px|-100px|false|false” custom_padding=”||0px|100px||” global_colors_info=”{}”]<\/p>\n

Seigneur<\/a>\u00a0E, Wang J,\u00a0Dai J<\/span><\/span>,\u00a0Polepalli<\/a> J, S\u00fcdhof TC.<\/span>\u00a0Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. Molecular Psychiatry<\/span><\/span>, 2022 Jun;\u00a026(12)<\/b>,\u00a07509\u20137521. LINK<\/em><\/span><\/span><\/span><\/a><\/h4>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_font_size=”13px” text_line_height=”1.1em” min_height=”287.6px” custom_margin=”|||-2px|false|false” custom_padding=”0px|||0px||” global_colors_info=”{}”]<\/p>\n

Cerebellin-1 (Cbln1) and cerebellin-2 (Cbln2) are secreted glycoproteins that are expressed in distinct subsets of neurons throughout the brain. Cbln1 and Cbln2 simultaneously bind to presynaptic neurexins and postsynaptic GluD1 and GluD2, thereby forming\u00a0trans<\/i>-synaptic adhesion complexes. Genetic associations link cerebellins, neurexins and GluD\u2019s to neuropsychiatric disorders involving compulsive behaviors, such as Tourette syndrome, attention-deficit hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD). Extensive evidence implicates dysfunction of serotonergic signaling in these neuropsychiatric disorders. Here, we report that constitutive Cbln2 KO mice, but not Cbln1 KO mice, display robust compulsive behaviors, including stereotypic pattern running, marble burying, explosive jumping, and excessive nest building, and exhibit decreased brain serotonin levels. Strikingly, treatment of Cbln2 KO mice with the serotonin precursor 5-hydroxytryptophan or the serotonin reuptake-inhibitor fluoxetine alleviated compulsive behaviors. Conditional deletion of Cbln2 both from dorsal raphe neurons and from presynaptic neurons synapsing onto dorsal raphe neurons reproduced the compulsive behaviors of Cbln2 KO mice. Finally, injection of recombinant Cbln2 protein into the dorsal raphe of Cbln2 KO mice largely reversed their compulsive behaviors. Taken together, our results show that Cbln2 controls compulsive behaviors by regulating serotonergic circuits in the dorsal raphe.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” max_width=”1400px” custom_padding=”||50px|||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/nature.png” title_text=”nature” _builder_version=”4.16″ _module_preset=”default” custom_margin=”|-5px||||” custom_padding=”|130px|||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_4_letter_spacing=”-1px” custom_margin=”-7px||10px|-100px|false|false” custom_padding=”0px||0px|99px||” global_colors_info=”{}”]<\/p>\n

Dai J<\/span>, Patzke C<\/a>, Liakath-Ali K, Golf SR, S\u00fcdhof TC. GluD1 is a signal transduction device disguised as an ionotropic receptor. Nature,\u00a02021<\/span> Jul; 595(7866), 261-265. LINK<\/em><\/span><\/a><\/span><\/h4>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_font_size=”13px” text_line_height=”1.1em” min_height=”287.6px” custom_margin=”|||-7px|false|false” custom_padding=”0px|||6px||” global_colors_info=”{}”]<\/p>\n

Ionotropic glutamate delta receptors 1 (GluD1) and 2 (GluD2) exhibit the molecular architecture of postsynaptic ionotropic glutamate receptors, but assemble into trans-synaptic adhesion complexes by binding to secreted cerebellins that in turn interact with presynaptic neurexins<\/sup>. It is unclear whether neurexin\u2013cerebellin\u2013GluD1\/2 assemblies serve an adhesive synapse-formation function or mediate trans-synaptic signalling. Here we show in hippocampal synapses, that binding of presynaptic neurexin\u2013cerebellin complexes to postsynaptic GluD1 controls glutamate receptor activity without affecting synapse numbers. Specifically, neurexin-1\u2013cerebellin-2 and neurexin-3\u2013cerebellin-2 complexes differentially regulate NMDA (N<\/i>-methyl-D<\/span>-aspartate) receptors and AMPA (\u03b1-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors by activating distinct postsynaptic GluD1 effector signals. Of note, minimal GluD1 and GluD2 constructs containing only their N-terminal cerebellin-binding and C-terminal cytoplasmic domains, joined by an unrelated transmembrane region, fully control the levels of NMDA and AMPA receptors. The distinct signalling specificity of presynaptic neurexin-1 and neurexin-3\u00a0<\/sup>is encoded by their alternatively spliced splice site 4 sequences, whereas the regulatory functions of postsynaptic GluD1 are mediated by conserved cytoplasmic sequence motifs spanning 5\u201313 residues. Thus, GluDs are signalling molecules that regulate NMDA and AMPA receptors by an unexpected transduction mechanism that bypasses their ionotropic receptor architecture and directly converts extracellular neurexin\u2013cerebellin signals into postsynaptic receptor responses.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” max_width=”1400px” custom_padding=”53px||50px|||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/cell-paper.jpg” title_text=”cell paper” _builder_version=”4.16″ _module_preset=”default” custom_margin=”|-8px||||” custom_padding=”0px|130px|||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_4_letter_spacing=”-1px” min_height=”78.2px” custom_margin=”-7px||10px|-4px|false|false” custom_padding=”||0px|||” global_colors_info=”{}”]<\/p>\n

Patzke C,\u00a0<\/span><\/span><\/span><\/a>Brockmann MM,\u00a0<\/span><\/span><\/a><\/span><\/span>Dai J<\/span><\/span>,\u00a0<\/span><\/span><\/a><\/span>Gan KJ<\/span><\/span><\/a>,\u00a0<\/span>Grauel MK,\u00a0<\/span><\/span><\/a><\/span>Fenske P,\u00a0<\/span><\/span><\/a><\/span>Liu Y,\u00a0<\/span><\/span><\/a><\/span>Acuna C,\u00a0<\/span><\/span><\/a><\/span>Rosenmund C<\/span><\/span><\/a>, S\u00fcdhof TC.\u00a0Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell, 2019<\/span> Oct;\u00a0179 (2), 498-513. LINK<\/span><\/em><\/a><\/span><\/span><\/h4>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_font_size=”13px” text_line_height=”1.1em” min_height=”287.6px” custom_margin=”|||-100px|false|false” custom_padding=”0px|||100px||” global_colors_info=”{}”]<\/p>\n

Neuromodulators bind to pre- and postsynaptic G protein-coupled receptors (GPCRs), are able to quickly change intracellular\u00a0cyclic AMP<\/a>\u00a0(cAMP) and Ca2+<\/sup>\u00a0levels, and are thought to play important roles in neuropsychiatric and neurodegenerative diseases. Here, we discovered in human neurons an unanticipated\u00a0presynaptic mechanism<\/a>\u00a0that acutely changes synaptic ultrastructure and regulates synaptic communication. Activation of neuromodulator receptors bidirectionally controlled\u00a0synaptic vesicle<\/a>\u00a0numbers within nerve terminals. This control correlated with changes in the levels of cAMP-dependent protein kinase A-mediated phosphorylation of synapsin-1. Using a conditional deletion approach, we reveal that the neuromodulator-induced control of synaptic vesicle numbers was largely dependent on synapsin-1. We propose a mechanism whereby non-phosphorylated synapsin-1 \u201clatches\u201d synaptic vesicles to presynaptic clusters at the active zone. cAMP-dependent phosphorylation of synapsin-1 then removes the vesicles. cAMP-independent\u00a0dephosphorylation<\/a>\u00a0of synapsin-1 in turn recruits vesicles. Synapsin-1 thereby bidirectionally regulates synaptic vesicle numbers and modifies presynaptic\u00a0neurotransmitter release<\/a>\u00a0as an effector of neuromodulator signaling in human neurons.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” max_width=”1400px” custom_padding=”53px|||||” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/neuron-paper.jpg” title_text=”neuron paper” _builder_version=”4.16″ _module_preset=”default” custom_margin=”|-8px||||” custom_padding=”0px|130px|||false|false” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_4_letter_spacing=”-1px” min_height=”78.2px” custom_margin=”-7px||10px|-100px|false|false” custom_padding=”||0px|100px||” global_colors_info=”{}”]<\/p>\n

Dai J<\/span><\/span>,\u00a0<\/span><\/span><\/a><\/span>Aoto J<\/span><\/span><\/a>,\u00a0<\/span><\/span><\/a>S\u00fcdhof TC. Alternative splicing of presynaptic neurexins differentially controls postsynaptic NMDA and AMPA receptor responses<\/a>. Neuron, 2019<\/span> Jun; 102 (5), 993-1008<\/span>. LINK<\/em><\/span><\/a><\/span><\/span><\/h4>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” text_font_size=”13px” text_line_height=”1.1em” min_height=”287.6px” custom_margin=”|||-100px|false|false” custom_padding=”0px|||100px||” global_colors_info=”{}”]<\/p>\n

AMPA- and NMDA-type\u00a0glutamate receptors<\/a>\u00a0mediate distinct postsynaptic signals that differ characteristically among synapses. How postsynaptic AMPA- and NMDA-receptor levels are regulated, however, remains unclear. Using newly generated conditional knockin mice that enable genetic control of\u00a0neurexin<\/a>\u00a0alternative splicing, we show that in hippocampal synapses, alternative splicing of presynaptic neurexin-1 at splice site 4 (SS4) dramatically enhanced postsynaptic NMDA-receptor-mediated, but not AMPA-receptor-mediated, synaptic responses without altering synapse density. In contrast, alternative splicing of neurexin-3 at SS4 suppressed AMPA-receptor-mediated,\u00a0but not NMDA-receptor-mediated, synaptic responses, while alternative splicing of neurexin-2 at SS4 had no effect on NMDA- or AMPA-receptor-mediated responses. Presynaptic overexpression of the neurexin-1\u03b2 and neurexin-3\u03b2 SS4+ splice variants, but not of their SS4\u2212 splice variants, replicated the respective SS4+ knockin phenotypes. Thus, different neurexins perform distinct nonoverlapping functions at hippocampal synapses that are independently regulated by alternative splicing. These functions transsynaptically control\u00a0NMDA<\/a>\u00a0and\u00a0AMPA<\/a>\u00a0receptors, thereby mediating presynaptic control of postsynaptic responses.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_image=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/neuron-part2.png” parallax=”on” parallax_method=”off” custom_margin=”||-128px|||” custom_padding=”54px|0px|260px|0px|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(38,38,38,0.8)” width=”100%” max_width=”2560px” min_height=”100px” height=”100px” max_height=”100px” custom_margin=”-58px|auto|14px|auto||” custom_padding=”34px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” header_font=”Playfair Display||||||||” header_font_size=”32px” min_height=”65px” custom_margin=”-8px||||false|false” custom_padding=”0px||0px|||” text_text_shadow_style=”preset3″ text_text_shadow_blur_strength=”1em” text_text_shadow_color=”#FFFFFF” global_colors_info=”{}”]<\/p>\n

CURRENT OPENINGS<\/span><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ max_width=”1400px” min_height=”280px” custom_margin=”|auto|-5px|auto||” custom_padding=”51px|0px|51px|0px|true|false” border_radii=”off||||” border_color_all=”#FFFFFF” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Verdana||||||||” text_line_height=”2em” header_font=”||||||||” header_3_font=”Playfair Display|700|||||||” header_3_font_size=”23px” header_3_line_height=”1.3em” header_4_font=”Rubik|500||on|||||” header_4_text_color=”#098cf2″ header_4_font_size=”12px” header_4_letter_spacing=”2px” header_4_line_height=”2em” max_width=”500px” custom_padding=”0px||0px|||” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|phone” header_3_font_size_tablet=”24px” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

<\/h3>\n

Postdoctoral Fellow<\/span><\/h3>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”Arial|600|||||||” text_font_size=”17px” text_line_height=”1.2em” header_font=”||||||||” header_3_font=”Playfair Display|700|||||||” header_3_font_size=”32px” header_3_line_height=”1.5em” header_4_font=”Rubik|500||on|||||” header_4_text_color=”#098cf2″ header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”2em” width=”100%” max_width=”100%” module_alignment=”right” min_height=”100px” custom_margin=”|-188px|-1px|-93px|false|false” custom_padding=”22px|0px|||false|false” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

We seek a highly motivated scientist with strong organizational and communication skills to join our enthusiastic, collaborative, and creative team in an outstanding scientific environment. Please be sure to send your CV, research statement (a description of research experience and scientific interests), career goals, and the names and contact information of 3 references to Dr. Jinye Dai at jinye.dai@mssm.edu<\/a>. LINK for DETAILS<\/span><\/em><\/a><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ max_width=”1400px” min_height=”100px” custom_margin=”|auto|-5px|auto||” custom_padding=”0px|0px|0px|0px|true|false” border_radii=”off||||” border_color_all=”#FFFFFF” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_line_height=”2em” header_font=”||||||||” header_3_font=”Playfair Display|700|||||||” header_3_font_size=”23px” header_3_line_height=”1.3em” header_4_font=”Rubik|500||on|||||” header_4_text_color=”#098cf2″ header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”2em” max_width=”500px” custom_padding=”0px||0px|||” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|phone” header_3_font_size_tablet=”24px” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

<\/h4>\n

Research Assistant<\/span><\/h3>\n

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We also seek a highly motivated research assistant with strong organizational and communication skills to join our team. Please be sure to send your CV, research experience, career goals, and the names and contact information of 2 references to Dr. Jinye Dai at jinye.dai@mssm.edu<\/a>.<\/span> LINK for DETAILS<\/em><\/span><\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ max_width=”1400px” custom_margin=”-5px|auto|-5px|auto||” custom_padding=”0px|0px|0px|0px|true|false” border_radii=”off||||” border_color_all=”#FFFFFF” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.16″ text_font=”||||||||” text_line_height=”2em” header_font=”||||||||” header_3_font=”Playfair Display|700|||||||” header_3_font_size=”23px” header_3_line_height=”1.3em” header_4_font=”Rubik|500||on|||||” header_4_text_color=”#098cf2″ header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”2em” max_width=”500px” custom_margin=”|38px||||” custom_padding=”0px|48px|0px|||” text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|phone” header_3_font_size_tablet=”24px” header_3_font_size_phone=”18px” header_3_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}”]<\/p>\n

<\/h4>\n

Graduate Student & M.D.\/Ph.D. Students<\/span><\/h3>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”Arial|600|||||||” text_font_size=”17px” text_line_height=”1.2em” header_font=”||||||||” header_3_font=”Playfair Display|700|||||||” header_3_font_size=”32px” header_3_line_height=”1.5em” header_4_font=”Rubik|500||on|||||” header_4_text_color=”#098cf2″ header_4_font_size=”14px” header_4_letter_spacing=”2px” header_4_line_height=”2em” width=”100%” max_width=”100%” module_alignment=”right” min_height=”204.7px” custom_margin=”|-2px|-1px|-93px|false|false” custom_padding=”21px|0px|||false|false” hover_enabled=”0″ text_font_size_tablet=”” text_font_size_phone=”14px” text_font_size_last_edited=”on|phone” locked=”off” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Interested prospective graduate students and M.D.\/Ph.D. students should apply to the\u00a0<\/span>Graduate School at Mount Sinai<\/span>.<\/span> Students who are interested in rotation projects, please contact Dr. Jinye Dai at\u00a0<\/span><\/a>jinye.dai@mssm.edu for more information.<\/span><\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ background_enable_image=”off” parallax=”on” parallax_method=”off” custom_margin=”||-123px|||” custom_padding=”54px|0px|18px|0px|false|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(38,38,38,0.8)” width=”100%” max_width=”2560px” min_height=”100px” height=”100px” max_height=”100px” custom_margin=”-58px|auto|14px|auto||” custom_padding=”34px||0px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Arial||||||||” header_font=”Playfair Display||||||||” header_font_size=”32px” min_height=”65px” custom_margin=”-8px||17px||false|false” custom_padding=”0px||0px|||” text_text_shadow_style=”preset3″ text_text_shadow_blur_strength=”1em” text_text_shadow_color=”#FFFFFF” global_colors_info=”{}”]<\/p>\n

CONTACT US<\/span><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”3_5,2_5″ _builder_version=”4.16″ _module_preset=”default” max_width=”1400px” custom_padding=”86px||106px|||” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_video src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/Welcome-to-Mount-Sinai.mov” _builder_version=”4.16″ _module_preset=”default” custom_margin=”||-1px|||” global_colors_info=”{}”][\/et_pb_video][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Playfair Display||||||||” text_line_height=”1em” custom_margin=”10px|||||” text_text_shadow_style=”preset2″ global_colors_info=”{}”]<\/p>\n

Our Location: 1425 Madison Ave, New York, NY, 10029<\/p>\n

[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Playfair Display||||||||” text_line_height=”1em” custom_margin=”-25px||3px||false|false” custom_padding=”||0px|||” global_colors_info=”{}”]<\/p>\n

Please contact us with the response form or email at jinye.dai@mssm.edu<\/span>.<\/p>\n

[\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-content\/uploads\/sites\/444\/2022\/09\/Picture9-e1664399402376.png” title_text=”Picture9″ url=”https:\/\/twitter.com\/JinyeDaiLab” _builder_version=”4.16″ _module_preset=”default” width=”100%” custom_margin=”|36px||-11px|false|false” custom_padding=”|113px|0px|0px||” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” header_font=”Playfair Display|700|||||||” header_font_size=”32px” custom_margin=”-10px||||false|false” custom_padding=”0px|||||” global_colors_info=”{}”]<\/p>\n

We’d Love to Hear From You!<\/h1>\n

[\/et_pb_text][et_pb_contact_form captcha=”off” email=”jinye.dai@mssm.edu” _builder_version=”4.16″ _module_preset=”default” _unique_id=”0d5afcb9-eb25-4861-b90c-731edfc80e4f” form_field_background_color=”rgba(104,104,104,0.32)” form_field_text_color=”rgba(255,255,255,0.57)” form_field_focus_text_color=”#FFFFFF” title_text_color=”#919191″ captcha_text_color=”#e8e8e8″ form_field_font=”Arial||||||||” form_field_font_size=”14px” form_field_line_height=”1em” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”rgba(12,113,195,0.47)” button_border_width=”0px” button_border_radius=”43px” custom_margin=”-28px|||||” global_colors_info=”{}”][et_pb_contact_field field_id=”Name” field_title=”Name” _builder_version=”4.16″ background_color=”#000000″ background_enable_color=”on” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Email” field_title=”Email Address” field_type=”email” _builder_version=”4.16″ global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][et_pb_contact_field field_id=”Message” field_title=”Message” field_type=”text” fullwidth_field=”on” _builder_version=”4.16″ background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”][\/et_pb_contact_field][\/et_pb_contact_form][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Welcome to DAI LABSYNAPTOPATHY OF NEUROPSYCHIATRIC DISORDERS RESEARCHTHE ULTIMATE AIM OF OUR “SYNTHERAPY” LAB IS TO FIND SYNAPTIC THERAPY TO TREAT GENETIC FACTOR OR STRESS FACTOR INDUCED NEUROPSYCHIATRIC DISORDERS.\u00a0TO ACHIEVE THIS, we combine cutting-edge experimental techniques, including RNA sequencing, CRISPR\/CAS9, Immunostaining, Electrophysiology, and Behaviroal test, using mouse models and human stem cell models to provide […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-5","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-json\/wp\/v2\/pages\/5","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":365,"href":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":888,"href":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-json\/wp\/v2\/pages\/5\/revisions\/888"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinyedailab\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}