{"id":2494,"date":"2022-12-20T11:44:55","date_gmt":"2022-12-20T16:44:55","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=2494"},"modified":"2026-02-18T21:20:55","modified_gmt":"2026-02-19T02:20:55","slug":"publications","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/hongzhenhulab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1 ” module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.16″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/hongzhenhulab2\/wp-content\/uploads\/sites\/618\/2022\/07\/ai-002-1.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” saved_tabs=”all” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” custom_padding=”||0px|||” border_color_all=”RGBA(0,0,0,0)” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet” global_colors_info=”{}”][et_pb_text admin_label=”Text – Title” _builder_version=”4.27.4″ _module_preset=”b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa” header_font=”||||||||” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||10px||false|false” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop” global_colors_info=”{}”]<\/p>\n

Publications<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” min_height=”173.3px” custom_margin=”-27px|||||” custom_padding=”||0px|||” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”10px|||||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”26px” global_colors_info=”{}”]<\/p>\n

Selected Publications<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Section 28 – Blog Style Publications” module_class=”section28_blog_style_publications” _builder_version=”4.9.0″ background_color=”#FFFFFF” background_image=”https:\/\/labs.icahn.mssm.edu\/hongzhenhulab2\/wp-content\/uploads\/sites\/618\/2022\/10\/Background-1.png” parallax=”on” parallax_method=”off” custom_padding=”1px||||false|false” global_module=”2511″ saved_tabs=”all” locked=”off” collapsed=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/38134932\/ ” link_option_url_new_window=”on” hover_enabled=”0″ box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Zhang W, Emanuel ER, Yano H, Uddin J, Gaudino S, Xie Z, Ichise H, Wang Z, Cowan MN, Lyu M, Hou X, Zeng P, Hu E, Ribeiro de Godoy V, Grier A, Estep N, Ishibashi JR, Anover-Sombke S, Skene PJ, Mayassi T, Xavier RJ, Germain RN, Globig AM, Heeg M, Goldrath AW, Kim BS,\u00a0Hu H, Artis D.\u00a0<\/em><\/p>\n

Neuro-epithelial circuits promote sensory convergence and intestinal immunity<\/strong><\/p>\n

Nature 2026 Jan<\/span><\/p>\n

DOI: 10.1038\/s41586-025-09921-z<\/a><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/40132579\/ ” link_option_url_new_window=”on” hover_enabled=”0″ box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Spencer NJ, Hibberd TJ, Hu H. <\/em><\/p>\n

Gut-brain communication: types of sensory nerves and mechanisms of activation<\/strong><\/p>\n

Nat Rev Gastroenterol Hepatol 2025 Oct<\/p>\n

DOI: 10.1038\/s41575-025-01132-1<\/a><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/38134932\/ ” link_option_url_new_window=”on” hover_enabled=”0″ box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

Tamari M, Del Bel KL, Ver Heul AM, Zamidar L, Orimo K, Hoshi M, Trier AM, Yano H, Yang TL, Biggs CM, Motomura K, Shibuya R, Yu CD, Xie Z, Iriki H, Wang Z, Auyeung K, Damle G, Demircioglu D, Gregory JK, Hasson D, Dai J, Chang RB, Morita H, Matsumoto K, Jain S, Van Dyken S, Milner JD, Bogunovic D, Hu H, Artis D, Turvey SE, Kim BS.<\/em><\/p>\n

Sensory neurons promote immune homeostasis in the lung<\/strong><\/p>\n

Cell 2024 Jan<\/p>\n

DOI: 10.1016\/j.cell.2023.11.027<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/40132579\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Xie Z*, Rose L*, Feng J, Zhao Y, Lu Y, Othman R, Kane H, Hibberd TJ, Hu X, Zang K, Yang X, Richardson Q, Venezia OL, Zhakyp A, Gao F, Abe N, Wang Z, Vigeland K, Wang H, Branch C, Dong X, Kim BS, Spencer NJ, Hu H#, and Jackson R#<\/em><\/p>\n

Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force<\/strong><\/p>\n

Cell. 2025 May<\/p>\n

DOI:\u00a010.1016\/j.cell.2025.02.031<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36973289\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

He Z*<\/sup>, Zhao Y*<\/sup>, Rau M, Fitzpatrick J, Sah R, Hu H#<\/sup>, Yuan P#<\/sup>.<\/em><\/p>\n

Structural and functional analysis of human pannexin 2 channel<\/strong><\/p>\n

Nat Commun. 2023 Mar<\/p>\n

DOI:\u00a010.1038\/s41467-023-37413-z<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36961815\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Lu P*<\/sup>, Zhao Y*<\/sup>, Xie Z*<\/sup>, Zhou H, Dong X, Wu GF, Kim BS, Feng J#<\/sup>, Hu H#<\/sup>.<\/em><\/p>\n

MrgprA3-expressing preceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel<\/strong><\/p>\n

Cell Rep 2023 Apr<\/p>\n

DOI:\u00a010.1016\/j.celrep.2023.112283<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36701202\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Hu X*<\/sup>, Du L*<\/sup>, Liu S*<\/sup>, Lan Z, Zang K, Zhao Y, Yang X, Xie Z, Wang PL, Chen L, Samineni VK, Wang Y, Lavine KJ, Gereau IV RW, Wu GF#<\/sup>, Hu H#<\/sup>.<\/em><\/p>\n

A TRPV4-dependent neuro-immune axis in the spinal cord promotes neuropathic pain<\/strong><\/p>\n

J Clin Invest 2023 Mar<\/p>\n

DOI:\u00a010.1172\/JCI161507<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36563677\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Xie Z*<\/sup>, Feng J*<\/sup>, Hibberd TJ*<\/sup>, Chen BN, Zhao Y, Zang K, Hu X, Yang X, Brookes SJ, Spencer NJ#<\/sup>, Hu H#<\/sup>.<\/em><\/p>\n

Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity<\/strong><\/p>\n

Neuron 2023 Feb<\/p>\n

DOI:\u00a010.1016\/j.neuron.2022.11.015<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/35420999\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Xie Z*<\/sup>, Feng J*<\/sup>, Cai T*<\/sup>, McCarthy R, Eschbach MD, Wang Y, Yi Z, Zhao Y, Zang K, Yuan Y, Hu X, Li F, Liu Q, Das A, England SK and Hu H.<\/em><\/p>\n

Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain<\/strong><\/p>\n

JCI Insight 2022 May<\/p>\n

DOI:\u00a010.1172\/jci.insight.149107<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/36240781\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Zhang W, Lyu M, Bessman NJ, Xie Z, Arifuzzaman M, Yano H, Parkhurst CN, Coco Chu C, Zhou L, Zhou J, Putzel GG, Li TT, Jin WB, Hu H, Tsou AM, Guo CJ, Artis D.<\/em><\/p>\n

Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection<\/strong><\/p>\n

Cell 2022 Oct<\/p>\n

DOI:\u00a010.1016\/j.cell.2022.09.008<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/35857641\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Feng J#<\/sup>, Zhao Y, Xie Z, Zang K, Sviben S, Hu X, Fitzpatrick JJ, Wen L, Liu Y, Wang T, Lawson K, Liu Q, Yan Y, Dong X, Han L, Wu GF, Kim BS, Hu H#<\/sup>.<\/em><\/p>\n

Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle<\/strong><\/p>\n

Sci Transl Med 2022 Jul<\/p>\n

DOI:\u00a010.1126\/scitranslmed.abn4819<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/34663597\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Lan Z*<\/sup>, Chen L*<\/sup>, Feng J, Xie Z, Liu Z, Wang F, Liu P, Yue X, Du L, Zhao Y, Yang p, Luo J, Zhu Z, Hu X, Cao L, Lu P, Sah R, Lavine K, Kim BS, Hu H.<\/em><\/p>\n

The mechanosensitive TRPV4 is required for crystal-induced inflammation<\/strong><\/p>\n

Ann Rheum Dis 2021 Dec<\/p>\n

DOI:\u00a010.1136\/annrheumdis-2021-220295<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/34320366\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ.<\/em><\/p>\n

Resident cardiac macrophages mediate adaptive myocardial remodeling<\/strong><\/p>\n

Immunity 2021 Sep<\/p>\n

DOI:\u00a010.1016\/j.immuni.2021.07.003<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/33627432\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Deng Z, Zhao y, Feng J, Zhang J, Zhao Y, Rau MJ, Fitzpatrick J, Hu H, Yuan P. <\/em><\/p>\n

Cryo-EM structure of a proton-activated chloride channel TMEM206<\/strong><\/p>\n

Sci Adv 2021 Feb<\/p>\n

DOI:\u00a010.1126\/sciadv.abe5983<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/33450207\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Wang F, Trier AM, Li F, Kim S, Chen Z, Chai JN, Mack MR, Morrison SA, Hamilton JD, Baek J, Yang TLB, Ver Heul AM, Xu AZ, Xie Z, Dong X, Kubo M, Hu H, Hsieh CS, Dong X, Liu Q, Margolis DJ, Ardeleanu M, Miller MJ, Kim BS.<\/em><\/p>\n

A Basophil-Neuronal Axis Promotes Itch<\/strong><\/p>\n

Cell 2021 Jan<\/p>\n

DOI:\u00a010.1016\/j.cell.2020.12.033<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/33568652\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Arnold WR, Carnevale LN, Xie Z, Baylon JL, Tajkhorshid E, Hu H, Das A.<\/em><\/p>\n

Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel<\/strong><\/p>\n

Nat Commun 2021 Feb<\/p>\n

DOI:\u00a010.1038\/s41467-021-20946-6<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/32152479\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Spencer NJ, Hu H.<\/em><\/p>\n

Enteric Nervous System: Sensory transduction, neural circuits and gastrointestinal motility<\/strong><\/p>\n

Nat Rev Gastroenterol Hepatol 2020<\/p>\n

DOI:\u00a010.1038\/s41575-020-0271-2<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/32572252\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Deng Z, Maksaev G, Rau M, Xie Z, Hu H, Fitzpatrick JAJ & Yuan P.<\/em><\/p>\n

Gating of human TRPV3 in a lipid bilayer<\/strong><\/p>\n

Nat Struct Mol Biol 2020<\/p>\n

DOI:\u00a010.1038\/s41594-020-0428-2<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/31831729\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Li F, Yang W, Jiang H, Guo C, Andrew J. W. Huang AJW, Hu H & Liu Q. <\/em><\/p>\n

TRPV1 activity and substance P release are required for corneal cold nociception<\/strong><\/p>\n

Nat Commun 2019 Dec<\/p>\n

DOI:\u00a010.1038\/s41467-019-13536-0<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/29958798\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Luo J, Qian A, Oetjen LK, Yu W, Yang P, Feng J, Xie Z, Liu S, Yin S, Dryn D, Cheng J, Riehl TE, Zholos AV, Stenson WF, Kim BS#<\/sup>, Hu H#<\/sup>.<\/em><\/p>\n

TRPV4 channel signaling in macrophages promotes gastrointestinal motility via direct effects on smooth muscle cells<\/strong><\/p>\n

Immunity 2018 Jul<\/p>\n

DOI:\u00a010.1016\/j.immuni.2018.04.021<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/29724954\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Feng J, Luo J, Yang P, Du J, Kim BS, Hu H. <\/em><\/p>\n

Piezo2 channel-merkel cell signaling modulates the conversion of touch to itch<\/strong><\/p>\n

Science 2018 May<\/p>\n

DOI:\u00a010.1126\/science.aar5703<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/29782847\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Hibberd TJ*<\/sup>, Feng J*<\/sup>, Samineni VK, Luo J, Yang P, Gereau RW 4th, Hu H#<\/sup>, Spencer NJ#<\/sup>.<\/em><\/p>\n

Optogenetic induction of colonic motility in mice<\/strong><\/p>\n

Gastroenterology 2018 Aug<\/p>\n

DOI:\u00a010.1053\/j.gastro.2018.05.029<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/28807414\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Luo J*<\/sup>, Feng J*<\/sup>, Yu g, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Yin S, Xu A, Cheng J, Liu Q, O’Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Liu Q#<\/sup>, Hu H#<\/sup>.<\/em><\/p>\n

Transient receptor potential vanilloid 4-expressing macrophages and keratinocytes contribute differentially to allergic and nonallergic chronic itch<\/strong><\/p>\n

J Allergy Clin Immun 2018 Feb<\/p>\n

DOI:\u00a010.1016\/j.jaci.2017.05.051<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/28890086\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS.<\/em><\/p>\n

Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch<\/strong><\/p>\n

Cell 2017 Sep<\/p>\n

DOI:\u00a010.1016\/j.cell.2017.08.006<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/29081531\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Feng J*<\/sup>, Yang P*<\/sup>, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Yin S, Kim BS, Hu H.<\/em><\/p>\n

Sensory TRP channels contribute differentially to skin inflammation and persistent itch in a mouse model of contact dermatitis<\/strong><\/p>\n

Nat Commun 2017 Oct<\/p>\n

DOI:\u00a010.1038\/s41467-017-01056-8<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/26293964\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Zhou Y, Wong CO, Cho KJ, van der Hoeven D, Liang H, Thakur DP, Luo J, Babic M, Zinsmaier KE, Zhu MX, Hu H, Venkatachalam K, Hancock JF.<\/em><\/p>\n

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling<\/strong><\/p>\n

Science 2015 Aug<\/p>\n

DOI:\u00a010.1126\/science.aaa5619<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font_size=”14px” text_line_height=”1.5em” background_color=”#FFFFFF” custom_padding=”20px|20px|20px|20px|true|true” link_option_url=”https:\/\/pubmed.ncbi.nlm.nih.gov\/23925292\/ ” link_option_url_new_window=”on” box_shadow_style=”preset1″ box_shadow_vertical=”0px” box_shadow_blur=”40px” box_shadow_color=”rgba(0,0,0,0.14)” global_colors_info=”{}”]<\/p>\n

Yin S*<\/sup>, Luo J*<\/sup>, Qian A, Du J, Yang Q, Zhou S, Yu W, Du G, Clark RB, Walters ET, Carlton SM, Hu H.<\/em><\/p>\n

Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity<\/strong><\/p>\n

J Clin Invest 2013<\/p>\n

DOI:\u00a010.1172\/JCI66413<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.27.4″ _module_preset=”default” scroll_fade_enable=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” link_option_url=”https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/collections\/mybibliography\/” link_option_url_new_window=”on” global_colors_info=”{}”]<\/p>\n

*<\/sup> Co-first authorship<\/p>\n

#<\/sup> Corresponding authors<\/p>\n

See all publications (116 items): https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/collections\/mybibliography\/<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”on|on|on” admin_label=”Footer – Section 13″ module_class=”footer-section” _builder_version=”4.9.0″ background_color=”#c7eafb” background_image=”https:\/\/labs.icahn.mssm.edu\/hongzhenhulab2\/wp-content\/uploads\/sites\/618\/2022\/10\/Rectangle-3.png” max_width=”80%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|40px|0px||” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” disabled=”on” global_module=”425″ saved_tabs=”all” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto||147px||” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_social_media_follow _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” text_orientation=”center” global_colors_info=”{}”][et_pb_social_media_follow_network social_network=”linkedin” url=”https:\/\/www.linkedin.com\/school\/icahnmountsinai\/%20″ use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]linkedin[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”facebook” url=”https:\/\/www.facebook.com\/IcahnMountSinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]facebook[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”twitter” url=”https:\/\/twitter.com\/icahnmountsinai” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”youtube” url=”https:\/\/www.youtube.com\/user\/MountSinaiSchool” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]youtube[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=”instagram” url=”https:\/\/www.instagram.com\/icahnmountsinai\/” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.16″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” global_colors_info=”{}”]instagram[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”24px” global_colors_info=”{}”]<\/p>\n

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Lab Address <\/strong>
One Gustave L. Levy Place
Annenberg
New York, NY 10029<\/p>\n

Mailing Address <\/strong><\/p>\n

Lab Name
Icahn School of Medicine
at Mount Sinai
One Gustave L. Levy Place
<\/span>Annenberg
<\/span>New York, NY 10029<\/span><\/p>\n

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PublicationsSelected PublicationsZhang W, Emanuel ER, Yano H, Uddin J, Gaudino S, Xie Z, Ichise H, Wang Z, Cowan MN, Lyu M, Hou X, Zeng P, Hu E, Ribeiro de Godoy V, Grier A, Estep N, Ishibashi JR, Anover-Sombke S, Skene PJ, Mayassi T, Xavier RJ, Germain RN, Globig AM, Heeg M, Goldrath AW, Kim BS,\u00a0Hu […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-2494","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/hongzhenhulab\/wp-json\/wp\/v2\/pages\/2494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/hongzhenhulab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/hongzhenhulab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/hongzhenhulab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/hongzhenhulab\/wp-json\/wp\/v2\/comments?post=2494"}],"version-history":[{"count":17,"href":"https:\/\/labs.icahn.mssm.edu\/hongzhenhulab\/wp-json\/wp\/v2\/pages\/2494\/revisions"}],"predecessor-version":[{"id":4801,"href":"https:\/\/labs.icahn.mssm.edu\/hongzhenhulab\/wp-json\/wp\/v2\/pages\/2494\/revisions\/4801"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/hongzhenhulab\/wp-json\/wp\/v2\/media?parent=2494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}