{"id":95,"date":"2015-12-21T21:22:43","date_gmt":"2015-12-21T21:22:43","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/iatridislab\/?page_id=95"},"modified":"2023-02-15T19:36:48","modified_gmt":"2023-02-15T23:36:48","slug":"articles","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/iatridislab\/articles\/","title":{"rendered":"Peer-Reviewed Articles"},"content":{"rendered":"

Most Recent<\/h1>\n
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Please see our pubmed link<\/a>\u00a0for our latest paper.<\/p>\n<\/div>\n<\/div>\n

2018<\/h1>\n
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Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs.\u00a0<\/a>Cruz MA, Hom WW, DiStefano TJ, Merrill R, Torre OM, Lin HA, Hecht AC, Illien-Junger S,\u00a0Iatridis JC<\/b>.\u00a0Tissue Eng Part A<\/span>. 2018 Feb;24(3-4):187-198. doi: 10.1089\/ten.TEA.2017.0334. Epub 2018 Jan 11. PMID: 29214889<\/p>\n<\/div>\n<\/div>\n

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2017<\/h1>\n
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Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain.\u00a0<\/a>Mosley GE, Evashwick-Rogler TW, Lai A,\u00a0Iatridis JC.\u00a0Ann N Y Acad Sci<\/span>. 2017 Dec;1409(1):51-66. doi: 10.1111\/nyas.13429. Epub 2017 Aug 10. Review. PMID: 28797134<\/p>\n<\/div>\n<\/div>\n

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Dietary Advanced Glycation End Products have Sex-and Age Dependent Effects on Vertebral Bone Microstructure and Mechanical Function in Mice.\u00a0<\/a>Illien-J\u00fcnger S, Palacio-Mancheno P, Kindschuh WF, Chen X, Sroga GE, Vashishth D,\u00a0Iatridis JC.\u00a0J Bone Miner Res<\/span>. 2017 Nov 21. doi: 10.1002\/jbmr.3321. [Epub ahead of print] PMID: 29160901<\/p>\n<\/div>\n<\/div>\n

Accumulation and localization of macrophage phenotypes with human intervertebral disc degeneration.\u00a0<\/a>Nakazawa KR, Walter BA, Laudier DM, Krishnamoorthy D, Mosley GE, Spiller KL,\u00a0Iatridis JC. Spine J. 2017 Oct 11. pii: S1529-9430(17)31048-3. doi: 10.1016\/j.spinee.2017.09.018. [Epub ahead of print] PMID:29031872<\/p>\n

Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape.\u00a0<\/a>Rolfe RA, Bezer JH, Kim T, Zaidon AZ, Oyen ML,\u00a0Iatridis JC, Nowlan NC. J Orthop Res. 2017 Oct;35(10):2135-2144. doi: 10.1002\/jor.23518. Epub 2017 May 12. PMID: 28079273\u00a0Free PMC Article<\/a><\/p>\n

Animal models for studying the etiology and treatment of low back pain.\u00a0<\/a>Shi C, Qiu S, Riester SM, Das V, Zhu B, Wallace AA, van Wijnen AJ, Mwale F,\u00a0Iatridis JC, Sakai D, Votta-Velis G, Yuan W, Im HJ. J Orthop Res. 2017 Sep 18. doi: 10.1002\/jor.23741. [Epub ahead of print] Review. PMID:28921656<\/p>\n

Hyperosmolarity induces notochordal cell differentiation with aquaporin3 upregulation and reduced N-cadherin expression.\u00a0<\/a>Palacio-Mancheno PE, Evashwick-Rogler TW, Laudier DM, Purmessur D,\u00a0Iatridis JC. J Orthop Res. 2017 Aug 29. doi: 10.1002\/jor.23715. [Epub ahead of print] PMID:28853179<\/p>\n

Looking beyond the intervertebral disc: the need for behavioral assays in models of discogenic pain.\u00a0<\/a>Mosley GE, Evashwick-Rogler TW, Lai A,\u00a0Iatridis JC. Ann N Y Acad Sci. 2017 Aug 10. doi: 10.1111\/nyas.13429. [Epub ahead of print] Review. PMID:28797134<\/p>\n

Structural and Chemical Modification to Improve Adhesive and Material Properties of Fibrin-Genipin for Repair of Annulus Fibrosus Defects in Intervertebral Disks.\u00a0<\/a>Cruz MA, McAnany S, Gupta N, Long RG, Nasser P, Eglin D, Hecht AC, Illien-Junger S,\u00a0Iatridis JC. J Biomech Eng. 2017 Aug 1;139(8). doi: 10.1115\/1.4036623. PMID: 28464119<\/p>\n

Intervertebral Disk Degeneration and Repair.\u00a0<\/a>Dowdell J, Erwin M, Choma T, Vaccaro A,\u00a0Iatridis J, Cho SK. Neurosurgery. 2017 Mar 1;80(3S):S46-S54. doi: 10.1093\/neuros\/nyw078. Review. PMID:28350945<\/p>\n

New horizons in spine research: Intervertebral disc repair and regeneration.\u00a0<\/a>Iatridis JC, Kang J, Kandel R, Risbud MV. J Orthop Res. 2017 Jan;35(1):5-7. doi: 10.1002\/jor.23499. No abstract available. PMID: 28114734<\/p>\n

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2016<\/h1>\n
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AGEs induce ectopic endochondral ossification in intervertebral discs\u00a0<\/a>Illien-J\u00fcnger S, Torre OM, Kindschuh WF, Chen X, Laudier DM,\u00a0Iatridis JC.\u00a0Eur Cell Mater<\/span>. 2016 Nov 18;32:257-270. PMID: 27858401 Free PMC Article<\/a><\/p>\n

In vitro and biomechanical screening of polyethylene glycol and poly(trimethylene carbonate) block copolymers for annulus fibrosus repair.\u00a0<\/a>Long RG, Rotman SG, Hom WW, Assael DJ, Illien-J\u00fcnger S, Grijpma DW, Iatridis JC.\u00a0J Tissue Eng Regen Med<\/span>. 2016 Nov 12. doi: 10.1002\/term.2356. [Epub ahead of print] PMID: 27860368<\/p>\n

Does type 2 diabetes mellitus promote intervertebral disc degeneration?\u00a0<\/a>Fabiane SM, Ward KJ, Iatridis JC, Williams FM.\u00a0Eur Spine J<\/span>. 2016 Sep;25(9):2716-20. doi: 10.1007\/s00586-016 4612-3. Epub 2016 Jun 6. PMID: 27272275 Free PMC Article<\/a><\/div>\n<\/div>\n<\/div>\n
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New Horizons in Spine Research: Disc biology, spine biomechanics and pathomechanisms of back pain.\u00a0<\/a>Iatridis JC, Kang J, Kandel R, Risbud MV.\u00a0J Orthop Res<\/span>. 2016 Aug;34(8):1287-8. doi: 10.1002\/jor.23375. No abstract available. PMID: 27571441\u00a0Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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Molecular mechanisms of biological aging in intervertebral discs.\u00a0<\/a>Vo NV, Hartman RA, Patil PR, Risbud MV, Kletsas D, Iatridis JC, Hoyland JA, Le Maitre CL, Sowa GA, Kang JD.\u00a0J Orthop Res<\/span>. 2016 Aug;34(8):1289-306. doi: 10.1002\/jor.23195. Epub 2016 Aug 12. Review. PMID: 26890203 Free PMC Article<\/a><\/p>\n

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Reduced tissue osmolarity increases TRPV4 expression and pro-inflammatory cytokines in intervertebral disc cells.\u00a0<\/a>Walter BA, Purmessur D, Moon A, Occhiogrosso J, Laudier DM, Hecht AC,\u00a0Iatridis JC.\u00a0Eur Cell Mater<\/span>. 2016 Jul 19;32:123-36. PMID: 27434269 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Do mechanical strain and TNF-\u03b1 interact to amplify pro-inflammatory cytokine production in human annulus fibrosus cells?\u00a0<\/a>Likhitpanichkul M, Torre OM, Gruen J, Walter BA, Hecht AC, Iatridis JC.\u00a0J Biomech<\/span>. 2016 May 3;49(7):1214-1220. doi: 10.1016\/j.jbiomech.2016.02.029. Epub 2016 Feb 18.PMID: 26924657 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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Development of a bovine decellularized extracellular matrix-biomaterial for nucleus pulposus regeneration.\u00a0<\/a>Illien-J\u00fcnger S, Sedaghatpour DD, Laudier DM, Hecht AC, Qureshi SA, Iatridis JC.\u00a0J Orthop Res<\/span>. 2016 May;34(5):876-88. doi: 10.1002\/jor.23088. Epub 2015 Dec 1. PMID: 26509556 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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Annular puncture with tumor necrosis factor-alpha injection enhances painful behavior with disc degeneration in vivo.\u00a0<\/a>Lai A, Moon A, Purmessur D, Skovrlj B, Laudier DM, Winkelstein BA, Cho SK, Hecht AC, Iatridis JC.\u00a0Spine J<\/span>. 2016 Mar;16(3):420-31. doi: 10.1016\/j.spinee.2015.11.019. Epub 2015 Dec 2. PMID: 26610672 Free PMC Article<\/a><\/p>\n

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Design Requirements for Annulus Fibrosus Repair: Review of Forces, Displacements, and Material Properties of the Intervertebral Disk and a Summary of Candidate Hydrogels for Repair.\u00a0<\/a>Long RG, Torre OM, Hom WW, Assael DJ, Iatridis JC.\u00a0J Biomech Eng<\/span>. 2016 Feb;138(2):021007. doi: 10.1115\/1.4032353. PMID: 26720265 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Mechanical restoration and failure analyses of a hydrogel and scaffold composite strategy for annulus fibrosus repair.\u00a0<\/a>Long RG, B\u00fcrki A, Zysset P, Eglin D, Grijpma DW, Blanquer SBG, Hecht AC, Iatridis JC.\u00a0Acta Biomater<\/span>. 2016 Jan;30:116-125. doi: 10.1016\/j.actbio.2015.11.015. Epub 2015 Nov 11. PMID: 26577987 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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2015<\/h1>\n
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Form and function of the intervertebral disc in health and disease: a morphological and stain comparison study.\u00a0<\/a>Walter BA, Torre OM, Laudier D, Naidich TP, Hecht AC,\u00a0Iatridis JC.\u00a0J Anat<\/span>. 2015 Dec;227(6):707-16. doi: 10.1111\/joa.12258. Epub 2014 Nov 25. PMID: 25424497 Free PMC Article<\/a><\/p>\n

Association Between BMP-2 and Carcinogenicity.\u00a0<\/a>Skovrlj B, Koehler SM, Anderson PA, Qureshi SA, Hecht AC, Iatridis JC, Cho SK.\u00a0Spine (Phila Pa 1976)<\/span>. 2015 Dec;40(23):1862-71. doi: 10.1097\/BRS.0000000000001126. Review. PMID: 26274524<\/p>\n<\/div>\n<\/div>\n

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Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNF\u03b1 drug.\u00a0<\/a>Likhitpanichkul M, Kim Y, Torre OM, See E, Kazezian Z, Pandit A, Hecht AC, Iatridis JC.\u00a0Spine J<\/span>. 2015 Sep 1;15(9):2045-54. doi: 10.1016\/j.spinee.2015.04.026. Epub 2015 Apr 23. PMID: 25912501 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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Inflammatory Kinetics and Efficacy of Anti-inflammatory Treatments on Human Nucleus Pulposus Cells.\u00a0<\/a>Walter BA, Purmessur D, Likhitpanichkul M, Weinberg A, Cho SK, Qureshi SA, Hecht AC, Iatridis JC.\u00a0Spine (Phila Pa 1976)<\/span>. 2015 Jul 1;40(13):955-63. doi: 10.1097\/BRS.0000000000000932. PMID: 25893355 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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Assessment of functional and behavioral changes sensitive to painful disc degeneration.\u00a0<\/a>Lai A, Moon A, Purmessur D, Skovrlj B, Winkelstein BA, Cho SK, Hecht AC, Iatridis JC.\u00a0J Orthop Res<\/span>. 2015 May;33(5):755-64. doi: 10.1002\/jor.22833. Epub 2015 Mar 31. PMID: 25731955 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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Intact glycosaminoglycans from intervertebral disc-derived notochordal cell-conditioned media inhibit neurite growth while maintaining neuronal cell viability.\u00a0<\/a>Purmessur D, Cornejo MC, Cho SK, Roughley PJ, Linhardt RJ, Hecht AC, Iatridis JC.\u00a0Spine J<\/span>. 2015 May 1;15(5):1060-9. doi: 10.1016\/j.spinee.2015.02.003. Epub 2015 Feb 7. PMID: 25661435 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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TNF\u03b1 transport induced by dynamic loading alters biomechanics of intact intervertebral discs.\u00a0<\/a>Walter BA, Likhitpanichkul M, Illien-Junger S, Roughley PJ, Hecht AC, Iatridis JC.\u00a0PLoS One<\/span>. 2015 Mar 3;10(3):e0118358. doi: 10.1371\/journal.pone.0118358. eCollection 2015. PMID: 25734788 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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Defining the phenotype of young healthy nucleus pulposus cells: recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting.\u00a0<\/a>Risbud MV, Schoepflin ZR, Mwale F, Kandel RA, Grad S, Iatridis JC, Sakai D, Hoyland JA.\u00a0J Orthop Res<\/span>. 2015 Mar;33(3):283-93. doi: 10.1002\/jor.22789. Epub 2015 Jan 21. PMID: 25411088 Free PMC Article<\/a><\/p>\n

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Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines.\u00a0<\/a>Cornejo MC, Cho SK, Giannarelli C,\u00a0Iatridis JC, Purmessur D.\u00a0Osteoarthritis Cartilage<\/span>. 2015 Mar;23(3):487-96. doi: 10.1016\/j.joca.2014.12.010. Epub 2014 Dec 19. PMID: 25534363\u00a0Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice.\u00a0<\/a>Illien-J\u00fcnger S, Lu Y, Qureshi SA, Hecht AC, Cai W, Vlassara H, Striker GE, Iatridis JC.\u00a0PLoS One<\/span>. 2015 Feb 10;10(2):e0116625. doi: 10.1371\/journal.pone.0116625. eCollection 2015. PMID: 25668621 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n

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Organ culture bioreactors–platforms to study human intervertebral disc degeneration and regenerative therapy.\u00a0<\/a>Gantenbein B, Illien-J\u00fcnger S, Chan SC, Walser J, Haglund L, Ferguson SJ, Iatridis JC, Grad S.\u00a0Curr Stem Cell Res Ther<\/span>. 2015;10(4):339-52. Review. PMID: 25764196 Free PMC Article<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Most Recent Please see our pubmed link\u00a0for our latest paper. 2018 Cell-Seeded Adhesive Biomaterial for Repair of Annulus Fibrosus Defects in Intervertebral Discs.\u00a0Cruz MA, Hom WW, DiStefano TJ, Merrill R, Torre OM, Lin HA, Hecht AC, Illien-Junger S,\u00a0Iatridis JC.\u00a0Tissue Eng Part A. 2018 Feb;24(3-4):187-198. doi: 10.1089\/ten.TEA.2017.0334. Epub 2018 Jan 11. PMID: 29214889 2017 Looking beyond […]<\/p>\n","protected":false},"author":86,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-95","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/iatridislab\/wp-json\/wp\/v2\/pages\/95","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/iatridislab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/iatridislab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/iatridislab\/wp-json\/wp\/v2\/users\/86"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/iatridislab\/wp-json\/wp\/v2\/comments?post=95"}],"version-history":[{"count":24,"href":"https:\/\/labs.icahn.mssm.edu\/iatridislab\/wp-json\/wp\/v2\/pages\/95\/revisions"}],"predecessor-version":[{"id":1720,"href":"https:\/\/labs.icahn.mssm.edu\/iatridislab\/wp-json\/wp\/v2\/pages\/95\/revisions\/1720"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/iatridislab\/wp-json\/wp\/v2\/media?parent=95"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}