{"id":1054,"date":"2021-01-26T14:58:41","date_gmt":"2021-01-26T14:58:41","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/jinlab\/?page_id=1054"},"modified":"2021-01-26T15:01:45","modified_gmt":"2021-01-26T15:01:45","slug":"protacs","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/jinlab\/protacs\/","title":{"rendered":"PROTACs"},"content":{"rendered":"<h3><span style=\"color: #ff6600\"><strong>Our Novel Degraders Targeting Oncogenic Proteins:<\/strong><\/span><\/h3>\n<p><strong>MS4077 &amp; MS4078<\/strong>: ALK degrader (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=29627725\">PMID:\u00a029627725<\/a>)<\/p>\n<p><strong>MS432<\/strong>: MEK1\/2 degrader (<a href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.jmedchem.9b01528\">PMID:31730343<\/a>)<\/p>\n<p><strong>MS1943<\/strong>: EZH2 degrader (<a href=\"https:\/\/www.nature.com\/articles\/s41589-019-0421-4\">PMID:31819273<\/a>)<\/p>\n<p><strong>MS39:<\/strong> EGFR degrader (PMID: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.9b01566\">31895569<\/a>)<\/p>\n<p><strong>MS154:<\/strong> EGFR degrader (PMID: <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.9b01566\">31895569<\/a>)<\/p>\n<p><strong>Opto-pomalidomide:<\/strong> light-induced pomalidomide (PMID:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32128407\">32128407<\/a>)<\/p>\n<p><strong>Opto-dBET1:<\/strong>\u00a0light-induced BET degrader (PMID:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32128407\">32128407<\/a>)<\/p>\n<p><strong>Opto-dALK:<\/strong>\u00a0light-induced ALK degrader (PMID:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32128407\">32128407<\/a>)<\/p>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Combined_C.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-941 alignnone\" src=\"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Combined_C-534x1024.jpg\" alt=\"\" width=\"534\" height=\"1024\" srcset=\"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Combined_C-534x1024.jpg 534w, https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Combined_C-157x300.jpg 157w, https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Combined_C-768x1472.jpg 768w, https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Combined_C.jpg 1709w\" sizes=\"auto, (max-width: 534px) 100vw, 534px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our Novel Degraders Targeting Oncogenic Proteins: MS4077 &amp; MS4078: ALK degrader (PMID:\u00a029627725) MS432: MEK1\/2 degrader (PMID:31730343) MS1943: EZH2 degrader (PMID:31819273) MS39: EGFR degrader (PMID: 31895569) MS154: EGFR degrader (PMID: 31895569) Opto-pomalidomide: light-induced pomalidomide (PMID:\u00a032128407) Opto-dBET1:\u00a0light-induced BET degrader (PMID:\u00a032128407) Opto-dALK:\u00a0light-induced ALK degrader (PMID:\u00a032128407)<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1054","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1054","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/comments?post=1054"}],"version-history":[{"count":2,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1054\/revisions"}],"predecessor-version":[{"id":1061,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1054\/revisions\/1061"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/media?parent=1054"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}