{"id":1037,"date":"2025-07-09T15:15:51","date_gmt":"2025-07-09T15:15:51","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/jinlab\/?page_id=1037"},"modified":"2025-07-09T19:00:10","modified_gmt":"2025-07-09T19:00:10","slug":"news","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/jinlab\/research-2\/news\/","title":{"rendered":"Jin Lab News"},"content":{"rendered":"<h1 style=\"text-align: center\"><\/h1>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong>Drs.Xing Qiu, Yan Xiong, Jerrel Catlett, Zhijie Deng and Jian Jin, and Their Collaborators Published a Research Article Entitled \u201cDiscovery of an LSD1 PROTAC degrader\u201d in PNAS <\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p style=\"padding-left: 160px\">The research team led by Drs. Jian Jin and Yang Shi, a Professor at Ludwig Institute for Cancer Research, University of Oxford, discovered the first-in-class LSD1 small-molecule degrader, MS9117, which potently and selectively degraded LSD1, a well-known lysine demethylase that is overexpressed in various cancers including acute myeloid leukemia (AML) pnas.2425812122 <a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2425812122\">10.1073\/pnas.2425812122<\/a> https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2425812122 MS9117 effectively targeted both catalytic and noncatalytic oncogenic functions of LSD1 and displayed superior antiproliferative effects in AML cells, compared to LSD1 catalytic inhibitors.<\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong>Drs. Chao Qian, Yan Xiong, Yue Zhong and Jian Jin, and Their Collaborators Published a Research Article Entitled \u201cUSP28-Based Deubiquitinase-Targeting Chimeras for Cancer Treatment\u201d in Journal of the American Chemical Society <\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p style=\"padding-left: 160px\">The research team led by Dr. Wenyi Wei, a Professor at Harvard Medical School, and Dr. Jian Jin has demonstrated for the first time that USP28, a deubiquitinase (DUB), can be harnessed for development of Deubiquitinase-Targeting Chimeras (DUBTACs) utilizing a non-covalent small-molecule inhibitor of USP28 (<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c01889\">https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c01889)<\/a>. Using this technology, the team developed proof-of-concept USP28-recruiting DUBTACs that stabilize CFTR, cGAS and PPAR\u03b3, respectively..<\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong>Drs. Chao Qian, Yan Xiong, Yue Zhong and Jian Jin, and Their Collaborators Published a Research Article Entitled \u201cHarnessing the Deubiquitinase USP1 for Targeted Protein Stabilization\u201d in Journal of the American Chemical Society<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p style=\"padding-left: 160px\">The research team led by Drs. Jian Jin and Wenyi Wei, a Professor at Harvard Medical School, has demonstrated for the first time that USP1, a deubiquitinase (DUB) that is overexpressed in several human cancers, can be harnessed for targeted protein stabilization. <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c01662\">https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.5c01662 <\/a>By utilizing a non-covalent small-molecule inhibitor of USP1, the team developed the first UTX Deubiquitinase-Targeting Chimera (DUBTAC) that selectively stabilizes and activates the tumor suppressor UTX and simultaneously inhibits the oncoprotein JMJD3. This work advances the TPS field.<\/p>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong>Md Kabir, Xiaoping Hu, Dmitry Pokushalov, Yue Zhong, Yan Xiong, and Prof. Jin, and their Collaborators Published a Research Article Entitled \u201cHarnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53\u201d in Advanced Science.<\/strong><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Drs.Xing Qiu, Yan Xiong, Jerrel Catlett, Zhijie Deng and Jian Jin, and Their Collaborators Published a Research Article Entitled \u201cDiscovery of an LSD1 PROTAC degrader\u201d in PNAS The research team led by Drs. Jian Jin and Yang Shi, a Professor at Ludwig Institute for Cancer Research, University of Oxford, discovered the first-in-class LSD1 small-molecule degrader, [&hellip;]<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":38,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1037","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1037","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/comments?post=1037"}],"version-history":[{"count":110,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1037\/revisions"}],"predecessor-version":[{"id":2304,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/1037\/revisions\/2304"}],"up":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/pages\/38"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/jinlab\/wp-json\/wp\/v2\/media?parent=1037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}