Publications

Selected Publications:

1. He Z*, Zhao Y*, Rau M, Fitzpatrick J, Sah R, Hu H#, Yuan P#. Structural and functional analysis of human pannexin 2 channel. Nat Commun. 2023: 14(1):1712.

2. Lu P*, Zhao Y*, Xie Z*, Zhou H, Dong X, Wu GF, Kim BS, Feng J#, Hu H#. MrgprA3-expressing preceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel. Cell Rep 2023: 42(4):112283.

3. Hu X*, Du L*, Liu S*, Lan Z, Zang K, Zhao Y, Yang X, Xie Z, Wang PL, Chen L, Samineni VK, Wang Y, Lavine KJ, Gereau IV RW, Wu GF#, Hu H#. A TRPV4-dependent neuro-immune axis in the spinal cord promotes neuropathic pain. J Clin Invest 2023: 133(5): e161507.

4. Xie Z*, Feng J*, Hibberd TJ*, Chen BN, Zhao Y, Zang K, Hu X, Yang X, Brookes SJ, Spencer NJ#, Hu H#. Colon-innervating PIEZO2-expressing TRPV1-lineage neurons mediate visceral mechanical hypersensitivity. Neuron 2023: 111(4):526-538.e4.

5. Xie Z*, Feng J*, Cai T*, McCarthy R, Eschbach MD, Wang Y, Yi Z, Zhao Y, Zang K, Yuan Y, Hu X, Li F, Liu Q, Das A, England SK and Hu H. Estrogen metabolites increase nociceptor hyperactivity in a mouse model of uterine pain. JCI Insight 2022: 7(10):e149107.

6. Zhang W, Lyu M, Bessman NJ, Xie Z, Arifuzzaman M, Yano H, Parkhurst CN, Coco Chu C, Zhou L, Zhou J, Putzel GG, Li TT, Jin WB, Hu H, Tsou AM, Guo CJ, Artis D. Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell 2022: 185(22):4170-4189.e20.

7. Feng J#, Zhao Y, Xie Z, Zang K, Sviben S, Hu X, Fitzpatrick JJ, Wen L, Liu Y, Wang T, Lawson K, Liu Q, Yan Y, Dong X, Han L, Wu GF, Kim BS, Hu H#. Miswiring of Merkel cell and pruriceptive C fiber drives the itch-scratch cycle. Sci Transl Med 2022: 14(653): eabn4819.

8. Lan Z*, Chen L*, Feng J, Xie Z, Liu Z, Wang F, Liu P, Yue X, Du L, Zhao Y, Yang p, Luo J, Zhu Z, Hu X, Cao L, Lu P, Sah R, Lavine K, Kim BS, Hu H. The mechanosensitive TRPV4 is required for crystal-induced inflammation. Ann Rheum Dis 2021: 80(12):1604-1614.

9. Wong NR, Mohan J, Kopecky BJ, Guo S, Du L, Leid J, Feng G, Lokshina I, Dmytrenko O, Luehmann H, Bajpai G, Ewald L, Bell L, Patel N, Bredemeyer A, Weinheimer CJ, Nigro JM, Kovacs A, Morimoto S, Bayguinov PO, Fisher MR, Stump WT, Greenberg M, Fitzpatrick JAJ, Epelman S, Kreisel D, Sah R, Liu Y, Hu H, Lavine KJ. Resident cardiac macrophages mediate adaptive myocardial remodeling. Immunity 2021: 54(9): 2072-2088.e7.

10. Deng Z, Zhao y, Feng J, Zhang J, Zhao Y, Rau MJ, Fitzpatrick J, Hu H, Yuan P. Cryo-EM structure of a proton-activated chloride channel TMEM206. Sci Adv 2021: 7(9): eabe5983.

11. Wang F, Trier AM, Li F, Kim S, Chen Z, Chai JN, Mack MR, Morrison SA, Hamilton JD, Baek J, Yang TLB, Ver Heul AM, Xu AZ, Xie Z, Dong X, Kubo M, Hu H, Hsieh CS, Dong X, Liu Q, Margolis DJ, Ardeleanu M, Miller MJ, Kim BS. A Basophil-Neuronal Axis Promotes Itch. Cell 2021: 184(2): 422-440.e17.

12. Arnold WR, Carnevale LN, Xie Z, Baylon JL, Tajkhorshid E, Hu H, Das A. Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel. Nat Commun 2021: 12(1): 926.

13. Spencer NJ, Hu H. Enteric Nervous System: Sensory transduction, neural circuits and gastrointestinal motility. Nat Rev Gastroenterol Hepatol 2020: 17(6): 338-351.

14. Deng Z, Maksaev G, Rau M, Xie Z, Hu H, Fitzpatrick JAJ & Yuan P. Gating of human TRPV3 in a lipid bilayer. Nat Struct Mol Biol 2020: 27(7): 635-644.

15. Li F, Yang W, Jiang H, Guo C, Andrew J. W. Huang AJW, Hu H & Liu Q. TRPV1 activity and substance P release are required for corneal cold nociception. Nat Commun 2019: 10(1): 5678.

16. Luo J, Qian A, Oetjen LK, Yu W, Yang P, Feng J, Xie Z, Liu S, Yin S, Dryn D, Cheng J, Riehl TE, Zholos AV, Stenson WF, Kim BS#, Hu H#. TRPV4 channel signaling in macrophages promotes gastrointestinal motility via direct effects on smooth muscle cells. Immunity 2018: 49(1): 107-119.

17. Feng J, Luo J, Yang P, Du J, Kim BS, Hu H. Piezo2 channel-merkel cell signaling modulates the conversion of touch to itch. Science 2018: 360 (6388): 530-533.

18. Hibberd TJ*, Feng J*, Samineni VK, Luo J, Yang P, Gereau RW 4th, Hu H#, Spencer NJ#. Optogenetic induction of colonic motility in mice. Gastroenterology 2018: 155(2): 514-528.

19. Luo J*, Feng J*, Yu g, Yang P, Mack MR, Du J, Yu W, Qian A, Zhang Y, Liu S, Yin S, Xu A, Cheng J, Liu Q, O’Neil RG, Xia Y, Ma L, Carlton SM, Kim BS, Liu Q#, Hu H#. TRPV4-expressing macrophages and keratinocytes contribute differentially to allergic and non-allergic chronic itch. J Allergy Clin Immun 2018: 141(2): 608-619.

20. Oetjen LK, Mack MR, Feng J, Whelan TM, Niu H, Guo CJ, Chen S, Trier AM, Xu AZ, Tripathi SV, Luo J, Gao X, Yang L, Hamilton SL, Wang PL, Brestoff JR, Council ML, Brasington R, Schaffer A, Brombacher F, Hsieh CS, Gereau RW 4th, Miller MJ, Chen ZF, Hu H, Davidson S, Liu Q, Kim BS. Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch. Cell 2017: 171(1): 217-228.

21. Feng J*, Yang P*, Dryn D, Luo J, Gong X, Liu S, Oetjen LK, Zholos AV, Mei Z, Yin S, Kim BS, Hu H. Sensory TRP channels contribute differentially to skin inflammation and persistent itch in a mouse model of contact dermatitis. Nat Commun 2017: 8(1):980.

22. Zhou Y, Wong CO, Cho KJ, van der Hoeven D, Liang H, Thakur DP, Luo J, Babic M, Zinsmaier KE, Zhu MX, Hu H, Venkatachalam K, Hancock JF. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling. Science 2015: 349: 873-876.

23. Yin S*, Luo J*, Qian A, Du J, Yang Q, Zhou S, Yu W, Du G, Clark RB, Walters ET, Carlton SM, Hu H. Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. J Clin Invest 2013: 123: 3941-3951.

See all publications (116 items): https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/

* Co-first authorship

# Corresponding authors