Chronic kidney disease (CKD) is progressive loss in renal function that afflicts approximately 25 million adults in the United States alone, with the majority remaining undiagnosed. Our current study found distinctive microbiota features associated with CKD status were found in specific oral locations. A combination of some of those taxa features was reasonably predictable of the CKD status suggesting a sampling from specific oral locations as a potential noninvasive test to identify individuals with or at risk of developing CKD.