Dr. Iomini is an Assistant Professor of Ophthalmology and Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai, New York, NY. His laboratory is also part of the Friedman Brain Institute at Mount Sinai.
Dr. Iomini obtained his BA degree from the University of Milano, Italy and received his PhD in Cell Biology and Zoology from the National Museum of Natural History in Paris, France for his studies on the biology of cilia and flagella in a group of parasitic flatworms relevant for human health. Subsequently, during his postdoctoral training at Mount Sinai School of Medicine (New York) and Washington University (St. Louis) he applied a multidisciplinary approach including enhanced video-microscopy, genetics and biochemistry to study the Intraflagellar transport (IFT) in Chlamydomonas. He discovered the role of IFT-A complex in retrograde IFT and novel flagellar proteins involved in light response signaling pathway in Chlamydomonas. He also pioneered studies on primary cilia in vascular endothelial cells demonstrating for the first time the ability of endothelial cilia to respond to laminar shear stress forces by undergoing disassembly.
Dr. Iomini’s current research addresses the role of primary cilia during cellular morphogenesis in the context of complex tissues using the eye as a model system. Using mouse genetics, biochemistry and intravital microscopy he aims to uncover the role of primary cilia in poorly understood anterior segment disorders including abnormal iridocorneal angle, sclerocornea, keratoconus, microcornea, glaucoma, corneal thickening, edema, and cataract that often coexist with systemic ciliopathies.