{"id":14,"date":"2017-09-13T15:59:04","date_gmt":"2017-09-13T15:59:04","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/ishikawalab\/?page_id=14"},"modified":"2024-11-20T22:52:31","modified_gmt":"2024-11-20T22:52:31","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

\u00ad\u00ad \u00ad\u00a0 The Cardiology Laboratory for Translational Research of CVRC has several unique large animal models that closely mimic human cardiac diseases and uses these models for studying physiology, biology, imaging, and efficacy of therapeutic approaches. Independent clinical catheterization laboratory dedicated to CVRC large animal studies allows daily catheter procedures and echocardiography as well as pressure-volume loop evaluations within the laboratory. It also has access to state-of-the-art imaging modalities in The Translational and Molecular Imaging Institute including magnetic resonance imaging and positron emission tomography.
\n\u00ad\u00a0\u00a0\u00adOur lab is unique in having not only the acute heart failure models but having repertories of chronic heart failure models with different characteristics. These include, chronic myocardial infarction, chronic ischemia with hibernating myocardium, mitral regurgitation induced volume-overload, aortic banding induced pressure overload, combined myocardial infarction and aortic banding, post-capillary pulmonary hypertension, and chronic pulmonary embolism (See Animal Models<\/a> page). These models provide important opportunities to evaluate therapeutic effects in respective phenotype of diseases that reflect clinical population.
\n\u00ad\u00a0\u00a0 Recent successful demonstration of nebulization gene therapy in preventing the progression of pulmonary hypertension as well as a new viral vector based heart failure therapy in pigs are expected to be translated into clinical trials in near future.
\n\u00ad\u00a0\u00ad\u00a0\u00a0Our lab also focuses on defining the physiological and molecular changes induced by altering the cardiac load both in acute and chronic heart failure.<\/p>\n

Available modalities of in vivo physiological assessment and manipulation within the lab
\n\u2022 Mobile C-arm OEC Elite CFD<\/a> (GE)<\/p>\n

\u2022 Pressure-volume conductance system (Millar, EMKA)
\n\u2022 Echocardiography: Epiq CVX (Philips),\u00a0 ie-33 (Philips), vivid-i (GE)
\n\u2022 Q-lab software for echo strain analysis and 3D echo
\n\u2022 Implantable telemetry system (EMKA)
\n\u2022 Transonic Flow probe
\n\u2022 Flow and pressure wire measurement (Volcano)
\n\u2022 Coroflow system for coronary pressure and thermodilution (Abbott)
\n\u2022 Tissue perfusion assessment using fluorescent microspheres
\n\u2022 Swan-Ganz cardiac output
\n\u2022 Pacing (Harvard Apparatus)
\n\u2022 ICD and loop recorders (Medtronic)
\n\u2022 Impella (Abiomed)
\n\u2022 ECMO: Bio console 560 (Medtronic)
\n\u2022 IABP (Datascope)
\n\u2022 ThermoGard endovascular cooling system (Zoll)
\n\u2022 Near infra-red live imager<\/p>\n

Access to
\n\u2022 Cardiac MRI (3T, 7T)
\n\u2022 Cardiac CT<\/p>\n

\u2022 PET\/MRI\"\"<\/a><\/p>\n

 <\/p>\n

\"\"<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u00ad\u00ad \u00ad\u00a0 The Cardiology Laboratory for Translational Research of CVRC has several unique large animal models that closely mimic human cardiac diseases and uses these models for studying physiology, biology, imaging, and efficacy of therapeutic approaches. Independent clinical catheterization laboratory dedicated to CVRC large animal studies allows daily catheter procedures and echocardiography as well as […]<\/p>\n","protected":false},"author":246,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-14","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/wp-json\/wp\/v2\/pages\/14","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/wp-json\/wp\/v2\/users\/246"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/wp-json\/wp\/v2\/comments?post=14"}],"version-history":[{"count":17,"href":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/wp-json\/wp\/v2\/pages\/14\/revisions"}],"predecessor-version":[{"id":551,"href":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/wp-json\/wp\/v2\/pages\/14\/revisions\/551"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/ishikawalab\/wp-json\/wp\/v2\/media?parent=14"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}