{"id":1048,"date":"2021-01-26T14:56:41","date_gmt":"2021-01-26T14:56:41","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/jinlab\/?page_id=1048"},"modified":"2024-09-10T15:35:28","modified_gmt":"2024-09-10T15:35:28","slug":"inhibitors","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/jinlab\/inhibitors\/","title":{"rendered":"HMT Inhibitors"},"content":{"rendered":"<h3><span style=\"color: #ff6600\"><strong>Our\u00a0Selective Inhibitors for Histone Methyltransferases:<\/strong><\/span><\/h3>\n<p><strong>UNC0638<\/strong>: G9a\/GLP (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=A+Chemical+Probe+Selectively+Inhibits+G9a+and+GLP+Methyltransferase+Activity+in+Cells\">PMID:\u00a021743462<\/a>)<\/p>\n<p><strong>UNC0642<\/strong>: G9a\/GLP (in vivo probe) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24102134\">PMID:\u00a024102134<\/a>)<\/p>\n<p><strong>MS012<\/strong>: GLP (Glucagon-like peptide ) (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28662962\">PMID:\u00a028662962<\/a>)<\/p>\n<p><strong>UNC1999<\/strong>: EZH2\/EZH1 (Orally bioavailable) (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23614352\">PMID:\u00a023614352<\/a>)<\/p>\n<p><strong>MS2177 (UNC0379) &amp;\u00a0MS453 (Covalent inhibitor):<\/strong>\u00a0SETD8 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=27804297\">PMID:\u00a027804297<\/a>)<\/p>\n<p><strong>SGC707<\/strong>: PRMT3 (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25728001\">PMID:\u00a025728001<\/a>)<\/p>\n<p><strong>MS023<\/strong>: Type I PRMTs (<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26598975\">PMID: 26598975<\/a>)<\/p>\n<p><strong>MS049<\/strong>: Dual CARM1 and PRMT6 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=27584694\">PMID: <\/a><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27584694\">27584694<\/a>)<\/p>\n<p><strong>HUK1-121<\/strong>: CARM1 (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=28042453\">PMID: <\/a><span class=\"highlight\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=28042453\">28042453<\/a><\/span>)<\/p>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2017\/03\/JinLabInhibitors_v2.1-01.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-large wp-image-510 alignnone\" src=\"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2017\/03\/JinLabInhibitors_v2.1-01-571x1024.png\" alt=\"\" width=\"571\" height=\"1024\" srcset=\"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2017\/03\/JinLabInhibitors_v2.1-01-571x1024.png 571w, https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-content\/uploads\/sites\/64\/2017\/03\/JinLabInhibitors_v2.1-01-167x300.png 167w\" sizes=\"auto, (max-width: 571px) 100vw, 571px\" \/><\/a><\/p>\n<h3><\/h3>\n","protected":false},"excerpt":{"rendered":"<p>Our\u00a0Selective Inhibitors for Histone Methyltransferases: UNC0638: G9a\/GLP (PMID:\u00a021743462) UNC0642: G9a\/GLP (in vivo probe) (PMID:\u00a024102134) MS012: GLP (Glucagon-like peptide ) (PMID:\u00a028662962) UNC1999: EZH2\/EZH1 (Orally bioavailable) (PMID:\u00a023614352) MS2177 (UNC0379) &amp;\u00a0MS453 (Covalent inhibitor):\u00a0SETD8 (PMID:\u00a027804297) SGC707: PRMT3 (PMID:\u00a025728001) MS023: Type I PRMTs (PMID: 26598975) MS049: Dual CARM1 and PRMT6 (PMID: 27584694) HUK1-121: CARM1 (PMID: 28042453)<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1048","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1048","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/comments?post=1048"}],"version-history":[{"count":4,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1048\/revisions"}],"predecessor-version":[{"id":1633,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1048\/revisions\/1633"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/media?parent=1048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}