The relative abundance of Barnesiellaceae and Blautia in PSC and non-PSC-IBD at multiple locations. Boxplots (left panel) show the mean and variance of the relative abundance; Dot plots (right panel) show the relative abundance for each individual samples and the lines link the samples from the same subject. Green: non-PSC IBD; blue: PSC.
A recent research with collaboration with SHARE explored the mucosa-associated microbiota in primary sclerosing cholangitis (PSC) patients across different locations in the gut, and to compare it with inflammatory bowel disease (IBD)-only patients and healthy controls. We found that the overall microbiota profile was similar across multiple locations in the gut from the same individual regardless of disease status. In this study, the mucosa associated-microbiota of patients with primary sclerosing cholangitis was characterised by enrichment of Blautia andBarnesiellaceae and by major shifts in operational taxa units within Clostridiales order.