{"id":2167,"date":"2025-12-08T22:24:27","date_gmt":"2025-12-08T22:24:27","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/jinlab\/?page_id=2167"},"modified":"2025-12-12T16:06:53","modified_gmt":"2025-12-12T16:06:53","slug":"2025-publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/jinlab\/2025-publications\/","title":{"rendered":"2025 Publications"},"content":{"rendered":"<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/jian.jin.1\/bibliography\/public\/\"><strong>Jin Lab Full Publication List<\/strong><\/a><\/p>\n<p><a href=\"https:\/\/scholar.google.co.uk\/citations?user=-nb3tbYAAAAJ&amp;hl=en&amp;oi=ao\"><strong>Dr<\/strong>.<strong> Jin\u00a0Google Scholar Citations<\/strong><\/a><\/p>\n<p style=\"text-align: center\"><strong>2025<\/strong><\/p>\n<p><u>Xu, Z.<\/u>; <u>Pokushalov, D.<\/u>; Kabir, M.; Lee, Y.; Chattopadhyay, M.; Jenkins, E. C.; Choo, C.; Kaniskan, H. \u00dc.; Germain, D.*; <u>Jin, J.*<\/u>\u201cTargeting the Mitochondrial Protease ClpP for Anticancer Therapy\u201d. <strong>Journal of Medicinal Chemistry<\/strong>, 2025, 68(20):21377-21393. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41032690\/\">41032690<\/a>.<\/p>\n<p><u>Chen, L.<\/u>; <u>Deng, Z.<\/u>; <u>Xiong, Y.<\/u>; <u>Liu, J.<\/u>; Huang, D.; Wang, J.; Chen, Y.; Inuzuka, H.; Xie, L.; Chen, X.; Jin, J.*; Wei, W.* \u201cDeubiquitinase-Targeting Chimeras Mediated Stabilization of Tumor Suppressive E3 Ligase Proteins as a Strategy for Cancer Therapy\u201d. <strong>Journal of the American Chemical Society<\/strong>, 2025, 147(33):29875-29883. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40767969\/\">PMC12395470<\/a>.<\/p>\n<p><u>Hu, X.<\/u>; <u>Graciano, K.<\/u>; Hu, J.; Liu, C.; Zhang, J.; Xie, L.; Chen, X.; Xiong, Y.; Jin, J.*; Xu, J.* \u201cDiscovery of the first-in-class Aurora B kinase selective degrader\u201d <strong>European Journal of Medicinal Chemistry<\/strong>, 2025, 298: 118006. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40730065\/\">PMC12379206<\/a>.<\/p>\n<p class=\"p1\"><u>Hosseini, A.; Qiu, X.<\/u>; Xiong, Y.*; Chiang, K. H. N.; Catlett, J.; Kaltheuner, I.; Deng, Z.; Ghosh, S.; Shi, Y.*; Jin, J.* \u201cDiscovery of an LSD1 PROTAC Degrader\u201d, <strong> Proceedings of the National Academy Sciences of the United States of America (PNAS)<\/strong>, 2025, 122(20):e2425812122. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40366693\/\">PMC12107161<\/a>.<\/p>\n<p class=\"p1\"><u>Qian, C.; Wang, Z.; Xiong, Y.; Zhang, D.; Zhong, Y.;<\/u>Inuzuka, H.; Qi, Y.; Xie, L.; Chen, X.; Wei, W.* ; Jin, J.* , \u201cHarnessing the Deubiquitinase\u00a0USP1\u00a0for Targeted Protein Stabilization\u201d. <strong> Journal of the American Chemical Society ,<\/strong> 2025, 147(17):14564-14573. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40252079\/\">PMC12077936<\/a>.<\/p>\n<p class=\"p1\"><u>Zhong, Y.<\/u>; Kim, H. S.; Qian, C.; Xie, L.; Chen, X.; Xiong, Y.; Hu, J.; Chen, M.; Guccione, E.; Shen, Y.*; Jin, J.* , \u201cDiscovery of A Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader\u201d. <strong>Journal of Medicinal Chemistry,<\/strong> 2025, 68(8): 8543\u20138563. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40232306\/\">PMC12080994<\/a>.<\/p>\n<p class=\"p1\">Deng, Z.; Catlett, J.; Lee, Y.; Wu, Q.; Xu, Z.; Xie, L.; Chen, X.; Xiong, Y.; Kaniskan, H. U.*; Jin, J.*; \u201cHarnessing the SPOP E3 Ubiquitin Ligase via Bridged Proteolysis Targeting Chimera (PROTAC) Strategy for Targeted Protein Degradation\u201d, <strong> Journal of Medicinal Chemistry<\/strong>, 2025, 68(8):8634-8647. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40202531\/\">PMC12043353.<\/a><\/p>\n<ul id=\"full-view-identifiers\" class=\"identifiers\"><\/ul>\n<p class=\"p1\"><u>Yim, H.; Sun, R.; Xu, Z.<\/u>; Kim, H. S.; Kim, M.; Cao, T.; Xie, L.; Chen, X.; Kaniskan, H. U.*; Jin, J.*; \u201cDiscovery of the First-in-class DOT1L PROTAC Degrader\u201d <strong> European Journal of Medicinal Chemistry <\/strong>, 2025, 291:117595. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40186895\/\">PMC12045715<\/a>.<\/p>\n<p class=\"p1\"><u>Qian,C.; Lee,Y.; Han,Y.; Zhong,Y.<\/u>; Zhou,J.; Hrit, J.; Xie,L.; Chen, Q.; Kaniskan, H. U.; Chen, X.; Rothbart, S.; Cheng, X.; Xiong, Y.*; Jin, J.* , \u201cStructure-activity Relationship Studies of DNA Methyltransferase 1 (DNMT1) Monovalent Degraders\u201d. <strong> Journal of Medicinal Chemistry<\/strong>, 2025, 68(3):2903\u20132919. \u00a0PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39905966\/\">PMC11932022<\/a>.<\/p>\n<p class=\"p1\"><span style=\"color: #333300\"><u>Deng, Z; Chen, L; Qian, C; Liu,J; Wu,Q; Song,X; Xiong,Y.<\/u>; Wang, Z; Hu, X; Inuzuka, H; Zhong, Y; Lin; Y; Pham, N.D.; Shi,Y; Wei ;W.*;\u00a0Jin,J.* <em><strong>Angewandte Chemie International Edition<\/strong>,<\/em> \u201cThe First-in-class Deubiquitinase-targeting Chimera Stabilizes and Activates cGAS.&#8221;,2025, 64(3):e202415168. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39150898\/\">PMC11738674<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39150898\">.<\/a><\/span><\/p>\n<p class=\"p1\"><span style=\"color: #333300\"> <u> Kabir. M.; Hu, X.<\/u> Martin, T. C.; Pokushalov, D.; Kim, Y. J.; Chen, Y.; Zhong, Y.;\u00a0Wu, Q; Chipuk, J. Y.; Shi, Y; Xiong, Y.; Gu, W.; Parsons, R. E.;\u00a0and\u00a0Jin, J.* , \u201cHarnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53\u201d, <strong>Advanced Science<\/strong>, 2025, 12(7):e2413377.<\/span>\u00a0PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39716936\">PMC11831463<\/a>.<\/p>\n<p class=\"p1\"><u>Wang, Z.; Qian, C.; Xiong, Y.; Zhang, D.<\/u>; Inuzuka, H.; Zhong, Y.; Xie, L.; Chen, X.; Jin, J.*; Wei, W.*, \u201cUSP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment&#8221;, <strong> Journal of the American Chemical Society<\/strong>,2025, 147(16):13754\u201313763. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40214647\/\">PMC12105324<\/a>.<\/p>\n<p class=\"p1\">Zhu, Z.; Chen, H.; Qiu, X.; Kaniskan, H. \u00dc.; Xie, L.; Chen, X.; Jin, J.*; Liu, P.* &#8220;(GGAA)3-based TF-PROTACs enable targeted degradation of ETV6 to inhibit Ewing sarcoma growth&#8221;, <strong>Journal of the American Chemical Society<\/strong>, 2025, 147(16):13396\u201313404. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40215343\/\">40215343<\/a>.<\/p>\n<p class=\"p1\"><u> Teichman , E. M.; Hu , J.;<\/u> in, H.; Fisher, R. F.; Blando, A.; Hu, X.; Kaniskan , H. U; Montgomery, S. E.; Cai, M.; Parise, L.; Wang, J.; Russo, S.; Han, M.*; Jin , J.*; Morel, C.* , \u201cDesign and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype\u201d. <strong> Molecular Psychiatry, <\/strong>2025, 30(9):3937-3950.PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40199995\/\">PMC12339378<\/a>.<\/p>\n<p><u>Xie, L<\/u>; <u>Sheehy, RN<\/u>; <u>Muneer, A<\/u>; <u>Xiong, Y<\/u>; Wrobel, JA; Zhang, F; Park, KS; Velez, J; Liu, J; Luo, YJ; Asrican, B; Dong, P; Li, YD; Damian, C; Quintanilla, L; Li, Y; Xu, C; Deshmukh, M; Coleman, LG Jr; Ming, GL; Song, H; Wen, Z; Jin, J*; Song, J*; Chen, X*. \u201cDevelopment of a brain-penetrant G9a methylase inhibitor to target Alzheimer&#8217;s disease-associated proteopathology\u201d. <strong>Nature Communication<\/strong>, \u00a02025. 16(1):4222. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40328756\/\">PMC12056044<\/a>.<\/p>\n<p class=\"p1\">Yu, Y.; Yu, X.; Pan, B.; Chan, H. M.; Kaniskan, H. \u00dc.; Jin, J.; Cai, L.*; Wang, G. G.*, \u201cPharmacologic degradation of WDR5 suppresses oncogenic activities of SS18::SSX and provides a therapeutic of synovial sarcoma\u201d. <strong>Science Advances <\/strong>, 2025, 11:eads7876. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40267190\/\">PMC12017321<\/a>.<\/p>\n<p>Nelson, T.; Kemper, R.; Chiarella, A.; Gonzalez, T. S.; Carroll, M.; Tripathi, S.; Clarke, B.; Yu, X.; Hu, X.; Cooke, A.; Chirumamilla, B.; Chandler, A.; McGilvary, E.; Pattenden, S.; <u>Jin, J.<\/u>; Crona, D.*; Hathaway, N.* \u201cA first-in-class chemical-induced proximity system achieves dose-dependent control of Tumor Protein 53 (TP53) gene activation in preclinical models of gastric cancer\u201d, <strong>ACS Pharmacology &amp; Translational Science<\/strong>, 2025, 8(10):3585-3599. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41098562\/\">PMC12519258<\/a>.<\/p>\n<p>Dutta, R. P.; Lee, H. H.; Leshchenko, V. V.; Shukla, R. P.; Yan, F.; Liu, Y.; Kaniskan, H. \u00dc.; Qiu, X.; <u>Jin, J.<\/u>; Alinari, L.; Wang, M.; Parekh, S.* \u201cSOX11 Modulates BCR Signaling Through the PAX5\/CD19 Axis for Therapeutic Targeting in BTK Resistant Mantle Cell Lymphoma\u201d, <strong>Blood Advances<\/strong>, 2025, doi: 10.1182\/bloodadvances.2025016801. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40845256\/\">40845256<\/a>.<\/p>\n<p>Wang, SE; Cheng, Y; Lim, J; Jang, MA; Forrest, EN; Kim, Y; Donahue, M; Jo, S; Qiao, SN; Lee, DE; Hong, JY; Xiong, Y; Jin, J; Wang, S; Jiang, YH. \u201cMechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome\u201d. <strong>Nature Communication<\/strong>,\u00a02025, 16(1):6125. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40610428\/\">PMC12229668<\/a>.<\/p>\n<p>Tiedje, V.; Greenberg, J.; Qin, T.; Im, S. Y.; Krishnamoorthy, G. P.; Boucai, L.; Xu, B.; French, J. D.; Sherman, E. J.; Ho, A. L.; de Stanchina, E.; Socci, N. D.; <u>Jin, J.<\/u>; Ghossein, R. A.; Knauf, J. A.; Koche, R. P.; Fagin, J. A.*\u00a0\u201cLoss of tumor cell MHC class II drives MAPK inhibitor insensitivity of BRAF-mutant anaplastic thyroid cancers\u201d <strong>The Journal of Clinical Investigation<\/strong>, 2025, 135(20): e191781.\u00a0 PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40828595\/\">PMC12520682<\/a>.<\/p>\n<p>Atienza P\u00e1rraga, A.; Nylund, P.; Diamanti, K.; Garrido-Zabala, B.; Tziola, S. I.; Vasquez, L.; Pyl, P. T.; Raykova, D.; Skaftason, A.; Ma, A.; Jin, J.; Mart\u00edn-Subero, J. I.; \u00d6berg, F.; De Bruyne, E.; Komorowski, J.; Jernberg Wiklund, H.*; Kalushkova, A.* \u201cCombinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation\u201d <strong>Scientific Reports<\/strong>, 2025, 15(1):31568. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40866476\/\">PMC12391466<\/a>.<\/p>\n<p>Haspula, D.; Cui, Z.; Pittala, S.; Cui, Y.; Lu, H.; Xiong, Y.; Jin, J.; Gavrilova, O.; Hwang, E.; Ajwani, J.; Portillo, B.; Williams, K. W.; Inoue, A.; Weiss, J.* \u201cG proteins of the G12 family expressed by POMC neurons regulate key metabolic functions\u201d <strong>Science Advances<\/strong>, 2025, 11(28):eadu1670. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40644553\/\">PMC12248387<\/a>.<\/p>\n<p class=\"p1\"><span style=\"color: #333300\"> <u> Martinez, Criseyda; Xiong, Yan;<\/u> Bartkowski, Alison; Harada, Ibuki; Ren, Xiaoxiao; Byerly, Jessica; Port, Elisa; Jian\u00a0Jin*; Irie, Hanna*. \u201cA PROTAC degrader suppresses oncogenic functions of PTK6 inducing apoptosis of breast cancer cells\u201d, <strong>Cell Chemical Biology<\/strong>, 2025, 32(2):255-266.E8. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39541980\/\">PMC11845306.<\/a><\/span><\/p>\n<p class=\"p1\"><span style=\"color: #333300\"> Gumpper, R. H.*; Jain, M. K.; Kim, K.; Sun, R.; Sun, N.; Xu, Z.; DiBerto, J. F.; Krumm, B. E.; Kapolka, N. J.; <\/span>Kaniskan, H. U.; Nichols, D. E.; Jin, J.; Fay, J. F.; Roth, B. L.* &#8220;The Structural Diversity of Psychedelic Drug Actions Revealed&#8221;<strong>, Nature Communications<\/strong>, 2025, 16:2734. PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40108183\/\">40108183.<\/a><\/p>\n<p class=\"p1\">H, Su; Sun, Y; Han, G; Chen, S; Liu, S; Gao, A; Zhao, R; Glen, R; Jin, J; Qu, C; Yu, M; Klug, C.; K., A.; Zheng, G., Y.; Ballinger, S.; Kutny, M.; Chen, Y.; Luo, M*; Zhao, X.*, \u201cPRMT1-Mediated Metabolic Reprogramming Promotes Leukemogenesis\u201d. <strong> eLife<\/strong>,\u00a0 2025, 14: RP105318. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40801789\/\">PMC12349897.<\/a><\/p>\n<p class=\"p1\">Bauer, L.G., Ward, J.A., D\u00edaz-S\u00e1ez, L., Sundstr\u00f6m, Y., Tolvanen, T., Barrera, J. C. A., Kostidis, S., Rogers, C.M., Panagakou, I., Singh, U., Rothweiler, E.M., Gonzalez, Orta A, Kaniskan, H. \u00dc., Hu, J., Jin, J., Sievers, S., Waldmann, H., Giera, M., Sundstr\u00f6m, M., Berg, L., Huber, K., \u201cPhenomics-based Discovery of Novel Orthosteric Choline Kinase Inhibitors\u201d. <strong>Angewandte Chemie International Edition<\/strong>, 2025, 64(7):e202420149. PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39740997\/\">39740997<\/a><\/p>\n<p class=\"\u201cp1\u201d\">Tian, Y.; Bhattacharya, R.; Yoo, S.; Jiang, F.; Park, E.; Laragranados, G.; Shen, Y.; Park, K.-S.; Kaniskan, H. U,; Jin, J.; Hopkins, B.; Zhu, J.; Watanabe, H.*. \u201cEpigenomic Analysis Identifies DTP Subpopulation Using HOPX to Develop Targeted Therapy Resistance in Lung Adenocarcinoma \u201d, <strong>iScience <\/strong>, 2025, 28(5):112387. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40352726\/\">PMC12063144.<\/a><\/p>\n<p class=\"p1\">Muneer, A.; Xie, L.; Xie, X.; Zhang, F.; Wrobel, J. A.; Xiong, Y.; Yu, X.; Wang. C.; Gheorghe, C.; Wu, P.; Song, J.; Ming, G. L.; Jin, J.; Song, H.; Shi, P. Y.; Chen, X.* \u201cTargeting G9a-m6A translational mechanism of SARS-CoV-2 pathogenesis for multifaceted therapeutics of COVID-19 and its sequalae\u201d , <strong> iScience<\/strong>, 2025, 28(6):112632. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40510117\/\">PMC12159498.<\/a><\/p>\n<p>Yum, C.; Schaefer, R.; Wang, R.; Wang, T.; Lu, X.; Liu, Q.; Ren, Y.; Meng, Q.; Yang, Y.; Zhang, X.; Xiong, Y.; Yu, X.; Zhang, X.; Jin, J.; Dong, X.; Yi, Y.; Yang, R.; Cao, Q.* &#8220;Ketone drink enhances therapeutic efficacy in prostate cancer by targeting EZH2&#8221;, <strong>Oncogenesis<\/strong>, 2025, 14(1):24. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40651983\/\">PMC12255682<\/a>.<\/p>\n<p>Zhu, S.; Gao, H.; Jiang, D.; Guo, G.; Hou, J.; Han, Y.; Zhang, C.; Hu, X.; Indulkar, S.; Kloeber, J. A.; Hu, Q.; Jiang, Y.; Zeng, X.; Ouyang, Y.; Lu, J.; Yin, P.; Luo, K.; Huang, J.; Wu, Z.; Chen, B.; Xiao, H.; Dragojevic, S.; Qin, H.; Zhou, X.; <u>Jin, J.<\/u>; Tu, X.; Wang, L.; Luo, Z.* \u201cIsoform-Specific Function of NSD3 in DNA Replication Stress Confers Resistance to PARP Inhibitors in Prostate Cancer\u201d, <strong>Molecular Cell<\/strong>, 2025, 85(14):2673-2687.e8. PMCID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40578344\/\">PMC12276998<\/a>.<\/p>\n<p>Zwergel, C.; Lambona, C.; Fioravanti, R.; Raucci, A.; Fiorentino, F.; Nchugoua Tchieh, G.; Jallet, C.;Lacroix, L.; Pierrettori, M.; Pellegrini, F. R.; Xiong, Y.; Jin, J.; Arimondo, P.; Trisciuoglio, D.; Mai,A.*; Valente, S.* &#8220;Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties&#8221;, <strong>Journal of Medicinal Chemistry <\/strong>, 2025, 68, 23886-23909. PMCID: <a href=\"\/\/pubmed.ncbi.nlm.nih.gov\/40578344\/PMC12670401\u201d\"> PMC12670401<\/a><\/p>\n<p class=\"p1\"><span style=\"color: #333300\"> Chen, L.; Bu, X.; Sun, Y.; Huang, D.; Chen, Y.; Hou, T.; Hu, X.; Wang, J.; Yan, P.; Qi, Y.; Jiang, W.;Xiong, Y.; Liu, J.; Gao, Y.; Huan, M.; Wang, B.; Liu, Q.; Dai, X.; Dang, F.; Asara, J. M.; Fujimoto,M.; Inuzuka, H.; Jin, J.; Zhang, J.*; Freeman, G. J.*; Wei, W.* \u201cTargeted destruction of VISTA boosts anti-tumor immunotherapy\u201d, <strong>Cell Research<\/strong>, 2025, DOI:<br \/>\n<a href=\"https:\/\/doi.org\/10.1038\/s41422-025-01194-5\"> https:\/\/doi.org\/doi:10.1038\/s41422-025-01194-5<\/a><\/p>\n<p>Vogt, K. C.; Panagiotakopoulou, M.; Manzari Honu, M. T.; Perea, A. M.; Hu, X.; Yu, X.; Raziuddin, R.;LaPlant, Q.; Ruiz, S.; Raju, G. P.; Jin, J.; Scheinberg, D. A.; Heller, D. A.* \u201cTumor microenvironment-targeted PROTAC nanoparticle self-assembly broadly predicted by structural descriptors\u201d <strong>Science Advances<\/strong>, 2025, 11(49):eadu2292.<\/p>\n<p>Yi, Y.; Fry, J.; Yum, C.; Wang, R.; Wu, S.; Narayan, S.; Liu, Q.; Zhang, X.; Oo, H. Z.; Xie, N.; Li, Y.;Gao, X.; Yu, X.; Hu, X.; Li, Q.; Keseroglu, K.; \u00d6zbudak, E. M.; Abdulkadir, S. A.; Chen, K.; Jin, J.; Zhao, J. C.; Dong, X.; Arango, D.; Yang, R.; Cao, Q.* &#8220;EZH2 crosstalk with RNA methylation promotes prostate cancer progression through modulation of the m6A autoregulation pathway&#8221; <strong>Journal of Clinical Investigation <\/strong>, 2025, Nov 18:e195840. doi: 10.1172\/JCI195840.<\/p>\n<p>Liu, Z.; et al, Jin, J.; et al, Veschi, V.* \u201cSGSS05-NS3 as a potent and selective SETD8 inhibitor that activates p53 pathway in Neuroblastoma\u201d <strong>Journal of Experimental &amp; Clinical Cancer Research<\/strong>, in press.<\/p>\n<p style=\"text-align: center\"><strong>For papers published before 2025, please see Dr. Jin&#8217;s full publication list <\/strong><\/p>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/2025-publications\/\"> Jin Lab by year Tabs <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Jin Lab Full Publication List Dr. Jin\u00a0Google Scholar Citations 2025 Xu, Z.; Pokushalov, D.; Kabir, M.; Lee, Y.; Chattopadhyay, M.; Jenkins, E. C.; Choo, C.; Kaniskan, H. \u00dc.; Germain, D.*; Jin, J.*\u201cTargeting the Mitochondrial Protease ClpP for Anticancer Therapy\u201d. Journal of Medicinal Chemistry, 2025, 68(20):21377-21393. PMID: 41032690. Chen, L.; Deng, Z.; Xiong, Y.; Liu, J.; [&hellip;]<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2167","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/2167","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/comments?post=2167"}],"version-history":[{"count":15,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/2167\/revisions"}],"predecessor-version":[{"id":2353,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/2167\/revisions\/2353"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/media?parent=2167"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}