{"id":84,"date":"2017-12-03T01:55:50","date_gmt":"2017-12-03T01:55:50","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/horowitzlab\/?page_id=84"},"modified":"2020-10-12T10:19:28","modified_gmt":"2020-10-12T10:19:28","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/","title":{"rendered":"Home"},"content":{"rendered":"<p>Our work focuses on human NK cells and T cells and their functional roles in cancer, microbial infections, transplantation, and in autoimmunity. Our analyses are designed to identify specific subsets of NK cells and T cells with enhanced immunotherapeutic potential as well as to identify pathways regulating NK cell and T cell function that can be perturbed for therapeutic benefit. To achieve this goal, our lab uses mass cytometry (CyTOF<sup>TM<\/sup>), imaging mass cytometry, single cell RNA sequencing, and Olink Proteomics<sup>TM<\/sup> along with genomic data to study NK cells and T cells with ultra-resolution.<\/p>\n<p>Currently, the lab has studies focused on bladder cancer, kidney cancer, head and neck cancer, kidney transplantation, and Type 1 diabetes.<\/p>\n<p>Our approach combines:<\/p>\n<ol>\n<li>epidemiologic analyses of\u00a0<em>HLA<\/em>\u00a0and\u00a0<em>KIR<\/em>\u00a0alleles in genomic studies of cancers, immunotherapy, transplantation and Type 1 Diabetes;<\/li>\n<li><em>Ex-vivo<\/em>\u00a0phenotyping and\u00a0<em>in-vitro<\/em>\u00a0mechanistic studies using high-resolution transcriptomic and proteomic analyses (CyTOF<sup>TM<\/sup>, imaging mass cytometry, single-cell RNAseq, spatial-sequencing, and Olink proteomics<sup>TM<\/sup>)<\/li>\n<\/ol>\n<p>We invite you to scroll through our\u00a0<a href=\"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/projects\/\">Projects Page<\/a>\u00a0for more details on our current studies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our work focuses on human NK cells and T cells and their functional roles in cancer, microbial infections, transplantation, and in autoimmunity. Our analyses are designed to identify specific subsets of NK cells and T cells with enhanced immunotherapeutic potential as well as to identify pathways regulating NK cell and T cell function that can [&hellip;]<\/p>\n","protected":false},"author":249,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-84","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/wp-json\/wp\/v2\/pages\/84","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/wp-json\/wp\/v2\/users\/249"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/wp-json\/wp\/v2\/comments?post=84"}],"version-history":[{"count":13,"href":"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/wp-json\/wp\/v2\/pages\/84\/revisions"}],"predecessor-version":[{"id":232,"href":"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/wp-json\/wp\/v2\/pages\/84\/revisions\/232"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/horowitzlab\/wp-json\/wp\/v2\/media?parent=84"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}