
{"id":1349,"date":"2022-10-13T17:37:32","date_gmt":"2022-10-13T21:37:32","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=1349"},"modified":"2025-08-19T13:58:29","modified_gmt":"2025-08-19T17:58:29","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/iyengarlab\/","title":{"rendered":"Home"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Header Title Description &#8211; Section &#8211; Header &#8211; Fullwidth Slider &#8221; module_id=&#8221;header-title-description-slider-section1&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;rgba(0,174,239,0.09)&#8221; background_enable_color=&#8221;off&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/07\/ai-002-1.jpg&#8221; parallax=&#8221;on&#8221; custom_padding=&#8221;||||false|false&#8221; bottom_divider_style=&#8221;ramp2&#8243; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_height=&#8221;11vw&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221;][et_pb_fullwidth_slider arrows_custom_color=&#8221;#D80B8C&#8221; dot_nav_custom_color=&#8221;#D80B8C&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_slide heading=&#8221;About us&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; header_text_align=&#8221;left&#8221; body_text_align=&#8221;left&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/07\/ai-002-1.jpg&#8221; background_enable_image=&#8221;on&#8221; text_orientation=&#8221;left&#8221; custom_padding=&#8221;|||80px|false|false&#8221; sticky_transition=&#8221;on&#8221;]<\/p>\n<p>The Iyengar laboratory is interested in understanding how signals are routed and processed through cellular signaling networks including mechanisms of information sorting and integration.<\/p>\n<p>[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; custom_padding_last_edited=&#8221;on|tablet&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Fullwidth Two Column Header and Image (no slider) &#8211; Section 1 (Desktop only)&#8221; module_class=&#8221;section1_header_no_slider&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#00aeef&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/10\/Background-2.png&#8221; parallax=&#8221;on&#8221; custom_margin=&#8221;||30px||false|false&#8221; custom_padding=&#8221;||||false|false&#8221; custom_padding_tablet=&#8221;0px||0px||false|false&#8221; custom_padding_phone=&#8221;&#8221; bottom_divider_style=&#8221;slant&#8221; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_arrangement=&#8221;above_content&#8221; custom_css_main_element=&#8221;padding: 0px !important;&#8221; disabled=&#8221;on&#8221; locked=&#8221;on&#8221; collapsed=&#8221;on&#8221;][et_pb_row column_structure=&#8221;2_5,3_5&#8243; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; module_alignment=&#8221;right&#8221; custom_padding=&#8221;||||false|false&#8221; border_color_all=&#8221;RGBA(0,0,0,0)&#8221; collapsed=&#8221;on&#8221;][et_pb_column type=&#8221;2_5&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_padding=&#8221;10%||8vw||false|false&#8221; custom_padding_tablet=&#8221;0vw||0vw||true|false&#8221; custom_padding_phone=&#8221;&#8221; custom_padding_last_edited=&#8221;on|desktop&#8221;][et_pb_text admin_label=&#8221;Title &#8211; Text&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;da86b6f0-f83c-4c7c-bdd8-3019777ddffe&#8221; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;32px&#8221; header_text_align=&#8221;left&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_font_size=&#8221;48px&#8221; header_line_height=&#8221;60px&#8221; custom_margin=&#8221;||2%||false|false&#8221; text_font_size_tablet=&#8221;15px&#8221; text_font_size_phone=&#8221;14px&#8221; text_font_size_last_edited=&#8221;on|desktop&#8221; header_font_size_tablet=&#8221;40px&#8221; header_font_size_phone=&#8221;24px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; custom_css_main_element=&#8221;\/*margin-right: 8vw!important;*\/&#8221;]<\/p>\n<h1>Welcome to the Rendl Lab<\/h1>\n<p>[\/et_pb_text][et_pb_text admin_label=&#8221;Description &#8211; Text&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;da86b6f0-f83c-4c7c-bdd8-3019777ddffe&#8221; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;20px&#8221; text_line_height=&#8221;32px&#8221; header_text_align=&#8221;left&#8221; custom_margin=&#8221;||||false|false&#8221; text_font_size_tablet=&#8221;15px&#8221; text_font_size_phone=&#8221;14px&#8221; text_font_size_last_edited=&#8221;on|desktop&#8221; custom_css_main_element=&#8221;\/*margin-right: 9vw!important;*\/&#8221;]<\/p>\n<p>Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;3_5&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg&#8221; align=&#8221;right&#8221; force_fullwidth=&#8221;on&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;80px|0px|0px|0px|false|false&#8221; custom_padding=&#8221;20px|0px|0px|0px|false|false&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_spread=&#8221;15px&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; disabled=&#8221;on&#8221; collapsed=&#8221;on&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_blurb title=&#8221;Welcome to the Rendl Lab&#8221; admin_label=&#8221;Blurb &#8211; Left Side Content&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; header_text_color=&#8221;#FFFFFF&#8221; body_text_color=&#8221;#FFFFFF&#8221; custom_margin=&#8221;80px||||false|false&#8221;]<\/p>\n<h1 style=\"color: white\">Welcome to the Rendl Lab<\/h1>\n<p>Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_blurb image=&#8221;https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg&#8221; icon_alignment=&#8221;right&#8221; admin_label=&#8221;Blurb &#8211; Right-Side Image&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;80px|-40%|0px||false|false&#8221; custom_margin_tablet=&#8221;|0%|||false|false&#8221; custom_margin_phone=&#8221;|0%|||false|false&#8221; custom_margin_last_edited=&#8221;on|phone&#8221;][\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Header and Image (no slider) &#8211; Section 1 (Tablet and Mobile only)&#8221; module_class=&#8221;section1_header_no_slider_mobile&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#00AEEF&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/10\/Background-2.png&#8221; parallax=&#8221;on&#8221; width=&#8221;100%&#8221; custom_margin=&#8221;||30px||false|false&#8221; custom_padding=&#8221;80px|0px|63px|0px||&#8221; mix_blend_mode=&#8221;multiply&#8221; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_height=&#8221;150px&#8221; bottom_divider_flip=&#8221;horizontal&#8221; disabled=&#8221;on&#8221; locked=&#8221;on&#8221; collapsed=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; background_position=&#8221;top_left&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_line_height=&#8221;1.7em&#8221;]<\/p>\n<h1><strong>Welcome to the Rendl Lab<\/strong><\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221;]<\/p>\n<p>Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; background_position=&#8221;top_left&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/07\/210629-Nivi-graduation-scaled.jpg&#8221; title_text=&#8221;AdobeStock_436735485&#8243; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.9.0&#8243; animation_style=&#8221;slide&#8221; animation_direction=&#8221;left&#8221; animation_intensity_slide=&#8221;10%&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_blur=&#8221;30px&#8221; box_shadow_color=&#8221;#58595B&#8221; always_center_on_mobile=&#8221;off&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Two Column Image and Text over Button &#8211; Section 6 (Collections)&#8221; module_class=&#8221;section6_two_col_img_txt_over_btn&#8221; _builder_version=&#8221;4.9.0&#8243; custom_margin=&#8221;30px||100px||false|false&#8221; custom_margin_tablet=&#8221;100px||||false|false&#8221; custom_margin_phone=&#8221;&#8221; custom_margin_last_edited=&#8221;on|desktop&#8221; custom_padding=&#8221;0px|0px|0px|0px|false|false&#8221; custom_css_main_element=&#8221;padding: 0px !important;&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.9.0&#8243; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|auto|0px|auto||&#8221; custom_padding=&#8221;0px||0px|||&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_color=&#8221;#58595B&#8221; collapsed=&#8221;off&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#ff6a88&#8243; background_color_gradient_end=&#8221;#ff99ac&#8221; background_color_gradient_direction=&#8221;35deg&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/08\/Rectangle-3-copy-5.jpg&#8221; custom_padding=&#8221;|5%||5%&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/08\/AdobeStock_182052860.png&#8221; title_text=&#8221;AdobeStock_182052860&#8243; align=&#8221;center&#8221; align_tablet=&#8221;center&#8221; align_phone=&#8221;&#8221; align_last_edited=&#8221;on|desktop&#8221; _builder_version=&#8221;4.9.0&#8243; background_enable_image=&#8221;off&#8221; background_size=&#8221;initial&#8221; custom_margin=&#8221;-20px||-20px|&#8221; custom_padding=&#8221;|||&#8221; animation_style=&#8221;zoom&#8221; animation_direction=&#8221;left&#8221; animation_intensity_zoom=&#8221;10%&#8221; animation_starting_opacity=&#8221;100%&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/08\/ai-008-bwSm-1.png&#8221; background_position=&#8221;center_right&#8221; custom_padding=&#8221;40px|40px|40px|40px|true|true&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.9.0&#8243; header_font=&#8221;|700|||||||&#8221; header_text_color=&#8221;#141414&#8243; header_font_size=&#8221;36px&#8221; header_3_font=&#8221;|700|||||||&#8221; header_3_text_color=&#8221;#2b2b2b&#8221; header_3_font_size=&#8221;28px&#8221; header_3_line_height=&#8221;1.5em&#8221; custom_margin=&#8221;||10px|&#8221; custom_padding=&#8221;5%||||false|false&#8221;]<\/p>\n<h1><strong>Overview<\/strong><\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#000000&#8243; text_line_height=&#8221;22px&#8221; header_font=&#8221;||||&#8221; header_text_color=&#8221;#000000&#8243; header_4_text_color=&#8221;#FFFFFF&#8221; header_5_text_color=&#8221;#FFFFFF&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; max_width=&#8221;700px&#8221; custom_padding=&#8221;2%||5%||false|false&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;top&#8221; animation_intensity_slide=&#8221;4%&#8221;]<\/p>\n<p>The Iyengar laboratory is interested in understanding how signals are routed and processed through cellular signaling networks including mechanisms of information sorting and integration.<\/p>\n<p>We are interested in understanding dynamics of network topology. For this we focus on identifying regulatory motifs such as feedback and feedforward loops and determining their information processing capability. We have constructed and analyzed dynamic maps of these motifs to understand how cellular signaling networks engage the various cellular machinery to produce physiological responses to extra-cellular signals. To study complex cell signaling networks we utilize a combination of experimental and theoretical approaches. Multidimensional experimental approaches currently being used in the laboratory include reverse-phase phosphoproteomic arrays, transcription factor arrays, ChIP-Seq and mRNA profiling by sequencing. These experimental approaches are being integrated with theoretical analysis using both graph theory approaches and differential equation based modeling to understand network regulation of cell proliferation and activity induced synaptic plasticity.<\/p>\n<p>We are interested in understanding how spatial organization within cells and tissues contributes to dynamic stability. We are studying the role of cell shape in regulating information processing within signaling networks. For these studies at the experimental level we are using approaches to observe and quantify biochemical signaling reactions in live cells. We are also using patterned surfaces at the nano and microscale as to obtain cells of specific shapes that can be imaged. To decipher the information content in cell shape we are analyzing signaling networks using partial differential equations. We are developing spatially realistic models of signaling networks to understand the origins and dynamics of microdomains of signaling components. We are also interested in understanding the dynamics underlying tissue integrity. We are developing multi-scale models as well as experimentally engineered systems to determine if a dynamic loop that integrates signaling networks in multiple cell types forms the basis for tissue integrity.<\/p>\n<p>We are developing systems level approaches to understanding drug action at a genome-wide level. We are constructing large scale networks to capture all of the known protein-protein interactions in the human genome to computationally identify selective regions (disease neighborhood) within the interaction space associated with specific diseases. We are analyzing the relationship between drug targets and other cellular components to understand the relationship between disease neighborhood and targets of drugs used to treat the disease. From such analyses we are attempting to predict adverse events and explain adverse events reports in the FDA\u2013AERS database.<\/p>\n<p>Systems biology and systems pharmacology<br \/>Computational cell biology<br \/>Cellular signaling networks<br \/>Spatial modeling of cell signaling<br \/>G-protein mediated intracellular signaling in neurons<br \/>Spatiotemporal organization of cellular networks<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;off|off|off&#8221; admin_label=&#8221;Two Column Image and Text over Button &#8211; Section 4&#8243; module_class=&#8221;section4_two_col_img_txt_over_btn&#8221; _builder_version=&#8221;3.22&#8243; background_color=&#8221;#00AEEF&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/12\/Background-1ALT.png&#8221; parallax=&#8221;on&#8221; width=&#8221;100%&#8221; custom_margin=&#8221;30px||||false|false&#8221; custom_padding=&#8221;80px|0px|63px|0px||&#8221; mix_blend_mode=&#8221;multiply&#8221; bottom_divider_style=&#8221;ramp2&#8243; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_height=&#8221;150px&#8221; bottom_divider_flip=&#8221;horizontal&#8221; bottom_divider_arrangement=&#8221;above_content&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; background_position=&#8221;top_left&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/rendl-lab\/wp-content\/uploads\/sites\/292\/2022\/08\/Stalled-follicles_03MR-2560&#215;1440-1.jpg&#8221; title_text=&#8221;AdobeStock_436735485&#8243; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.9.0&#8243; animation_style=&#8221;slide&#8221; animation_direction=&#8221;left&#8221; animation_intensity_slide=&#8221;10%&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_color=&#8221;#58595B&#8221; always_center_on_mobile=&#8221;off&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; background_position=&#8221;top_left&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;22px&#8221; header_font=&#8221;||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_4_text_color=&#8221;#FFFFFF&#8221; header_5_text_color=&#8221;#FFFFFF&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; max_width=&#8221;700px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;top&#8221; animation_intensity_slide=&#8221;4%&#8221;]<\/p>\n<h3><strong>In the News<\/strong><\/h3>\n<ul>\n<li>Interconnected Network Motifs Control Podocyte Morphology and Kidney Function Science Signaling Podcast<\/li>\n<li>GLP-1, TZD Combo May Cut Heart Risk MedPage Today<\/li>\n<li>Can &#8216;Big Data&#8217; Help Increase Drug Safety? Healthcare Informatics<\/li>\n<li>Big Data Reaps Big Rewards in Drug Safety ScienceDaily<\/li>\n<li>New Genetic Framework Could Help Explain Drug Side Effects Computing Life<\/li>\n<li>Systems Pharmacology of Arrhythmias Science Signaling Podcast<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/labs.icahn.mssm.edu\/design\/option1-research&#8221; button_text=&#8221;Find Out More &#8221; disabled_on=&#8221;on|on|on&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_color=&#8221;#d80b8c&#8221; button_bg_color=&#8221;#FFFFFF&#8221; button_border_radius=&#8221;0px&#8221; box_shadow_style=&#8221;preset1&#8243; disabled=&#8221;on&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; fullwidth=&#8221;on&#8221; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Paralax Background fullwidth Image &#8211; Section 3&#8243; module_class=&#8221;section3_paralax_bg_fullwidth_img&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; disabled=&#8221;on&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221;][et_pb_fullwidth_image title_text=&#8221;3&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/10\/3.png&#8221; parallax=&#8221;on&#8221; parallax_method=&#8221;off&#8221; min_height=&#8221;217.5px&#8221; custom_margin=&#8221;-2px|||||&#8221; filter_opacity=&#8221;20%&#8221;][\/et_pb_fullwidth_image][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Two Column Title Over Text Next to Image &#8211; Section 5&#8243; module_class=&#8221;section5_two_col_title_over_txt_next_to_img&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; disabled=&#8221;on&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; make_equal=&#8221;on&#8221; admin_label=&#8221;5 (Module)&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#FFFFFF&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; module_alignment=&#8221;center&#8221; custom_padding=&#8221;6px||3px|||&#8221; global_module=&#8221;956&#8243;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#00AEEF&#8221; header_font=&#8221;|700|||||||&#8221; header_text_color=&#8221;#00AEEF&#8221; header_font_size=&#8221;36px&#8221; module_alignment=&#8221;center&#8221; custom_padding=&#8221;10%||10%||true|false&#8221;]<\/p>\n<h1><strong>Growth Control and Regeneration<\/strong><\/h1>\n<p>How is tissue growth, homeostasis and renewal by stem cells regulated throughout life? Understanding the core molecular controls is fundamental for realizing the therapeutic potential of the instructive niche (Rezza et al, Current Topics in Developmental Biology 2014). After initial morphogenesis of hair follicles, the Dermal Condensate gives rise to the adult follicle inductive niche, the Dermal Papilla. Dermal Papilla cells signal to progenitors in the follicle bulb to control continuous production and outgrowth of hair. They are also critical for activating stem cells to regenerate a new follicle during the hair growth cycle. Remarkably, isolated niche cells can induce new hair formation after cell transplantation into skin in mice, a yet unrealized goal in human.<\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/07\/ai-008.png&#8221; title_text=&#8221;ai-008&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#FFFFFF&#8221;][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Two Column Image with Title and Text Over Button  &#8211; Section 4 (Desktop Only)&#8221; module_class=&#8221;section4_two_col_img_next_to_title_over_txt_over_btn_desktop&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#00AEEF&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#00aeef&#8221; background_color_gradient_end=&#8221;#d80b8c&#8221; background_color_gradient_direction=&#8221;33deg&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/10\/Background-2.png&#8221; parallax=&#8221;on&#8221; module_alignment=&#8221;center&#8221; height=&#8221;558px&#8221; custom_margin=&#8221;||200px||false|false&#8221; disabled=&#8221;on&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/08\/2021-Hero-Shot-2-smallest-scaled-3.png&#8221; title_text=&#8221;2021-Hero-Shot-2-smallest-scaled-3&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; width=&#8221;91%&#8221; max_width=&#8221;91%&#8221; min_height=&#8221;550px&#8221; height=&#8221;550px&#8221; max_height=&#8221;550px&#8221; custom_padding=&#8221;40px||||false|false&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; header_text_align=&#8221;center&#8221; header_text_color=&#8221;#FFFFFF&#8221; text_orientation=&#8221;center&#8221; custom_padding=&#8221;||||false|false&#8221;]<\/p>\n<h1><strong>Tissue Regression and Reorganization<\/strong><\/h1>\n<p style=\"text-align: left\">How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/labs.icahn.mssm.edu\/design\/option1-research&#8221; button_text=&#8221;Find Out More&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_color=&#8221;#d80b8c&#8221; button_bg_color=&#8221;#FFFFFF&#8221; button_border_radius=&#8221;0px&#8221; box_shadow_style=&#8221;preset1&#8243; locked=&#8221;off&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Two Column Image with Title and Text Over Button  &#8211; Section 4 (Mobile and Tablet Only)&#8221; module_class=&#8221;section4_one_col_img_over_title_over_txt_over_btn_mobile_tablet&#8221; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;#00AEEF&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_start=&#8221;#00aeef&#8221; background_color_gradient_end=&#8221;#d80b8c&#8221; background_color_gradient_direction=&#8221;33deg&#8221; background_image=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/10\/Background-1.png&#8221; parallax=&#8221;on&#8221; width=&#8221;100%&#8221; custom_margin=&#8221;||100px||false|false&#8221; custom_padding=&#8221;80px|0px|63px|0px||&#8221; bottom_divider_color=&#8221;#FFFFFF&#8221; bottom_divider_height=&#8221;150px&#8221; bottom_divider_flip=&#8221;horizontal&#8221; bottom_divider_arrangement=&#8221;above_content&#8221; disabled=&#8221;on&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221;][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;3.25&#8243; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; custom_margin=&#8221;|||&#8221; custom_padding=&#8221;|||&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; background_position=&#8221;top_left&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_image src=&#8221;https:\/\/labs.icahn.mssm.edu\/iyengarlab-2\/wp-content\/uploads\/sites\/585\/2022\/08\/2021-Hero-Shot-2-smallest-scaled-3.png&#8221; title_text=&#8221;2021-Hero-Shot-2-smallest-scaled-3&#8243; disabled_on=&#8221;off|off|off&#8221; _builder_version=&#8221;4.9.0&#8243; animation_style=&#8221;slide&#8221; animation_direction=&#8221;left&#8221; animation_intensity_slide=&#8221;10%&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_color=&#8221;#58595B&#8221; always_center_on_mobile=&#8221;off&#8221;][\/et_pb_image][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; background_position=&#8221;top_left&#8221; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;22px&#8221; header_font=&#8221;||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_4_text_color=&#8221;#FFFFFF&#8221; header_5_text_color=&#8221;#FFFFFF&#8221; background_size=&#8221;initial&#8221; background_position=&#8221;top_left&#8221; background_repeat=&#8221;repeat&#8221; max_width=&#8221;700px&#8221; animation_style=&#8221;slide&#8221; animation_direction=&#8221;top&#8221; animation_intensity_slide=&#8221;4%&#8221;]<\/p>\n<h1><strong>Tissue Regression and Reorganization<\/strong><\/h1>\n<p style=\"text-align: left\">How tissues regenerate from stem cells and how different organs balance cell loss with new growth is under intensive investigation in the regenerative biology field. In the natural hair growth cycle after years of continuous hair growth, follicles enter a wave of massive progenitor death along the hair axis that \u2013 as we are just beginning to unravel \u2013 is controlled by the niche microenvironment. During this follicle regression, the Dermal Papilla niche needs to relocate from the base of growing hair bulbs to the stem cell reservoir in the upper follicle for new growth activation.<\/p>\n<p>[\/et_pb_text][et_pb_button button_url=&#8221;https:\/\/labs.icahn.mssm.edu\/design\/option1-research&#8221; button_text=&#8221;Find Out More&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; custom_button=&#8221;on&#8221; button_text_color=&#8221;#d80b8c&#8221; button_bg_color=&#8221;#FFFFFF&#8221; button_border_radius=&#8221;0px&#8221; box_shadow_style=&#8221;preset1&#8243; locked=&#8221;off&#8221;][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; disabled_on=&#8221;on|on|on&#8221; admin_label=&#8221;Fullwidth Video over Background &#8211; Section 9&#8243; module_class=&#8221;fullwidth-video-over-background-section-9&#8243; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#ededed&#8221; 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background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=&#8221;youtube&#8221; url=&#8221;https:\/\/www.youtube.com\/user\/MountSinaiSchool&#8221; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]youtube[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=&#8221;instagram&#8221; url=&#8221;https:\/\/www.instagram.com\/icahnmountsinai\/&#8221; use_icon_font_size=&#8221;on&#8221; icon_font_size=&#8221;24px&#8221; _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_enable_color=&#8221;on&#8221;]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=&#8221;4.9.0&#8243; _module_preset=&#8221;default&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_font_size=&#8221;24px&#8221;]<\/p>\n<p style=\"text-align: center\"><strong>Contact Us<\/strong><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_2,1_2&#8243; _builder_version=&#8221;4.9.0&#8243; background_color=&#8221;RGBA(0,0,0,0)&#8221; background_color_gradient_direction=&#8221;38deg&#8221; module_alignment=&#8221;center&#8221; custom_margin=&#8221;|auto|-2px|auto||&#8221; custom_padding=&#8221;0px|||||&#8221; locked=&#8221;off&#8221; collapsed=&#8221;off&#8221;][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;4.9.0&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;1.25em&#8221; header_font=&#8221;||||||||&#8221; header_4_font=&#8221;|700||on|||||&#8221; header_4_font_size=&#8221;16px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.5em&#8221; background_layout=&#8221;dark&#8221; locked=&#8221;off&#8221;]<strong>Lab Address <\/strong><\/p>\n<p>Ravi Iyengar, PhD <br \/>Dorothy H. <\/br> and Lewis Rosenstiel <\/br>Professor, Department of Pharmacology and Systems Therapeutics Director, Systems Biology Center New York (SBCNY)<\/p>\n<p><strong>Mailing Address <\/strong><\/p>\n<p>Iyengar Laboratory<br \/>\nIcahn School of Medicine<br \/>\nat Mount Sinai<br \/>\n<span style=\"font-size: 16px;\">Room 12-70C (Office) 12-52 (Lab) <\/span><br \/>\n<span style=\"font-size: 16px;\">Pharmacology and Systems Therapeutics <\/span><br \/>\n<span style=\"font-size: 16px;\">1425 Madison Avenue<\/span><br \/>\n<span style=\"font-size: 16px;\">New York, NY 10029<\/span>[\/et_pb_text][\/et_pb_column][et_pb_column type=&#8221;1_2&#8243; _builder_version=&#8221;3.25&#8243; custom_padding=&#8221;|||&#8221; custom_padding__hover=&#8221;|||&#8221;][et_pb_text _builder_version=&#8221;4.9.0&#8243; text_font=&#8221;||||||||&#8221; text_text_color=&#8221;#FFFFFF&#8221; text_line_height=&#8221;1.25em&#8221; header_font=&#8221;||||||||&#8221; header_4_font=&#8221;|700||on|||||&#8221; header_4_font_size=&#8221;16px&#8221; header_4_letter_spacing=&#8221;1px&#8221; header_4_line_height=&#8221;1.5em&#8221; background_layout=&#8221;dark&#8221; locked=&#8221;off&#8221;]<\/p>\n<p><strong>Phone<br \/><\/strong>212-659-1707<\/p>\n<p><strong>Fax<br \/><\/strong>212-831-0114<\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Iyengar laboratory is interested in understanding how signals are routed and processed through cellular signaling networks including mechanisms of information sorting and integration.Welcome to the Rendl LabOur current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.Welcome to the Rendl Lab Our current research focuses [&hellip;]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-1349","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/iyengarlab\/wp-json\/wp\/v2\/pages\/1349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/iyengarlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/iyengarlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/iyengarlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/iyengarlab\/wp-json\/wp\/v2\/comments?post=1349"}],"version-history":[{"count":15,"href":"https:\/\/labs.icahn.mssm.edu\/iyengarlab\/wp-json\/wp\/v2\/pages\/1349\/revisions"}],"predecessor-version":[{"id":4483,"href":"https:\/\/labs.icahn.mssm.edu\/iyengarlab\/wp-json\/wp\/v2\/pages\/1349\/revisions\/4483"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/iyengarlab\/wp-json\/wp\/v2\/media?parent=1349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}