{"id":18,"date":"2017-09-13T15:59:29","date_gmt":"2017-09-13T15:59:29","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/ishikawalab\/?page_id=18"},"modified":"2026-03-04T16:42:21","modified_gmt":"2026-03-04T16:42:21","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<h2><b>2026<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong>Veera S, Lin NH, Mavropoulos SA, <u>Ishikawa K<\/u><\/strong>. <u>New approaches to cardiac gene therapy delivery<\/u>. Can J Cardiol. 2026 Feb 26:S0828-282X(26)00149-2. doi: 10.1016\/j.cjca.2026.02.031. Epub ahead of print. PMID: 41763359.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2025<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Gallinat A, Li X, Raisinghani NP, La Salvia S, Phan A, Zhang S,<strong> Mavropoulos SA, Veera S,<\/strong> Yoon S,<u><strong> Ishikawa K<\/strong><\/u>, Sahoo S. <u>Flow cytometry of the myocardium: An end-to-end analysis of adult cardiomyocytes isolated from pig and mouse hearts<\/u>. J Mol Cell Cardiol. 2025 Nov;208:49-59. doi: 10.1016\/j.yjmcc.2025.09.003. Epub 2025 Sep 4. PMID: 40914413; PMCID: PMC12457073.<\/li>\n<li><strong>Veera S, Watanabe K, <u>Ishikawa K.<\/u><\/strong> <u>Intra-aortic Entrainment Pump for LV unloading: What Phase of the Cardiac Cycle Does the Device Unload?<\/u> J Card Fail. 2025 Mar;31(3):549-550. doi: 10.1016\/j.cardfail.2025.01.006. Epub 2025 Jan 28. PMID: 39884643; PMCID: PMC12477817.<\/li>\n<li><strong>Mavropoulos SA, Aikawa T, Mazurek R, Sakata T, Yamada K, Watanabe K, Sunagawa G, Veera S, Singleton DT, Leonard K, Kariya T,<\/strong> Sahoo S, <u><strong>Ishikawa K<\/strong><\/u>.<u>\u00a0 A minimally invasive swine model of chronic kidney disease-associated heart failure<\/u>. Am J Physiol Heart Circ Physiol. 2025 Feb 1;328(2):H260-H270. doi: 10.1152\/ajpheart.00449.2024. Epub 2024 Dec 23. PMID: 39716867; PMCID: PMC12169141.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2024<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong>Mazurek R, Tharakan S, Mavropoulos SA, Singleton DT, Bikou O, Sakata T, Kariya T, Yamada K, <\/strong>Kohlbrenner E, Liang L, <strong>Ravichandran AJ, Watanabe S, <\/strong>Hajjar RJ,<strong> K<u>Ishikawa K. <\/u><\/strong> <u>AAV delivery strategy with mechanical support for safe and efficacious cardiac gene transfer in swine.<\/u> Nat Commun. 2024 Dec 1;15(1):10450. doi: 10.1038\/s41467-024-54635-x. PMID: 39617804; PMCID: PMC11609281.<\/li>\n<li><strong>Sakata T, Mavropoulos SA, Mazurek R, Romeo FJ, Ravichandran AJ, Marx JM, Kariya T, <u>Ishikawa K<\/u><\/strong>. <u>Reduction of left ventricular diastolic pressure as a key regulator of infarct coronary flow under mechanical left ventricular support<\/u>. J Physiol. 2024 Mar 8. doi: 10.1113\/JP285586. Epub ahead of print. PMID: 38457313<\/li>\n<li>Xu Y, Korayem A, Cruz-Solbes AS, Chandel N,<strong> Sakata T, Mazurek R, Mavropoulos SA, Kariya T, Aikawa T, Yamada KP<\/strong>, D&#8217;Escamard V, V&#8217;Gangula B, Baker AH, Ma L, Bj\u00c3\u00b6rkegren JLM, Fuster V, Boehm M, Fish KM, Tadros R, <u><strong>Ishikawa K<\/strong><\/u>, Kovacic JC. <u>Inhibition of endothelial to mesenchymal transition in a large animal preclinical arterio-venous fistula model leads to improved remodeling and reduced stenosis<\/u>. Cardiovasc Res. 2024 Jul 26:cvae157. doi: 10.1093\/cvr\/cvae157.Epub ahead of print. PMID: 39056563<\/li>\n<li>Katz MG, Eliyahu E, <u><strong>Ishikawa K<\/strong><\/u>. <u>Gene delivery in a rodent lung transplant model<\/u>. J Thorac Cardiovasc Surg. 2024 May;167(5):e142-e143. doi: 10.1016\/j.jtcvs.2024.01.016. Epub 2024 Feb 15. PMID: 38363258.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2023<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong>Mazurek R, Kariya T, Sakata T, Mavropoulos SA, Ravichandran AJ, Romeo FJ, Yamada KP, <u>Ishikawa K<\/u><\/strong>. <u>Negative Impact of Acute Reloading after Mechanical Left Ventricular Unloading.<\/u> J Cardiovasc Transl Res. 2023 Apr 6. doi: 10.1007\/s12265-023-10371-z. PMID: 37022610.<\/li>\n<li>Santos-Gallego CG, Requena-Ib\u00e1\u00f1ez JA, Picatoste B, Fardman B, <strong><u>Ishikawa K<\/u>, Mazurek R<\/strong>, Pieper M, Sartori S, Rodriguez-Capit\u00e1n J, Fuster V, Badimon JJ. <u>Cardioprotective Effect of Empagliflozin and Circulating Ketone Bodies During Acute Myocardial Infarction.<\/u> Circ Cardiovasc Imaging. 2023 Apr;16(4):e015298. doi: 10.1161\/CIRCIMAGING.123.015298. Epub 2023 Apr 12. PMID: 37042253.<\/li>\n<li>Gorski PA, Lee A, Lee P, Oh JG, Vangheluwe P,<strong><u> Ishikawa K<\/u><\/strong>, Hajjar R, Kho C. <u>Identification and Characterization of p300-Mediated Lysine Residues in Cardiac SERCA2a.<\/u> Int J Mol Sci. 2023 Feb 9;24(4):3502. doi: 10.3390\/ijms24043502. PMID: 36834924; PMCID: PMC9959367.<\/li>\n<li><strong>Romeo FJ, Mavropoulos SA, <u>Ishikawa K.<\/u><\/strong> <u>Progress in Clinical Gene Therapy for Cardiac Disorders.<\/u> Mol Diagn Ther. 2023 Mar;27(2):179-191. doi: 10.1007\/s40291-022-00632-z. Epub 2023 Jan 15. PMID: 36641770; PMCID:PMC10023344.<\/li>\n<li><strong>Ravichandran AJ, Romeo FJ, Mazurek R, <u>Ishikawa K<\/u><\/strong>. <u>Barriers in Heart Failure Gene Therapy and Approaches to Overcome Them.<\/u> Heart Lung Circ. 2023 Apr 11:S1443-9506(23)00115-4. doi: 10.1016\/j.hlc.2023.02.011. Epub ahead of print. PMID: 37045653.<\/li>\n<li><strong>Uchiyama S, Sakata T, Tharakan S, Ishikawa K<\/strong>. <u>Body temperature as a predictor of mortality in COVID-19<\/u>. Sci Rep. 2023 Aug 16;13(1):13354. doi:10.1038\/s41598-023-40414-z. PMID: 37587219; PMCID: PMC10432378.<\/li>\n<li><strong>Sakata T,<\/strong> Kohno H, Inui T, Ikeuchi H, Shiko Y, Kawasaki Y, Suzuki S, Tanaka, S, Obana M, <u><strong>Ishikawa K<\/strong><\/u>, Fujio Y, Matsumiya G. <u>Cardioprotective effect of Interleukin-11 against warm ischemia-reperfusion injury in a rat heart donor model<\/u>. Eur J Pharmacol. 2023 Dec 15;961:176145. doi:10.1016\/j.ejphar.2023.176145. Epub 2023 Nov 2. PMID: 37923160<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2022<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong>Romeo FJ, Mazurek R, Sakata T, Mavropoulos SA, <u>Ishikawa K<\/u>. <\/strong><u>Device-Based Approaches Targeting Cardioprotection in Myocardial Infarction: The Expanding Armamentarium of Innovative Strategies<\/u>. J Am Heart Assoc. 2022 Nov 16:e7728. doi: 10.1161\/JAHA.122.026474. Epub ahead of print. PMID: 36382949.<\/li>\n<li>Li J, Kelly SC, Ivey JR, Thorne PK, Fertig B, Ling J, Nollet EE, Dobi S, Busiau T, <strong><u>Ishikawa K<\/u><\/strong>, <strong>Yamada K<\/strong>, Lee A, Kho C, Wills L, Tibbo AJ, Scott M, Grant K, Campbell KS, Birks EJ, MacQuaide N, Hajjar R, Smith GL, van der Velden J, Baillie GS. <u>SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+<\/u>. FEBS J. 2022 May 27. doi: 10.1111\/febs.16537. Epub ahead of print. PMID: 35633070.<\/li>\n<li><strong>Sakata T, Mazurek R, Mavropoulos SA, Romeo FJ, Ravichandran AJ, Watanabe S, Kariya T, <u>Ishikawa K<\/u><\/strong>. <u>Impact of ischemia on left atrial remodeling and dysfunction in swine models of mitral regurgitation<\/u>. Am J Physiol Heart Circ Physiol. 2022 Jun 1;322(6):H914-H923. doi: 10.1152\/ajpheart.00009.2022. Epub 2022 Mar 25. PMID: 35333115;<\/li>\n<li><strong>Bikou O., Tharakan S., Yamada KP, Kariya T., Aguero J., Gordon A., Mazurek R., Aikawa T.<\/strong>, Kohlbrenner E., Fish K., Hajjar R.J., <strong><u>Ishikawa K.<\/u><\/strong>\u00a0<u>Endo-bronchial aerosolized AAV1.SERCA2a gene therapy in a pulmonary hypertension pig model: addressing the lung delivery bottleneck.<\/u> Hum Gene Ther. 2022 Mar 16. doi: 10.1089\/hum.2021.274. PMID: 35293228<\/li>\n<li><strong>Sakata T, Watanabe S, Mazurek R, Mavropoulos S, Romeo F, Yamada KP, <u>Ishikawa K.<\/u><\/strong>\u00a0<u>Impaired Diastolic Function Predicts Improved Ischemic Myocardial Flow by Mechanical Left Ventricular Unloading in a Swine Model of Ischemic Heart Failure.<\/u> 2022;8. doi: 10.3389\/fcvm.2021.795322<\/li>\n<li>Koplev S, Seldin M, Sukhavasi K, Ermel R, Pang S, Zeng L, Bankier S, Di Narzo A, Cheng H, Meda V, Ma A, Talukdar H, Cohain A, Amadori L, Argmann C, Houten SM, Franz\u00e9n O, Mocci G, Meelu OA,<strong> <u>Ishikawa K,<\/u><\/strong> Whatling C, Jain A, Jain RK, Gan L-M, Giannarelli C, Roussos P, Hao K, Schunkert H, Michoel T, Ruusalepp A, Schadt EE, Kovacic JC, Lusis AJ, Bj\u00f6rkegren JLM (2022) <u>A mechanistic framework for cardiometabolic and coronary artery diseases.<\/u> Nature Cardiovascular Research 1 (1):85-100. doi:10.1038\/s44161-021-00009-1<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2021<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>\n<div class=\"docsum-citation full-citation\"><span class=\"docsum-authors full-authors\"><strong><u>Ishikawa K<\/u><\/strong>, Meyns B, Kapur NK. <u>Editorial: Science in Mechanical Circulatory Support.<\/u> <\/span><span class=\"docsum-journal-citation full-journal-citation\">Front Cardiovasc Med. 2021 May 17;8:676595. doi: 10.3389\/fcvm.2021.676595. eCollection 2021.<\/span><span class=\"citation-part\">PMID:\u00a0<span class=\"docsum-pmid\">34079830<\/span><\/span><\/div>\n<\/li>\n<li><strong>Yamada KP, Kariya T, Aikawa T, <u>Ishikawa K<\/u><\/strong>. <u>Effects of Therapeutic Hypothermia on Normal and Ischemic Heart<\/u>. Front Cardiovasc Med. 2021 Feb 15;8:642843. doi: 10.3389\/fcvm.2021.642843. PMID: 33659283; PMCID: PMC7919696.<\/li>\n<li><strong>Sahoo S, Kariya T, <u>Ishikawa K.<\/u><\/strong> <u>Targeted delivery of therapeutic agents to the heart.<\/u> Nat Rev Cardiol. 2021 Jan 26. doi: 10.1038\/s41569-020-00499-9. Epub ahead<br \/>\nof print. PMID: 33500578.<\/li>\n<li><strong>Aikawa T<\/strong>, Takagi H, <strong><u>Ishikawa K<\/u><\/strong>, Kuno T. <u>Myocardial injury characterized by elevated cardiac troponin and in-hospital mortality of COVID-19: An insight from a meta-analysis.<\/u> J Med Virol. 2021;93(1):51-5. Epub 2020\/06\/03. doi: 10.1002\/jmv.26108. PubMed PMID: 32484975; PubMed Central PMCID: PMC7301031.<\/li>\n<li>\u00a0<strong>Miyashita S, Kariya T, Yamada KP, Bikou O, Tharakan S<\/strong>, Kapur NK, <strong><u>Ishikawa K<\/u><\/strong>. <u>Left Ventricular Assist Devices for Acute Myocardial Infarct Size Reduction: Meta-analysis.<\/u> J Cardiovasc Transl Res.2021;14(3):467-75. Epub 2020\/08\/30. doi: 10.1007\/s12265-020-10068-7. PubMed PMID: 32860130; PMCID: PMC7914262.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2020<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Santos-Gallego CG, Requena-Ibanez JA, San Antonio R, Garcia-Ropero A,<strong> <u>Ishikawa K<\/u><\/strong>, <strong>Watanabe S<\/strong>, Picatoste B, Vargas-Delgado AP, Flores-Umanzor EJ, Sanz J, Fuster V, Badimon JJ. <u>Empagliflozin Ameliorates Diastolic Dysfunction and Left Ventricular Fibrosis\/Stiffness in Nondiabetic Heart\u00a0Failure: A Multimodality Study.<\/u> JACC Cardiovasc Imaging. 2020 Oct 28:S1936-878X(20)30799-3. doi: 10.1016\/j.jcmg.2020.07.042. Epub ahead of print. PMID: 33129742.<\/li>\n<li><strong>Kariya T,Yamada KP, Bikou O, Tharakan S, Miyashita S, <u>Ishikawa K<\/u><\/strong>. <u>Novel Porcine Model of Coronary Dissection Reveals the Impact of Impella on Dissected Coronary Arterial Hemodynamics.<\/u> Front Cardiovasc Med. 2020 Sep 15;7:162. doi: 10.3389\/fcvm.2020.00162. PMID: 33110912; PMCID: PMC7522595.<\/li>\n<li>Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, P\u00e9rez-Medina C, Teunissen AJP, Toner YC,<strong> <u>Ishikawa K<\/u><\/strong>, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P,<br \/>\nSwirski FK, Weissleder R, Mulder WJM. <u>Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor &lt;sup&gt;64&lt;\/sup&gt;Cu-Macrin<br \/>\nin Mice, Rabbits, and Pigs.<\/u> Circ Cardiovasc Imaging. 2020 Oct;13(10):e010586. doi: 10.1161\/CIRCIMAGING.120.010586. Epub 2020 Oct 20. PMID: 33076700; PMCID:<br \/>\nPMC7583675.<\/li>\n<li><strong>Aikawa T, Kariya T, Yamada KP, Miyashita S, Bikou O, Tharakan S<\/strong>, Fish K, <strong><u>Ishikawa K<\/u><\/strong>. <u>Impaired left ventricular global longitudinal strain is associated with elevated left ventricular filling pressure after myocardial infarction.<\/u> Am J Physiol Heart Circ Physiol. 2020 Oct 9. doi: 10.1152\/ajpheart.00502.2020. Epub ahead of print. PMID: 33035440.<\/li>\n<li>Garcia-Ropero A, Santos-Gallego CG, Vargas-Delgado AP, Requena-Ibanez JA, Picatoste B,<strong> <u>Ishikawa K<\/u><\/strong>, Sanz J, Tunon J, Badimon JJ. <u>Correlation between myocardial strain and adverse remodeling in a non-diabetic model of heart failure following empagliflozin therapy.<\/u> Expert Rev Cardiovasc Ther. 2020<br \/>\nSep;18(9):635-642. doi: 10.1080\/14779072.2020.1802247. Epub 2020 Aug 9. PMID: 32713221.<\/li>\n<li>Nix C,<strong><u> Ishikawa K<\/u><\/strong>, Meyns B, Yasuda S, Adriaenssens T, Barth S, Zayat R, Leprince P, Lebreton G. <u>Comparison of Hemodynamic Support by Impella vs. Peripheral Extra-Corporeal Membrane Oxygenation: A Porcine Model of Acute Myocardial Infaction.<\/u> Front Cardiovasc Med. 2020 Jun 10;7:99. doi: 10.3389\/fcvm.2020.00099. PMID: 32587862; PMCID: PMC7299088.<\/li>\n<li><strong>Tharakan S<\/strong>, <strong>Nomoto K<\/strong>, <strong>Miyashita S<\/strong>,<strong><u> Ishikawa K<\/u><\/strong>. <u>Body temperature correlates with mortality in COVID-19 patients.<\/u> Version 2. Crit Care. 2020 Jun 5;24(1):298. doi: 10.1186\/s13054-020-03045-8. PMID: 32503659; PMCID: PMC7274509.<\/li>\n<li>Yamada KP, Tharakan S, <strong><u>Ishikawa K<\/u><\/strong>. <u>Consideration of clinical translation of cardiac AAV gene therapy.<\/u> Cell &amp; Gene Therapy Insights. 2020 May; 6(5):609-615. NIHMSID: NIHMS1607304.doi: 10.18609\/cgti.2020.073.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2019<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Oh JG, <strong><u>Ishikawa K<\/u><\/strong>. <u>Recent highlights and advances in cardiac gene therapy<\/u>. Discov Med. 2019 Nov-Dec;28(155):229-235. PubMed PMID: 32053763.<\/li>\n<li>\u00a0<strong>Miyashita S<\/strong>, Hammoudi N, Watanabe S, <strong>Bikou O<\/strong>, <strong>Yamada K<\/strong>, Aguero J, Nomoto K,<strong> Kariya T<\/strong>, Fish K, Hajjar RJ, <strong><u>Ishikawa K<\/u><\/strong>. <u>Echocardiographic Left Ventricular Mass\u00a0Estimation: Two-Dimensional Area-Length Method is Superior to M-Mode Linear Method in Swine Models of Cardiac Diseases<\/u>. J Cardiovasc Transl Res. 2019 Dec 11. doi: 10.1007\/s12265-019-09937-7. [Epub ahead of print] PubMed PMID: 31828537.<\/li>\n<li>\u00a0<strong>Yamada KP<\/strong>, <strong>Kariya T<\/strong>, <strong><u>Ishikawa K<\/u><\/strong>. <u>AAV shedding after intracoronary delivery: just a safety concern?<\/u> Gene Ther. 2019 Dec 3. doi: 10.1038\/s41434-019-0115-2. [Epub ahead of print] PubMed PMID: 31796896.<\/li>\n<li>\u00a0<strong>Bikou O<\/strong>, <strong>Tharakan S<\/strong>, <strong>Yamada KP<\/strong>, <strong>Kariya T<\/strong>, Gordon A, <strong>Miyashita S<\/strong>, Watanabe S, Sassi Y, Fish K, <strong><u>Ishikawa K<\/u><\/strong>. <u>A Novel Large Animal Model of Thrombogenic Coronary\u00a0 Microembolization<\/u>. Front Cardiovasc Med. 2019 Nov 5;6:157. doi: 10.3389\/fcvm.2019.00157. eCollection 2019. PubMed PMID: 31750316; PubMed Central PMCID: PMC6848058.<\/li>\n<li>\u00a0<strong>Kariya T<\/strong>, <strong><u>Ishikawa K<\/u><\/strong>. <u>The Art of War in Drug Development<\/u>. JACC Basic Transl Sci. 2019 Oct 28;4(6):715-716. doi: 10.1016\/j.jacbts.2019.09.002. eCollection 2019 Oct. PubMed PMID: 31713541; PubMed Central PMCID: PMC6834934.<\/li>\n<li>\u00a0Santos-Gallego CG, Requena-Ibanez JA, San Antonio R, <strong><u>Ishikawa K<\/u><\/strong>, Watanabe S, Picatoste B, Flores E, Garcia-Ropero A, Sanz J, Hajjar RJ, Fuster V, Badimon JJ.\u00a0 <u>Empagliflozin Ameliorates Adverse Left\u00a0Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics<\/u>. J Am Coll Cardiol. 2019 Apr 23;73(15):1931-1944. doi: 10.1016\/j.jacc.2019.01.056. PubMed PMID: 30999996.<\/li>\n<li>\u00a0Katz MG, Fargnoli AS, Gubara SM, Fish K, Weber T, Bridges CR, Hajjar RJ, <strong><u>Ishikawa K<\/u><\/strong>. <u>Targeted Gene Delivery through the Respiratory System: Rationale for\u00a0 Intratracheal Gene Transfer<\/u>. J Cardiovasc Dev Dis. 2019 Feb 15;6(1). pii: E8. doi: 10.3390\/jcdd6010008. Review. PubMed PMID: 30781363.<\/li>\n<li>Chandrasekaran U, Burkhoff D, <strong><u>Ishikawa K<\/u><\/strong>, Swain L, Sunagawa K, M\u00f8ller J, Santos-Gallego C, Annamalai S, Udelson J, Westenfeld R, Kapur N, Qiao X, Wiora J, Sch\u00e4fer A, Bernhardt A, Kochar A, Kloner R, Faraz H. <u>Proceedings of the 3rd annual Acute Cardiac Unloading and REcovery (A-CURE) symposium<\/u>. BMC Cardiovasc Disord. 2019 Feb 7;19(Suppl 2):27. doi: 10.1186\/s12872-019-1000-z. PubMed PMID: 30732562; PubMed Central PMCID: PMC6366036.<\/li>\n<li>Oh JG, Kho C, Hajjar RJ, <strong><u>Ishikawa K<\/u><\/strong>. <u>Experimental models of cardiac physiology and pathology<\/u>. Heart Fail Rev. 2019 Jan 22. doi: 10.1007\/s10741-019-09769-2. [Epub ahead of print] Review. PubMed PMID: 30666533.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2018<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Kapur NK, Annamalai S, Reyelt L, Karmiy SJ, Razavi AA, Foroutanjazi S, Chennojwala A, <strong><u>Ishikawa K<\/u><\/strong>. <u>From bedside to bench and back again: translational studies of mechanical unloading of the left ventricle to promote recovery after acute myocardial infarction<\/u>. F1000Res. 2018 Nov 27;7. pii: F1000 Faculty Rev-1852. doi: 10.12688\/f1000research.14597.1. eCollection 2018. Review. PubMed PMID: 30542612; PubMed Central PMCID: PMC6259487.<\/li>\n<li><strong>Bikou O<\/strong>, Kho C, <u><strong>Ishikawa K<\/strong><\/u>. <u>Atrial stretch and arrhythmia after myocardial infarction<\/u>. Aging (Albany NY). 2018 Dec 28;11(1):11-12. doi: 10.18632\/aging.101729. PubMed PMID: 30594913; PubMed Central PMCID: PMC6339802.<\/li>\n<li>Motloch LJ, Cacheux M, <strong><u>Ishikawa K<\/u><\/strong>, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ,\u00a0 Akar FG. <u>Primary Effect of SERCA 2a Gene Transfer on Conduction Reserve in Chronic Myocardial Infarction<\/u>. J Am Heart Assoc. 2018 Sep 18;7(18):e009598. doi:\u00a0 10.1161\/JAHA.118.009598. PubMed PMID: 30371209; PubMed Central PMCID: PMC6222964.<\/li>\n<li><u><strong>Ishikawa K<\/strong><\/u>, Weber T, Hajjar RJ. <u>Human Cardiac Gene Therapy<\/u>. Circ Res. 2018 Aug<br \/>\n17;123(5):601-613. doi: 10.1161\/CIRCRESAHA.118.311587. PubMed PMID: 30355138.<\/li>\n<li><strong>Watanabe S<\/strong>, <strong><u>Ishikawa K<\/u><\/strong>, Plataki M, <strong>Bikou O<\/strong>, Kohlbrenner E, Aguero J, Hadri L, Zarragoikoetxea I, Fish K, Leopold JA, Hajjar RJ. <u>Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension.<\/u> Pulm Circ. 2018 Oct-Dec;8(4):2045894018799738. doi:<br \/>\n10.1177\/2045894018799738. Epub 2018 Aug 21. PubMed PMID: 30129881<\/li>\n<li><u><strong>Ishikawa K<\/strong><\/u>, <strong>Watanabe S<\/strong>, Lee P, Akar FG, Lee A, <strong>Bikou O<\/strong>, Fish K, Kho C, Hajjar RJ. <u>Acute Left Ventricular Unloading Reduces Atrial Stretch and Inhibits\u00a0Atrial\u00a0Arrhythmias.<\/u> J Am Coll Cardiol. 2018 Aug 14;72(7):738-750. doi:10.1016\/j.jacc.2018.05.059. PMID: 30092950.<\/li>\n<li><u><strong>Ishikawa K<\/strong><\/u>, Meyns B. <u>Acute Mechanical LV Unloading in Ischemia Reperfusion Injury: Be Prepared.<\/u> J Am Coll Cardiol. 2018 Jul 31;72(5):515-517. doi: 10.1016\/j.jacc.2018.05.035. PMID: 30049312.<\/li>\n<li>Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D, Zhang S, Kohlbrenner E, Chepurko E, Chen J, Trivieri MG, Singh R, Bouchareb R, Fish K, <u><strong>Ishikawa K<\/strong><\/u>, Lebeche D, Hajjar RJ, Sahoo S. <u>FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair.<\/u> Circulation. 2018 Jul 11. pii: CIRCULATIONAHA.118.033794. doi: 10.1161\/CIRCULATIONAHA.118.033794.\u00a0PMID: 29997116.<\/li>\n<li>Ziegler T, <u><strong>Ishikawa K<\/strong><\/u>, Hinkel R, Kupatt C. <u>Translational Aspects of Adeno-Associated Virus-Mediated Cardiac Gene Therapy.<\/u> Hum Gene Ther. 2018 Jul 24. doi: 10.1089\/hum.2017.229. PMID: 29848073.<\/li>\n<li>Hammoudi N, <strong>Watanabe S<\/strong>, <strong>Bikou O<\/strong>, Ceccaldi A, Fish K, Yamada KP, Miyashita S, Lebreton G, Hajjar RJ, <u><strong>Ishikawa K<\/strong><\/u>. <u>Speckle-Tracking Echocardiographic Strain Analysis Reliably Estimates Degree of Acute LV Unloading During Mechanical LV Support by Impella.<\/u> J Cardiovasc Transl Res. 2018 May 29. doi: 10.1007\/s12265-018-9812-2. PMID: 29845440.<\/li>\n<li><u><strong>Ishikawa K.<\/strong><\/u> <u>LV-MEMS: A New Challenger Against the CHAMPION?\u00a0<\/u> Circ Cardiovasc Interv. 2018 May;11(5):e006768. doi: 10.1161\/CIRCINTERVENTIONS.118.006768. PMID: 29748221;<\/li>\n<li>Rodriguez P, Sassi Y, Troncone L, Benard L, <u><strong>Ishikawa K<\/strong><\/u>, Gordon RE, Lamas S, Laborda J, Hajjar RJ, Lebeche D. <u>Deletion of delta-like 1 homologue accelerates fibroblast-myofibroblast differentiation and induces myocardial fibrosis.<\/u> Eur Heart J. 2018 Apr 13. doi: 10.1093\/eurheartj\/ehy188. PMID: 29668883.<\/li>\n<li><strong>Watanabe S<\/strong>, Fish K, Kovacic JC, <strong>Bikou O<\/strong>, Leonardson L, Nomoto K, Aguero J, Kapur NK, Hajjar RJ, <u><strong>Ishikawa K<\/strong><\/u>. <u>Left Ventricular Unloading Using an Impella CP Improves Coronary Flow and Infarct Zone Perfusion in Ischemic Heart Failure.<\/u><br \/>\nJ Am Heart Assoc. 2018 Mar 7;7(6). pii: e006462. doi: 10.1161\/JAHA.117.006462. Erratum in: J Am Heart Assoc. 2018 Apr 23;7(9):. PMID: 29514806<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2017<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Hajjar RJ, <strong><u>Ishikawa K<\/u><\/strong>, Kovacic JC, Fuster V. <u>Cardiovascular Research Center at Icahn School of Medicine at Mount Sinai\u00a0 Translational Mission.<\/u> Circ Res. 2017 Dec 8;121(12):1316-1319. doi: 10.1161\/ PubMed [citation] PMID: 29217711<\/li>\n<li><strong><u>Ishikawa K<\/u>, Watanabe S, <\/strong>Hammoudi N, Aguero J, Bikou O, Fish K, Hajjar RJ. <u>Reduced Longitudinal Contraction is Associated with Ischemic Mitral Regurgitation after Posterior MI.<\/u> Am J Physiol Heart Circ Physiol. 2017 Nov 3: ajpheart.00546.2017. doi: 10.1152\/ajpheart.00546.2017.\u00a0 PMID: 29101180<\/li>\n<li>Fish KM,<strong> <u>Ishikawa K<\/u>, <\/strong>Hajjar RJ. <u>Stem cell therapy for acute myocardialinfarction: on the horizon or still a dream?<\/u> Coron Artery Dis. 2017 Nov 14. doi: 10.1097\/MCA.0000000000000589. PMID: 29140809<\/li>\n<li><strong>Watanabe S<\/strong>,<strong> <u>Ishikawa K<\/u><\/strong>, Fish K, Oh JG, Motloch LJ, Kohlbrenner E, Lee P, Xie C,\u00a0Lee A, Liang L, Kho C, Leonardson L, McIntyre M, Wilson S, Samulski RJ, Kranias\u00a0EG, Weber T, Akar FG, Hajjar RJ. <u>Protein Phosphatase Inhibitor-1 Gene\u00a0Therapy in\u00a0a Swine Model of Nonischemic\u00a0Heart Failure.<\/u> Journal of the American College of\u00a0Cardiology. 2017; 70(14):1744-1756. PubMed [journal] PMID: 28958332<\/li>\n<li><strong>Watanabe S<\/strong>, Fish K, Bonnet G, Santos-Gallego CG, Leonardson L, Hajjar RJ,<strong> <u>Ishikawa K<\/u><\/strong>. <u>Echocardiographic and hemodynamic assessment for predicting early\u00a0clinical events in severe acute mitral regurgitation.<\/u> The international journal\u00a0of cardiovascular imaging. 2017; PubMed [journal] PMID: 28735413<\/li>\n<li><strong>Bikou O<\/strong>, <strong><u>Ishikawa K<\/u><\/strong>. <u>Gene therapy for heart failure: status quo and quo vadis.<\/u>\u00a0Discovery medicine. 2017; 23(129):371-377. PubMed [journal] PMID: 28877448<\/li>\n<li>Motloch LJ, <strong><u>Ishikawa K<\/u><\/strong>, Xie C, Hu J, Aguero J, Fish KM, Hajjar RJ, Akar FG.\u00a0<u>Increased afterload following myocardial infarction promotes conduction-dependent\u00a0arrhythmias that are unmasked by hypokalemia.<\/u> JACC. Basic to translational\u00a0science. 2017; 2(3):258-269. NIHMSID: NIHMS881712 PubMed [journal] PMID:\u00a028798965, PMCID: PMC5547890<\/li>\n<li><strong>Watanabe S<\/strong>, <strong><u>Ishikawa K<\/u><\/strong>. Editorial Commentary: <u>Clinical gene therapy trials for\u00a0heart failure: Did they fail?<\/u> Trends in cardiovascular medicine. 2017;\u00a027(3):223-224. PubMed [journal] PMID: 28040326<\/li>\n<li>Aguero J, Lobo Gonzalez M, <strong><u>Ishikawa K<\/u><\/strong>. <u>Route TESI: Main Street for MSC?<\/u>\u00a0Circulation research. 2017; 120(7):1055-1056. PubMed [journal] PMID: 28360340<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>. <u>The Transgenic Diabetic Pig Heart: A &#8220;Sweet Heart&#8221; for Translational \u00a0Cardiovascular Research.<\/u> Journal of the American College of Cardiology. 2017;\u00a069(2):144-146. PubMed [journal] PMID: 28081823<\/li>\n<li>Hajjar RJ, <strong><u>Ishikawa K<\/u><\/strong>. <u>Introducing Genes to the Heart: All About Delivery.<\/u>\u00a0Circulation research. 2017; 120(1):33-35. NIHMSID: NIHMS827918 PubMed [journal]\u00a0PMID: 28057788, PMCID: PMC5221570<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2016<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Hulot JS, <strong><u>Ishikawa K<\/u><\/strong>, Hajjar RJ. <u>Gene therapy for the treatment of heart failure:\u00a0promise postponed.<\/u> European heart journal. 2016; 37(21):1651-8. PubMed [journal] \u00a0PMID: 26922809, PMCID: PMC4887702<\/li>\n<li>Aguero J, <strong><u>Ishikawa K<\/u><\/strong>, Hadri L, Santos-Gallego CG, Fish KM, Kohlbrenner E,\u00a0Hammoudi N, Kho C, Lee A, Ib\u00e1\u00f1ez B, Garc\u00eda-Alvarez A, Zsebo K, Maron BA, Plataki \u00a0M, Fuster V, Leopold JA, Hajjar RJ. <u>Intratracheal Gene Delivery of SERCA2a\u00a0Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal\u00a0Model.<\/u> \u00a0Journal of the American College of Cardiology. 2016; 67(17):2032-46. PubMed\u00a0[journal] PMID: 27126531<\/li>\n<li>Santos-Gallego CG, Vahl TP, Goliasch G, Picatoste B, Arias T, <strong><u>Ishikawa K<\/u><\/strong>, Njerve \u00a0IU, Sanz J, Narula J, Sengupta PP, Hajjar RJ, Fuster V, Badimon JJ.\u00a0<u>Sphingosine-1-Phosphate Receptor Agonist Fingolimod Increases Myocardial Salvage and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Porcine\u00a0Model of Ischemia\/Reperfusion.<\/u> Circulation. 2016; 133(10):954-66. PubMed\u00a0[journal] PMID: 26826180<\/li>\n<li>Turnbull IC, Eltoukhy AA, Fish KM, Nonnenmacher M, <strong><u>Ishikawa K<\/u><\/strong>, Chen J, Hajjar RJ,\u00a0Anderson DG, Costa KD. <u>Myocardial Delivery of Lipidoid Nanoparticle Carrying\u00a0modRNA Induces Rapid and Transient Expression.<\/u> Molecular therapy : the journal of\u00a0the American Society of Gene Therapy. 2016; 24(1):66-75. PubMed [journal] PMID:\u00a026471463, PMCID: PMC4754552<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2015<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Hajjar RJ. <u>Revisiting Old Players in the Revitalized Field of\u00a0Cardiovascular Gene Therapy.<\/u> Journal of the American College of Cardiology. 2015;\u00a066(2):166-8. PubMed [journal] PMID: 26160632<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>. <u>Response to Letter Regarding Article, &#8220;Intracoronary Injection of\u00a0Large Stem Cells: Size Matters&#8221;.<\/u> Circulation. Cardiovascular interventions. 2015;\u00a08(7):e002855. PubMed [journal] PMID: 26136422<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Aguero J, Oh JG, Hammoudi N, Fish LA, Leonardson L, Picatoste B,\u00a0Santos-Gallego CG, Fish KM, Hajjar RJ. <u>Increased stiffness is the major early\u00a0abnormality in a pig model of severe aortic stenosis and predisposes to\u00a0congestive heart failure in the absence of systolic dysfunction.<\/u> Journal of the\u00a0American Heart Association. 2015; 4(5). PubMed [journal] PMID: 25994443, PMCID:\u00a0PMC4599422<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>. <u>Intracoronary injection of large stem cells: size matters.<\/u>\u00a0Circulation. Cardiovascular interventions. 2015; 8(5). PubMed [journal] PMID:\u00a025953824<\/li>\n<li>Hammoudi N, <strong><u>Ishikawa K<\/u><\/strong>, Hajjar RJ. <u>Adeno-associated virus-mediated gene therapy\u00a0in cardiovascular disease.<\/u> Current opinion in cardiology. 2015; 30(3):228-34.\u00a0NIHMSID: NIHMS678838 PubMed [journal] PMID: 25783685, PMCID: PMC4417622<\/li>\n<li>Fish KM, <strong><u>Ishikawa K<\/u><\/strong>. <u>Advances in gene therapy for heart failure.<\/u> Discovery\u00a0medicine. 2015; 19(105):285-91. PubMed [journal] PMID: 25977191<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego \u00a0CG, Fish K, Levine RA, Hajjar RJ. <u>Reply to &#8220;Letter to the editor: Characterizing preclinical model of ischemic heart failure: difference between LAD and LCx\u00a0infarctions&#8221;.<\/u> American journal of physiology. Heart and circulatory physiology.\u00a02015; 308(4):H365-6. PubMed [journal] PMID: 25684739<\/li>\n<li>Aguero J, <strong><u>Ishikawa K<\/u><\/strong>, Fish KM, Hammoudi N, Hadri L, Garcia-Alvarez A, Ibanez B,\u00a0Fuster V, Hajjar RJ, Leopold JA. <u>Combination proximal pulmonary artery coiling\u00a0and distal embolization induces chronic elevations in pulmonary artery pressure\u00a0in Swine.<\/u> PloS one. 2015; 10(4):e0124526. PubMed [journal] PMID: 25923775, PMCID:\u00a0PMC4414513<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Fish K, Aguero J, Yaniz-Galende E, Jeong D, Kho C, Tilemann L, Fish\u00a0L, Liang L, Eltoukhy AA, Anderson DG, Zsebo K, Costa KD, Hajjar RJ. <u>Stem cell\u00a0factor gene transfer improves cardiac function after myocardial infarction in\u00a0swine.<\/u> Circulation. Heart failure. 2015; 8(1):167-74. NIHMSID: NIHMS637932 PubMed\u00a0[journal] PMID: 25342737, PMCID: PMC4303518<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2014<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Fish KM, Tilemann L, Rapti K, Aguero J, Santos-Gallego CG, Lee A,\u00a0Karakikes I, Xie C, Akar FG, Shimada YJ, Gwathmey JK, Asokan A, McPhee S,\u00a0Samulski J, Samulski RJ, Sigg DC, Weber T, Kranias EG, Hajjar RJ. <u>Cardiac I-1c\u00a0overexpression with reengineered AAV improves cardiac function in swine ischemic \u00a0heart failure.<\/u> Molecular therapy : the journal of the American Society of Gene\u00a0Therapy. 2014; 22(12):2038-45. PubMed [journal] PMID: 25023328, PMCID: PMC4429688<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Aguero J, Tilemann L, Ladage D, Hammoudi N, Kawase Y, Santos-Gallego \u00a0CG, Fish K, Levine RA, Hajjar RJ. <u>Characterizing preclinical models of ischemic\u00a0heart failure: differences between LAD and LCx infarctions.<\/u> American journal of\u00a0physiology. Heart and circulatory physiology. 2014; 307(10):H1478-86. PubMed\u00a0[journal] PMID: 25217654, PMCID: PMC4233300<\/li>\n<li>Aguero J, <strong><u>Ishikawa K<\/u><\/strong>, Hadri L, Santos-Gallego C, Fish K, Hammoudi N, Chaanine A, \u00a0Torquato S, Naim C, Ibanez B, Pereda D, Garc\u00eda-Alvarez A, Fuster V, Sengupta PP, \u00a0Leopold JA, Hajjar RJ. <u>Characterization of right ventricular remodeling and\u00a0failure in a chronic pulmonary hypertension model.<\/u> American journal of\u00a0physiology. Heart and circulatory physiology. 2014; 307(8):H1204-15. PubMed\u00a0[journal] PMID: 25158063, PMCID: PMC4200337<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><b>2013<\/b><\/h2>\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li style=\"list-style-type: none\">\n<ul>\n<li>Tilemann L, Lee A, <strong><u>Ishikawa K<\/u><\/strong>, Aguero J, Rapti K, Santos-Gallego C, Kohlbrenner\u00a0E, Fish KM, Kho C, Hajjar RJ. <u>SUMO-1 gene transfer improves cardiac function in a\u00a0large-animal model of heart failure.<\/u> Science translational medicine. 2013;\u00a05(211):211ra159. PubMed [journal] PMID: 24225946<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Aguero J, Naim C, Fish K, Hajjar RJ. <u>Percutaneous approaches forefficient cardiac gene delivery.<\/u> Journal of cardiovascular translational\u00a0research. 2013; 6(4):649-59. PubMed [journal] PMID: 23749638<\/li>\n<li>Hadri L, Kratlian RG, Benard L, Maron BA, Dorfm\u00fcller P, Ladage D, Guignabert C, <strong><u>Ishikawa K<\/u><\/strong>, Aguero J, Ibanez B, Turnbull IC, Kohlbrenner E, Liang L, Zsebo K,\u00a0Humbert M, Hulot JS, Kawase Y, Hajjar RJ, Leopold JA. <u>Therapeutic efficacy of\u00a0AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.<\/u>\u00a0Circulation. 2013; 128(5):512-23. NIHMSID: NIHMS546892 PubMed [journal] PMID:\u00a023804254, PMCID: PMC3908449<\/li>\n<li>Fish KM, Ladage D, Kawase Y, Karakikes I, Jeong D, Ly H, <strong><u>Ishikawa K<\/u><\/strong>, Hadri L,\u00a0Tilemann L, Muller-Ehmsen J, Samulski RJ, Kranias EG, Hajjar RJ. <u>AAV9.I-1c\u00a0delivered via direct coronary infusion in a porcine model of heart failure\u00a0improves contractility and mitigates adverse remodeling.<\/u> Circulation. Heart\u00a0failure. 2013; 6(2):310-7. NIHMSID: NIHMS439923 PubMed [journal] PMID: 23271792,\u00a0PMCID: PMC3605211<\/li>\n<li>Ladage D, Yaniz-Galende E, Rapti K, <strong><u>Ishikawa K<\/u><\/strong>, Tilemann L, Shapiro S, Takewa Y,Muller-Ehmsen J, Schwarz M, Garcia MJ, Sanz J, Hajjar RJ, Kawase Y. <u>Stimulating\u00a0myocardial regeneration with periostin Peptide in large mammals improves function\u00a0post-myocardial infarction but increases myocardial fibrosis.<\/u> PloS one. 2013;\u00a08(5):e59656. 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PubMed [journal] PMID: 22231467<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Tilemann L, Ladage D, Aguero J, Leonardson L, Fish K, Kawase Y.\u00a0<u>Cardiac gene therapy in large animals: bridge from bench to bedside.<\/u> Gene\u00a0therapy. 2012; 19(6):670-7. PubMed [journal] PMID: 22301438<\/li>\n<li>Ladage D, <strong><u>Ishikawa K<\/u><\/strong>, Tilemann L, M\u00fcller-Ehmsen J, Kawase Y. <u>Percutaneous methods\u00a0of vector delivery in preclinical models.<\/u> Gene therapy. 2012; 19(6):637-41.\u00a0PubMed [journal] PMID: 22418064<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Chemaly ER, Tilemann L, Fish K, Ladage D, Aguero J, Vahl T,\u00a0Santos-Gallego C, Kawase Y, Hajjar RJ. <u>Assessing left ventricular systolic\u00a0dysfunction after myocardial infarction: are ejection fraction and dP\/dt(max)\u00a0complementary or redundant?<\/u> American journal of physiology. Heart and circulatory\u00a0physiology. 2012; 302(7):H1423-8. PubMed [journal] PMID: 22307667, PMCID:\u00a0PMC3330783<\/li>\n<li><strong><u>Ishikawa K<\/u><\/strong>, Aoyama Y, Hirayama H. <u>Management of drug-eluting stent restenosis.\u00a0The Journal of invasive cardiology.<u> 2012; 24(4):178-82. PubMed [journal] PMID:\u00a022477755<\/u><\/u><\/li>\n<li>Tilemann L, <strong><u>Ishikawa K<\/u><\/strong>, Weber T, Hajjar RJ. <u>Gene therapy for heart failure.\u00a0Circulation research.<\/u> 2012; 110(5):777-93. NIHMSID: NIHMS361108 PubMed [journal]\u00a0PMID: 22383712, PMCID: PMC3594844<\/li>\n<li>Karakikes I, Hadri L, Rapti K, Ladage D, <strong><u>Ishikawa K<\/u><\/strong>, Tilemann L, Yi GH, Morel C,\u00a0Gwathmey JK, Zsebo K, Weber T, Kawase Y, Hajjar RJ. <u>Concomitant intravenous\u00a0nitroglycerin with intracoronary delivery of AAV1.SERCA2a enhances gene transfer\u00a0in porcine hearts.<\/u> Molecular therapy : the journal of the American Society of\u00a0Gene Therapy. 2012; 20(3):565-71. 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PubMed [journal] PMID:\u00a020461063, PMCID: PMC2911258<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<hr \/>\n<p>&nbsp;<\/p>\n<h1><\/h1>\n","protected":false},"excerpt":{"rendered":"<p>2026 Veera S, Lin NH, Mavropoulos SA, Ishikawa K. New approaches to cardiac gene therapy delivery. Can J Cardiol. 2026 Feb 26:S0828-282X(26)00149-2. doi: 10.1016\/j.cjca.2026.02.031. Epub ahead of print. PMID: 41763359. 2025 Gallinat A, Li X, Raisinghani NP, La Salvia S, Phan A, Zhang S, Mavropoulos SA, Veera S, Yoon S, Ishikawa K, Sahoo S. 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