{"id":1052,"date":"2021-01-26T14:58:27","date_gmt":"2021-01-26T14:58:27","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/jinlab\/?page_id=1052"},"modified":"2024-05-08T20:34:05","modified_gmt":"2024-05-08T20:34:05","slug":"gpcr-ligands","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/jinlab\/gpcr-ligands\/","title":{"rendered":"GPCR ligands"},"content":{"rendered":"<h3><strong><span style=\"color: #ff6600\">Our\u00a0Biased Ligands for G Protein-coupled Receptors:<\/span><\/strong><\/h3>\n<p><strong>UNC9994<\/strong>:\u00a0\u00df-Arrestin biased D<sub>2<\/sub>R ligand (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Discovery+of+Beta-Arrestin-Biased+Dopamine+D2+Ligands+for+Probing+Signal+Transduction+Pathways+Essential+for+Antipsychotic+Efficacy\">PMID:\u00a022025698<\/a>\u00a0&amp; <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27911814\">PMID:\u00a027911814<\/a>)<\/p>\n<p><strong>UNC9975<\/strong>:\u00a0\u00df-Arrestin biased D<sub>2<\/sub>R ligand (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=Discovery+of+Beta-Arrestin-Biased+Dopamine+D2+Ligands+for+Probing+Signal+Transduction+Pathways+Essential+for+Antipsychotic+Efficacy\">PMID:\u00a022025698<\/a>\u00a0&amp; <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26129680\">PMID: 26129680<\/a>)<\/p>\n<p><strong>MS1768<\/strong> (Compound 38):\u00a0G-protein biased D<sub>2<\/sub>R partial agonist (<a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.9b00508\">PMID:30964661<\/a>)<\/p>\n<p><strong>Compound 21<\/strong>:\u00a0Selective agonist at excitatory (hM3D<sub>q<\/sub>) &amp; inhibitory (hM4D<sub>i<\/sub>) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=25587888\">PMID: 25587888<\/a>\u00a0&amp; <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.8b00012\">PMID:30868140<\/a>)<\/p>\n<p><strong>Compound 10<\/strong>:\u00a0Non-catechol D<sub>1<\/sub>R full agonist (<a href=\"https:\/\/doi.org\/10.1021\/acschemneuro.9b00410\">PMID: 31387346<\/a>)<\/p>\n<p><strong>Compound 71<\/strong>:\u00a0Selective GPR68 PAM (<a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.9b00869\">PMID: 31298539<\/a>)<\/p>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Our-GPCR-Ligands_04212020_C.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-933 alignnone\" src=\"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Our-GPCR-Ligands_04212020_C-959x1024.jpg\" alt=\"\" width=\"542\" height=\"579\" srcset=\"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Our-GPCR-Ligands_04212020_C-959x1024.jpg 959w, https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Our-GPCR-Ligands_04212020_C-281x300.jpg 281w, https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Our-GPCR-Ligands_04212020_C-768x820.jpg 768w, https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2020\/04\/Our-GPCR-Ligands_04212020_C.jpg 1318w\" sizes=\"auto, (max-width: 542px) 100vw, 542px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our\u00a0Biased Ligands for G Protein-coupled Receptors: UNC9994:\u00a0\u00df-Arrestin biased D2R ligand (PMID:\u00a022025698\u00a0&amp; PMID:\u00a027911814) UNC9975:\u00a0\u00df-Arrestin biased D2R ligand (PMID:\u00a022025698\u00a0&amp; PMID: 26129680) MS1768 (Compound 38):\u00a0G-protein biased D2R partial agonist (PMID:30964661) Compound 21:\u00a0Selective agonist at excitatory (hM3Dq) &amp; inhibitory (hM4Di) (PMID: 25587888\u00a0&amp; PMID:30868140) Compound 10:\u00a0Non-catechol D1R full agonist (PMID: 31387346) Compound 71:\u00a0Selective GPR68 PAM (PMID: 31298539)<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1052","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1052","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/comments?post=1052"}],"version-history":[{"count":3,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1052\/revisions"}],"predecessor-version":[{"id":1488,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1052\/revisions\/1488"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/media?parent=1052"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}